diff --git a/submission.yaml b/submission.yaml
index 8b1378917..518bd800b 100644
--- a/submission.yaml
+++ b/submission.yaml
@@ -1 +1,1071 @@
+- directed: true
+  graph:
+    disease: Candidiasis of skin
+    disease_mesh: MESH:D002179
+    drug: miconazole
+    drug_mesh: MESH:D008825
+    drugbank: DB:DB01110
+  links:
+    - key: negatively regulates
+      source: MESH:D008825
+      target: UniProt:P10613
+    - key: positively regulates
+      source: UniProt:P10613
+      target: GO:0006696
+    - key: in taxon
+      source: GO:0006696
+      target: NCBITaxon:237561
+    - key: causes
+      source: NCBITaxon:237561
+      target: MESH:D002179
+  multigraph: true
+  nodes:
+    - id: MESH:D008825
+      label: Drug
+      name: miconazole
+    - id: UniProt:P10613
+      label: Protein
+      name: Lanosterol 14-alpha demethylase
+    - id: GO:0006696
+      label: BiologicalProcess
+      name: ergosterol biosynthetic process
+    - id: NCBITaxon:237561
+      label: OrganismTaxon
+      name: Candida albicans SC5314
+    - id: MESH:D002179
+      label: Disease
+      name: Candidiasis of skin
+  reference:
+    - https://go.drugbank.com/drugs/DB01110
+    - https://en.wikipedia.org/wiki/Miconazole#Mechanism_of_action
+    - https://en.wikipedia.org/wiki/Ergosterol#Target_for_antifungal_drugs
+  comment: In addition to its antifungal actions, miconazole has antiglucocorticoid effects (https://pubmed.ncbi.nlm.nih.gov/16608920/).
+- directed: true
+  graph:
+    disease: Pityriasis versicolor
+    disease_mesh: MESH:D014010
+    drug: miconazole
+    drug_mesh: MESH:D008825
+    drugbank: DB:DB01110
+  links:
+    - key: negatively regulates
+      source: MESH:D008825
+      target: InterPro:IPR001128
+    - key: positively regulates
+      source: UniProt:P10613
+      target: GO:0006696
+    - key: in taxon
+      source: GO:0006696
+      target: NCBITaxon:76773
+    - key: causes
+      source: NCBITaxon:76773
+      target: MESH:D014010
+  multigraph: true
+  nodes:
+    - id: MESH:D008825
+      label: Drug
+      name: miconazole
+    - id: InterPro:IPR001128
+      label: GeneFamily
+      name: Cytochrome P450
+    - id: GO:0006696
+      label: BiologicalProcess
+      name: ergosterol biosynthetic process
+    - id: NCBITaxon:76773
+      label: OrganismTaxon
+      name: Malassezia globosa
+    - id: MESH:D014010
+      label: Disease
+      name: Pityriasis versicolor
+  reference:
+    - https://go.drugbank.com/drugs/DB01110
+    - https://en.wikipedia.org/wiki/Miconazole#Mechanism_of_action
+    - https://en.wikipedia.org/wiki/Ergosterol#Target_for_antifungal_drugs
+  comment: In addition to its antifungal actions, miconazole has antiglucocorticoid effects (https://pubmed.ncbi.nlm.nih.gov/16608920/).
+- directed: true
+  graph:
+    disease: Candidal vulvovaginitis
+    disease_mesh: MESH:D002181
+    drug: miconazole
+    drug_mesh: MESH:D008825
+    drugbank: DB:DB01110
+  links:
+    - key: negatively regulates
+      source: MESH:D008825
+      target: UniProt:P10613
+    - key: positively regulates
+      source: UniProt:P10613
+      target: GO:0006696
+    - key: in taxon
+      source: GO:0006696
+      target: NCBITaxon:237561
+    - key: causes
+      source: NCBITaxon:237561
+      target: MESH:D002181
+  multigraph: true
+  nodes:
+    - id: MESH:D008825
+      label: Drug
+      name: miconazole
+    - id: UniProt:P10613
+      label: Protein
+      name: Lanosterol 14-alpha demethylase
+    - id: GO:0006696
+      label: BiologicalProcess
+      name: ergosterol biosynthetic process
+    - id: NCBITaxon:237561
+      label: OrganismTaxon
+      name: Candida albicans SC5314
+    - id: MESH:D002181
+      label: Disease
+      name: Candidal vulvovaginitis
+  reference:
+    - https://go.drugbank.com/drugs/DB01110
+    - https://en.wikipedia.org/wiki/Miconazole#Mechanism_of_action
+    - https://en.wikipedia.org/wiki/Ergosterol#Target_for_antifungal_drugs
+  comment: In addition to its antifungal actions, miconazole has antiglucocorticoid effects (https://pubmed.ncbi.nlm.nih.gov/16608920/).
