From 5a518f372bf0173ba75ae980eb8295b893bd6b1c Mon Sep 17 00:00:00 2001 From: TanskaAnnna Date: Fri, 5 Mar 2021 16:08:28 +0000 Subject: [PATCH 1/3] Commit from GitHub Actions (Validate PR) --- indication_paths.json | 1699 +++++++++++++++++++++++++++++++++++++++++ indication_paths.yaml | 1054 ++++++++++++++++++++++++- 2 files changed, 2752 insertions(+), 1 deletion(-) diff --git a/indication_paths.json b/indication_paths.json index 1a130de02..cb15ad686 100644 --- a/indication_paths.json +++ b/indication_paths.json @@ -58286,5 +58286,1704 @@ } ], "reference": "https://pubchem.ncbi.nlm.nih.gov/compound/Talinolol#section=Pharmacology-and-Biochemistry https://pubmed.ncbi.nlm.nih.gov/8829891/" + }, + { + "directed": true, + "graph": { + "disease": "Allergic conjunctivitis", + "disease_mesh": "MESH:D003233", + "drug": "Cyproheptadine", + "drug_mesh": "MESH:D003533", + "drugbank": "DB:DB00434" + }, + "links": [ + { + "key": "decreases activity of", + "source": "MESH:D003533", + "target": 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"disease": "Vernal conjunctivitis", + "disease_mesh": "MESH:D003233", + "drug": "Lodoxamide", + "drug_mesh": "MESH:C021702,MESH:C022028", + "drugbank": "DB:DB06794" + }, + "links": [ + { + "key": "negatively regulates", + "source": "DB:DB06794", + "target": "GO:0043303" + }, + { + "key": "positively regulates", + "source": "GO:0043303", + "target": "GO:0001821" + }, + { + "key": "positively regulates", + "source": "GO:0001821", + "target": "GO:0006954" + }, + { + "key": "causes", + "source": "GO:0006954", + "target": "MESH:D003233" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "DB:DB06794", + "label": "Drug", + "name": "Lodoxamide" + }, + { + "id": "GO:0043303", + "label": "BiologicalProcess", + "name": "Mast cell degranulation" + }, + { + "id": "GO:0001821", + "label": "BiologicalProcess", + "name": "Histamine secretion" + }, + { + "id": "GO:0006954", + "label": "BiologicalProcess", + "name": "Inflammatory response" + }, + { + "id": "MESH:D003233", + "label": "Disease", + "name": "Vernal conjunctivitis" + } + ], + "reference": "https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201266/ https://go.drugbank.com/drugs/DB06794" + }, + { + "directed": true, + "graph": { + "disease": "Constipation", + "disease_mesh": "MESH:D003248", + "drug": "Sodium phosphate", + "drug_mesh": "MESH:C018279", + "drugbank": "DB:DB09449" + }, + "links": [ + { + "key": "positively regulates", + "source": "MESH:C018279", + "target": "GO:0120054" + }, + { + "key": "negatively correlated with", + "source": "GO:0120054", + "target": "MESH:D003248" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:C018279", + "label": "Drug", + "name": "Sodium phosphate" + }, + { + "id": "GO:0120054", + "label": "BiologicalProcess", + "name": "Intestinal motility" + }, + { + "id": "MESH:D003248", + "label": "Disease", + "name": "Constipation" + } + ], + "reference": "https://go.drugbank.com/drugs/DB09449" } ] \ No newline at end of file diff --git a/indication_paths.yaml b/indication_paths.yaml index 161854aa7..476192578 100644 --- a/indication_paths.yaml +++ b/indication_paths.yaml @@ -35128,7 +35128,7 @@ name: D-glucopyranose - id: CHEBI:28061 label: ChemicalSubstance - name: "α-D-galactose" + name: "\u03B1-D-galactose" - id: GO:0050892 label: BiologicalProcess name: intestinal absorption @@ -36238,3 +36238,1055 @@ name: Hypertensive disorder reference: https://pubchem.ncbi.nlm.nih.gov/compound/Talinolol#section=Pharmacology-and-Biochemistry https://pubmed.ncbi.nlm.nih.gov/8829891/ +- directed: true + graph: + disease: Allergic conjunctivitis + disease_mesh: MESH:D003233 + drug: Cyproheptadine + drug_mesh: MESH:D003533 + drugbank: DB:DB00434 + links: + - key: decreases activity of + source: MESH:D003533 + target: UniProt:P35367 + - key: positively correlated with + source: UniProt:P35367 + target: MESH:D006632 + - key: positively regulates + source: MESH:D006632 + target: UBERON:0035501 + - key: positively regulates + source: UBERON:0035501 + target: GO:0070075 + - key: manifestation of + source: GO:0070075 + target: MESH:D003233 + multigraph: true + nodes: + - id: MESH:D003533 + label: Drug + name: Cyproheptadine + - id: UniProt:P35367 + label: Protein + name: Histamine H1 receptor + - id: MESH:D006632 + label: ChemicalSubstance + name: Histamine + - id: UBERON:0035501 + label: GrossAnatomicalStructure + name: Free nerve ending + - id: GO:0070075 + label: BiologicalProcess + name: Tear secretion + - id: MESH:D003233 + label: Disease + name: Allergic conjunctivitis + reference: https://go.drugbank.com/drugs/DB00434 https://en.wikipedia.org/wiki/Allergic_conjunctivitis +- directed: true + graph: + disease: Itching of skin + disease_mesh: MESH:D011537 + drug: Cyproheptadine + drug_mesh: MESH:D003533 + drugbank: DB:DB00434 + links: + - key: negatively regulates + source: MESH:D003533 + target: UniProt:P35367 + - key: positively correlated with + source: UniProt:P35367 + target: MESH:D006632 + - key: positively regulates + source: MESH:D006632 + target: UniProt:Q8NER1 + - key: positively regulates + source: UniProt:Q8NER1 + target: CL:0000197 + - key: contributes to + source: CL:0000197 + target: MESH:D011537 + multigraph: true + nodes: + - id: MESH:D003533 + label: Drug + name: Cyproheptadine + - id: UniProt:P35367 + label: Protein + name: Histamine H1 receptor + - id: MESH:D006632 + label: ChemicalSubstance + name: Histamine + - id: UniProt:Q8NER1 + label: Protein + name: Transient receptor potential cation channel subfamily V member 1 + - id: CL:0000197 + label: Cell + name: Sensory Receptor Cell + - id: MESH:D011537 + label: Disease + name: Itching of skin + reference: https://go.drugbank.com/drugs/DB00434 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519061/ +- directed: true + graph: + disease: Urticaria + disease_mesh: MESH:D014581 + drug: Cyproheptadine + drug_mesh: MESH:D003533 + drugbank: DB:DB00434 + links: + - key: decreases activity of + source: MESH:D003533 + target: UniProt:P35367 + - key: positively regulates + source: UniProt:P35367 + target: GO:0004969 + - key: participates in + source: GO:0004969 + target: GO:0071420 + - key: positively correlated with + source: GO:0071420 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D014581 + multigraph: true + nodes: + - id: MESH:D003533 + label: Drug + name: Cyproheptadine + - id: UniProt:P35367 + label: Protein + name: Histamine H1 receptor + - id: GO:0004969 + label: MolecularActivity + name: Histamine receptor activity + - id: GO:0071420 + label: BiologicalProcess + name: Cellular response to histamine + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D014581 + label: Disease + name: Urticaria + reference: https://go.drugbank.com/drugs/DB00434 https://en.wikipedia.org/wiki/Hives +- directed: true + graph: + disease: Sneezing + disease_mesh: MESH:D012912 + drug: Cyproheptadine + drug_mesh: MESH:D003533 + drugbank: DB:DB00434 + links: + - key: decreases activity of + source: MESH:D003533 + target: UniProt:P35367 + - key: participates in + source: UniProt:P35367 + target: GO:0051381 + - key: positively regulates + source: GO:0051381 + target: GO:0023041 + - key: located in + source: GO:0023041 + target: UBERON:0000004 + - key: affected by + source: UBERON:0000004 + target: UBERON:0001645 + - key: contributes to + source: UBERON:0001645 + target: MESH:D012912 + multigraph: true + nodes: + - id: MESH:D003533 + label: Drug + name: Cyproheptadine + - id: UniProt:P35367 + label: Protein + name: Histamine H1 receptor + - id: GO:0051381 + label: MolecularActivity + name: Histamine binding + - id: GO:0023041 + label: BiologicalProcess + name: neuronal signal transduction + - id: UBERON:0000004 + label: GrossAnatomicalStructure + name: Nose + - alt_ids: MESH:D014276 + id: UBERON:0001645 + label: GrossAnatomicalStructure + name: Trigeminal nerve + - id: MESH:D012912 + label: Disease + name: Sneezing + reference: https://go.drugbank.com/drugs/DB00434 https://en.wikipedia.org/wiki/Sneeze +- directed: true + graph: + disease: Allergic rhinitis + disease_mesh: MESH:D065631 + drug: Cyproheptadine + drug_mesh: MESH:D003533 + drugbank: DB:DB00434 + links: + - key: negatively regulates + source: MESH:D003533 + target: UniProt:P35367 + - key: positively correlated with + source: UniProt:P35367 + target: MESH:D006632 + - key: positively regulates + source: MESH:D006632 + target: GO:0071159 + - key: positively regulates + source: GO:0071159 + target: GO:0006954 + - key: located in + source: GO:0006954 + target: UBERON:0000004 + - key: affected by + source: UBERON:0000004 + target: MESH:D065631 + multigraph: true + nodes: + - id: MESH:D003533 + label: Drug + name: Cyproheptadine + - id: UniProt:P35367 + label: Protein + name: Histamine H1 receptor + - id: MESH:D006632 + label: ChemicalSubstance + name: Histamine + - id: GO:0071159 + label: CellularComponent + name: NF-kappaB complex + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: UBERON:0000004 + label: GrossAnatomicalStructure + name: Nose + - id: MESH:D065631 + label: Disease + name: Allergic rhinitis + reference: https://pubmed.ncbi.nlm.nih.gov/14561186/ https://go.drugbank.com/drugs/DB00434 +- directed: true + graph: + disease: Hypertensive disorder + disease_mesh: MESH:D006973 + drug: Pindolol + drug_mesh: MESH:D010869 + drugbank: DB:DB00960 + links: + - key: decreases activity of + source: MESH:D010869 + target: UniProt:P08588 + - key: positively regulates + source: UniProt:P08588 + target: HP:0033533 + - key: positively regulates + source: UniProt:P08588 + target: UniProt:P00797 + - key: positively regulates + source: UniProt:P00797 + target: GO:0042310 + - key: positively regulates + source: GO:0042310 + target: GO:0008217 + - key: positively correlated with + source: GO:0008217 + target: MESH:D006973 + - key: positively correlated with + source: HP:0033533 + target: MESH:D006973 + multigraph: true + nodes: + - id: MESH:D010869 + label: Drug + name: Pindolol + - id: UniProt:P08588 + label: Protein + name: Beta-1 adrenergic receptor + - id: HP:0033533 + label: PhenotypicFeature + name: Increased cardiac output + - id: UniProt:P00797 + label: Protein + name: Renin + - id: GO:0042310 + label: BiologicalProcess + name: Vasoconstriction + - id: GO:0008217 + label: BiologicalProcess + name: Blood Pressure + - id: MESH:D006973 + label: Disease + name: Hypertensive disorder + reference: https://en.wikipedia.org/wiki/Beta-1_adrenergic_receptor https://go.drugbank.com/drugs/DB00960#BE0000694 +- directed: true + graph: + disease: Mantle cell lymphoma + disease_mesh: MESH:D020522 + drug: Bortezomib + drug_mesh: MESH:D000069286 + drugbank: DB:DB00188 + links: + - key: decreases activity of + source: MESH:D000069286 + target: UniProt:P28074 + - key: decreases activity of + source: MESH:D000069286 + target: UniProt:P20618 + - key: decreases activity of + source: MESH:D000069286 + target: GO:0071159 + - key: participates in + source: UniProt:P28074 + target: GO:0043161 + - key: participates in + source: UniProt:P20618 + target: GO:0043161 + - key: negatively regulates + source: GO:0071159 + target: GO:0006915 + - key: negatively regulates + source: GO:0043161 + target: GO:0006915 + - key: negatively correlated with + source: GO:0006915 + target: MESH:D020522 + multigraph: true + nodes: + - id: MESH:D000069286 + label: Drug + name: Bortezomib + - id: UniProt:P28074 + label: Protein + name: Proteasome subunit beta type-5 + - id: UniProt:P20618 + label: Protein + name: Proteasome subunit beta type-1 + - id: GO:0071159 + label: CellularComponent + name: NF-kappaB complex + - id: GO:0043161 + label: BiologicalProcess + name: Proteasome-mediated ubiquitin-dependent protein catabolic process + - id: GO:0006915 + label: BiologicalProcess + name: Apoptotic process + - id: MESH:D020522 + label: Disease + name: Mantle cell lymphoma + reference: https://en.wikipedia.org/wiki/Bortezomib https://go.drugbank.com/drugs/DB00188 +- directed: true + graph: + disease: Multiple myeloma + disease_mesh: MESH:D009101 + drug: Bortezomib + drug_mesh: MESH:D000069286 + drugbank: DB:DB00188 + links: + - key: decreases activity of + source: MESH:D000069286 + target: UniProt:P28074 + - key: decreases activity of + source: MESH:D000069286 + target: UniProt:P20618 + - key: decreases activity of + source: MESH:D000069286 + target: GO:0071159 + - key: participates in + source: UniProt:P28074 + target: GO:0043161 + - key: participates in + source: UniProt:P20618 + target: GO:0043161 + - key: negatively regulates + source: GO:0071159 + target: GO:0006915 + - key: negatively regulates + source: GO:0043161 + target: GO:0006915 + - key: negatively correlated with + source: GO:0006915 + target: MESH:D009101 + multigraph: true + nodes: + - id: MESH:D000069286 + label: Drug + name: Bortezomib + - id: UniProt:P28074 + label: Protein + name: Proteasome subunit beta type-5 + - id: UniProt:P20618 + label: Protein + name: Proteasome subunit beta type-1 + - id: GO:0071159 + label: CellularComponent + name: NF-kappaB complex + - id: GO:0043161 + label: BiologicalProcess + name: Proteasome-mediated ubiquitin-dependent protein catabolic process + - id: GO:0006915 + label: BiologicalProcess + name: Apoptotic process + - id: MESH:D009101 + label: Disease + name: Multiple myeloma + reference: https://en.wikipedia.org/wiki/Bortezomib https://go.drugbank.com/drugs/DB00188 +- directed: true + graph: + disease: Malignant tumor of ovary + disease_mesh: MESH:D010051 + drug: Melphalan + drug_mesh: MESH:D008558 + drugbank: DB:DB01042 + links: + - key: disrupts + source: MESH:D008558 + target: MESH:D004247 + - key: participates in + source: MESH:D004247 + target: GO:0090592 + - key: part of + source: GO:0090592 + target: GO:0008283 + - key: positively correlated with + source: GO:0008283 + target: MESH:D010051 + multigraph: true + nodes: + - id: MESH:D008558 + label: Drug + name: Melphalan + - id: MESH:D004247 + label: ChemicalSubstance + name: DNA + - id: GO:0090592 + label: BiologicalProcess + name: DNA synthesis involved in DNA replication + - id: GO:0008283 + label: BiologicalProcess + name: Cell population proliferation + - id: MESH:D010051 + label: Disease + name: Malignant tumor of ovary + reference: https://go.drugbank.com/drugs/DB01042 +- directed: true + graph: + disease: Multiple myeloma + disease_mesh: MESH:D009101 + drug: Melphalan + drug_mesh: MESH:D008558 + drugbank: DB:DB01042 + links: + - key: disrupts + source: MESH:D008558 + target: MESH:D004247 + - key: participates in + source: MESH:D004247 + target: GO:0090592 + - key: part of + source: GO:0090592 + target: GO:0008283 + - key: positively correlated with + source: GO:0008283 + target: MESH:D009101 + multigraph: true + nodes: + - id: MESH:D008558 + label: Drug + name: Melphalan + - id: MESH:D004247 + label: ChemicalSubstance + name: DNA + - id: GO:0090592 + label: BiologicalProcess + name: DNA synthesis involved in DNA replication + - id: GO:0008283 + label: BiologicalProcess + name: Cell population proliferation + - id: MESH:D009101 + label: Disease + name: Multiple myeloma + reference: https://go.drugbank.com/drugs/DB01042 +- directed: true + graph: + disease: Hyperuricemia + disease_mesh: MESH:D033461 + drug: Sulfinpyrazone + drug_mesh: MESH:D013442 + drugbank: DB:DB01138 + links: + - key: decreases activity of + source: MESH:D013442 + target: UniProt:Q96S37 + - key: negatively correlated with + source: UniProt:Q96S37 + target: GO:0097744 + - key: negatively correlated with + source: GO:0097744 + target: MESH:D033461 + multigraph: true + nodes: + - id: MESH:D013442 + label: Drug + name: Sulfinpyrazone + - id: UniProt:Q96S37 + label: Protein + name: Solute carrier family 22 member 12 + - id: GO:0097744 + label: BiologicalProcess + name: Urate salt excretion + - id: MESH:D033461 + label: Disease + name: Hyperuricemia + reference: https://go.drugbank.com/drugs/DB01138 +- directed: true + graph: + disease: Backache + disease_mesh: MESH:D001416 + drug: Magnesium salicylate + drug_mesh: MESH:C496892 + drugbank: DB:DB01397 + links: + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P23219 + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P23219 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D001416 + multigraph: true + nodes: + - id: MESH:C496892 + label: Drug + name: Magnesium salicylate + - id: UniProt:P23219 + label: Protein + name: Cox-1 + - id: UniProt:P35354 + label: Protein + name: Cox-2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D001416 + label: Disease + name: Backache + reference: https://go.drugbank.com/drugs/DB01397 +- directed: true + graph: + disease: Bursitis + disease_mesh: MESH:D002062 + drug: Magnesium salicylate + drug_mesh: MESH:C496892 + drugbank: DB:DB01397 + links: + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P23219 + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P23219 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D002062 + multigraph: true + nodes: + - id: MESH:C496892 + label: Drug + name: Magnesium salicylate + - id: UniProt:P23219 + label: Protein + name: Cox-1 + - id: UniProt:P35354 + label: Protein + name: Cox-2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D002062 + label: Disease + name: Bursitis + reference: https://go.drugbank.com/drugs/DB01397 +- directed: true + graph: + disease: Joint pain + disease_mesh: MESH:D018771 + drug: Magnesium salicylate + drug_mesh: MESH:C496892 + drugbank: DB:DB01397 + links: + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P23219 + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P23219 