From 2b39f28e8cbdfc6189977a05e12cbb06d91caf57 Mon Sep 17 00:00:00 2001 From: dede2021 Date: Sat, 26 Mar 2022 19:42:35 +0000 Subject: [PATCH] Commit from GitHub Actions (Update Indications on Merge) --- indication_paths.json | 1955 +++++++++++++++++++++++++++++++++++++++++ indication_paths.yaml | 1232 ++++++++++++++++++++++++++ submission.yaml | 1206 +------------------------ 3 files changed, 3188 insertions(+), 1205 deletions(-) diff --git a/indication_paths.json b/indication_paths.json index d219d0fff..ba0653cd6 100644 --- a/indication_paths.json +++ b/indication_paths.json @@ -305249,5 +305249,1960 @@ "https://en.wikipedia.org/wiki/Angina", "https://en.wikipedia.org/wiki/Atherosclerosis" ] + }, + { + "directed": true, + "graph": { + "_id": "DB01122_MESH_D009157_1", + "disease": "Myasthenia Gravis", + "disease_mesh": "MESH:D009157", + "drug": "ambenonium", + "drug_mesh": "MESH:D000549", + "drugbank": "DB:DB01122" + }, + "links": [ + { + "key": "decreases activity of", + "source": 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"MESH:D000787", + "drug": "imolamine", + "drug_mesh": "MESH:C002787", + "drugbank": "DB:DB09284" + }, + "links": [ + { + "key": "positively regulates", + "source": "MESH:C002787", + "target": "GO:0042311" + }, + { + "key": "negatively correlated with", + "source": "GO:0042311", + "target": "MESH:D017202" + }, + { + "key": "contributes to", + "source": "MESH:D017202", + "target": "MESH:D000787" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:C002787", + "label": "Drug", + "name": "imolamine" + }, + { + "id": "GO:0042311", + "label": "BiologicalProcess", + "name": "vasodilation" + }, + { + "id": "MESH:D017202", + "label": "Disease", + "name": "Myocardial Ischemia" + }, + { + "id": "MESH:D000787", + "label": "Disease", + "name": "Angina Pectoris" + } + ], + "reference": [ + "https://drugs.ncats.io/drug/K5F4RU5VQJ", + "https://en.wikipedia.org/wiki/Angina" + ] + }, + { + "directed": true, + "graph": { + "_id": "DB12465_MESH_D006973_1", + "disease": "Hypertension", + 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+ } + ], + "reference": [ + "https://go.drugbank.com/drugs/DB12465#mechanism-of-action", + "https://drugs.ncats.io/drug/97F9DE4CT4", + "https://www.uniprot.org/uniprot/P28223#function", + "https://en.wikipedia.org/wiki/Hypertension" + ] + }, + { + "directed": true, + "graph": { + "_id": "DB00763_MESH_D006980_1", + "disease": "Hyperthyroidism", + "disease_mesh": "MESH:D006980", + "drug": "methimazole", + "drug_mesh": "MESH:D008713", + "drugbank": "DB:DB00763" + }, + "links": [ + { + "key": "decreases activity of", + "source": "MESH:D008713", + "target": "UniProt:P07202" + }, + { + "key": "positively regulates", + "source": "UniProt:P07202", + "target": "GO:0006590" + }, + { + "key": "increases abundance of", + "source": "GO:0006590", + "target": "MESH:D013963" + }, + { + "key": "positively correlated with", + "source": "MESH:D013963", + "target": "MESH:D006980" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:D008713", + "label": "Drug", + "name": "methimazole" + }, + { + "id": "UniProt:P07202", + "label": "Protein", + "name": "Thyroid peroxidase" + }, + { + "id": "GO:0006590", + "label": "BiologicalProcess", + "name": "thyroid hormone generation" + }, + { + "id": "MESH:D013963", + "label": "ChemicalSubstance", + "name": "Thyroid Hormones" + }, + { + "id": "MESH:D006980", + "label": "Disease", + "name": "Hyperthyroidism" + } + ], + "reference": [ + "https://go.drugbank.com/drugs/DB00763#mechanism-of-action", + "https://www.uniprot.org/uniprot/P07202#function", + "https://en.wikipedia.org/wiki/Hyperthyroidism" + ] + }, + { + "comment": "Moexipril hydrochloride is a non-sulfhydryl of Moexipril, and acts as a prodrug of Moexiprilat.", + "directed": true, + "graph": { + "_id": "DB00691_MESH_D006973_1", + "disease": "Hypertension", + "disease_mesh": "MESH:D006973", + "drug": "moexipril", + "drug_mesh": "MESH:C058302", + "drugbank": "DB:DB00691" + }, + "links": [ + { + "key": "has metabolite", + "source": "MESH:C058302", + "target": "MESH:C059506" + }, + { + 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"BiologicalProcess", + "name": "membrane depolarization" + }, + { + "id": "GO:0019228", + "label": "BiologicalProcess", + "name": "neuronal action potential" + }, + { + "id": "GO:0050806", + "label": "BiologicalProcess", + "name": "positive regulation of synaptic transmission" + }, + { + "id": "MESH:D004830", + "label": "Disease", + "name": "Epilepsy, Tonic-Clonic" + } + ], + "reference": [ + "https://go.drugbank.com/drugs/DB00273#mechanism-of-action", + "https://en.wikipedia.org/wiki/Generalized_tonic%E2%80%93clonic_seizure" + ] + }, + { + "directed": true, + "graph": { + "_id": "DB00273_MESH_D065768_1", + "disease": "Lennox Gastaut Syndrome", + "disease_mesh": "MESH:D065768", + "drug": "topiramate", + "drug_mesh": "MESH:D000077236", + "drugbank": "DB:DB00273" + }, + "links": [ + { + "key": "increases activity of", + "source": "MESH:D000077236", + "target": "GO:0022851" + }, + { + "key": "decreases activity of", + "source": "MESH:D000077236", + "target": "InterPro:IPR001696" + }, + { + "key": "negatively correlated with", + "source": "GO:0022851", + "target": "GO:0051899" + }, + { + "key": "positively correlated with", + "source": "InterPro:IPR001696", + "target": "GO:0051899" + }, + { + "key": "positively regulates", + "source": "GO:0051899", + "target": "GO:0019228" + }, + { + "key": "regulates", + "source": "GO:0019228", + "target": "GO:0050806" + }, + { + "key": "positively correlated with", + "source": "GO:0050806", + "target": "MESH:D065768" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:D000077236", + "label": "Drug", + "name": "topiramate" + }, + { + "id": "GO:0022851", + "label": "MolecularActivity", + "name": "GABA-gated chloride ion channel activity" + }, + { + "id": "InterPro:IPR001696", + "label": "GeneFamily", + "name": "Voltage gated sodium channel, alpha subunit" + }, + { + "id": "GO:0051899", + "label": "BiologicalProcess", + "name": "membrane depolarization" + }, + { + "id": "GO:0019228", + "label": "BiologicalProcess", + "name": "neuronal action potential" + }, + { + "id": "GO:0050806", + "label": "BiologicalProcess", + "name": "positive regulation of synaptic transmission" + }, + { + "id": "MESH:D065768", + "label": "Disease", + "name": "Lennox Gastaut Syndrome" + } + ], + "reference": [ + "https://go.drugbank.com/drugs/DB00273#mechanism-of-action", + "https://en.wikipedia.org/wiki/Lennox%E2%80%93Gastaut_syndrome" + ] } ] \ No newline at end of file diff --git a/indication_paths.yaml b/indication_paths.yaml index 3a64c386a..c4f0d8c31 100644 --- a/indication_paths.yaml +++ b/indication_paths.yaml @@ -191870,3 +191870,1235 @@ - https://www.uniprot.org/uniprot/P42765#function - https://en.wikipedia.org/wiki/Angina - https://en.wikipedia.org/wiki/Atherosclerosis +- directed: true + graph: + _id: DB01122_MESH_D009157_1 + disease: Myasthenia Gravis + disease_mesh: MESH:D009157 + drug: ambenonium + drug_mesh: MESH:D000549 + drugbank: DB:DB01122 + links: + - key: decreases activity of + source: MESH:D000549 + target: UniProt:P22303 + - key: positively regulates + source: UniProt:P22303 + target: GO:0001507 + - key: contributes to + source: GO:0001507 + target: HP:0001324 + - key: manifestation of + source: HP:0001324 + target: MESH:D009157 + multigraph: true + nodes: + - id: MESH:D000549 + label: Drug + name: ambenonium + - id: UniProt:P22303 + label: Protein + name: Acetylcholinesterase + - id: GO:0001507 + label: BiologicalProcess + name: acetylcholine catabolic process in synaptic cleft + - id: HP:0001324 + label: PhenotypicFeature + name: Muscle weakness + - id: MESH:D009157 + label: Disease + name: Myasthenia Gravis + reference: + - https://go.drugbank.com/drugs/DB01122#mechanism-of-action + - https://www.uniprot.org/uniprot/P22303#function + - https://en.wikipedia.org/wiki/Myasthenia_gravis +- directed: true + graph: + _id: DB04812_MESH_D001172_1 + disease: Arthritis, Rheumatoid + disease_mesh: MESH:D001172 + drug: benoxaprofen + drug_mesh: MESH:C011677 + drugbank: DB:DB04812 + links: + - key: decreases activity of + source: MESH:C011677 + target: UniProt:P09917 + - key: positively regulates + source: UniProt:P09917 + target: GO:0019370 + - key: increases abundance of + source: GO:0019370 + target: MESH:D015289 + - key: positively regulates + source: MESH:D015289 + target: GO:0006954 + - key: has phenotype + source: GO:0006954 + target: HP:0002829 + - key: manifestation of + source: HP:0002829 + target: MESH:D001172 + multigraph: true + nodes: + - id: MESH:C011677 + label: Drug + name: benoxaprofen + - id: UniProt:P09917 + label: Protein + name: Polyunsaturated fatty acid 5-lipoxygenase + - id: GO:0019370 + label: BiologicalProcess + name: leukotriene biosynthetic process + - id: MESH:D015289 + label: ChemicalSubstance + name: Leukotrienes + - id: GO:0006954 + label: BiologicalProcess + name: inflammatory response + - id: HP:0002829 + label: PhenotypicFeature + name: Arthralgia + - id: MESH:D001172 + label: Disease + name: Arthritis, Rheumatoid + reference: + - https://drugs.ncats.io/drug/K274V650EH + - https://www.uniprot.org/uniprot/P09917#function + - https://pubmed.ncbi.nlm.nih.gov/24593197/ + - https://en.wikipedia.org/wiki/Arthralgia + - https://en.wikipedia.org/wiki/Rheumatoid_arthritis +- directed: true + graph: + _id: DB00493_MESH_D001170_1 + disease: Arthritis, Infectious + disease_mesh: MESH:D001170 + drug: cefotaxime + drug_mesh: MESH:D002439 + drugbank: DB:DB00493 + links: + - key: decreases activity of + source: MESH:D002439 + target: InterPro:IPR001460 + - key: participates in + source: InterPro:IPR001460 + target: GO:0009252 + - key: positively correlated with + source: GO:0009252 + target: GO:0009273 + - key: occurs in + source: GO:0009273 + target: NCBITaxon:2 + - key: causes + source: NCBITaxon:2 + target: MESH:D001170 + multigraph: true + nodes: + - id: MESH:D002439 + label: Drug + name: cefotaxime + - id: InterPro:IPR001460 + label: GeneFamily + name: Penicillin-binding protein, transpeptidase + - id: GO:0009252 + label: BiologicalProcess + name: peptidoglycan biosynthetic process + - id: GO:0009273 + label: BiologicalProcess + name: peptidoglycan-based cell wall biogenesis + - id: NCBITaxon:2 + label: OrganismTaxon + name: Bacteria + - id: MESH:D001170 + label: Disease + name: Arthritis, Infectious + reference: + - https://go.drugbank.com/drugs/DB00493#mechanism-of-action + - https://www.ebi.ac.uk/interpro/entry/InterPro/IPR001460/ +- directed: true + graph: + _id: DB00493_MESH_D059413_1 + disease: Intraabdominal Infections + disease_mesh: MESH:D059413 + drug: cefotaxime + drug_mesh: MESH:D002439 + drugbank: DB:DB00493 + links: + - key: decreases activity of + source: MESH:D002439 + target: InterPro:IPR001460 + - key: participates in + source: InterPro:IPR001460 + target: GO:0009252 + - key: positively correlated with + source: GO:0009252 + target: GO:0009273 + - key: occurs in + source: GO:0009273 + target: NCBITaxon:2 + - key: causes + source: NCBITaxon:2 + target: MESH:D059413 + multigraph: true + nodes: + - id: MESH:D002439 + label: Drug + name: cefotaxime + - id: InterPro:IPR001460 + label: GeneFamily + name: Penicillin-binding protein, transpeptidase + - id: GO:0009252 + label: BiologicalProcess + name: peptidoglycan biosynthetic process + - id: GO:0009273 + label: BiologicalProcess + name: peptidoglycan-based cell wall biogenesis + - id: NCBITaxon:2 + label: OrganismTaxon + name: Bacteria + - id: MESH:D059413 + label: Disease + name: Intraabdominal Infections + reference: + - https://go.drugbank.com/drugs/DB00493#mechanism-of-action + - https://www.ebi.ac.uk/interpro/entry/InterPro/IPR001460/ +- directed: true + graph: + _id: DB00493_MESH_D016920_1 + disease: Meningitis, Bacterial + disease_mesh: MESH:D016920 + drug: cefotaxime + drug_mesh: MESH:D002439 + drugbank: DB:DB00493 + links: + - key: decreases activity of + source: MESH:D002439 + target: InterPro:IPR001460 + - key: participates in + source: InterPro:IPR001460 + target: GO:0009252 + - key: positively correlated with + source: GO:0009252 + target: GO:0009273 + - key: occurs in + source: GO:0009273 + target: NCBITaxon:2 + - key: causes + source: NCBITaxon:2 + target: MESH:D016920 + multigraph: true + nodes: + - id: MESH:D002439 + label: Drug + name: cefotaxime + - id: InterPro:IPR001460 + label: GeneFamily + name: Penicillin-binding protein, transpeptidase + - id: GO:0009252 + label: BiologicalProcess + name: peptidoglycan biosynthetic process + - id: GO:0009273 + label: BiologicalProcess + name: peptidoglycan-based cell wall biogenesis + - id: NCBITaxon:2 + label: OrganismTaxon + name: Bacteria + - id: MESH:D016920 + label: Disease + name: Meningitis, Bacterial + reference: + - https://go.drugbank.com/drugs/DB00493#mechanism-of-action + - https://www.ebi.ac.uk/interpro/entry/InterPro/IPR001460/ +- directed: true + graph: + _id: DB00493_MESH_D020814_1 + disease: Meningitis, Escherichia coli + disease_mesh: MESH:D020814 + drug: cefotaxime + drug_mesh: MESH:D002439 + drugbank: DB:DB00493 + links: + - key: decreases activity of + source: MESH:D002439 + target: InterPro:IPR001460 + - key: participates in + source: InterPro:IPR001460 + target: GO:0009252 + - key: positively correlated with + source: GO:0009252 + target: GO:0009273 + - key: occurs in + source: GO:0009273 + target: NCBITaxon:562 + - key: causes + source: NCBITaxon:562 + target: MESH:D020814 + multigraph: true + nodes: + - id: MESH:D002439 + label: Drug + name: cefotaxime + - id: InterPro:IPR001460 + label: GeneFamily + name: Penicillin-binding protein, transpeptidase + - id: GO:0009252 + label: BiologicalProcess + name: peptidoglycan biosynthetic process + - id: GO:0009273 + label: BiologicalProcess + name: peptidoglycan-based cell wall biogenesis + - id: NCBITaxon:562 + label: OrganismTaxon + name: Escherichia coli + - id: MESH:D020814 + label: Disease + name: Meningitis, Escherichia coli + reference: + - https://go.drugbank.com/drugs/DB00493#mechanism-of-action + - https://www.ebi.ac.uk/interpro/entry/InterPro/IPR001460/ +- directed: true + graph: + _id: DB00493_MESH_D008585_1 + disease: Meningitis, Meningococcal + disease_mesh: MESH:D008585 + drug: cefotaxime + drug_mesh: MESH:D002439 + drugbank: DB:DB00493 + links: + - key: decreases activity of + source: MESH:D002439 + target: InterPro:IPR001460 + - key: participates in + source: InterPro:IPR001460 + target: GO:0009252 + - key: positively correlated with + source: GO:0009252 + target: GO:0009273 + - key: occurs in + source: GO:0009273 + target: NCBITaxon:487 + - key: causes + source: NCBITaxon:487 + target: MESH:D008585 + multigraph: true + nodes: + - id: MESH:D002439 + label: Drug + name: cefotaxime + - id: InterPro:IPR001460 + label: GeneFamily + name: Penicillin-binding protein, transpeptidase + - id: GO:0009252 + label: BiologicalProcess + name: peptidoglycan biosynthetic process + - id: GO:0009273 + label: BiologicalProcess + name: peptidoglycan-based cell wall biogenesis + - id: NCBITaxon:487 + label: OrganismTaxon + name: Neisseria meningitidis + - id: MESH:D008585 + label: Disease + name: Meningitis, Meningococcal + reference: + - https://go.drugbank.com/drugs/DB00493#mechanism-of-action + - https://www.ebi.ac.uk/interpro/entry/InterPro/IPR001460/ +- directed: true + graph: + _id: DB00493_MESH_D000071074_1 + disease: Neonatal Sepsis + disease_mesh: MESH:D000071074 + drug: cefotaxime + drug_mesh: MESH:D002439 + drugbank: DB:DB00493 + links: + - key: decreases activity of + source: MESH:D002439 + target: InterPro:IPR001460 + - key: participates in + source: InterPro:IPR001460 + target: GO:0009252 + - key: positively correlated with + source: GO:0009252 + target: GO:0009273 + - key: occurs in + source: GO:0009273 + target: NCBITaxon:2 + - key: causes + source: NCBITaxon:2 + target: MESH:D000071074 + multigraph: true + nodes: + - id: MESH:D002439 + label: Drug + name: cefotaxime + - id: InterPro:IPR001460 + label: GeneFamily + name: Penicillin-binding protein, transpeptidase + - id: GO:0009252 + label: BiologicalProcess + name: peptidoglycan biosynthetic process + - id: GO:0009273 + label: BiologicalProcess + name: peptidoglycan-based cell wall biogenesis + - id: NCBITaxon:2 + label: OrganismTaxon + name: Bacteria + - id: MESH:D000071074 + label: Disease + name: Neonatal Sepsis + reference: + - https://go.drugbank.com/drugs/DB00493#mechanism-of-action + - https://www.ebi.ac.uk/interpro/entry/InterPro/IPR001460/ +- directed: true + graph: + _id: DB00493_MESH_D018410_1 + disease: Pneumonia, Bacterial + disease_mesh: MESH:D018410 + drug: cefotaxime + drug_mesh: MESH:D002439 + drugbank: DB:DB00493 + links: + - key: decreases activity of + source: MESH:D002439 + target: InterPro:IPR001460 + - key: participates in + source: InterPro:IPR001460 + target: GO:0009252 + - key: positively correlated with + source: GO:0009252 + target: GO:0009273 + - key: occurs in + source: GO:0009273 + target: NCBITaxon:2 + - key: causes + source: NCBITaxon:2 + target: MESH:D018410 + multigraph: true + nodes: + - id: MESH:D002439 + label: Drug + name: cefotaxime + - id: InterPro:IPR001460 + label: GeneFamily + name: Penicillin-binding protein, transpeptidase + - id: GO:0009252 + label: BiologicalProcess + name: peptidoglycan biosynthetic process + - id: GO:0009273 + label: BiologicalProcess + name: peptidoglycan-based cell wall biogenesis + - id: NCBITaxon:2 + label: OrganismTaxon + name: Bacteria + - id: MESH:D018410 + label: Disease + name: Pneumonia, Bacterial + reference: + - https://go.drugbank.com/drugs/DB00493#mechanism-of-action + - https://www.ebi.ac.uk/interpro/entry/InterPro/IPR001460/ +- directed: true + graph: + _id: DB00493_MESH_D011018_1 + disease: Pneumonia, Pneumococcal + disease_mesh: MESH:D011018 + drug: cefotaxime + drug_mesh: MESH:D002439 + drugbank: DB:DB00493 + links: + - key: decreases activity of + source: MESH:D002439 + target: InterPro:IPR001460 + - key: participates in + source: InterPro:IPR001460 + target: GO:0009252 + - key: positively correlated with + source: GO:0009252 + target: GO:0009273 + - key: occurs in + source: GO:0009273 + target: NCBITaxon:1313 + - key: causes + source: NCBITaxon:1313 + target: MESH:D011018 + multigraph: true + nodes: + - id: MESH:D002439 + label: Drug + name: cefotaxime + - id: InterPro:IPR001460 + label: GeneFamily + name: Penicillin-binding protein, transpeptidase + - id: GO:0009252 + label: BiologicalProcess + name: peptidoglycan biosynthetic process + - id: GO:0009273 + label: BiologicalProcess + name: peptidoglycan-based cell wall biogenesis + - id: NCBITaxon:1313 + label: OrganismTaxon + name: Streptococcus pneumoniae + - id: MESH:D011018 + label: Disease + name: Pneumonia, Pneumococcal + reference: + - https://go.drugbank.com/drugs/DB00493#mechanism-of-action + - https://www.ebi.ac.uk/interpro/entry/InterPro/IPR001460/ +- directed: true + graph: + _id: DB00493_MESH_D011023_1 + disease: Pneumonia, Staphylococcal + disease_mesh: MESH:D011023 + drug: cefotaxime + drug_mesh: MESH:D002439 + drugbank: DB:DB00493 + links: + - key: decreases activity of + source: MESH:D002439 + target: InterPro:IPR001460 + - key: participates in + source: InterPro:IPR001460 + target: GO:0009252 + - key: positively correlated with + source: GO:0009252 + target: GO:0009273 + - key: occurs in + source: GO:0009273 + target: NCBITaxon:1279 + - key: causes + source: NCBITaxon:1279 + target: MESH:D011023 + multigraph: true + nodes: + - id: MESH:D002439 + label: Drug + name: cefotaxime + - id: InterPro:IPR001460 + label: GeneFamily + name: Penicillin-binding protein, transpeptidase + - id: GO:0009252 + label: BiologicalProcess + name: peptidoglycan biosynthetic process + - id: GO:0009273 + label: BiologicalProcess + name: peptidoglycan-based cell wall biogenesis + - id: NCBITaxon:1279 + label: OrganismTaxon + name: Staphylococcus + - id: MESH:D011023 + label: Disease + name: Pneumonia, Staphylococcal + reference: + - https://go.drugbank.com/drugs/DB00493#mechanism-of-action + - https://www.ebi.ac.uk/interpro/entry/InterPro/IPR001460/ +- directed: true + graph: + _id: DB00493_MESH_D016868_1 + disease: Serratia Infections + disease_mesh: MESH:D016868 + drug: cefotaxime + drug_mesh: MESH:D002439 + drugbank: DB:DB00493 + links: + - key: decreases activity of + source: MESH:D002439 + target: InterPro:IPR001460 + - key: participates in + source: InterPro:IPR001460 + target: GO:0009252 + - key: positively correlated with + source: GO:0009252 + target: GO:0009273 + - key: occurs in + source: GO:0009273 + target: NCBITaxon:613 + - key: causes + source: NCBITaxon:613 + target: MESH:D016868 + multigraph: true + nodes: + - id: MESH:D002439 + label: Drug + name: cefotaxime + - id: InterPro:IPR001460 + label: GeneFamily + name: Penicillin-binding protein, transpeptidase + - id: GO:0009252 + label: BiologicalProcess + name: peptidoglycan biosynthetic process + - id: GO:0009273 + label: BiologicalProcess + name: peptidoglycan-based cell wall biogenesis + - id: NCBITaxon:613 + label: OrganismTaxon + name: Serratia + - id: MESH:D016868 + label: Disease + name: Serratia Infections + reference: + - https://go.drugbank.com/drugs/DB00493#mechanism-of-action + - https://www.ebi.ac.uk/interpro/entry/InterPro/IPR001460/ +- directed: true + graph: + _id: DB02266_MESH_D010146_1 + disease: Pain + disease_mesh: MESH:D010146 + drug: flufenamic acid + drug_mesh: MESH:D005439 + drugbank: DB:DB02266 + links: + - key: decreases activity of + source: MESH:D005439 + target: UniProt:P23219 + - key: decreases activity of + source: MESH:D005439 + target: UniProt:P35354 + - key: participates in + source: UniProt:P23219 + target: GO:0001516 + - key: participates in + source: UniProt:P35354 + target: GO:0001516 + - key: increases abundance of + source: GO:0001516 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D010146 + multigraph: true + nodes: + - id: MESH:D005439 + label: Drug + name: flufenamic acid + - id: UniProt:P23219 + label: Protein + name: Prostaglandin G/H synthase 1 + - id: UniProt:P35354 + label: Protein + name: Prostaglandin G/H synthase 2 + - id: GO:0001516 + label: BiologicalProcess + name: prostaglandin biosynthetic process + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: inflammatory response + - id: MESH:D010146 + label: Disease + name: Pain + reference: + - https://go.drugbank.com/drugs/DB02266#mechanism-of-action + - https://www.uniprot.org/uniprot/P23219#function + - https://www.uniprot.org/uniprot/P35354#function + - https://en.wikipedia.org/wiki/Pain +- comment: Imolamine is a coronary vasodilator, that is used in the treatment of + angina pectoris. + directed: true + graph: + _id: DB09284_MESH_D000787_1 + disease: Angina pectoris + disease_mesh: MESH:D000787 + drug: imolamine + drug_mesh: MESH:C002787 + drugbank: DB:DB09284 + links: + - key: positively regulates + source: MESH:C002787 + target: GO:0042311 + - key: negatively correlated with + source: GO:0042311 + target: MESH:D017202 + - key: contributes to + source: MESH:D017202 + target: MESH:D000787 + multigraph: true + nodes: + - id: MESH:C002787 + label: Drug + name: imolamine + - id: GO:0042311 + label: BiologicalProcess + name: vasodilation + - id: MESH:D017202 + label: Disease + name: Myocardial Ischemia + - id: MESH:D000787 + label: Disease + name: Angina Pectoris + reference: + - https://drugs.ncats.io/drug/K5F4RU5VQJ + - https://en.wikipedia.org/wiki/Angina +- directed: true + graph: + _id: DB12465_MESH_D006973_1 + disease: Hypertension + disease_mesh: MESH:D006973 + drug: ketanserin + drug_mesh: MESH:D007650 + drugbank: DB:DB12465 + links: + - key: decreases activity of + source: MESH:D007650 + target: UniProt:P28223 + - key: positively regulates + source: UniProt:P28223 + target: GO:0042310 + - key: positively correlated with + source: GO:0042310 + target: HP:0032263 + - key: manifestation of + source: HP:0032263 + target: MESH:D006973 + multigraph: true + nodes: + - id: MESH:D007650 + label: Drug + name: ketanserin + - id: UniProt:P28223 + label: Protein + name: 5-hydroxytryptamine receptor 2A + - id: GO:0042310 + label: BiologicalProcess + name: vasoconstriction + - id: HP:0032263 + label: PhenotypicFeature + name: Increased blood pressure + - id: MESH:D006973 + label: Disease + name: Hypertension + reference: + - https://go.drugbank.com/drugs/DB12465#mechanism-of-action + - https://drugs.ncats.io/drug/97F9DE4CT4 + - https://www.uniprot.org/uniprot/P28223#function + - https://en.wikipedia.org/wiki/Hypertension +- directed: true + graph: + _id: DB00763_MESH_D006980_1 + disease: Hyperthyroidism + disease_mesh: MESH:D006980 + drug: methimazole + drug_mesh: MESH:D008713 + drugbank: DB:DB00763 + links: + - key: decreases activity of + source: MESH:D008713 + target: UniProt:P07202 + - key: positively regulates + source: UniProt:P07202 + target: GO:0006590 + - key: increases abundance of + source: GO:0006590 + target: MESH:D013963 + - key: positively correlated with + source: MESH:D013963 + target: MESH:D006980 + multigraph: true + nodes: + - id: MESH:D008713 + label: Drug + name: methimazole + - id: UniProt:P07202 + label: Protein + name: Thyroid peroxidase + - id: GO:0006590 + label: BiologicalProcess + name: thyroid hormone generation + - id: MESH:D013963 + label: ChemicalSubstance + name: Thyroid Hormones + - id: MESH:D006980 + label: Disease + name: Hyperthyroidism + reference: + - https://go.drugbank.com/drugs/DB00763#mechanism-of-action + - https://www.uniprot.org/uniprot/P07202#function + - https://en.wikipedia.org/wiki/Hyperthyroidism +- comment: Moexipril hydrochloride is a non-sulfhydryl of Moexipril, and acts as + a prodrug of Moexiprilat. + directed: true + graph: + _id: DB00691_MESH_D006973_1 + disease: Hypertension + disease_mesh: MESH:D006973 + drug: moexipril + drug_mesh: MESH:C058302 + drugbank: DB:DB00691 + links: + - key: has metabolite + source: MESH:C058302 + target: MESH:C059506 + - key: decreases activity of + source: MESH:C059506 + target: UniProt:P12821 + - key: positively regulates + source: UniProt:P12821 + target: GO:0042310 + - key: positively regulates + source: UniProt:P12821 + target: GO:0035932 + - key: participates in + source: GO:0042310 + target: GO:0045777 + - key: participates in + source: GO:0035932 + target: GO:0045777 + - key: contributes to + source: GO:0045777 + target: MESH:D006973 + multigraph: true + nodes: + - id: MESH:C058302 + label: Drug + name: moexipril + - id: MESH:C059506 + label: ChemicalSubstance + name: moexiprilat + - id: UniProt:P12821 + label: Protein + name: Angiotensin-converting enzyme + - id: GO:0042310 + label: BiologicalProcess + name: vasoconstriction + - id: GO:0035932 + label: BiologicalProcess + name: aldosterone secretion + - id: GO:0045777 + label: BiologicalProcess + name: positive regulation of blood pressure + - id: MESH:D006973 + label: Disease + name: Hypertension + reference: + - https://go.drugbank.com/drugs/DB00691#mechanism-of-action + - https://www.uniprot.org/uniprot/P12821#function + - https://en.wikipedia.org/wiki/Hypertension +- comment: Molsidomine is a drug that is metabolized in the liver to the active + metabolite linsidomine which releases nitric oxide, a vasodilating compound. + directed: true + graph: + _id: DB09282_MESH_D000787_1 + disease: Angina pectoris + disease_mesh: MESH:D000787 + drug: molsidomine + drug_mesh: MESH:D008981 + drugbank: DB:DB09282 + links: + - key: has metabolite + source: MESH:D008981 + target: MESH:C002385 + - key: produces + source: MESH:C002385 + target: MESH:D009569 + - key: positively regulates + source: MESH:D009569 + target: GO:0004383 + - key: increases abundance of + source: GO:0004383 + target: MESH:D006152 + - key: positively correlated with + source: MESH:D006152 + target: GO:0042311 + - key: negatively correlated with + source: GO:0042311 + target: MESH:D017202 + - key: contributes to + source: MESH:D017202 + target: MESH:D000787 + multigraph: true + nodes: + - id: MESH:D008981 + label: Drug + name: molsidomine + - id: MESH:C002385 + label: ChemicalSubstance + name: linsidomine + - id: MESH:D009569 + label: ChemicalSubstance + name: Nitric Oxide + - id: GO:0004383 + label: MolecularActivity + name: guanylate cyclase activity + - id: MESH:D006152 + label: ChemicalSubstance + name: Cyclic GMP + - id: GO:0042311 + label: BiologicalProcess + name: vasodilation + - id: MESH:D017202 + label: Disease + name: Myocardial Ischemia + - id: MESH:D000787 + label: Disease + name: Angina Pectoris + reference: + - https://go.drugbank.com/drugs/DB09282#mechanism-of-action + - https://drugs.ncats.io/drug/D46583G77X + - https://en.wikipedia.org/wiki/Angina +- directed: true + graph: + _id: DB00517_MESH_D010437_1 + disease: Peptic Ulcer + disease_mesh: MESH:D010437 + drug: octatropine methylbromide + drug_mesh: MESH:C100237 + drugbank: DB:DB00517 + links: + - key: decreases activity of + source: MESH:C100237 + target: UniProt:P11229 + - key: decreases activity of + source: MESH:C100237 + target: UniProt:P08172 + - key: decreases activity of + source: MESH:C100237 + target: UniProt:P20309 + - key: positively regulates + source: UniProt:P11229 + target: GO:0095500 + - key: positively regulates + source: UniProt:P08172 + target: GO:0095500 + - key: positively regulates + source: UniProt:P20309 + target: GO:0095500 + - key: positively correlated with + source: GO:0095500 + target: MESH:D000109 + - key: positively correlated with + source: MESH:D000109 + target: GO:0001696 + - key: contributes to + source: GO:0001696 + target: MESH:D010437 + multigraph: true + nodes: + - id: MESH:C100237 + label: Drug + name: octatropine methylbromide + - id: UniProt:P11229 + label: Protein + name: Muscarinic acetylcholine receptor M1 + - id: UniProt:P08172 + label: Protein + name: Muscarinic acetylcholine receptor M2 + - id: UniProt:P20309 + label: Protein + name: Muscarinic acetylcholine receptor M3 + - id: GO:0095500 + label: BiologicalProcess + name: acetylcholine receptor signaling pathway + - id: MESH:D000109 + label: ChemicalSubstance + name: Acetylcholine + - id: GO:0001696 + label: BiologicalProcess + name: gastric acid secretion + - id: MESH:D010437 + label: Disease + name: Peptic Ulcer + reference: + - https://go.drugbank.com/drugs/DB00517#mechanism-of-action + - https://www.uniprot.org/uniprot/P11229#function + - https://www.uniprot.org/uniprot/P08172#function + - https://www.uniprot.org/uniprot/P20309#function + - https://en.wikipedia.org/wiki/Peptic_ulcer_disease +- directed: true + graph: + _id: DB00517_MESH_D013276_1 + disease: Stomach Ulcer + disease_mesh: MESH:D013276 + drug: octatropine methylbromide + drug_mesh: MESH:C100237 + drugbank: DB:DB00517 + links: + - key: decreases activity of + source: MESH:C100237 + target: UniProt:P11229 + - key: decreases activity of + source: MESH:C100237 + target: UniProt:P08172 + - key: decreases activity of + source: MESH:C100237 + target: UniProt:P20309 + - key: positively regulates + source: UniProt:P11229 + target: GO:0095500 + - key: positively regulates + source: UniProt:P08172 + target: GO:0095500 + - key: positively regulates + source: UniProt:P20309 + target: GO:0095500 + - key: positively correlated with + source: GO:0095500 + target: MESH:D000109 + - key: positively correlated with + source: MESH:D000109 + target: GO:0001696 + - key: contributes to + source: GO:0001696 + target: MESH:D010437 + - key: located in + source: MESH:D010437 + target: UBERON:0000945 + - key: location of + source: UBERON:0000945 + target: MESH:D013276 + multigraph: true + nodes: + - id: MESH:C100237 + label: Drug + name: octatropine methylbromide + - id: UniProt:P11229 + label: Protein + name: Muscarinic acetylcholine receptor M1 + - id: UniProt:P08172 + label: Protein + name: Muscarinic acetylcholine receptor M2 + - id: UniProt:P20309 + label: Protein + name: Muscarinic acetylcholine receptor M3 + - id: GO:0095500 + label: BiologicalProcess + name: acetylcholine receptor signaling pathway + - id: MESH:D000109 + label: ChemicalSubstance + name: Acetylcholine + - id: GO:0001696 + label: BiologicalProcess + name: gastric acid secretion + - id: MESH:D010437 + label: Disease + name: Peptic Ulcer + - id: UBERON:0000945 + label: GrossAnatomicalStructure + name: stomach + - id: MESH:D013276 + label: Disease + name: Stomach Ulcer + reference: + - https://go.drugbank.com/drugs/DB00517#mechanism-of-action + - https://www.uniprot.org/uniprot/P11229#function + - https://www.uniprot.org/uniprot/P08172#function + - https://www.uniprot.org/uniprot/P20309#function + - https://en.wikipedia.org/wiki/Peptic_ulcer_disease +- directed: true + graph: + _id: DB08883_MESH_D004828_1 + disease: Epilepsies, Partial + disease_mesh: MESH:D004828 + drug: perampanel + drug_mesh: MESH:C551441 + drugbank: DB:DB08883 + links: + - key: decreases activity of + source: MESH:C551441 + target: UniProt:P42261 + - key: positively regulates + source: UniProt:P42261 + target: GO:0004971 + - key: positively correlated with + source: GO:0004971 + target: GO:0019228 + - key: contributes to + source: GO:0019228 + target: GO:0050806 + - key: positively correlated with + source: GO:0050806 + target: MESH:D004828 + multigraph: true + nodes: + - id: MESH:C551441 + label: Drug + name: perampanel + - id: UniProt:P42261 + label: Protein + name: Glutamate receptor 1 + - id: GO:0004971 + label: MolecularActivity + name: AMPA glutamate receptor activity + - id: GO:0019228 + label: BiologicalProcess + name: neuronal action potential + - id: GO:0050806 + label: BiologicalProcess + name: positive regulation of synaptic transmission + - id: MESH:D004828 + label: Disease + name: Epilepsies, Partial + reference: + - https://go.drugbank.com/drugs/DB08883#mechanism-of-action + - https://www.uniprot.org/uniprot/P42261#function +- directed: true + graph: + _id: DB00273_MESH_D004828_1 + disease: Epilepsies, Partial + disease_mesh: MESH:D004828 + drug: topiramate + drug_mesh: MESH:D000077236 + drugbank: DB:DB00273 + links: + - key: increases activity of + source: MESH:D000077236 + target: GO:0022851 + - key: decreases activity of + source: MESH:D000077236 + target: InterPro:IPR001696 + - key: negatively correlated with + source: GO:0022851 + target: GO:0051899 + - key: positively correlated with + source: InterPro:IPR001696 + target: GO:0051899 + - key: positively regulates + source: GO:0051899 + target: GO:0019228 + - key: regulates + source: GO:0019228 + target: GO:0050806 + - key: positively correlated with + source: GO:0050806 + target: MESH:D004828 + multigraph: true + nodes: + - id: MESH:D000077236 + label: Drug + name: topiramate + - id: GO:0022851 + label: MolecularActivity + name: GABA-gated chloride ion channel activity + - id: InterPro:IPR001696 + label: GeneFamily + name: Voltage gated sodium channel, alpha subunit + - id: GO:0051899 + label: BiologicalProcess + name: membrane depolarization + - id: GO:0019228 + label: BiologicalProcess + name: neuronal action potential + - id: GO:0050806 + label: BiologicalProcess + name: positive regulation of synaptic transmission + - id: MESH:D004828 + label: Disease + name: Epilepsies, Partial + reference: + - https://go.drugbank.com/drugs/DB00273#mechanism-of-action + - https://en.wikipedia.org/wiki/Focal_seizure +- directed: true + graph: + _id: DB00273_MESH_D004830_1 + disease: Epilepsy, Tonic-Clonic + disease_mesh: MESH:D004830 + drug: topiramate + drug_mesh: MESH:D000077236 + drugbank: DB:DB00273 + links: + - key: increases activity of + source: MESH:D000077236 + target: GO:0022851 + - key: decreases activity of + source: MESH:D000077236 + target: InterPro:IPR001696 + - key: negatively correlated with + source: GO:0022851 + target: GO:0051899 + - key: positively correlated with + source: InterPro:IPR001696 + target: GO:0051899 + - key: positively regulates + source: GO:0051899 + target: GO:0019228 + - key: regulates + source: GO:0019228 + target: GO:0050806 + - key: positively correlated with + source: GO:0050806 + target: MESH:D004830 + multigraph: true + nodes: + - id: MESH:D000077236 + label: Drug + name: topiramate + - id: GO:0022851 + label: MolecularActivity + name: GABA-gated chloride ion channel activity + - id: InterPro:IPR001696 + label: GeneFamily + name: Voltage gated sodium channel, alpha subunit + - id: GO:0051899 + label: BiologicalProcess + name: membrane depolarization + - id: GO:0019228 + label: BiologicalProcess + name: neuronal action potential + - id: GO:0050806 + label: BiologicalProcess + name: positive regulation of synaptic transmission + - id: MESH:D004830 + label: Disease + name: Epilepsy, Tonic-Clonic + reference: + - https://go.drugbank.com/drugs/DB00273#mechanism-of-action + - https://en.wikipedia.org/wiki/Generalized_tonic%E2%80%93clonic_seizure +- directed: true + graph: + _id: DB00273_MESH_D065768_1 + disease: Lennox Gastaut Syndrome + disease_mesh: MESH:D065768 + drug: topiramate + drug_mesh: MESH:D000077236 + drugbank: DB:DB00273 + links: + - key: increases activity of + source: MESH:D000077236 + target: GO:0022851 + - key: decreases activity of + source: MESH:D000077236 + target: InterPro:IPR001696 + - key: negatively correlated with + source: GO:0022851 + target: GO:0051899 + - key: positively correlated with + source: InterPro:IPR001696 + target: GO:0051899 + - key: positively regulates + source: GO:0051899 + target: GO:0019228 + - key: regulates + source: GO:0019228 + target: GO:0050806 + - key: positively correlated with + source: GO:0050806 + target: MESH:D065768 + multigraph: true + nodes: + - id: MESH:D000077236 + label: Drug + name: topiramate + - id: GO:0022851 + label: MolecularActivity + name: GABA-gated chloride ion channel activity + - id: InterPro:IPR001696 + label: GeneFamily + name: Voltage gated sodium channel, alpha subunit + - id: GO:0051899 + label: BiologicalProcess + name: membrane depolarization + - id: GO:0019228 + label: BiologicalProcess + name: neuronal action potential + - id: GO:0050806 + label: BiologicalProcess + name: positive regulation of synaptic transmission + - id: MESH:D065768 + label: Disease + name: Lennox Gastaut Syndrome + reference: + - https://go.drugbank.com/drugs/DB00273#mechanism-of-action + - https://en.wikipedia.org/wiki/Lennox%E2%80%93Gastaut_syndrome diff --git a/submission.yaml b/submission.yaml index 0414d503e..8b1378917 100644 --- a/submission.yaml +++ b/submission.yaml @@ -1,1205 +1 @@ -- directed: true - graph: - disease: Myasthenia Gravis - disease_mesh: MESH:D009157 - drug: ambenonium - drug_mesh: MESH:D000549 - drugbank: DB:DB01122 - links: - - key: decreases activity of - source: MESH:D000549 - target: UniProt:P22303 - - key: positively regulates - source: UniProt:P22303 - target: GO:0001507 - - key: contributes to - source: GO:0001507 - target: HP:0001324 - - key: manifestation of - source: HP:0001324 - target: MESH:D009157 - multigraph: true - nodes: - - id: MESH:D000549 - label: Drug - name: ambenonium - - id: UniProt:P22303 - label: Protein - name: Acetylcholinesterase - - id: GO:0001507 - label: BiologicalProcess - name: acetylcholine catabolic process in synaptic cleft - - id: HP:0001324 - label: PhenotypicFeature - name: Muscle weakness - - id: MESH:D009157 - label: Disease - name: Myasthenia Gravis - reference: - - https://go.drugbank.com/drugs/DB01122#mechanism-of-action - - https://www.uniprot.org/uniprot/P22303#function - - https://en.wikipedia.org/wiki/Myasthenia_gravis -- directed: true - graph: - disease: Arthritis, Rheumatoid - disease_mesh: MESH:D001172 - drug: benoxaprofen - drug_mesh: MESH:C011677 - drugbank: DB:DB04812 - links: - - key: decreases activity of - source: MESH:C011677 - target: UniProt:P09917 - - key: positively regulates - source: UniProt:P09917 - target: GO:0019370 - - key: increases abundance of - source: GO:0019370 - target: MESH:D015289 - - key: positively regulates - source: MESH:D015289 - target: GO:0006954 - - key: causes - source: GO:0006954 - target: HP:0002829 - - key: manifestation of - source: HP:0002829 - target: MESH:D001172 - multigraph: true - nodes: - - id: MESH:C011677 - label: Drug - name: benoxaprofen - - id: UniProt:P09917 - label: Protein - name: Polyunsaturated fatty acid 5-lipoxygenase - - id: GO:0019370 - label: BiologicalProcess - name: leukotriene biosynthetic process - - id: MESH:D015289 - label: ChemicalSubstance - name: Leukotrienes - - id: GO:0006954 - label: BiologicalProcess - name: inflammatory response - - id: HP:0002829 - label: PhenotypicFeature - name: Arthralgia - - id: MESH:D001172 - label: Disease - name: Arthritis, Rheumatoid - reference: - - https://drugs.ncats.io/drug/K274V650EH - - https://www.uniprot.org/uniprot/P09917#function - - https://pubmed.ncbi.nlm.nih.gov/24593197/ - - https://en.wikipedia.org/wiki/Arthralgia - - https://en.wikipedia.org/wiki/Rheumatoid_arthritis -- directed: true - graph: - disease: Arthritis, Infectious - disease_mesh: MESH:D001170 - drug: cefotaxime - drug_mesh: MESH:D002439 - drugbank: DB:DB00493 - links: - - key: decreases activity of - source: MESH:D002439 - target: InterPro:IPR001460 - - key: participates in - source: InterPro:IPR001460 - target: GO:0009252 - - key: positively correlated with - source: GO:0009252 - target: GO:0009273 - - key: occurs in - source: GO:0009273 - target: NCBITaxon:2 - - key: causes - source: NCBITaxon:2 - target: MESH:D001170 - multigraph: true - nodes: - - id: MESH:D002439 - label: Drug - name: cefotaxime - - id: InterPro:IPR001460 - label: GeneFamily - name: Penicillin-binding protein, transpeptidase - - id: GO:0009252 - label: BiologicalProcess - name: peptidoglycan biosynthetic process - - id: GO:0009273 - label: BiologicalProcess - name: peptidoglycan-based cell wall biogenesis - - id: NCBITaxon:2 - label: OrganismTaxon - name: Bacteria - - id: MESH:D001170 - label: Disease - name: Arthritis, Infectious - reference: - - https://go.drugbank.com/drugs/DB00493#mechanism-of-action - - https://www.ebi.ac.uk/interpro/entry/InterPro/IPR001460/ -- directed: true - graph: - disease: Intraabdominal Infections - disease_mesh: MESH:D059413 - drug: cefotaxime - drug_mesh: MESH:D002439 - drugbank: DB:DB00493 - links: - - key: decreases activity of - source: MESH:D002439 - target: InterPro:IPR001460 - - key: participates in - source: InterPro:IPR001460 - target: GO:0009252 - - key: positively correlated with - source: GO:0009252 - target: GO:0009273 - - key: occurs in - source: GO:0009273 - target: NCBITaxon:2 - - key: causes - source: NCBITaxon:2 - target: MESH:D059413 - multigraph: true - nodes: - - id: MESH:D002439 - label: Drug - name: cefotaxime - - id: InterPro:IPR001460 - label: GeneFamily - name: Penicillin-binding protein, transpeptidase - - id: GO:0009252 - label: BiologicalProcess - name: peptidoglycan biosynthetic process - - id: GO:0009273 - label: BiologicalProcess - name: peptidoglycan-based cell wall biogenesis - - id: NCBITaxon:2 - label: OrganismTaxon - name: Bacteria - - id: MESH:D059413 - label: Disease - name: Intraabdominal Infections - reference: - - https://go.drugbank.com/drugs/DB00493#mechanism-of-action - - https://www.ebi.ac.uk/interpro/entry/InterPro/IPR001460/ -- directed: true - graph: - disease: Meningitis, Bacterial - disease_mesh: MESH:D016920 - drug: cefotaxime - drug_mesh: MESH:D002439 - drugbank: DB:DB00493 - links: - - key: decreases activity of - source: MESH:D002439 - target: InterPro:IPR001460 - - key: participates in - source: InterPro:IPR001460 - target: GO:0009252 - - key: positively correlated with - source: GO:0009252 - target: GO:0009273 - - key: occurs in - source: GO:0009273 - target: NCBITaxon:2 - - key: causes - source: NCBITaxon:2 - target: MESH:D016920 - multigraph: true - nodes: - - id: MESH:D002439 - label: Drug - name: cefotaxime - - id: InterPro:IPR001460 - label: GeneFamily - name: Penicillin-binding protein, transpeptidase - - id: GO:0009252 - label: BiologicalProcess - name: peptidoglycan biosynthetic process - - id: GO:0009273 - label: BiologicalProcess - name: peptidoglycan-based cell wall biogenesis - - id: NCBITaxon:2 - label: OrganismTaxon - name: Bacteria - - id: MESH:D016920 - label: Disease - name: Meningitis, Bacterial - reference: - - https://go.drugbank.com/drugs/DB00493#mechanism-of-action - - https://www.ebi.ac.uk/interpro/entry/InterPro/IPR001460/ -- directed: true - graph: - disease: Meningitis, Escherichia coli - disease_mesh: MESH:D020814 - drug: cefotaxime - drug_mesh: MESH:D002439 - drugbank: DB:DB00493 - links: - - key: decreases activity of - source: MESH:D002439 - target: InterPro:IPR001460 - - key: participates in - source: InterPro:IPR001460 - target: GO:0009252 - - key: positively correlated with - source: GO:0009252 - target: GO:0009273 - - key: occurs in - source: GO:0009273 - target: NCBITaxon:562 - - key: causes - source: NCBITaxon:562 - target: MESH:D020814 - multigraph: true - nodes: - - id: MESH:D002439 - label: Drug - name: cefotaxime - - id: InterPro:IPR001460 - label: GeneFamily - name: Penicillin-binding protein, transpeptidase - - id: GO:0009252 - label: BiologicalProcess - name: peptidoglycan biosynthetic process - - id: GO:0009273 - label: BiologicalProcess - name: peptidoglycan-based cell wall biogenesis - - id: NCBITaxon:562 - label: OrganismTaxon - name: Escherichia coli - - id: MESH:D020814 - label: Disease - name: Meningitis, Escherichia coli - reference: - - https://go.drugbank.com/drugs/DB00493#mechanism-of-action - - https://www.ebi.ac.uk/interpro/entry/InterPro/IPR001460/ -- directed: true - graph: - disease: Meningitis, Meningococcal - disease_mesh: MESH:D008585 - drug: cefotaxime - drug_mesh: MESH:D002439 - drugbank: DB:DB00493 - links: - - key: decreases activity of - source: MESH:D002439 - target: InterPro:IPR001460 - - key: participates in - source: InterPro:IPR001460 - target: GO:0009252 - - key: positively correlated with - source: GO:0009252 - target: GO:0009273 - - key: occurs in - source: GO:0009273 - target: NCBITaxon:487 - - key: causes - source: NCBITaxon:487 - target: MESH:D008585 - multigraph: true - nodes: - - id: MESH:D002439 - label: Drug - name: cefotaxime - - id: InterPro:IPR001460 - label: GeneFamily - name: Penicillin-binding protein, transpeptidase - - id: GO:0009252 - label: BiologicalProcess - name: peptidoglycan biosynthetic process - - id: GO:0009273 - label: BiologicalProcess - name: peptidoglycan-based cell wall biogenesis - - id: NCBITaxon:487 - label: OrganismTaxon - name: Neisseria meningitidis - - id: MESH:D008585 - label: Disease - name: Meningitis, Meningococcal - reference: - - https://go.drugbank.com/drugs/DB00493#mechanism-of-action - - https://www.ebi.ac.uk/interpro/entry/InterPro/IPR001460/ -- directed: true - graph: - disease: Neonatal Sepsis - disease_mesh: MESH:D000071074 - drug: cefotaxime - drug_mesh: MESH:D002439 - drugbank: DB:DB00493 - links: - - key: decreases activity of - source: MESH:D002439 - target: InterPro:IPR001460 - - key: participates in - source: InterPro:IPR001460 - target: GO:0009252 - - key: positively correlated with - source: GO:0009252 - target: GO:0009273 - - key: occurs in - source: GO:0009273 - target: NCBITaxon:2 - - key: causes - source: NCBITaxon:2 - target: MESH:D000071074 - multigraph: true - nodes: - - id: MESH:D002439 - label: Drug - name: cefotaxime - - id: InterPro:IPR001460 - label: GeneFamily - name: Penicillin-binding protein, transpeptidase - - id: GO:0009252 - label: BiologicalProcess - name: peptidoglycan biosynthetic process - - id: GO:0009273 - label: BiologicalProcess - name: peptidoglycan-based cell wall biogenesis - - id: NCBITaxon:2 - label: OrganismTaxon - name: Bacteria - - id: MESH:D000071074 - label: Disease - name: Neonatal Sepsis - reference: - - https://go.drugbank.com/drugs/DB00493#mechanism-of-action - - https://www.ebi.ac.uk/interpro/entry/InterPro/IPR001460/ -- directed: true - graph: - disease: Pneumonia, Bacterial - disease_mesh: MESH:D018410 - drug: cefotaxime - drug_mesh: MESH:D002439 - drugbank: DB:DB00493 - links: - - key: decreases activity of - source: MESH:D002439 - target: InterPro:IPR001460 - - key: participates in - source: InterPro:IPR001460 - target: GO:0009252 - - key: positively correlated with - source: GO:0009252 - target: GO:0009273 - - key: occurs in - source: GO:0009273 - target: NCBITaxon:2 - - key: causes - source: NCBITaxon:2 - target: MESH:D018410 - multigraph: true - nodes: - - id: MESH:D002439 - label: Drug - name: cefotaxime - - id: InterPro:IPR001460 - label: GeneFamily - name: Penicillin-binding protein, transpeptidase - - id: GO:0009252 - label: BiologicalProcess - name: peptidoglycan biosynthetic process - - id: GO:0009273 - label: BiologicalProcess - name: peptidoglycan-based cell wall biogenesis - - id: NCBITaxon:2 - label: OrganismTaxon - name: Bacteria - - id: MESH:D018410 - label: Disease - name: Pneumonia, Bacterial - reference: - - https://go.drugbank.com/drugs/DB00493#mechanism-of-action - - https://www.ebi.ac.uk/interpro/entry/InterPro/IPR001460/ -- directed: true - graph: - disease: Pneumonia, Pneumococcal - disease_mesh: MESH:D011018 - drug: cefotaxime - drug_mesh: MESH:D002439 - drugbank: DB:DB00493 - links: - - key: decreases activity of - source: MESH:D002439 - target: InterPro:IPR001460 - - key: participates in - source: InterPro:IPR001460 - target: GO:0009252 - - key: positively correlated with - source: GO:0009252 - target: GO:0009273 - - key: occurs in - source: GO:0009273 - target: NCBITaxon:1313 - - key: causes - source: NCBITaxon:1313 - target: MESH:D011018 - multigraph: true - nodes: - - id: MESH:D002439 - label: Drug - name: cefotaxime - - id: InterPro:IPR001460 - label: GeneFamily - name: Penicillin-binding protein, transpeptidase - - id: GO:0009252 - label: BiologicalProcess - name: peptidoglycan biosynthetic process - - id: GO:0009273 - label: BiologicalProcess - name: peptidoglycan-based cell wall biogenesis - - id: NCBITaxon:1313 - label: OrganismTaxon - name: Streptococcus pneumoniae - - id: MESH:D011018 - label: Disease - name: Pneumonia, Pneumococcal - reference: - - https://go.drugbank.com/drugs/DB00493#mechanism-of-action - - https://www.ebi.ac.uk/interpro/entry/InterPro/IPR001460/ -- directed: true - graph: - disease: Pneumonia, Staphylococcal - disease_mesh: MESH:D011023 - drug: cefotaxime - drug_mesh: MESH:D002439 - drugbank: DB:DB00493 - links: - - key: decreases activity of - source: MESH:D002439 - target: InterPro:IPR001460 - - key: participates in - source: InterPro:IPR001460 - target: GO:0009252 - - key: positively correlated with - source: GO:0009252 - target: GO:0009273 - - key: occurs in - source: GO:0009273 - target: NCBITaxon:1279 - - key: causes - source: NCBITaxon:1279 - target: MESH:D011023 - multigraph: true - nodes: - - id: MESH:D002439 - label: Drug - name: cefotaxime - - id: InterPro:IPR001460 - label: GeneFamily - name: Penicillin-binding protein, transpeptidase - - id: GO:0009252 - label: BiologicalProcess - name: peptidoglycan biosynthetic process - - id: GO:0009273 - label: BiologicalProcess - name: peptidoglycan-based cell wall biogenesis - - id: NCBITaxon:1279 - label: OrganismTaxon - name: Staphylococcus - - id: MESH:D011023 - label: Disease - name: Pneumonia, Staphylococcal - reference: - - https://go.drugbank.com/drugs/DB00493#mechanism-of-action - - https://www.ebi.ac.uk/interpro/entry/InterPro/IPR001460/ -- directed: true - graph: - disease: Serratia Infections - disease_mesh: MESH:D016868 - drug: cefotaxime - drug_mesh: MESH:D002439 - drugbank: DB:DB00493 - links: - - key: decreases activity of - source: MESH:D002439 - target: InterPro:IPR001460 - - key: participates in - source: InterPro:IPR001460 - target: GO:0009252 - - key: positively correlated with - source: GO:0009252 - target: GO:0009273 - - key: occurs in - source: GO:0009273 - target: NCBITaxon:613 - - key: causes - source: NCBITaxon:613 - target: MESH:D016868 - multigraph: true - nodes: - - id: MESH:D002439 - label: Drug - name: cefotaxime - - id: InterPro:IPR001460 - label: GeneFamily - name: Penicillin-binding protein, transpeptidase - - id: GO:0009252 - label: BiologicalProcess - name: peptidoglycan biosynthetic process - - id: GO:0009273 - label: BiologicalProcess - name: peptidoglycan-based cell wall biogenesis - - id: NCBITaxon:613 - label: OrganismTaxon - name: Serratia - - id: MESH:D016868 - label: Disease - name: Serratia Infections - reference: - - https://go.drugbank.com/drugs/DB00493#mechanism-of-action - - https://www.ebi.ac.uk/interpro/entry/InterPro/IPR001460/ -- directed: true - graph: - disease: Pain - disease_mesh: MESH:D010146 - drug: flufenamic acid - drug_mesh: MESH:D005439 - drugbank: DB:DB02266 - links: - - key: decreases activity of - source: MESH:D005439 - target: UniProt:P23219 - - key: decreases activity of - source: MESH:D005439 - target: UniProt:P35354 - - key: participates in - source: UniProt:P23219 - target: GO:0001516 - - key: participates in - source: UniProt:P35354 - target: GO:0001516 - - key: increases abundance of - source: GO:0001516 - target: MESH:D011453 - - key: positively regulates - source: MESH:D011453 - target: GO:0006954 - - key: causes - source: GO:0006954 - target: MESH:D010146 - multigraph: true - nodes: - - id: MESH:D005439 - label: Drug - name: flufenamic acid - - id: UniProt:P23219 - label: Protein - name: Prostaglandin G/H synthase 1 - - id: UniProt:P35354 - label: Protein - name: Prostaglandin G/H synthase 2 - - id: GO:0001516 - label: BiologicalProcess - name: prostaglandin biosynthetic process - - id: MESH:D011453 - label: ChemicalSubstance - name: Prostaglandins - - id: GO:0006954 - label: BiologicalProcess - name: inflammatory response - - id: MESH:D010146 - label: Disease - name: Pain - reference: - - https://go.drugbank.com/drugs/DB02266#mechanism-of-action - - https://www.uniprot.org/uniprot/P23219#function - - https://www.uniprot.org/uniprot/P35354#function - - https://en.wikipedia.org/wiki/Pain -- comment: Imolamine is a coronary vasodilator, that is used in the treatment of angina pectoris. - directed: true - graph: - disease: Angina pectoris - disease_mesh: MESH:D000787 - drug: imolamine - drug_mesh: MESH:C002787 - drugbank: DB:DB09284 - links: - - key: positively regulates - source: MESH:C002787 - target: GO:0042311 - - key: negatively correlated with - source: GO:0042311 - target: MESH:D017202 - - key: contributes to - source: MESH:D017202 - target: MESH:D000787 - multigraph: true - nodes: - - id: MESH:C002787 - label: Drug - name: imolamine - - id: GO:0042311 - label: BiologicalProcess - name: vasodilation - - id: MESH:D017202 - label: Disease - name: Myocardial Ischemia - - id: MESH:D000787 - label: Disease - name: Angina Pectoris - reference: - - https://drugs.ncats.io/drug/K5F4RU5VQJ - - https://en.wikipedia.org/wiki/Angina -- directed: true - graph: - disease: Hypertension - disease_mesh: MESH:D006973 - drug: ketanserin - drug_mesh: MESH:D007650 - drugbank: DB:DB12465 - links: - - key: decreases activity of - source: MESH:D007650 - target: UniProt:P28223 - - key: positively regulates - source: UniProt:P28223 - target: GO:0042310 - - key: positively correlated with - source: GO:0042310 - target: HP:0032263 - - key: manifestation of - source: HP:0032263 - target: MESH:D006973 - multigraph: true - nodes: - - id: MESH:D007650 - label: Drug - name: ketanserin - - id: UniProt:P28223 - label: Protein - name: 5-hydroxytryptamine receptor 2A - - id: GO:0042310 - label: BiologicalProcess - name: vasoconstriction - - id: HP:0032263 - label: PhenotypicFeature - name: Increased blood pressure - - id: MESH:D006973 - label: Disease - name: Hypertension - reference: - - https://go.drugbank.com/drugs/DB12465#mechanism-of-action - - https://drugs.ncats.io/drug/97F9DE4CT4 - - https://www.uniprot.org/uniprot/P28223#function - - https://en.wikipedia.org/wiki/Hypertension -- directed: true - graph: - disease: Hyperthyroidism - disease_mesh: MESH:D006980 - drug: methimazole - drug_mesh: MESH:D008713 - drugbank: DB:DB00763 - links: - - key: decreases activity of - source: MESH:D008713 - target: UniProt:P07202 - - key: positively regulates - source: UniProt:P07202 - target: GO:0006590 - - key: increases abundance of - source: GO:0006590 - target: MESH:D013963 - - key: positively correlated with - source: MESH:D013963 - target: MESH:D006980 - multigraph: true - nodes: - - id: MESH:D008713 - label: Drug - name: methimazole - - id: UniProt:P07202 - label: Protein - name: Thyroid peroxidase - - id: GO:0006590 - label: BiologicalProcess - name: thyroid hormone generation - - id: MESH:D013963 - label: ChemicalSubstance - name: Thyroid Hormones - - id: MESH:D006980 - label: Disease - name: Hyperthyroidism - reference: - - https://go.drugbank.com/drugs/DB00763#mechanism-of-action - - https://www.uniprot.org/uniprot/P07202#function - - https://en.wikipedia.org/wiki/Hyperthyroidism -- comment: Moexipril hydrochloride is a non-sulfhydryl of Moexipril, and acts as a prodrug of Moexiprilat. - directed: true - graph: - disease: Hypertension - disease_mesh: MESH:D006973 - drug: moexipril - drug_mesh: MESH:C058302 - drugbank: DB:DB00691 - links: - - key: has metabolite - source: MESH:C058302 - target: MESH:C059506 - - key: decreases activity of - source: MESH:C059506 - target: UniProt:P12821 - - key: positively regulates - source: UniProt:P12821 - target: GO:0042310 - - key: positively regulates - source: UniProt:P12821 - target: GO:0035932 - - key: participates in - source: GO:0042310 - target: GO:0045777 - - key: participates in - source: GO:0035932 - target: GO:0045777 - - key: contributes to - source: GO:0045777 - target: MESH:D006973 - multigraph: true - nodes: - - id: MESH:C058302 - label: Drug - name: moexipril - - id: MESH:C059506 - label: ChemicalSubstance - name: moexiprilat - - id: UniProt:P12821 - label: Protein - name: Angiotensin-converting enzyme - - id: GO:0042310 - label: BiologicalProcess - name: vasoconstriction - - id: GO:0035932 - label: BiologicalProcess - name: aldosterone secretion - - id: GO:0045777 - label: BiologicalProcess - name: positive regulation of blood pressure - - id: MESH:D006973 - label: Disease - name: Hypertension - reference: - - https://go.drugbank.com/drugs/DB00691#mechanism-of-action - - https://www.uniprot.org/uniprot/P12821#function - - https://en.wikipedia.org/wiki/Hypertension -- comment: Molsidomine is a drug that is metabolized in the liver to the active metabolite linsidomine which releases nitric oxide, a vasodilating compound. - directed: true - graph: - disease: Angina pectoris - disease_mesh: MESH:D000787 - drug: molsidomine - drug_mesh: MESH:D008981 - drugbank: DB:DB09282 - links: - - key: has metabolite - source: MESH:D008981 - target: MESH:C002385 - - key: produces - source: MESH:C002385 - target: MESH:D009569 - - key: positively regulates - source: MESH:D009569 - target: GO:0004383 - - key: increases abundance of - source: GO:0004383 - target: MESH:D006152 - - key: positively correlated with - source: MESH:D006152 - target: GO:0042311 - - key: negatively correlated with - source: GO:0042311 - target: MESH:D017202 - - key: contributes to - source: MESH:D017202 - target: MESH:D000787 - multigraph: true - nodes: - - id: MESH:D008981 - label: Drug - name: molsidomine - - id: MESH:C002385 - label: ChemicalSubstance - name: linsidomine - - id: MESH:D009569 - label: ChemicalSubstance - name: Nitric Oxide - - id: GO:0004383 - label: MolecularActivity - name: guanylate cyclase activity - - id: MESH:D006152 - label: ChemicalSubstance - name: Cyclic GMP - - id: GO:0042311 - label: BiologicalProcess - name: vasodilation - - id: MESH:D017202 - label: Disease - name: Myocardial Ischemia - - id: MESH:D000787 - label: Disease - name: Angina Pectoris - reference: - - https://go.drugbank.com/drugs/DB09282#mechanism-of-action - - https://drugs.ncats.io/drug/D46583G77X - - https://en.wikipedia.org/wiki/Angina -- directed: true - graph: - disease: Peptic Ulcer - disease_mesh: MESH:D010437 - drug: octatropine methylbromide - drug_mesh: MESH:C100237 - drugbank: DB:DB00517 - links: - - key: decreases activity of - source: MESH:C100237 - target: UniProt:P11229 - - key: decreases activity of - source: MESH:C100237 - target: UniProt:P08172 - - key: decreases activity of - source: MESH:C100237 - target: UniProt:P20309 - - key: positively regulates - source: UniProt:P11229 - target: GO:0095500 - - key: positively regulates - source: UniProt:P08172 - target: GO:0095500 - - key: positively regulates - source: UniProt:P20309 - target: GO:0095500 - - key: positively correlated with - source: GO:0095500 - target: MESH:D000109 - - key: positively correlated