+- directed: true
+  graph:
+    disease: Onychomycosis due to dermatophyte
+    disease_mesh: MESH:D014009
+    drug: miconazole
+    drug_mesh: MESH:D008825
+    drugbank: DB:DB01110
+  links:
+    - key: negatively regulates
+      source: MESH:D008825
+      target: InterPro:IPR001128
+    - key: positively regulates
+      source: InterPro:IPR001128
+      target: GO:0006696
+    - key: in taxon
+      source: GO:0006696
+      target: NCBITaxon:5551
+    - key: causes
+      source: NCBITaxon:5551
+      target: MESH:D014009
+  multigraph: true
+  nodes:
+    - id: MESH:D008825
+      label: Drug
+      name: miconazole
+    - id: InterPro:IPR001128
+      label: GeneFamily
+      name: Cytochrome P450
+    - id: GO:0006696
+      label: BiologicalProcess
+      name: ergosterol biosynthetic process
+    - id: NCBITaxon:5551
+      label: OrganismTaxon
+      name: Trichophyton rubrum
+    - id: MESH:D014009
+      label: Disease
+      name: Onychomycosis due to dermatophyte
+  reference:
+    - https://go.drugbank.com/drugs/DB01110
+    - https://en.wikipedia.org/wiki/Miconazole#Mechanism_of_action
+    - https://en.wikipedia.org/wiki/Ergosterol#Target_for_antifungal_drugs
+  comment: In addition to its antifungal actions, miconazole has antiglucocorticoid effects (https://pubmed.ncbi.nlm.nih.gov/16608920/).
+- directed: true
+  graph:
+    disease: Tinea pedis
+    disease_mesh: MESH:D014008
+    drug: miconazole
+    drug_mesh: MESH:D008825
+    drugbank: DB:DB01110
+  links:
+    - key: negatively regulates
+      source: MESH:D008825
+      target: InterPro:IPR001128
+    - key: positively regulates
+      source: InterPro:IPR001128
+      target: GO:0006696
+    - key: in taxon
+      source: GO:0006696
+      target: NCBITaxon:5551
+    - key: causes
+      source: NCBITaxon:5551
+      target: MESH:D014008
+  multigraph: true
+  nodes:
+    - id: MESH:D008825
+      label: Drug
+      name: miconazole
+    - id: InterPro:IPR001128
+      label: GeneFamily
+      name: Cytochrome P450
+    - id: GO:0006696
+      label: BiologicalProcess
+      name: ergosterol biosynthetic process
+    - id: NCBITaxon:5551
+      label: OrganismTaxon
+      name: Trichophyton rubrum
+    - id: MESH:D014008
+      label: Disease
+      name: Tinea pedis
+  reference:
+    - https://go.drugbank.com/drugs/DB01110
+    - https://en.wikipedia.org/wiki/Miconazole#Mechanism_of_action
+    - https://en.wikipedia.org/wiki/Ergosterol#Target_for_antifungal_drugs
+  comment: In addition to its antifungal actions, miconazole has antiglucocorticoid effects (https://pubmed.ncbi.nlm.nih.gov/16608920/).
+- directed: true
+  graph:
+    disease: Diaper rash
+    disease_mesh: MESH:D003963
+    drug: miconazole
+    drug_mesh: MESH:D008825
+    drugbank: DB:DB01110
+  links:
+    - key: negatively regulates
+      source: MESH:D008825
+      target: UniProt:P10613
+    - key: positively regulates
+      source: UniProt:P10613
+      target: GO:0006696
+    - key: in taxon
+      source: GO:0006696
+      target: NCBITaxon:237561
+    - key: causes
+      source: NCBITaxon:237561
+      target: MESH:D003963
+  multigraph: true
+  nodes:
+    - id: MESH:D008825
+      label: Drug
+      name: miconazole
+    - id: UniProt:P10613
+      label: Protein
+      name: Lanosterol 14-alpha demethylase
+    - id: GO:0006696
+      label: BiologicalProcess
+      name: ergosterol biosynthetic process
+    - id: NCBITaxon:237561
+      label: OrganismTaxon
+      name: Candida albicans SC5314
+    - id: MESH:D003963
+      label: Disease
+      name: Diaper rash
+  reference:
+    - https://go.drugbank.com/drugs/DB01110
+    - https://en.wikipedia.org/wiki/Miconazole#Mechanism_of_action
+    - https://en.wikipedia.org/wiki/Ergosterol#Target_for_antifungal_drugs
+  comment: In addition to its antifungal actions, miconazole has antiglucocorticoid effects (https://pubmed.ncbi.nlm.nih.gov/16608920/).
