From c2d215f0dd268fec448922b432e49a36e38584bd Mon Sep 17 00:00:00 2001 From: BrindhaSridharan <100606129+BrindhaSridharan@users.noreply.github.com> Date: Sat, 26 Mar 2022 15:45:29 -0500 Subject: [PATCH] Group 160 submission Group 160 submission --- submission.yaml | 458 +++++++++++++++++++++++++++++++++++++++++++++++- 1 file changed, 457 insertions(+), 1 deletion(-) diff --git a/submission.yaml b/submission.yaml index 8b1378917..f36bac852 100644 --- a/submission.yaml +++ b/submission.yaml @@ -1 +1,457 @@ - +- directed: true + graph: + disease: Angina Pectoris + disease_mesh: MESH:D000787 + drug: atorvastatin + drug_mesh: MESH:D000069059 + drugbank: DB:DB01076 + links: + - key: decreases activity of + source: MESH:D000069059 + target: UniProt:P04035 + - key: positively regulates + source: UniProt:P04035 + target: GO:0006695 + - key: increases abundance of + source: GO:0006695 + target: MESH:D002784 + - key: positively correlated with + source: MESH:D002784 + target: HP:0002621 + - key: contributes to + source: HP:0002621 + target: MESH:D000787 + multigraph: true + nodes: + - id: MESH:D000069059 + label: Drug + name: atorvastatin + - id: UniProt:P04035 + label: Protein + name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase + - id: GO:0006695 + label: BiologicalProcess + name: cholesterol biosynthetic process + - id: MESH:D002784 + label: ChemicalSubstance + name: Cholesterol + - id: HP:0002621 + label: PhenotypicFeature + name: Atherosclerosis + - id: MESH:D000787 + label: Disease + name: Angina Pectoris + reference: + - https://go.drugbank.com/drugs/DB01076#mechanism-of-action + - https://www.uniprot.org/uniprot/P04035#function + - https://en.wikipedia.org/wiki/Atherosclerosis + - https://en.wikipedia.org/wiki/Angina +- directed: true + graph: + disease: Angina Pectoris, Variant + disease_mesh: MESH:D000788 + drug: atorvastatin + drug_mesh: MESH:D000069059 + drugbank: DB:DB01076 + links: + - key: decreases activity of + source: MESH:D000069059 + target: UniProt:P04035 + - key: positively regulates + source: UniProt:P04035 + target: GO:0006695 + - key: increases abundance of + source: GO:0006695 + target: MESH:D002784 + - key: positively correlated with + source: MESH:D002784 + target: HP:0002621 + - key: contributes to + source: HP:0002621 + target: MESH:D000788 + multigraph: true + nodes: + - id: MESH:D000069059 + label: Drug + name: atorvastatin + - id: UniProt:P04035 + label: Protein + name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase + - id: GO:0006695 + label: BiologicalProcess + name: cholesterol biosynthetic process + - id: MESH:D002784 + label: ChemicalSubstance + name: Cholesterol + - id: HP:0002621 + label: PhenotypicFeature + name: Atherosclerosis + - id: MESH:D000788 + label: Disease + name: Angina Pectoris, Variant + reference: + - https://go.drugbank.com/drugs/DB01076#mechanism-of-action + - https://www.uniprot.org/uniprot/P04035#function + - https://en.wikipedia.org/wiki/Atherosclerosis + - https://en.wikipedia.org/wiki/Variant_angina +- directed: true + graph: + disease: Arteriosclerosis + disease_mesh: MESH:D001161 + drug: atorvastatin + drug_mesh: MESH:D000069059 + drugbank: DB:DB01076 + links: + - key: decreases activity of + source: MESH:D000069059 + target: UniProt:P04035 + - key: positively regulates + source: UniProt:P04035 + target: GO:0006695 + - key: increases abundance of + source: GO:0006695 + target: MESH:D002784 + - key: positively correlated with + source: MESH:D002784 + target: HP:0002621 + - key: manifestation of + source: HP:0002621 + target: MESH:D001161 + multigraph: true + nodes: + - id: MESH:D000069059 + label: Drug + name: atorvastatin + - id: UniProt:P04035 + label: Protein + name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase + - id: GO:0006695 + label: BiologicalProcess + name: cholesterol biosynthetic process + - id: MESH:D002784 + label: ChemicalSubstance + name: Cholesterol + - id: HP:0002621 + label: PhenotypicFeature + name: Atherosclerosis + - id: MESH:D001161 + label: Disease + name: Arteriosclerosis + reference: + - https://go.drugbank.com/drugs/DB01076#mechanism-of-action + - https://www.uniprot.org/uniprot/P04035#function + - https://en.wikipedia.org/wiki/Atherosclerosis + - https://en.wikipedia.org/wiki/Arteriosclerosis +- directed: true + graph: + disease: Hypercholesterolemia + disease_mesh: MESH:D006937 + drug: atorvastatin + drug_mesh: MESH:D000069059 + drugbank: DB:DB01076 + links: + - key: decreases activity of + source: MESH:D000069059 + target: UniProt:P04035 + - key: positively regulates + source: UniProt:P04035 + target: GO:0006695 + - key: increases abundance of + source: GO:0006695 + target: MESH:D002784 + - key: positively correlated with + source: MESH:D002784 + target: HP:0003107 + - key: manifestation of + source: HP:0003107 + target: MESH:D006937 + multigraph: true + nodes: + - id: MESH:D000069059 + label: Drug + name: atorvastatin + - id: UniProt:P04035 + label: Protein + name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase + - id: GO:0006695 + label: BiologicalProcess + name: cholesterol biosynthetic process + - id: MESH:D002784 + label: ChemicalSubstance + name: Cholesterol + - id: HP:0003107 + label: PhenotypicFeature + name: Abnormal circulating cholesterol concentration + - id: MESH:D006937 + label: Disease + name: Hypercholesterolemia + reference: + - https://go.drugbank.com/drugs/DB01076#mechanism-of-action + - https://www.uniprot.org/uniprot/P04035#function + - https://en.wikipedia.org/wiki/Hypercholesterolemia +- directed: true + graph: + disease: Hyperlipidemia, Familial Combined + disease_mesh: MESH:D006950 + drug: atorvastatin + drug_mesh: MESH:D000069059 + drugbank: DB:DB01076 + links: + - key: decreases activity of + source: MESH:D000069059 + target: UniProt:P04035 + - key: increases activity of + source: MESH:D000069059 + target: UniProt:P06858 + - key: positively regulates + source: UniProt:P04035 + target: GO:0006695 + - key: positively regulates + source: UniProt:P06858 + target: GO:0019433 + - key: increases abundance of + source: GO:0006695 + target: MESH:D002784 + - key: decreases abundance of + source: GO:0019433 + target: MESH:D014280 + - key: positively correlated with + source: MESH:D002784 + target: MESH:D006950 + - key: positively correlated with + source: MESH:D014280 + target: MESH:D006950 + multigraph: true + nodes: + - id: MESH:D000069059 + label: Drug + name: atorvastatin + - id: UniProt:P04035 + label: Protein + name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase + - id: UniProt:P06858 + label: Protein + name: Lipoprotein lipase + - id: GO:0006695 + label: BiologicalProcess + name: cholesterol biosynthetic process + - id: GO:0019433 + label: BiologicalProcess + name: triglyceride catabolic process + - id: MESH:D002784 + label: ChemicalSubstance + name: Cholesterol + - id: MESH:D014280 + label: ChemicalSubstance + name: Triglycerides + - id: MESH:D006950 + label: Disease + name: Hyperlipidemia, Familial Combined + reference: + - https://go.drugbank.com/drugs/DB01076#mechanism-of-action + - https://www.uniprot.org/uniprot/P04035#function + - https://www.uniprot.org/uniprot/P06858#function + - https://pubmed.ncbi.nlm.nih.gov/15262189/ + - https://en.wikipedia.org/wiki/Hyperlipidemia +- directed: true + graph: + disease: Hyperlipoproteinemia Type III + disease_mesh: MESH:D006952 + drug: atorvastatin + drug_mesh: MESH:D000069059 + drugbank: DB:DB01076 + links: + - key: decreases activity of + source: MESH:D000069059 + target: UniProt:P04035 + - key: increases activity of + source: MESH:D000069059 + target: UniProt:P06858 + - key: positively regulates + source: UniProt:P04035 + target: GO:0006695 + - key: positively regulates + source: UniProt:P06858 + target: GO:0019433 + - key: increases abundance of + source: GO:0006695 + target: MESH:D002784 + - key: decreases abundance of + source: GO:0019433 + target: MESH:D014280 + - key: positively correlated with + source: MESH:D002784 + target: MESH:D006952 + - key: positively correlated with + source: MESH:D014280 + target: MESH:D006952 + multigraph: true + nodes: + - id: MESH:D000069059 + label: Drug + name: atorvastatin + - id: UniProt:P04035 + label: Protein + name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase + - id: UniProt:P06858 + label: Protein + name: Lipoprotein lipase + - id: GO:0006695 + label: BiologicalProcess + name: cholesterol biosynthetic process + - id: GO:0019433 + label: BiologicalProcess + name: triglyceride catabolic process + - id: MESH:D002784 + label: ChemicalSubstance + name: Cholesterol + - id: MESH:D014280 + label: ChemicalSubstance + name: Triglycerides + - id: MESH:D006952 + label: Disease + name: Hyperlipoproteinemia Type III + reference: + - https://go.drugbank.com/drugs/DB01076#mechanism-of-action + - https://www.uniprot.org/uniprot/P04035#function + - https://www.uniprot.org/uniprot/P06858#function + - https://pubmed.ncbi.nlm.nih.gov/15262189/ + - https://en.wikipedia.org/wiki/Familial_dysbetalipoproteinemia +- directed: true + graph: + disease: Hypertriglyceridemia + disease_mesh: MESH:D015228 + drug: atorvastatin + drug_mesh: MESH:D000069059 + drugbank: DB:DB01076 + links: + - key: increases activity of + source: MESH:D000069059 + target: UniProt:P06858 + - key: positively regulates + source: UniProt:P06858 + target: GO:0019433 + - key: decreases abundance of + source: GO:0019433 + target: MESH:D014280 + - key: positively correlated with + source: MESH:D014280 + target: MESH:D015228 + multigraph: true + nodes: + - id: MESH:D000069059 + label: Drug + name: atorvastatin + - id: UniProt:P06858 + label: Protein + name: Lipoprotein lipase + - id: GO:0019433 + label: BiologicalProcess + name: triglyceride catabolic process + - id: MESH:D014280 + label: ChemicalSubstance + name: Triglycerides + - id: MESH:D015228 + label: Disease + name: Hypertriglyceridemia + reference: + - https://go.drugbank.com/drugs/DB01076#mechanism-of-action + - https://www.uniprot.org/uniprot/P06858#function + - https://pubmed.ncbi.nlm.nih.gov/15262189/ + - https://en.wikipedia.org/wiki/Hypertriglyceridemia +- directed: true + graph: + disease: Stroke + disease_mesh: MESH:D020521 + drug: atorvastatin + drug_mesh: MESH:D000069059 + drugbank: DB:DB01076 + links: + - key: decreases activity of + source: MESH:D000069059 + target: UniProt:P04035 + - key: positively regulates + source: UniProt:P04035 + target: GO:0006695 + - key: increases abundance of + source: GO:0006695 + target: MESH:D002784 + - key: positively correlated with + source: MESH:D002784 + target: HP:0002621 + - key: contributes to + source: HP:0002621 + target: HP:0002637 + - key: manifestation of + source: HP:0002637 + target: MESH:D020521 + multigraph: true + nodes: + - id: MESH:D000069059 + label: Drug + name: atorvastatin + - id: UniProt:P04035 + label: Protein + name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase + - id: GO:0006695 + label: BiologicalProcess + name: cholesterol biosynthetic process + - id: MESH:D002784 + label: ChemicalSubstance + name: Cholesterol + - id: HP:0002621 + label: PhenotypicFeature + name: Atherosclerosis + - id: HP:0002637 + label: PhenotypicFeature + name: Cerebral ischemia + - id: MESH:D020521 + label: Disease + name: Stroke + reference: + - https://go.drugbank.com/drugs/DB01076#mechanism-of-action + - https://www.uniprot.org/uniprot/P04035#function + - https://en.wikipedia.org/wiki/Atherosclerosis + - https://en.wikipedia.org/wiki/Brain_ischemia + - https://en.wikipedia.org/wiki/Stroke +- directed: true + graph: + disease: Melanosis + disease_mesh: MESH:D008548 + drug: hydroquinone + drug_mesh: MESH:C031927 + drugbank: DB:DB09526 + links: + - key: decreases activity of + source: MESH:C031927 + target: UniProt:P14679 + - key: positively regulates + source: UniProt:P14679 + target: GO:0042438 + - key: increases abundance of + source: GO:0042438 + target: MESH:D008543 + - key: positively correlated with + source: MESH:D008543 + target: MESH:D008548 + multigraph: true + nodes: + - id: MESH:C031927 + label: Drug + name: hydroquinone + - id: UniProt:P14679 + label: Protein + name: Tyrosinase + - id: GO:0042438 + label: BiologicalProcess + name: melanin biosynthetic process + - id: MESH:D008543 + label: ChemicalSubstance + name: Melanins + - id: MESH:D008548 + label: Disease + name: Melanosis + reference: + - https://go.drugbank.com/drugs/DB09526#mechanism-of-action + - https://www.uniprot.org/uniprot/P14679#function + - https://en.wikipedia.org/wiki/Melanosis