with - source: MESH:D000109 - target: GO:0001696 - - key: contributes to - source: GO:0001696 - target: MESH:D010437 - multigraph: true - nodes: - - id: MESH:C100237 - label: Drug - name: octatropine methylbromide - - id: UniProt:P11229 - label: Protein - name: Muscarinic acetylcholine receptor M1 - - id: UniProt:P08172 - label: Protein - name: Muscarinic acetylcholine receptor M2 - - id: UniProt:P20309 - label: Protein - name: Muscarinic acetylcholine receptor M3 - - id: GO:0095500 - label: BiologicalProcess - name: acetylcholine receptor signaling pathway - - id: MESH:D000109 - label: ChemicalSubstance - name: Acetylcholine - - id: GO:0001696 - label: BiologicalProcess - name: gastric acid secretion - - id: MESH:D010437 - label: Disease - name: Peptic Ulcer - reference: - - https://go.drugbank.com/drugs/DB00517#mechanism-of-action - - https://www.uniprot.org/uniprot/P11229#function - - https://www.uniprot.org/uniprot/P08172#function - - https://www.uniprot.org/uniprot/P20309#function - - https://en.wikipedia.org/wiki/Peptic_ulcer_disease -- directed: true - graph: - disease: Stomach Ulcer - disease_mesh: MESH:D013276 - drug: octatropine methylbromide - drug_mesh: MESH:C100237 - drugbank: DB:DB00517 - links: - - key: decreases activity of - source: MESH:C100237 - target: UniProt:P11229 - - key: decreases activity of - source: MESH:C100237 - target: UniProt:P08172 - - key: decreases activity of - source: MESH:C100237 - target: UniProt:P20309 - - key: positively regulates - source: UniProt:P11229 - target: GO:0095500 - - key: positively regulates - source: UniProt:P08172 - target: GO:0095500 - - key: positively regulates - source: UniProt:P20309 - target: GO:0095500 - - key: positively correlated with - source: GO:0095500 - target: MESH:D000109 - - key: positively correlated with - source: MESH:D000109 - target: GO:0001696 - - key: contributes to - source: GO:0001696 - target: MESH:D010437 - - key: located in - source: MESH:D010437 - target: UBERON:0000945 - - key: location of - source: UBERON:0000945 - target: MESH:D013276 - multigraph: true - nodes: - - id: MESH:C100237 - label: Drug - name: octatropine methylbromide - - id: UniProt:P11229 - label: Protein - name: Muscarinic acetylcholine receptor M1 - - id: UniProt:P08172 - label: Protein - name: Muscarinic acetylcholine receptor M2 - - id: UniProt:P20309 - label: Protein - name: Muscarinic acetylcholine receptor M3 - - id: GO:0095500 - label: BiologicalProcess - name: acetylcholine receptor signaling pathway - - id: MESH:D000109 - label: ChemicalSubstance - name: Acetylcholine - - id: GO:0001696 - label: BiologicalProcess - name: gastric acid secretion - - id: MESH:D010437 - label: Disease - name: Peptic Ulcer - - id: UBERON:0000945 - label: GrossAnatomicalStructure - name: stomach - - id: MESH:D013276 - label: Disease - name: Stomach Ulcer - reference: - - https://go.drugbank.com/drugs/DB00517#mechanism-of-action - - https://www.uniprot.org/uniprot/P11229#function - - https://www.uniprot.org/uniprot/P08172#function - - https://www.uniprot.org/uniprot/P20309#function - - https://en.wikipedia.org/wiki/Peptic_ulcer_disease -- directed: true - graph: - disease: Epilepsies, Partial - disease_mesh: MESH:D004828 - drug: perampanel - drug_mesh: MESH:C551441 - drugbank: DB:DB08883 - links: - - key: decreases activity of - source: MESH:C551441 - target: UniProt:P42261 - - key: positively regulates - source: UniProt:P42261 - target: GO:0004971 - - key: positively correlated with - source: GO:0004971 - target: GO:0019228 - - key: contributes to - source: GO:0019228 - target: GO:0050806 - - key: positively correlated with - source: GO:0050806 - target: MESH:D004828 - multigraph: true - nodes: - - id: MESH:C551441 - label: Drug - name: perampanel - - id: UniProt:P42261 - label: Protein - name: Glutamate receptor 1 - - id: GO:0004971 - label: MolecularActivity - name: AMPA glutamate receptor activity - - id: GO:0019228 - label: BiologicalProcess - name: neuronal action potential - - id: GO:0050806 - label: BiologicalProcess - name: positive regulation of synaptic transmission - - id: MESH:D004828 - label: Disease - name: Epilepsies, Partial - reference: - - https://go.drugbank.com/drugs/DB08883#mechanism-of-action - - https://www.uniprot.org/uniprot/P42261#function -- directed: true - graph: - disease: Epilepsies, Partial - disease_mesh: MESH:D004828 - drug: topiramate - drug_mesh: MESH:D000077236 - drugbank: DB:DB00273 - links: - - key: increases activity of - source: MESH:D000077236 - target: GO:0022851 - - key: decreases activity of - source: MESH:D000077236 - target: InterPro:IPR001696 - - key: negatively correlated with - source: GO:0022851 - target: GO:0051899 - - key: positively correlated with - source: InterPro:IPR001696 - target: GO:0051899 - - key: positively regulates - source: GO:0051899 - target: GO:0019228 - - key: regulates - source: GO:0019228 - target: GO:0050806 - - key: positively correlated with - source: GO:0050806 - target: MESH:D004828 - multigraph: true - nodes: - - id: MESH:D000077236 - label: Drug - name: topiramate - - id: GO:0022851 - label: MolecularActivity - name: GABA-gated chloride ion channel activity - - id: InterPro:IPR001696 - label: GeneFamily - name: Voltage gated sodium channel, alpha subunit - - id: GO:0051899 - label: BiologicalProcess - name: membrane depolarization - - id: GO:0019228 - label: BiologicalProcess - name: neuronal action potential - - id: GO:0050806 - label: BiologicalProcess - name: positive regulation of synaptic transmission - - id: MESH:D004828 - label: Disease - name: Epilepsies, Partial - reference: - - https://go.drugbank.com/drugs/DB00273#mechanism-of-action - - https://en.wikipedia.org/wiki/Focal_seizure -- directed: true - graph: - disease: Epilepsy, Tonic-Clonic - disease_mesh: MESH:D004830 - drug: topiramate - drug_mesh: MESH:D000077236 - drugbank: DB:DB00273 - links: - - key: increases activity of - source: MESH:D000077236 - target: GO:0022851 - - key: decreases activity of - source: MESH:D000077236 - target: InterPro:IPR001696 - - key: negatively correlated with - source: GO:0022851 - target: GO:0051899 - - key: positively correlated with - source: InterPro:IPR001696 - target: GO:0051899 - - key: positively regulates - source: GO:0051899 - target: GO:0019228 - - key: regulates - source: GO:0019228 - target: GO:0050806 - - key: positively correlated with - source: GO:0050806 - target: MESH:D004830 - multigraph: true - nodes: - - id: MESH:D000077236 - label: Drug - name: topiramate - - id: GO:0022851 - label: MolecularActivity - name: GABA-gated chloride ion channel activity - - id: InterPro:IPR001696 - label: GeneFamily - name: Voltage gated sodium channel, alpha subunit - - id: GO:0051899 - label: BiologicalProcess - name: membrane depolarization - - id: GO:0019228 - label: BiologicalProcess - name: neuronal action potential - - id: GO:0050806 - label: BiologicalProcess - name: positive regulation of synaptic transmission - - id: MESH:D004830 - label: Disease - name: Epilepsy, Tonic-Clonic - reference: - - https://go.drugbank.com/drugs/DB00273#mechanism-of-action - - https://en.wikipedia.org/wiki/Generalized_tonic%E2%80%93clonic_seizure -- directed: true - graph: - disease: Lennox Gastaut Syndrome - disease_mesh: MESH:D065768 - drug: topiramate - drug_mesh: MESH:D000077236 - drugbank: DB:DB00273 - links: - - key: increases activity of - source: MESH:D000077236 - target: GO:0022851 - - key: decreases activity of - source: MESH:D000077236 - target: InterPro:IPR001696 - - key: negatively correlated with - source: GO:0022851 - target: GO:0051899 - - key: positively correlated with - source: InterPro:IPR001696 - target: GO:0051899 - - key: positively regulates - source: GO:0051899 - target: GO:0019228 - - key: regulates - source: GO:0019228 - target: GO:0050806 - - key: positively correlated with - source: GO:0050806 - target: MESH:D065768 - multigraph: true - nodes: - - id: MESH:D000077236 - label: Drug - name: topiramate - - id: GO:0022851 - label: MolecularActivity - name: GABA-gated chloride ion channel activity - - id: InterPro:IPR001696 - label: GeneFamily - name: Voltage gated sodium channel, alpha subunit - - id: GO:0051899 - label: BiologicalProcess - name: membrane depolarization - - id: GO:0019228 - label: BiologicalProcess - name: neuronal action potential - - id: GO:0050806 - label: BiologicalProcess - name: positive regulation of synaptic transmission - - id: MESH:D065768 - label: Disease - name: Lennox Gastaut Syndrome - reference: - - https://go.drugbank.com/drugs/DB00273#mechanism-of-action - - https://en.wikipedia.org/wiki/Lennox%E2%80%93Gastaut_syndrome +