+- directed: true
+  graph:
+    disease: Urticaria
+    disease_mesh: MESH:D014581
+    drug: methapyrilene
+    drug_mesh: MESH:D008701
+    drugbank: DB:DB04819
+  links:
+    - key: negatively regulates
+      source: MESH:D008701
+      target: UniProt:P35367
+    - key: positively regulates
+      source: UniProt:P35367
+      target: GO:0004969
+    - key: positively correlated with
+      source: GO:0004969
+      target: GO:0002441
+    - key: positively correlated with
+      source: GO:0002441
+      target: MESH:D014581
+  multigraph: true
+  nodes:
+    - id: MESH:D008701
+      label: Drug
+      name: methapyrilene
+    - id: UniProt:P35367
+      label: Protein
+      name: Histamine H1 receptor
+    - id: GO:0004969
+      label: MolecularActivity
+      name: histamine receptor activity
+    - id: GO:0002441
+      label: BiologicalProcess
+      name: histamine secretion involved in inflammatory response
+    - id: MESH:D014581
+      label: Disease
+      name: Urticaria
+  reference:
+    - https://en.wikipedia.org/wiki/Methapyrilene
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1411979/
+- directed: true
+  graph:
+    disease: Vasomotor rhinitis
+    disease_mesh: MESH:D012223
+    drug: methapyrilene
+    drug_mesh: MESH:D008701
+    drugbank: DB:DB04819
+  links:
+    - key: negatively regulates
+      source: MESH:D008701
+      target: UniProt:P35367
+    - key: positively regulates
+      source: UniProt:P35367
+      target: GO:0004969
+    - key: positively correlated with
+      source: GO:0004969
+      target: GO:0042311
+    - key: positively correlated with
+      source: GO:0042311
+      target: MESH:D012223
+  multigraph: true
+  nodes:
+    - id: MESH:D008701
+      label: Drug
+      name: methapyrilene
+    - id: UniProt:P35367
+      label: Protein
+      name: Histamine H1 receptor
+    - id: GO:0004969
+      label: MolecularActivity
+      name: histamine receptor activity
+    - id: GO:0042311
+      label: BiologicalProcess
+      name: vasodilation
+    - id: MESH:D012223
+      label: Disease
+      name: Vasomotor rhinitis
+  reference:
+    - https://en.wikipedia.org/wiki/Methapyrilene
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1411979/
+- directed: true
+  graph:
+    disease: Allergic rhinitis
+    disease_mesh: MESH:D065631
+    drug: methapyrilene
+    drug_mesh: MESH:D008701
+    drugbank: DB:DB04819
+  links:
+    - key: negatively regulates
+      source: MESH:D008701
+      target: UniProt:P35367
+    - key: positively regulates
+      source: UniProt:P35367
+      target: GO:0004969
+    - key: positively correlated with
+      source: GO:0004969
+      target: GO:0002441
+    - key: positively correlated with
+      source: GO:0002441
+      target: MESH:D065631
+  multigraph: true
+  nodes:
+    - id: MESH:D008701
+      label: Drug
+      name: methapyrilene
+    - id: UniProt:P35367
+      label: Protein
+      name: Histamine H1 receptor
+    - id: GO:0004969
+      label: MolecularActivity
+      name: histamine receptor activity
+    - id: GO:0002441
+      label: BiologicalProcess
+      name: histamine secretion involved in inflammatory response
+    - id: MESH:D065631
+      label: Disease
+      name: Allergic rhinitis
+  reference:
+    - https://en.wikipedia.org/wiki/Methapyrilene
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1411979/
+- directed: true
+  graph:
+    disease: Sneezing
+    disease_mesh: MESH:D012912
+    drug: methapyrilene
+    drug_mesh: MESH:D008701
+    drugbank: DB:DB04819
+  links:
+    - key: negatively regulates
+      source: MESH:D008701
+      target: UniProt:P35367
+    - key: positively regulates
+      source: UniProt:P35367
+      target: GO:0004969
+    - key: positively correlated with
+      source: GO:0004969
+      target: GO:0002441
+    - key: positively correlated with
+      source: GO:0002441
+      target: MESH:D012912
+  multigraph: true
+  nodes:
+    - id: MESH:D008701
+      label: Drug
+      name: methapyrilene
+    - id: UniProt:P35367
+      label: Protein
+      name: Histamine H1 receptor
+    - id: GO:0004969
+      label: MolecularActivity
+      name: histamine receptor activity
+    - id: GO:0002441
+      label: BiologicalProcess
+      name: histamine secretion involved in inflammatory response
+    - id: MESH:D012912
+      label: Disease
+      name: Sneezing
+  reference:
+    - https://en.wikipedia.org/wiki/Methapyrilene
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1411979/
+- directed: true
+  graph:
+    disease: Allergic conjunctivitis
+    disease_mesh: MESH:D003233
+    drug: methapyrilene
+    drug_mesh: MESH:D008701
+    drugbank: DB:DB04819
+  links:
+    - key: negatively regulates
+      source: MESH:D008701
+      target: UniProt:P35367
+    - key: positively regulates
+      source: UniProt:P35367
+      target: GO:0004969
+    - key: positively correlated with
+      source: GO:0004969
+      target: GO:0002441
+    - key: positively correlated with
+      source: GO:0002441
+      target: MESH:D003233
+  multigraph: true
+  nodes:
+    - id: MESH:D008701
+      label: Drug
+      name: methapyrilene
+    - id: UniProt:P35367
+      label: Protein
+      name: Histamine H1 receptor
+    - id: GO:0004969
+      label: MolecularActivity
+      name: histamine receptor activity
+    - id: GO:0002441
+      label: BiologicalProcess
+      name: histamine secretion involved in inflammatory response
+    - id: MESH:D003233
+      label: Disease
+      name: Allergic conjunctivitis
+  reference:
+    - https://en.wikipedia.org/wiki/Methapyrilene
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1411979/
+- directed: true
+  graph:
+    disease: Itching of skin
+    disease_mesh: MESH:D011537
+    drug: methapyrilene
+    drug_mesh: MESH:D008701
+    drugbank: DB:DB04819
+  links:
+    - key: negatively regulates
+      source: MESH:D008701
+      target: UniProt:P35367
+    - key: positively regulates
+      source: UniProt:P35367
+      target: GO:0004969
+    - key: positively correlated with
+      source: GO:0004969
+      target: GO:0002441
+    - key: positively correlated with
+      source: GO:0002441
+      target: MESH:D011537
+  multigraph: true
+  nodes:
+    - id: MESH:D008701
+      label: Drug
+      name: methapyrilene
+    - id: UniProt:P35367
+      label: Protein
+      name: Histamine H1 receptor
+    - id: GO:0004969
+      label: MolecularActivity
+      name: histamine receptor activity
+    - id: GO:0002441
+      label: BiologicalProcess
+      name: histamine secretion involved in inflammatory response
+    - id: MESH:D011537
+      label: Disease
+      name: Itching of skin
+  reference:
+    - https://en.wikipedia.org/wiki/Methapyrilene
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1411979/
+- directed: true
+  graph:
+    disease: Peptic ulcer
+    disease_mesh: MESH:D010437
+    drug: methylhomatropine
+    drug_mesh: MESH:C056244
+    drugbank: DB:DB00725
+  links:
+    - key: negatively regulates
+      source: MESH:C056244
+      target: UniProt:P11229
+    - key: negatively regulates
+      source: MESH:C056244
+      target: UniProt:P08172
+    - key: negatively regulates
+      source: MESH:C056244
+      target: UniProt:P20309
+    - key: negatively regulates
+      source: MESH:C056244
+      target: UniProt:P08173
+    - key: negatively regulates
+      source: MESH:C056244
+      target: UniProt:P08912
+    - key: participates in
+      source: UniProt:P11229
+      target: GO:0007197
+    - key: participates in
+      source: UniProt:P08172
+      target: GO:0007197
+    - key: participates in
+      source: UniProt:P20309
+      target: GO:0007197
+    - key: participates in
+      source: UniProt:P08173
+      target: GO:0007197
+    - key: participates in
+      source: UniProt:P08912
+      target: GO:0007197
+    - key: increases abundance of
+      source: GO:0007197
+      target: MESH:D005744
+    - key: contributes to
+      source: MESH:D005744
+      target: MESH:D010437
+  multigraph: true
+  nodes:
+    - id: MESH:C056244
+      label: Drug
+      name: methylhomatropine
+      alt_names:
+        - Homatropine methylbromide
+    - id: UniProt:P11229
+      label: Protein
+      name: Muscarinic acetylcholine receptor M1
+    - id: UniProt:P08172
+      label: Protein
+      name: Muscarinic acetylcholine receptor M2
+    - id: UniProt:P20309
+      label: Protein
+      name: Muscarinic acetylcholine receptor M3
+    - id: UniProt:P08173
+      label: Protein
+      name: Muscarinic acetylcholine receptor M4
+    - id: UniProt:P08912
+      label: Protein
+      name: Muscarinic acetylcholine receptor M5
+    - id: GO:0007197
+      label: BiologicalProcess
+      name: adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
+    - id: MESH:D005744
+      label: ChemicalSubstance
+      name: Gastric Acid
+    - id: MESH:D010437
+      label: Disease
+      name: Peptic ulcer
+  reference:
+    - https://go.drugbank.com/drugs/DB00725
+    - https://en.wikipedia.org/wiki/Homatropine_methylbromide
+    - https://pubmed.ncbi.nlm.nih.gov/2865092/
+- directed: true
+  graph:
+    disease: Cough
+    disease_mesh: MESH:D003371
+    drug: methylhomatropine
+    drug_mesh: MESH:C056244
+    drugbank: DB:DB00725
+  links:
+    - key: negatively regulates
+      source: MESH:C056244
+      target: UniProt:P11229
+    - key: negatively regulates
+      source: MESH:C056244
+      target: UniProt:P08172
+    - key: negatively regulates
+      source: MESH:C056244
+      target: UniProt:P20309
+    - key: negatively regulates
+      source: MESH:C056244
+      target: UniProt:P08173
+    - key: negatively regulates
+      source: MESH:C056244
+      target: UniProt:P08912
+    - key: participates in
+      source: UniProt:P11229
+      target: GO:0007197
+    - key: participates in
+      source: UniProt:P08172
+      target: GO:0007197
+    - key: participates in
+      source: UniProt:P20309
+      target: GO:0007197
+    - key: participates in
+      source: UniProt:P08173
+      target: GO:0007197
+    - key: participates in
+      source: UniProt:P08912
+      target: GO:0007197
+    - key: positively correlated with
+      source: GO:0007197
+      target: HP:4000007
+    - key: contributes to
+      source: HP:4000007
+      target: MESH:D003371
+  multigraph: true
+  nodes:
+    - id: MESH:C056244
+      label: Drug
+      name: methylhomatropine
+      alt_names:
+        - Homatropine methylbromide
+    - id: UniProt:P11229
+      label: Protein
+      name: Muscarinic acetylcholine receptor M1
+    - id: UniProt:P08172
+      label: Protein
+      name: Muscarinic acetylcholine receptor M2
+    - id: UniProt:P20309
+      label: Protein
+      name: Muscarinic acetylcholine receptor M3
+    - id: UniProt:P08173
+      label: Protein
+      name: Muscarinic acetylcholine receptor M4
+    - id: UniProt:P08912
+      label: Protein
+      name: Muscarinic acetylcholine receptor M5
+    - id: GO:0007197
+      label: BiologicalProcess
+      name: adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
+    - id: HP:4000007
+      label: PhenotypicFeature
+      name: Bronchoconstriction
+    - id: MESH:D003371
+      label: Disease
+      name: Cough
+  reference:
+    - https://go.drugbank.com/drugs/DB00725
+    - https://en.wikipedia.org/wiki/Homatropine_methylbromide
+    - https://wtcs.pressbooks.pub/pharmacology/chapter/5-11-anticholinergics/
+- directed: true
+  graph:
+    disease: Irritable bowel syndrome
+    disease_mesh: MESH:D043183
+    drug: methylhomatropine
+    drug_mesh: MESH:C056244
+    drugbank: DB:DB00725
+  links:
+    - key: negatively regulates
+      source: MESH:C056244
+      target: UniProt:P11229
+    - key: negatively regulates
+      source: MESH:C056244
+      target: UniProt:P08172
+    - key: negatively regulates
+      source: MESH:C056244
+      target: UniProt:P20309
+    - key: negatively regulates
+      source: MESH:C056244
+      target: UniProt:P08173
+    - key: negatively regulates
+      source: MESH:C056244
+      target: UniProt:P08912
+    - key: participates in
+      source: UniProt:P11229
+      target: GO:0007197
+    - key: participates in
+      source: UniProt:P08172
+      target: GO:0007197
+    - key: participates in
+      source: UniProt:P20309
+      target: GO:0007197
+    - key: participates in
+      source: UniProt:P08173
+      target: GO:0007197
+    - key: participates in
+      source: UniProt:P08912
+      target: GO:0007197
+    - key: positively correlated with
+      source: GO:0007197
+      target: HP:0032155
+    - key: manifestation of
+      source: HP:0032155
+      target: MESH:D043183
+  multigraph: true
+  nodes:
+    - id: MESH:C056244
+      label: Drug
+      name: methylhomatropine
+      alt_names:
+        - Homatropine methylbromide
+    - id: UniProt:P11229
+      label: Protein
+      name: Muscarinic acetylcholine receptor M1
+    - id: UniProt:P08172
+      label: Protein
+      name: Muscarinic acetylcholine receptor M2
+    - id: UniProt:P20309
+      label: Protein
+      name: Muscarinic acetylcholine receptor M3
+    - id: UniProt:P08173
+      label: Protein
+      name: Muscarinic acetylcholine receptor M4
+    - id: UniProt:P08912
+      label: Protein
+      name: Muscarinic acetylcholine receptor M5
+    - id: GO:0007197
+      label: BiologicalProcess
+      name: adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
+    - id: HP:0032155
+      label: PhenotypicFeature
+      name: Abdominal cramps
+    - id: MESH:D043183
+      label: Disease
+      name: Irritable bowel syndrome
+  reference:
+    - https://go.drugbank.com/drugs/DB00725
+    - https://en.wikipedia.org/wiki/Homatropine_methylbromide
+    - https://en.wikipedia.org/wiki/Irritable_bowel_syndrome#Medication
+- directed: true
+  graph:
+    disease: Glucosylceramide beta-glucosidase deficiency
+    disease_mesh: MESH:D005776
+    drug: miglustat
+    drug_mesh: MESH:C059896
+    drugbank: DB:DB00419
+  links:
+    - key: decreases activity of
+      source: MESH:C059896
+      target: UniProt:Q16739
+    - key: positively regulates
+      source: UniProt:Q16739
+      target: GO:0006679
+    - key: increases abundance of
+      source: GO:0006679
+      target: CHEBI:36500
+    - key: positively correlated with
+      source: CHEBI:36500
+      target: MESH:D005776
+  multigraph: true
+  nodes:
+    - id: MESH:C059896
+      label: Drug
+      name: miglustat
+    - id: UniProt:Q16739
+      label: Protein
+      name: Ceramide glucosyltransferase
+    - id: GO:0006679
+      label: BiologicalProcess
+      name: glucosylceramide biosynthetic process
+    - id: CHEBI:36500
+      label: ChemicalSubstance
+      name: glucosylceramide
+    - id: MESH:D005776
+      label: Disease
+      name: Glucosylceramide beta-glucosidase deficiency
+      alt_names:
+        - Gaucher Disease
+  reference:
+    - https://go.drugbank.com/drugs/DB00419
+    - https://en.wikipedia.org/wiki/Miglustat#Mechanism_of_action
+    - https://en.wikipedia.org/wiki/Gaucher%27s_disease
+    - https://en.wikipedia.org/wiki/Glucocerebrosidase#Clinical_significance
+    - https://en.wikipedia.org/wiki/Substrate_reduction_therapy
+  comment: Miglustat is an example of a substrate reduction therapy and it inhibits the synthesis of glucosylceramide (also known as glucocerebroside).
+- directed: true
+  graph:
+    disease: Niemann-Pick disease, type C
+    disease_mesh: MESH:D052556
+    drug: miglustat
+    drug_mesh: MESH:C059896
+    drugbank: DB:DB00419
+  links:
+    - key: decreases activity of
+      source: MESH:C059896
+      target: UniProt:Q16739
+    - key: positively regulates
+      source: UniProt:Q16739
+      target: GO:0006679
+    - key: increases abundance of
+      source: GO:0006679
+      target: CHEBI:36500
+    - key: positively correlated with
+      source: CHEBI:36500
+      target: HP:0000707
+    - key: manifestation of
+      source: HP:0000707
+      target: MESH:D052556
+  multigraph: true
+  nodes:
+    - id: MESH:C059896
+      label: Drug
+      name: miglustat
+    - id: UniProt:Q16739
+      label: Protein
+      name: Ceramide glucosyltransferase
+    - id: GO:0006679
+      label: BiologicalProcess
+      name: glucosylceramide biosynthetic process
+    - id: CHEBI:36500
+      label: ChemicalSubstance
+      name: glucosylceramide
+    - id: HP:0000707
+      label: PhenotypicFeature
+      name: Abnormality of the nervous system
+    - id: MESH:D052556
+      label: Disease
+      name: Niemann-Pick disease, type C
+  reference:
+    - https://go.drugbank.com/drugs/DB00419
+    - https://pubmed.ncbi.nlm.nih.gov/30111334/
+    - https://en.wikipedia.org/wiki/Niemann%E2%80%93Pick_disease,_type_C#Other_treatments_under_investigation
+    - https://en.wikipedia.org/wiki/Miglustat#Mechanism_of_action
+    - https://en.wikipedia.org/wiki/Substrate_reduction_therapy
+  comment: Miglustat is an example of a substrate reduction therapy and it inhibits the synthesis of glucosylceramide (also known as glucocerebroside).
+- directed: true
+  graph:
+    disease: Alzheimer's disease
+    disease_mesh: MESH:D000544
+    drug: galantamine
+    drug_mesh: MESH:D005702
+    drugbank: DB:DB00674
+  links:
+    - key: decreases activity of
+      source: MESH:D005702
+      target: UniProt:P22303
+    - key: positively regulates
+      source: UniProt:P22303
+      target: GO:0006581
+    - key: decreases abundance of
+      source: GO:0006581
+      target: CHEBI:15355
+    - key: negatively correlated with
+      source: CHEBI:15355
+      target: HP:0100543
+    - key: manifestation of
+      source: HP:0100543
+      target: MESH:D000544
+  multigraph: true
+  nodes:
+    - id: MESH:D005702
+      label: Drug
+      name: galantamine
+    - id: UniProt:P22303
+      label: Protein
+      name: Acetylcholinesterase
+    - id: GO:0006581
+      label: BiologicalProcess
+      name: acetylcholine catabolic process
+    - id: CHEBI:15355
+      label: ChemicalSubstance
+      name: acetylcholine
+    - id: HP:0100543
+      label: PhenotypicFeature
+      name: Cognitive impairment
+    - id: MESH:D000544
+      label: Disease
+      name: Alzheimer's disease
+  reference:
+    - https://go.drugbank.com/drugs/DB00674#BE0000426
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL659/
+  comment: The cause of cognitive impairment in Alzheimer's Disease is not fully understood. It's khown that acetylcholine producing neurons degenerate and it's believed that this cholinergic loss is correlated with cognitive impairment and a density of amyloid plaques (https://pubchem.ncbi.nlm.nih.gov/compound/9651#section=Mechanism-of-Action).
+- directed: true
+  graph:
+    disease: Migraine
+    disease_mesh: MESH:D008881
+    drug: zolmitriptan
+    drug_mesh: MESH:C089750
+    drugbank: DB:DB00315
+  links:
+    - key: positively regulates
+      source: MESH:C089750
+      target: UniProt:P28221
+    - key: positively regulates
+      source: MESH:C089750
+      target: UniProt:P28222
+    - key: positively regulates
+      source: MESH:C089750
+      target: UniProt:P30939
+    - key: negatively regulates
+      source: UniProt:P28221
+      target: GO:0150076
+    - key: negatively regulates
+      source: UniProt:P30939
+      target: GO:0150076
+    - key: positively regulates
+      source: UniProt:P28222
+      target: GO:0042310
+    - key: positively correlated with
+      source: GO:0150076
+      target: MESH:D008881
+    - key: negatively correlated with
+      source: GO:0042310
+      target: MESH:D008881
+  multigraph: true
+  nodes:
+    - id: MESH:C089750
+      label: Drug
+      name: zolmitriptan
+    - id: UniProt:P28221
+      label: Protein
+      name: 5-hydroxytryptamine receptor 1D
+    - id: UniProt:P28222
+      label: Protein
+      name: 5-hydroxytryptamine receptor 1B
+    - id: UniProt:P30939
+      label: Protein
+      name: 5-hydroxytryptamine receptor 1F
+    - id: GO:0042310
+      label: BiologicalProcess
+      name: vasoconstriction
+    - id: GO:0150076
+      label: BiologicalProcess
+      name: neuroinflammatory response
+    - id: MESH:D008881
+      label: Disease
+      name: Migraine
+  reference:
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1185/
+    - https://en.wikipedia.org/wiki/Zolmitriptan#Mechanism_of_action
+    - https://go.drugbank.com/drugs/DB00315
+    - https://pubmed.ncbi.nlm.nih.gov/31263254/
+    - https://pubmed.ncbi.nlm.nih.gov/15911785/
+    - https://pubmed.ncbi.nlm.nih.gov/15320857/
+- directed: true
+  graph:
+    disease: Cystic fibrosis
+    disease_mesh: MESH:D003550
+    drug: nafamostat
+    drug_mesh: MESH:C032855
+    drugbank: DB:DB12598
+  links:
+    - key: decreases activity of
+      source: MESH:C032855
+      target: InterPro:IPR001873
+    - key: positively regulates
+      source: InterPro:IPR001873
+      target: GO:0070254
+    - key: positively correlated with
+      source: GO:0070254
+      target: HP:0006536
+    - key: manifestation of
+      source: HP:0006536
+      target: MESH:D003550
+  multigraph: true
+  nodes:
+    - id: MESH:C032855
+      label: Drug
+      name: nafamostat
+    - id: InterPro:IPR001873
+      label: GeneFamily
+      name: Epithelial sodium channel
+    - id: GO:0070254
+      label: BiologicalProcess
+      name: mucus secretion
+    - id: HP:0006536
+      label: PhenotypicFeature
+      name: Airway obstruction
+    - id: MESH:D003550
+      label: Disease
+      name: Cystic fibrosis
+  reference:
+    - https://www.ema.europa.eu/en/medicines/human/orphan-designations/eu310782
+    - https://pubchem.ncbi.nlm.nih.gov/compound/4413
+  comment: Nafamostat mesilate is expected to work by reducing ENaC activity, stimulating the clearance of mucus and relieving the symptoms of the disease.
+- directed: true
+  graph:
+    disease: Sarcoma of soft tissue
+    disease_mesh: MESH:D012509
+    drug: olaratumab
+    drug_mesh: MESH:C000589393
+    drugbank: DB:DB06043
+  links:
+    - key: decreases activity of
+      source: MESH:C000589393
+      target: UniProt:P16234
+    - key: positively regulates
+      source: UniProt:P16234
+      target: GO:0008283
+    - key: positively correlated with
+      source: GO:0008283
+      target: MESH:D012509
+  multigraph: true
+  nodes:
+    - id: MESH:C000589393
+      label: Drug
+      name: olaratumab
+    - id: UniProt:P16234
+      label: Protein
+      name: Platelet-derived growth factor receptor alpha
+    - id: GO:0008283
+      label: BiologicalProcess
+      name: cell population proliferation
+    - id: MESH:D012509
+      label: Disease
+      name: Sarcoma of soft tissue
+  reference:
+    - https://go.drugbank.com/drugs/DB12598
+    - https://en.wikipedia.org/wiki/Olaratumab#Mechanism_of_action
+- directed: true
+  graph:
+    disease: Hairy cell leukemia
+    disease_mesh: MESH:D007943
+    drug: pentostatin
+    drug_mesh: MESH:D015649
+    drugbank: DB:DB00552
+  links:
+    - key: decreases activity of
+      source: MESH:D015649
+      target: UniProt:P00813
+    - key: negatively regulates
+      source: MESH:D015649
+      target: GO:0032774
+    - key: positively correlated with
+      source: GO:0032774
+      target: GO:0046651
+    - key: positively regulates
+      source: UniProt:P00813
+      target: GO:0046061
+    - key: decreases abundance of
+      source: GO:0046061
+      target: CHEBI:16284
+    - key: negatively correlated with
+      source: CHEBI:16284
+      target: GO:0006260
+    - key: positively correlated with
+      source: GO:0006260
+      target: GO:0046651
+    - key: positively correlated with
+      source: GO:0046651
+      target: MESH:D007943
+  multigraph: true
+  nodes:
+    - id: MESH:D015649
+      label: Drug
+      name: pentostatin
+    - id: UniProt:P00813
+      label: Protein
+      name: Adenosine deaminase
+    - id: GO:0046061
+      label: BiologicalProcess
+      name: dATP catabolic process
+    - id: GO:0032774
+      label: BiologicalProcess
+      name: RNA biosynthetic process
+    - id: CHEBI:16284
+      label: ChemicalSubstance
+      name: dATP
+    - id: GO:0006260
+      label: BiologicalProcess
+      name: DNA replication
+    - id: GO:0046651
+      label: BiologicalProcess
+      name: lymphocyte proliferation
+    - id: MESH:D007943
+      label: Disease
+      name: Hairy cell leukemia
+  reference:
+    - https://go.drugbank.com/drugs/DB00552
+    - https://pubchem.ncbi.nlm.nih.gov/compound/439693#section=Mechanism-of-Action