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D018771 + multigraph: true + nodes: + - id: MESH:C496892 + label: Drug + name: Magnesium salicylate + - id: UniProt:P23219 + label: Protein + name: Cox-1 + - id: UniProt:P35354 + label: Protein + name: Cox-2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D018771 + label: Disease + name: Joint pain + reference: https://go.drugbank.com/drugs/DB01397 +- directed: true + graph: + disease: Synovitis + disease_mesh: MESH:D013585 + drug: Magnesium salicylate + drug_mesh: MESH:C496892 + drugbank: DB:DB01397 + links: + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P23219 + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P23219 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D013585 + multigraph: true + nodes: + - id: MESH:C496892 + label: Drug + name: Magnesium salicylate + - id: UniProt:P23219 + label: Protein + name: Cox-1 + - id: UniProt:P35354 + label: Protein + name: Cox-2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D013585 + label: Disease + name: Synovitis + reference: https://go.drugbank.com/drugs/DB01397 +- directed: true + graph: + disease: Dysmenorrhea + disease_mesh: MESH:D004412 + drug: Magnesium salicylate + drug_mesh: MESH:C496892 + drugbank: DB:DB01397 + links: + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P23219 + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P23219 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D010146 + - key: manifestation of + source: MESH:D010146 + target: MESH:D004412 + multigraph: true + nodes: + - id: MESH:C496892 + label: Drug + name: Magnesium salicylate + - id: UniProt:P23219 + label: Protein + name: Cox-1 + - id: UniProt:P35354 + label: Protein + name: Cox-2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D010146 + label: Disease + name: Pain + - id: MESH:D004412 + label: Disease + name: Dysmenorrhea + reference: https://go.drugbank.com/drugs/DB01397 +- directed: true + graph: + disease: Osteoarthritis + disease_mesh: MESH:D010003 + drug: Magnesium salicylate + drug_mesh: MESH:C496892 + drugbank: DB:DB01397 + links: + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P23219 + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P23219 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D010003 + multigraph: true + nodes: + - id: MESH:C496892 + label: Drug + name: Magnesium salicylate + - id: UniProt:P23219 + label: Protein + name: Cox-1 + - id: UniProt:P35354 + label: Protein + name: Cox-2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D010003 + label: Disease + name: Osteoarthritis + reference: https://go.drugbank.com/drugs/DB01397 +- directed: true + graph: + disease: Pain + disease_mesh: MESH:D010146 + drug: Magnesium salicylate + drug_mesh: MESH:C496892 + drugbank: DB:DB01397 + links: + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P23219 + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P23219 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D010146 + multigraph: true + nodes: + - id: MESH:C496892 + label: Drug + name: Magnesium salicylate + - id: UniProt:P23219 + label: Protein + name: Cox-1 + - id: UniProt:P35354 + label: Protein + name: Cox-2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D010146 + label: Disease + name: Pain + reference: https://go.drugbank.com/drugs/DB01397 +- directed: true + graph: + disease: Fever + disease_mesh: MESH:D005334 + drug: Magnesium salicylate + drug_mesh: MESH:C496892 + drugbank: DB:DB01397 + links: + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P23219 + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P23219 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D005334 + multigraph: true + nodes: + - id: MESH:C496892 + label: Drug + name: Magnesium salicylate + - id: UniProt:P23219 + label: Protein + name: Cox-1 + - id: UniProt:P35354 + label: Protein + name: Cox-2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D005334 + label: Disease + name: Fever + reference: https://go.drugbank.com/drugs/DB01397 +- directed: true + graph: + disease: Rheumatoid arthritis + disease_mesh: MESH:D001172 + drug: Magnesium salicylate + drug_mesh: MESH:C496892 + drugbank: DB:DB01397 + links: + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P23219 + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P23219 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D001172 + multigraph: true + nodes: + - id: MESH:C496892 + label: Drug + name: Magnesium salicylate + - id: UniProt:P23219 + label: Protein + name: Cox-1 + - id: UniProt:P35354 + label: Protein + name: Cox-2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D001172 + label: Disease + name: Rheumatoid arthritis + reference: https://go.drugbank.com/drugs/DB01397 +- directed: true + graph: + disease: Headache disorder + disease_mesh: MESH:D020773 + drug: Magnesium salicylate + drug_mesh: MESH:C496892 + drugbank: DB:DB01397 + links: + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P23219 + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P23219 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D010146 + - key: manifestation of + source: MESH:D010146 + target: MESH:D020773 + multigraph: true + nodes: + - id: MESH:C496892 + label: Drug + name: Magnesium salicylate + - id: UniProt:P23219 + label: Protein + name: Cox-1 + - id: UniProt:P35354 + label: Protein + name: Cox-2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D010146 + label: Disease + name: Pain + - id: MESH:D020773 + label: Disease + name: Headache disorder + reference: https://go.drugbank.com/drugs/DB01397 +- directed: true + graph: + disease: Vernal conjunctivitis + disease_mesh: MESH:D003233 + drug: Lodoxamide + drug_mesh: MESH:C021702,MESH:C022028 + drugbank: DB:DB06794 + links: + - key: negatively regulates + source: DB:DB06794 + target: GO:0043303 + - key: positively regulates + source: GO:0043303 + target: GO:0001821 + - key: positively regulates + source: GO:0001821 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D003233 + multigraph: true + nodes: + - id: DB:DB06794 + label: Drug + name: Lodoxamide + - id: GO:0043303 + label: BiologicalProcess + name: Mast cell degranulation + - id: GO:0001821 + label: BiologicalProcess + name: Histamine secretion + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D003233 + label: Disease + name: Vernal conjunctivitis + reference: https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201266/ https://go.drugbank.com/drugs/DB06794 +- directed: true + graph: + disease: Constipation + disease_mesh: MESH:D003248 + drug: Sodium phosphate + drug_mesh: MESH:C018279 + drugbank: DB:DB09449 + links: + - key: positively regulates + source: MESH:C018279 + target: GO:0120054 + - key: negatively correlated with + source: GO:0120054 + target: MESH:D003248 + multigraph: true + nodes: + - id: MESH:C018279 + label: Drug + name: Sodium phosphate + - id: GO:0120054 + label: BiologicalProcess + name: Intestinal motility + - id: MESH:D003248 + label: Disease + name: Constipation + reference: https://go.drugbank.com/drugs/DB09449 From d2c787cd608b2dee74c5c79f6495fa616e890e1b Mon Sep 17 00:00:00 2001 From: TanskaAnnna Date: Fri, 5 Mar 2021 16:10:37 +0000 Subject: [PATCH 2/3] Commit from GitHub Actions (Validate PR) --- indication_paths.json | 1699 +++++++++++++++++++++++++++++++++++++++++ indication_paths.yaml | 1052 +++++++++++++++++++++++++ 2 files changed, 2751 insertions(+) diff --git a/indication_paths.json b/indication_paths.json index cb15ad686..9167a7afd 100644 --- a/indication_paths.json +++ b/indication_paths.json @@ -59945,6 +59945,1705 @@ ], "reference": "https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201266/ https://go.drugbank.com/drugs/DB06794" }, + { + "directed": true, + "graph": { + "disease": "Constipation", + "disease_mesh": "MESH:D003248", + "drug": "Sodium phosphate", + "drug_mesh": "MESH:C018279", + "drugbank": "DB:DB09449" + }, + "links": [ + { + "key": "positively regulates", + "source": "MESH:C018279", + "target": "GO:0120054" + }, + { + "key": "negatively correlated with", + "source": "GO:0120054", + "target": "MESH:D003248" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:C018279", + "label": "Drug", + "name": "Sodium phosphate" + }, + { + "id": "GO:0120054", + "label": "BiologicalProcess", + "name": "Intestinal motility" + }, + { + "id": "MESH:D003248", + "label": "Disease", + "name": "Constipation" + } + ], + "reference": "https://go.drugbank.com/drugs/DB09449" + }, + { + "directed": true, + "graph": { 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+ "name": "Histamine secretion" + }, + { + "id": "GO:0006954", + "label": "BiologicalProcess", + "name": "Inflammatory response" + }, + { + "id": "MESH:D003233", + "label": "Disease", + "name": "Vernal conjunctivitis" + } + ], + "reference": "https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201266/ https://go.drugbank.com/drugs/DB06794" + }, { "directed": true, "graph": { diff --git a/indication_paths.yaml b/indication_paths.yaml index 476192578..a3a09d8fe 100644 --- a/indication_paths.yaml +++ b/indication_paths.yaml @@ -37290,3 +37290,1055 @@ label: Disease name: Constipation reference: https://go.drugbank.com/drugs/DB09449 +- directed: true + graph: + disease: Allergic conjunctivitis + disease_mesh: MESH:D003233 + drug: Cyproheptadine + drug_mesh: MESH:D003533 + drugbank: DB:DB00434 + links: + - key: decreases activity of + source: MESH:D003533 + target: UniProt:P35367 + - key: positively correlated with + source: UniProt:P35367 + target: MESH:D006632 + - key: positively regulates + source: MESH:D006632 + target: UBERON:0035501 + - key: positively regulates + source: UBERON:0035501 + target: GO:0070075 + - key: manifestation of + source: GO:0070075 + target: MESH:D003233 + multigraph: true + nodes: + - id: MESH:D003533 + label: Drug + name: Cyproheptadine + - id: UniProt:P35367 + label: Protein + name: Histamine H1 receptor + - id: MESH:D006632 + label: ChemicalSubstance + name: Histamine + - id: UBERON:0035501 + label: GrossAnatomicalStructure + name: Free nerve ending + - id: GO:0070075 + label: BiologicalProcess + name: Tear secretion + - id: MESH:D003233 + label: Disease + name: Allergic conjunctivitis + reference: https://go.drugbank.com/drugs/DB00434 https://en.wikipedia.org/wiki/Allergic_conjunctivitis +- directed: true + graph: + disease: Itching of skin + disease_mesh: MESH:D011537 + drug: Cyproheptadine + drug_mesh: MESH:D003533 + drugbank: DB:DB00434 + links: + - key: negatively regulates + source: MESH:D003533 + target: UniProt:P35367 + - key: positively correlated with + source: UniProt:P35367 + target: MESH:D006632 + - key: positively regulates + source: MESH:D006632 + target: UniProt:Q8NER1 + - key: positively regulates + source: UniProt:Q8NER1 + target: CL:0000197 + - key: contributes to + source: CL:0000197 + target: MESH:D011537 + multigraph: true + nodes: + - id: MESH:D003533 + label: Drug + name: Cyproheptadine + - id: UniProt:P35367 + label: Protein + name: Histamine H1 receptor + - id: MESH:D006632 + label: ChemicalSubstance + name: Histamine + - id: UniProt:Q8NER1 + label: Protein + name: Transient receptor potential cation channel subfamily V member 1 + - id: CL:0000197 + label: Cell + name: Sensory Receptor Cell + - id: MESH:D011537 + label: Disease + name: Itching of skin + reference: https://go.drugbank.com/drugs/DB00434 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519061/ +- directed: true + graph: + disease: Urticaria + disease_mesh: MESH:D014581 + drug: Cyproheptadine + drug_mesh: MESH:D003533 + drugbank: DB:DB00434 + links: + - key: decreases activity of + source: MESH:D003533 + target: UniProt:P35367 + - key: positively regulates + source: UniProt:P35367 + target: GO:0004969 + - key: participates in + source: GO:0004969 + target: GO:0071420 + - key: positively correlated with + source: GO:0071420 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D014581 + multigraph: true + nodes: + - id: MESH:D003533 + label: Drug + name: Cyproheptadine + - id: UniProt:P35367 + label: Protein + name: Histamine H1 receptor + - id: GO:0004969 + label: MolecularActivity + name: Histamine receptor activity + - id: GO:0071420 + label: BiologicalProcess + name: Cellular response to histamine + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D014581 + label: Disease + name: Urticaria + reference: https://go.drugbank.com/drugs/DB00434 https://en.wikipedia.org/wiki/Hives +- directed: true + graph: + disease: Sneezing + disease_mesh: MESH:D012912 + drug: Cyproheptadine + drug_mesh: MESH:D003533 + drugbank: DB:DB00434 + links: + - key: decreases activity of + source: MESH:D003533 + target: UniProt:P35367 + - key: participates in + source: UniProt:P35367 + target: GO:0051381 + - key: positively regulates + source: GO:0051381 + target: GO:0023041 + - key: located in + source: GO:0023041 + target: UBERON:0000004 + - key: affected by + source: UBERON:0000004 + target: UBERON:0001645 + - key: contributes to + source: UBERON:0001645 + target: MESH:D012912 + multigraph: true + nodes: + - id: MESH:D003533 + label: Drug + name: Cyproheptadine + - id: UniProt:P35367 + label: Protein + name: Histamine H1 receptor + - id: GO:0051381 + label: MolecularActivity + name: Histamine binding + - id: GO:0023041 + label: BiologicalProcess + name: Neuronal signal transduction + - id: UBERON:0000004 + label: GrossAnatomicalStructure + name: Nose + - alt_ids: MESH:D014276 + id: UBERON:0001645 + label: GrossAnatomicalStructure + name: Trigeminal nerve + - id: MESH:D012912 + label: Disease + name: Sneezing + reference: https://go.drugbank.com/drugs/DB00434 https://en.wikipedia.org/wiki/Sneeze +- directed: true + graph: + disease: Allergic rhinitis + disease_mesh: MESH:D065631 + drug: Cyproheptadine + drug_mesh: MESH:D003533 + drugbank: DB:DB00434 + links: + - key: negatively regulates + source: MESH:D003533 + target: UniProt:P35367 + - key: positively correlated with + source: UniProt:P35367 + target: MESH:D006632 + - key: positively regulates + source: MESH:D006632 + target: GO:0071159 + - key: positively regulates + source: GO:0071159 + target: GO:0006954 + - key: located in + source: GO:0006954 + target: UBERON:0000004 + - key: affected by + source: UBERON:0000004 + target: MESH:D065631 + multigraph: true + nodes: + - id: MESH:D003533 + label: Drug + name: Cyproheptadine + - id: UniProt:P35367 + label: Protein + name: Histamine H1 receptor + - id: MESH:D006632 + label: ChemicalSubstance + name: Histamine + - id: GO:0071159 + label: CellularComponent + name: NF-kappaB complex + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: UBERON:0000004 + label: GrossAnatomicalStructure + name: Nose + - id: MESH:D065631 + label: Disease + name: Allergic rhinitis + reference: https://pubmed.ncbi.nlm.nih.gov/14561186/ https://go.drugbank.com/drugs/DB00434 +- directed: true + graph: + disease: Hypertensive disorder + disease_mesh: MESH:D006973 + drug: Pindolol + drug_mesh: MESH:D010869 + drugbank: DB:DB00960 + links: + - key: decreases activity of + source: MESH:D010869 + target: UniProt:P08588 + - key: positively regulates + source: UniProt:P08588 + target: HP:0033533 + - key: positively regulates + source: UniProt:P08588 + target: UniProt:P00797 + - key: positively regulates + source: UniProt:P00797 + target: GO:0042310 + - key: positively regulates + source: GO:0042310 + target: GO:0008217 + - key: positively correlated with + source: GO:0008217 + target: MESH:D006973 + - key: positively correlated with + source: HP:0033533 + target: MESH:D006973 + multigraph: true + nodes: + - id: MESH:D010869 + label: Drug + name: Pindolol + - id: UniProt:P08588 + label: Protein + name: Beta-1 adrenergic receptor + - id: HP:0033533 + label: PhenotypicFeature + name: Increased cardiac output + - id: UniProt:P00797 + label: Protein + name: Renin + - id: GO:0042310 + label: BiologicalProcess + name: Vasoconstriction + - id: GO:0008217 + label: BiologicalProcess + name: Blood Pressure + - id: MESH:D006973 + label: Disease + name: Hypertensive disorder + reference: https://en.wikipedia.org/wiki/Beta-1_adrenergic_receptor https://go.drugbank.com/drugs/DB00960#BE0000694 +- directed: true + graph: + disease: Mantle cell lymphoma + disease_mesh: MESH:D020522 + drug: Bortezomib + drug_mesh: MESH:D000069286 + drugbank: DB:DB00188 + links: + - key: decreases activity of + source: MESH:D000069286 + target: UniProt:P28074 + - key: decreases activity of + source: MESH:D000069286 + target: UniProt:P20618 + - key: decreases activity of + source: MESH:D000069286 + target: GO:0071159 + - key: participates in + source: UniProt:P28074 + target: GO:0043161 + - key: participates in + source: UniProt:P20618 + target: GO:0043161 + - key: negatively regulates + source: GO:0071159 + target: GO:0006915 + - key: negatively regulates + source: GO:0043161 + target: GO:0006915 + - key: negatively correlated with + source: GO:0006915 + target: MESH:D020522 + multigraph: true + nodes: + - id: MESH:D000069286 + label: Drug + name: Bortezomib + - id: UniProt:P28074 + label: Protein + name: Proteasome subunit beta type-5 + - id: UniProt:P20618 + label: Protein + name: Proteasome subunit beta type-1 + - id: GO:0071159 + label: CellularComponent + name: NF-kappaB complex + - id: GO:0043161 + label: BiologicalProcess + name: Proteasome-mediated ubiquitin-dependent protein catabolic process + - id: GO:0006915 + label: BiologicalProcess + name: Apoptotic process + - id: MESH:D020522 + label: Disease + name: Mantle cell lymphoma + reference: https://en.wikipedia.org/wiki/Bortezomib https://go.drugbank.com/drugs/DB00188 +- directed: true + graph: + disease: Multiple myeloma + disease_mesh: MESH:D009101 + drug: Bortezomib + drug_mesh: MESH:D000069286 + drugbank: DB:DB00188 + links: + - key: decreases activity of + source: MESH:D000069286 + target: UniProt:P28074 + - key: decreases activity of + source: MESH:D000069286 + target: UniProt:P20618 + - key: decreases activity of + source: MESH:D000069286 + target: GO:0071159 + - key: participates in + source: UniProt:P28074 + target: GO:0043161 + - key: participates in + source: UniProt:P20618 + target: GO:0043161 + - key: negatively regulates + source: GO:0071159 + target: GO:0006915 + - key: negatively regulates + source: GO:0043161 + target: GO:0006915 + - key: negatively correlated with + source: GO:0006915 + target: MESH:D009101 + multigraph: true + nodes: + - id: MESH:D000069286 + label: Drug + name: Bortezomib + - id: UniProt:P28074 + label: Protein + name: Proteasome subunit beta type-5 + - id: UniProt:P20618 + label: Protein + name: Proteasome subunit beta type-1 + - id: GO:0071159 + label: CellularComponent + name: NF-kappaB complex + - id: GO:0043161 + label: BiologicalProcess + name: Proteasome-mediated ubiquitin-dependent protein catabolic process + - id: GO:0006915 + label: BiologicalProcess + name: Apoptotic process + - id: MESH:D009101 + label: Disease + name: Multiple myeloma + reference: https://en.wikipedia.org/wiki/Bortezomib https://go.drugbank.com/drugs/DB00188 +- directed: true + graph: + disease: Malignant tumor of ovary + disease_mesh: MESH:D010051 + drug: Melphalan + drug_mesh: MESH:D008558 + drugbank: DB:DB01042 + links: + - key: disrupts + source: MESH:D008558 + target: MESH:D004247 + - key: participates in + source: MESH:D004247 + target: GO:0090592 + - key: part of + source: GO:0090592 + target: GO:0008283 + - key: positively correlated with + source: GO:0008283 + target: MESH:D010051 + multigraph: true + nodes: + - id: MESH:D008558 + label: Drug + name: Melphalan + - id: MESH:D004247 + label: ChemicalSubstance + name: DNA + - id: GO:0090592 + label: BiologicalProcess + name: DNA synthesis involved in DNA replication + - id: GO:0008283 + label: BiologicalProcess + name: Cell population proliferation + - id: MESH:D010051 + label: Disease + name: Malignant tumor of ovary + reference: https://go.drugbank.com/drugs/DB01042 +- directed: true + graph: + disease: Multiple myeloma + disease_mesh: MESH:D009101 + drug: Melphalan + drug_mesh: MESH:D008558 + drugbank: DB:DB01042 + links: + - key: disrupts + source: MESH:D008558 + target: MESH:D004247 + - key: participates in + source: MESH:D004247 + target: GO:0090592 + - key: part of + source: GO:0090592 + target: GO:0008283 + - key: positively correlated with + source: GO:0008283 + target: MESH:D009101 + multigraph: true + nodes: + - id: MESH:D008558 + label: Drug + name: Melphalan + - id: MESH:D004247 + label: ChemicalSubstance + name: DNA + - id: GO:0090592 + label: BiologicalProcess + name: DNA synthesis involved in DNA replication + - id: GO:0008283 + label: BiologicalProcess + name: Cell population proliferation + - id: MESH:D009101 + label: Disease + name: Multiple myeloma + reference: https://go.drugbank.com/drugs/DB01042 +- directed: true + graph: + disease: Hyperuricemia + disease_mesh: MESH:D033461 + drug: Sulfinpyrazone + drug_mesh: MESH:D013442 + drugbank: DB:DB01138 + links: + - key: decreases activity of + source: MESH:D013442 + target: UniProt:Q96S37 + - key: negatively correlated with + source: UniProt:Q96S37 + target: GO:0097744 + - key: negatively correlated with + source: GO:0097744 + target: MESH:D033461 + multigraph: true + nodes: + - id: MESH:D013442 + label: Drug + name: Sulfinpyrazone + - id: UniProt:Q96S37 + label: Protein + name: Solute carrier family 22 member 12 + - id: GO:0097744 + label: BiologicalProcess + name: Urate salt excretion + - id: MESH:D033461 + label: Disease + name: Hyperuricemia + reference: https://go.drugbank.com/drugs/DB01138 +- directed: true + graph: + disease: Backache + disease_mesh: MESH:D001416 + drug: Magnesium salicylate + drug_mesh: MESH:C496892 + drugbank: DB:DB01397 + links: + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P23219 + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P23219 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D001416 + multigraph: true + nodes: + - id: MESH:C496892 + label: Drug + name: Magnesium salicylate + - id: UniProt:P23219 + label: Protein + name: Cox-1 + - id: UniProt:P35354 + label: Protein + name: Cox-2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D001416 + label: Disease + name: Backache + reference: https://go.drugbank.com/drugs/DB01397 +- directed: true + graph: + disease: Bursitis + disease_mesh: MESH:D002062 + drug: Magnesium salicylate + drug_mesh: MESH:C496892 + drugbank: DB:DB01397 + links: + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P23219 + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P23219 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D002062 + multigraph: true + nodes: + - id: MESH:C496892 + label: Drug + name: Magnesium salicylate + - id: UniProt:P23219 + label: Protein + name: Cox-1 + - id: UniProt:P35354 + label: Protein + name: Cox-2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D002062 + label: Disease + name: Bursitis + reference: https://go.drugbank.com/drugs/DB01397 +- directed: true + graph: + disease: Joint pain + disease_mesh: MESH:D018771 + drug: Magnesium salicylate + drug_mesh: MESH:C496892 + drugbank: DB:DB01397 + links: + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P23219 + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P23219 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D018771 + multigraph: true + nodes: + - id: MESH:C496892 + label: Drug + name: Magnesium salicylate + - id: UniProt:P23219 + label: Protein + name: Cox-1 + - id: UniProt:P35354 + label: Protein + name: Cox-2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D018771 + label: Disease + name: Joint pain + reference: https://go.drugbank.com/drugs/DB01397 +- directed: true + graph: + disease: Synovitis + disease_mesh: MESH:D013585 + drug: Magnesium salicylate + drug_mesh: MESH:C496892 + drugbank: DB:DB01397 + links: + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P23219 + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P23219 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D013585 + multigraph: true + nodes: + - id: MESH:C496892 + label: Drug + name: Magnesium salicylate + - id: UniProt:P23219 + label: Protein + name: Cox-1 + - id: UniProt:P35354 + label: Protein + name: Cox-2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D013585 + label: Disease + name: Synovitis + reference: https://go.drugbank.com/drugs/DB01397 +- directed: true + graph: + disease: Dysmenorrhea + disease_mesh: MESH:D004412 + drug: Magnesium salicylate + drug_mesh: MESH:C496892 + drugbank: DB:DB01397 + links: + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P23219 + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P23219 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D010146 + - key: manifestation of + source: MESH:D010146 + target: MESH:D004412 + multigraph: true + nodes: + - id: MESH:C496892 + label: Drug + name: Magnesium salicylate + - id: UniProt:P23219 + label: Protein + name: Cox-1 + - id: UniProt:P35354 + label: Protein + name: Cox-2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D010146 + label: Disease + name: Pain + - id: MESH:D004412 + label: Disease + name: Dysmenorrhea + reference: https://go.drugbank.com/drugs/DB01397 +- directed: true + graph: + disease: Osteoarthritis + disease_mesh: MESH:D010003 + drug: Magnesium salicylate + drug_mesh: MESH:C496892 + drugbank: DB:DB01397 + links: + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P23219 + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P23219 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D010003 + multigraph: true + nodes: + - id: MESH:C496892 + label: Drug + name: Magnesium salicylate + - id: UniProt:P23219 + label: Protein + name: Cox-1 + - id: UniProt:P35354 + label: Protein + name: Cox-2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D010003 + label: Disease + name: Osteoarthritis + reference: https://go.drugbank.com/drugs/DB01397 +- directed: true + graph: + disease: Pain + disease_mesh: MESH:D010146 + drug: Magnesium salicylate + drug_mesh: MESH:C496892 + drugbank: DB:DB01397 + links: + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P23219 + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P23219 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D010146 + multigraph: true + nodes: + - id: MESH:C496892 + label: Drug + name: Magnesium salicylate + - id: UniProt:P23219 + label: Protein + name: Cox-1 + - id: UniProt:P35354 + label: Protein + name: Cox-2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D010146 + label: Disease + name: Pain + reference: https://go.drugbank.com/drugs/DB01397 +- directed: true + graph: + disease: Fever + disease_mesh: MESH:D005334 + drug: Magnesium salicylate + drug_mesh: MESH:C496892 + drugbank: DB:DB01397 + links: + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P23219 + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P23219 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D005334 + multigraph: true + nodes: + - id: MESH:C496892 + label: Drug + name: Magnesium salicylate + - id: UniProt:P23219 + label: Protein + name: Cox-1 + - id: UniProt:P35354 + label: Protein + name: Cox-2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D005334 + label: Disease + name: Fever + reference: https://go.drugbank.com/drugs/DB01397 +- directed: true + graph: + disease: Rheumatoid arthritis + disease_mesh: MESH:D001172 + drug: Magnesium salicylate + drug_mesh: MESH:C496892 + drugbank: DB:DB01397 + links: + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P23219 + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P23219 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D001172 + multigraph: true + nodes: + - id: MESH:C496892 + label: Drug + name: Magnesium salicylate + - id: UniProt:P23219 + label: Protein + name: Cox-1 + - id: UniProt:P35354 + label: Protein + name: Cox-2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D001172 + label: Disease + name: Rheumatoid arthritis + reference: https://go.drugbank.com/drugs/DB01397 +- directed: true + graph: + disease: Headache disorder + disease_mesh: MESH:D020773 + drug: Magnesium salicylate + drug_mesh: MESH:C496892 + drugbank: DB:DB01397 + links: + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P23219 + - key: decreases activity of + source: MESH:C496892 + target: UniProt:P35354 + - key: increases abundance of + source: UniProt:P23219 + target: MESH:D011453 + - key: increases abundance of + source: UniProt:P35354 + target: MESH:D011453 + - key: positively regulates + source: MESH:D011453 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D010146 + - key: manifestation of + source: MESH:D010146 + target: MESH:D020773 + multigraph: true + nodes: + - id: MESH:C496892 + label: Drug + name: Magnesium salicylate + - id: UniProt:P23219 + label: Protein + name: Cox-1 + - id: UniProt:P35354 + label: Protein + name: Cox-2 + - id: MESH:D011453 + label: ChemicalSubstance + name: Prostaglandins + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D010146 + label: Disease + name: Pain + - id: MESH:D020773 + label: Disease + name: Headache disorder + reference: https://go.drugbank.com/drugs/DB01397 +- directed: true + graph: + disease: Vernal conjunctivitis + disease_mesh: MESH:D003233 + drug: Lodoxamide + drug_mesh: MESH:C021702,MESH:C022028 + drugbank: DB:DB06794 + links: + - key: negatively regulates + source: DB:DB06794 + target: GO:0043303 + - key: positively regulates + source: GO:0043303 + target: GO:0001821 + - key: positively regulates + source: GO:0001821 + target: GO:0006954 + - key: causes + source: GO:0006954 + target: MESH:D003233 + multigraph: true + nodes: + - id: DB:DB06794 + label: Drug + name: Lodoxamide + - id: GO:0043303 + label: BiologicalProcess + name: Mast cell degranulation + - id: GO:0001821 + label: BiologicalProcess + name: Histamine secretion + - id: GO:0006954 + label: BiologicalProcess + name: Inflammatory response + - id: MESH:D003233 + label: Disease + name: Vernal conjunctivitis + reference: https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201266/ https://go.drugbank.com/drugs/DB06794 +- directed: true + graph: + disease: Constipation + disease_mesh: MESH:D003248 + drug: Sodium phosphate + drug_mesh: MESH:C018279 + drugbank: DB:DB09449 + links: + - key: positively regulates + source: MESH:C018279 + target: GO:0120054 + - key: negatively correlated with + source: GO:0120054 + target: MESH:D003248 + multigraph: true + nodes: + - id: MESH:C018279 + label: Drug + name: Sodium phosphate + - id: GO:0120054 + label: BiologicalProcess + name: Intestinal motility + - id: MESH:D003248 + label: Disease + name: Constipation + reference: https://go.drugbank.com/drugs/DB09449 From b5a7c502e98c79ae866c51ce6f4af61c697fae3c Mon Sep 17 00:00:00 2001 From: mmayers12 Date: Fri, 5 Mar 2021 16:17:09 +0000 Subject: [PATCH 3/3] Commit from GitHub Actions (Reset Submission File) --- submission.yaml | 1053 +---------------------------------------------- 1 file changed, 1 insertion(+), 1052 deletions(-) diff --git a/submission.yaml b/submission.yaml index 8322a3c28..8b1378917 100644 --- a/submission.yaml +++ b/submission.yaml @@ -1,1052 +1 @@ -- directed: true - graph: - disease: Allergic conjunctivitis - disease_mesh: MESH:D003233 - drug: Cyproheptadine - drug_mesh: MESH:D003533 - drugbank: DB:DB00434 - links: - - key: decreases activity of - source: MESH:D003533 - target: UniProt:P35367 - - key: positively correlated with - source: UniProt:P35367 - target: MESH:D006632 - - key: positively regulates - source: MESH:D006632 - target: UBERON:0035501 - - key: positively regulates - source: UBERON:0035501 - target: GO:0070075 - - key: manifestation of - source: GO:0070075 - target: MESH:D003233 - multigraph: true - nodes: - - id: MESH:D003533 - label: Drug - name: Cyproheptadine - - id: UniProt:P35367 - label: Protein - name: Histamine H1 receptor - - id: MESH:D006632 - label: ChemicalSubstance - name: Histamine - - id: UBERON:0035501 - label: GrossAnatomicalStructure - name: Free nerve ending - - id: GO:0070075 - label: BiologicalProcess - name: Tear secretion - - id: MESH:D003233 - label: Disease - name: Allergic conjunctivitis - reference: https://go.drugbank.com/drugs/DB00434 https://en.wikipedia.org/wiki/Allergic_conjunctivitis -- directed: true - graph: - disease: Itching of skin - disease_mesh: MESH:D011537 - drug: Cyproheptadine - drug_mesh: MESH:D003533 - drugbank: DB:DB00434 - links: - - key: negatively regulates - source: MESH:D003533 - target: UniProt:P35367 - - key: positively correlated with - source: UniProt:P35367 - target: MESH:D006632 - - key: positively regulates - source: MESH:D006632 - target: UniProt:Q8NER1 - - key: positively regulates - source: UniProt:Q8NER1 - target: CL:0000197 - - key: contributes to - source: CL:0000197 - target: MESH:D011537 - multigraph: true - nodes: - - id: MESH:D003533 - label: Drug - name: Cyproheptadine - - id: UniProt:P35367 - label: Protein - name: Histamine H1 receptor - - id: MESH:D006632 - label: ChemicalSubstance - name: Histamine - - id: UniProt:Q8NER1 - label: Protein - name: Transient receptor potential cation channel subfamily V member 1 - - id: CL:0000197 - label: Cell - name: Sensory Receptor Cell - - id: MESH:D011537 - label: Disease - name: Itching of skin - reference: https://go.drugbank.com/drugs/DB00434 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519061/ -- directed: true - graph: - disease: Urticaria - disease_mesh: MESH:D014581 - drug: Cyproheptadine - drug_mesh: MESH:D003533 - drugbank: DB:DB00434 - links: - - key: decreases activity of - source: MESH:D003533 - target: UniProt:P35367 - - key: positively regulates - source: UniProt:P35367 - target: GO:0004969 - - key: participates in - source: GO:0004969 - target: GO:0071420 - - key: positively correlated with - source: GO:0071420 - target: GO:0006954 - - key: causes - source: GO:0006954 - target: MESH:D014581 - multigraph: true - nodes: - - id: MESH:D003533 - label: Drug - name: Cyproheptadine - - id: UniProt:P35367 - label: Protein - name: Histamine H1 receptor - - id: GO:0004969 - label: MolecularActivity - name: Histamine receptor activity - - id: GO:0071420 - label: BiologicalProcess - name: Cellular response to histamine - - id: GO:0006954 - label: BiologicalProcess - name: Inflammatory response - - id: MESH:D014581 - label: Disease - name: Urticaria - reference: https://go.drugbank.com/drugs/DB00434 https://en.wikipedia.org/wiki/Hives -- directed: true - graph: - disease: Sneezing - disease_mesh: MESH:D012912 - drug: Cyproheptadine - drug_mesh: MESH:D003533 - drugbank: DB:DB00434 - links: - - key: decreases activity of - source: MESH:D003533 - target: UniProt:P35367 - - key: participates in - source: UniProt:P35367 - target: GO:0051381 - - key: positively regulates - source: GO:0051381 - target: GO:0023041 - - key: located in - source: GO:0023041 - target: UBERON:0000004 - - key: affected by - source: UBERON:0000004 - target: UBERON:0001645 - - key: contributes to - source: UBERON:0001645 - target: MESH:D012912 - multigraph: true - nodes: - - id: MESH:D003533 - label: Drug - name: Cyproheptadine - - id: UniProt:P35367 - label: Protein - name: Histamine H1 receptor - - id: GO:0051381 - label: MolecularActivity - name: Histamine binding - - id: GO:0023041 - label: BiologicalProcess - name: Neuronal signal transduction - - id: UBERON:0000004 - label: GrossAnatomicalStructure - name: Nose - - alt_ids: MESH:D014276 - id: UBERON:0001645 - label: GrossAnatomicalStructure - name: Trigeminal nerve - - id: MESH:D012912 - label: Disease - name: Sneezing - reference: https://go.drugbank.com/drugs/DB00434 https://en.wikipedia.org/wiki/Sneeze -- directed: true - graph: - disease: Allergic rhinitis - disease_mesh: MESH:D065631 - drug: Cyproheptadine - drug_mesh: MESH:D003533 - drugbank: DB:DB00434 - links: - - key: negatively regulates - source: MESH:D003533 - target: UniProt:P35367 - - key: positively correlated with - source: UniProt:P35367 - target: MESH:D006632 - - key: positively regulates - source: MESH:D006632 - target: GO:0071159 - - key: positively regulates - source: GO:0071159 - target: GO:0006954 - - key: located in - source: GO:0006954 - target: UBERON:0000004 - - key: affected by - source: UBERON:0000004 - target: MESH:D065631 - multigraph: true - nodes: - - id: MESH:D003533 - label: Drug - name: Cyproheptadine - - id: UniProt:P35367 - label: Protein - name: Histamine H1 receptor - - id: MESH:D006632 - label: ChemicalSubstance - name: Histamine - - id: GO:0071159 - label: CellularComponent - name: NF-kappaB complex - - id: GO:0006954 - label: BiologicalProcess - name: Inflammatory response - - id: UBERON:0000004 - label: GrossAnatomicalStructure - name: Nose - - id: MESH:D065631 - label: Disease - name: Allergic rhinitis - reference: https://pubmed.ncbi.nlm.nih.gov/14561186/ https://go.drugbank.com/drugs/DB00434 -- directed: true - graph: - disease: Hypertensive disorder - disease_mesh: MESH:D006973 - drug: Pindolol - drug_mesh: MESH:D010869 - drugbank: DB:DB00960 - links: - - key: decreases activity of - source: MESH:D010869 - target: UniProt:P08588 - - key: positively regulates - source: UniProt:P08588 - target: HP:0033533 - - key: positively regulates - source: UniProt:P08588 - target: UniProt:P00797 - - key: positively regulates - source: UniProt:P00797 - target: GO:0042310 - - key: positively regulates - source: GO:0042310 - target: GO:0008217 - - key: positively correlated with - source: GO:0008217 - target: MESH:D006973 - - key: positively correlated with - source: HP:0033533 - target: MESH:D006973 - multigraph: true - nodes: - - id: MESH:D010869 - label: Drug - name: Pindolol - - id: UniProt:P08588 - label: Protein - name: Beta-1 adrenergic receptor - - id: HP:0033533 - label: PhenotypicFeature - name: Increased cardiac output - - id: UniProt:P00797 - label: Protein - name: Renin - - id: GO:0042310 - label: BiologicalProcess - name: Vasoconstriction - - id: GO:0008217 - label: BiologicalProcess - name: Blood Pressure - - id: MESH:D006973 - label: Disease - name: Hypertensive disorder - reference: https://en.wikipedia.org/wiki/Beta-1_adrenergic_receptor https://go.drugbank.com/drugs/DB00960#BE0000694 -- directed: true - graph: - disease: Mantle cell lymphoma - disease_mesh: MESH:D020522 - drug: Bortezomib - drug_mesh: MESH:D000069286 - drugbank: DB:DB00188 - links: - - key: decreases activity of - source: MESH:D000069286 - target: UniProt:P28074 - - key: decreases activity of - source: MESH:D000069286 - target: UniProt:P20618 - - key: decreases activity of - source: MESH:D000069286 - target: GO:0071159 - - key: participates in - source: UniProt:P28074 - target: GO:0043161 - - key: participates in - source: UniProt:P20618 - target: GO:0043161 - - key: negatively regulates - source: GO:0071159 - target: GO:0006915 - - key: negatively regulates - source: GO:0043161 - target: GO:0006915 - - key: negatively correlated with - source: GO:0006915 - target: MESH:D020522 - multigraph: true - nodes: - - id: MESH:D000069286 - label: Drug - name: Bortezomib - - id: UniProt:P28074 - label: Protein - name: Proteasome subunit beta type-5 - - id: UniProt:P20618 - label: Protein - name: Proteasome subunit beta type-1 - - id: GO:0071159 - label: CellularComponent - name: NF-kappaB complex - - id: GO:0043161 - label: BiologicalProcess - name: Proteasome-mediated ubiquitin-dependent protein catabolic process - - id: GO:0006915 - label: BiologicalProcess - name: Apoptotic process - - id: MESH:D020522 - label: Disease - name: Mantle cell lymphoma - reference: https://en.wikipedia.org/wiki/Bortezomib https://go.drugbank.com/drugs/DB00188 -- directed: true - graph: - disease: Multiple myeloma - disease_mesh: MESH:D009101 - drug: Bortezomib - drug_mesh: MESH:D000069286 - drugbank: DB:DB00188 - links: - - key: decreases activity of - source: MESH:D000069286 - target: UniProt:P28074 - - key: decreases activity of - source: MESH:D000069286 - target: UniProt:P20618 - - key: decreases activity of - source: MESH:D000069286 - target: GO:0071159 - - key: participates in - source: UniProt:P28074 - target: GO:0043161 - - key: participates in - source: UniProt:P20618 - target: GO:0043161 - - key: negatively regulates - source: GO:0071159 - target: GO:0006915 - - key: negatively regulates - source: GO:0043161 - target: GO:0006915 - - key: negatively correlated with - source: GO:0006915 - target: MESH:D009101 - multigraph: true - nodes: - - id: MESH:D000069286 - label: Drug - name: Bortezomib - - id: UniProt:P28074 - label: Protein - name: Proteasome subunit beta type-5 - - id: UniProt:P20618 - label: Protein - name: Proteasome subunit beta type-1 - - id: GO:0071159 - label: CellularComponent - name: NF-kappaB complex - - id: GO:0043161 - label: BiologicalProcess - name: Proteasome-mediated ubiquitin-dependent protein catabolic process - - id: GO:0006915 - label: BiologicalProcess - name: Apoptotic process - - id: MESH:D009101 - label: Disease - name: Multiple myeloma - reference: https://en.wikipedia.org/wiki/Bortezomib https://go.drugbank.com/drugs/DB00188 -- directed: true - graph: - disease: Malignant tumor of ovary - disease_mesh: MESH:D010051 - drug: Melphalan - drug_mesh: MESH:D008558 - drugbank: DB:DB01042 - links: - - key: disrupts - source: MESH:D008558 - target: MESH:D004247 - - key: participates in - source: MESH:D004247 - target: GO:0090592 - - key: part of - source: GO:0090592 - target: GO:0008283 - - key: positively correlated with - source: GO:0008283 - target: MESH:D010051 - multigraph: true - nodes: - - id: MESH:D008558 - label: Drug - name: Melphalan - - id: MESH:D004247 - label: ChemicalSubstance - name: DNA - - id: GO:0090592 - label: BiologicalProcess - name: DNA synthesis involved in DNA replication - - id: GO:0008283 - label: BiologicalProcess - name: Cell population proliferation - - id: MESH:D010051 - label: Disease - name: Malignant tumor of ovary - reference: https://go.drugbank.com/drugs/DB01042 -- directed: true - graph: - disease: Multiple myeloma - disease_mesh: MESH:D009101 - drug: Melphalan - drug_mesh: MESH:D008558 - drugbank: DB:DB01042 - links: - - key: disrupts - source: MESH:D008558 - target: MESH:D004247 - - key: participates in - source: MESH:D004247 - target: GO:0090592 - - key: part of - source: GO:0090592 - target: GO:0008283 - - key: positively correlated with - source: GO:0008283 - target: MESH:D009101 - multigraph: true - nodes: - - id: MESH:D008558 - label: Drug - name: Melphalan - - id: MESH:D004247 - label: ChemicalSubstance - name: DNA - - id: GO:0090592 - label: BiologicalProcess - name: DNA synthesis involved in DNA replication - - id: GO:0008283 - label: BiologicalProcess - name: Cell population proliferation - - id: MESH:D009101 - label: Disease - name: Multiple myeloma - reference: https://go.drugbank.com/drugs/DB01042 -- directed: true - graph: - disease: Hyperuricemia - disease_mesh: MESH:D033461 - drug: Sulfinpyrazone - drug_mesh: MESH:D013442 - drugbank: DB:DB01138 - links: - - key: decreases activity of - source: MESH:D013442 - target: UniProt:Q96S37 - - key: negatively correlated with - source: UniProt:Q96S37 - target: GO:0097744 - - key: negatively correlated with - source: GO:0097744 - target: MESH:D033461 - multigraph: true - nodes: - - id: MESH:D013442 - label: Drug - name: Sulfinpyrazone - - id: UniProt:Q96S37 - label: Protein - name: Solute carrier family 22 member 12 - - id: GO:0097744 - label: BiologicalProcess - name: Urate salt excretion - - id: MESH:D033461 - label: Disease - name: Hyperuricemia - reference: https://go.drugbank.com/drugs/DB01138 -- directed: true - graph: - disease: Backache - disease_mesh: MESH:D001416 - drug: Magnesium salicylate - drug_mesh: MESH:C496892 - drugbank: DB:DB01397 - links: - - key: decreases activity of - source: MESH:C496892 - target: UniProt:P23219 - - key: decreases activity of - source: MESH:C496892 - target: UniProt:P35354 - - key: increases abundance of - source: UniProt:P23219 - target: MESH:D011453 - - key: increases abundance of - source: UniProt:P35354 - target: MESH:D011453 - - key: positively regulates - source: MESH:D011453 - target: GO:0006954 - - key: causes - source: GO:0006954 - target: MESH:D001416 - multigraph: true - nodes: - - id: MESH:C496892 - label: Drug - name: Magnesium salicylate - - id: UniProt:P23219 - label: Protein - name: Cox-1 - - id: UniProt:P35354 - label: Protein - name: Cox-2 - - id: MESH:D011453 - label: ChemicalSubstance - name: Prostaglandins - - id: GO:0006954 - label: BiologicalProcess - name: Inflammatory response - - id: MESH:D001416 - label: Disease - name: Backache - reference: https://go.drugbank.com/drugs/DB01397 -- directed: true - graph: - disease: Bursitis - disease_mesh: MESH:D002062 - drug: Magnesium salicylate - drug_mesh: MESH:C496892 - drugbank: DB:DB01397 - links: - - key: decreases activity of - source: MESH:C496892 - target: UniProt:P23219 - - key: decreases activity of - source: MESH:C496892 - target: UniProt:P35354 - - key: increases abundance of - source: UniProt:P23219 - target: MESH:D011453 - - key: increases abundance of - source: UniProt:P35354 - target: MESH:D011453 - - key: positively regulates - source: MESH:D011453 - target: GO:0006954 - - key: causes - source: GO:0006954 - target: MESH:D002062 - multigraph: true - nodes: - - id: MESH:C496892 - label: Drug - name: Magnesium salicylate - - id: UniProt:P23219 - label: Protein - name: Cox-1 - - id: UniProt:P35354 - label: Protein - name: Cox-2 - - id: MESH:D011453 - label: ChemicalSubstance - name: Prostaglandins - - id: GO:0006954 - label: BiologicalProcess - name: Inflammatory response - - id: MESH:D002062 - label: Disease - name: Bursitis - reference: https://go.drugbank.com/drugs/DB01397 -- directed: true - graph: - disease: Joint pain - disease_mesh: MESH:D018771 - drug: Magnesium salicylate - drug_mesh: MESH:C496892 - drugbank: DB:DB01397 - links: - - key: decreases activity of - source: MESH:C496892 - target: UniProt:P23219 - - key: decreases activity of - source: MESH:C496892 - target: UniProt:P35354 - - key: increases abundance of - source: UniProt:P23219 - target: MESH:D011453 - - key: increases abundance of - source: UniProt:P35354 - target: MESH:D011453 - - key: positively regulates - source: MESH:D011453 - target: GO:0006954 - - key: causes - source: GO:0006954 - target: MESH:D018771 - multigraph: true - nodes: - - id: MESH:C496892 - label: Drug - name: Magnesium salicylate - - id: UniProt:P23219 - label: Protein - name: Cox-1 - - id: UniProt:P35354 - label: Protein - name: Cox-2 - - id: MESH:D011453 - label: ChemicalSubstance - name: Prostaglandins - - id: GO:0006954 - label: BiologicalProcess - name: Inflammatory response - - id: MESH:D018771 - label: Disease - name: Joint pain - reference: https://go.drugbank.com/drugs/DB01397 -- directed: true - graph: - disease: Synovitis - disease_mesh: MESH:D013585 - drug: Magnesium salicylate - drug_mesh: MESH:C496892 - drugbank: DB:DB01397 - links: - - key: decreases activity of - source: MESH:C496892 - target: UniProt:P23219 - - key: decreases activity of - source: MESH:C496892 - target: UniProt:P35354 - - key: increases abundance of - source: UniProt:P23219 - target: MESH:D011453 - - key: increases abundance of - source: UniProt:P35354 - target: MESH:D011453 - - key: positively regulates - source: MESH:D011453 - target: GO:0006954 - - key: causes - source: GO:0006954 - target: MESH:D013585 - multigraph: true - nodes: - - id: MESH:C496892 - label: Drug - name: Magnesium salicylate - - id: UniProt:P23219 - label: Protein - name: Cox-1 - - id: UniProt:P35354 - label: Protein - name: Cox-2 - - id: MESH:D011453 - label: ChemicalSubstance - name: Prostaglandins - - id: GO:0006954 - label: BiologicalProcess - name: Inflammatory response - - id: MESH:D013585 - label: Disease - name: Synovitis - reference: https://go.drugbank.com/drugs/DB01397 -- directed: true - graph: - disease: Dysmenorrhea - disease_mesh: MESH:D004412 - drug: Magnesium salicylate - drug_mesh: MESH:C496892 - drugbank: DB:DB01397 - links: - - key: decreases activity of - source: MESH:C496892 - target: UniProt:P23219 - - key: decreases activity of - source: MESH:C496892 - target: UniProt:P35354 - - key: increases abundance of - source: UniProt:P23219 - target: MESH:D011453 - - key: increases abundance of - source: UniProt:P35354 - target: MESH:D011453 - - key: positively regulates - source: MESH:D011453 - target: GO:0006954 - - key: causes - source: GO:0006954 - target: MESH:D010146 - - key: manifestation of - source: MESH:D010146 - target: MESH:D004412 - multigraph: true - nodes: - - id: MESH:C496892 - label: Drug - name: Magnesium salicylate - - id: UniProt:P23219 - label: Protein - name: Cox-1 - - id: UniProt:P35354 - label: Protein - name: Cox-2 - - id: MESH:D011453 - label: ChemicalSubstance - name: Prostaglandins - - id: GO:0006954 - label: BiologicalProcess - name: Inflammatory response - - id: MESH:D010146 - label: Disease - name: Pain - - id: MESH:D004412 - label: Disease - name: Dysmenorrhea - reference: https://go.drugbank.com/drugs/DB01397 -- directed: true - graph: - disease: Osteoarthritis - disease_mesh: MESH:D010003 - drug: Magnesium salicylate - drug_mesh: MESH:C496892 - drugbank: DB:DB01397 - links: - - key: decreases activity of - source: MESH:C496892 - target: UniProt:P23219 - - key: decreases activity of - source: MESH:C496892 - target: UniProt:P35354 - - key: increases abundance of - source: UniProt:P23219 - target: MESH:D011453 - - key: increases abundance of - source: UniProt:P35354 - target: MESH:D011453 - - key: positively regulates - source: MESH:D011453 - target: GO:0006954 - - key: causes - source: GO:0006954 - target: MESH:D010003 - multigraph: true - nodes: - - id: MESH:C496892 - label: Drug - name: Magnesium salicylate - - id: UniProt:P23219 - label: Protein - name: Cox-1 - - id: UniProt:P35354 - label: Protein - name: Cox-2 - - id: MESH:D011453 - label: ChemicalSubstance - name: Prostaglandins - - id: GO:0006954 - label: BiologicalProcess - name: Inflammatory response - - id: MESH:D010003 - label: Disease - name: Osteoarthritis - reference: https://go.drugbank.com/drugs/DB01397 -- directed: true - graph: - disease: Pain - disease_mesh: MESH:D010146 - drug: Magnesium salicylate - drug_mesh: MESH:C496892 - drugbank: DB:DB01397 - links: - - key: decreases activity of - source: MESH:C496892 - target: UniProt:P23219 - - key: decreases activity of - source: MESH:C496892 - target: UniProt:P35354 - - key: increases abundance of - source: UniProt:P23219 - target: MESH:D011453 - - key: increases abundance of - source: UniProt:P35354 - target: MESH:D011453 - - key: positively regulates - source: MESH:D011453 - target: GO:0006954 - - key: causes - source: GO:0006954 - target: MESH:D010146 - multigraph: true - nodes: - - id: MESH:C496892 - label: Drug - name: Magnesium salicylate - - id: UniProt:P23219 - label: Protein - name: Cox-1 - - id: UniProt:P35354 - label: Protein - name: Cox-2 - - id: MESH:D011453 - label: ChemicalSubstance - name: Prostaglandins - - id: GO:0006954 - label: BiologicalProcess - name: Inflammatory response - - id: MESH:D010146 - label: Disease - name: Pain - reference: https://go.drugbank.com/drugs/DB01397 -- directed: true - graph: - disease: Fever - disease_mesh: MESH:D005334 - drug: Magnesium salicylate - drug_mesh: MESH:C496892 - drugbank: DB:DB01397 - links: - - key: decreases activity of - source: MESH:C496892 - target: UniProt:P23219 - - key: decreases activity of - source: MESH:C496892 - target: UniProt:P35354 - - key: increases abundance of - source: UniProt:P23219 - target: MESH:D011453 - - key: increases abundance of - source: UniProt:P35354 - target: MESH:D011453 - - key: positively regulates - source: MESH:D011453 - target: GO:0006954 - - key: causes - source: GO:0006954 - target: MESH:D005334 - multigraph: true - nodes: - - id: MESH:C496892 - label: Drug - name: Magnesium salicylate - - id: UniProt:P23219 - label: Protein - name: Cox-1 - - id: UniProt:P35354 - label: Protein - name: Cox-2 - - id: MESH:D011453 - label: ChemicalSubstance - name: Prostaglandins - - id: GO:0006954 - label: BiologicalProcess - name: Inflammatory response - - id: MESH:D005334 - label: Disease - name: Fever - reference: https://go.drugbank.com/drugs/DB01397 -- directed: true - graph: - disease: Rheumatoid arthritis - disease_mesh: MESH:D001172 - drug: Magnesium salicylate - drug_mesh: MESH:C496892 - drugbank: DB:DB01397 - links: - - key: decreases activity of - source: MESH:C496892 - target: UniProt:P23219 - - key: decreases activity of - source: MESH:C496892 - target: UniProt:P35354 - - key: increases abundance of - source: UniProt:P23219 - target: MESH:D011453 - - key: increases abundance of - source: UniProt:P35354 - target: MESH:D011453 - - key: positively regulates - source: MESH:D011453 - target: GO:0006954 - - key: causes - source: GO:0006954 - target: MESH:D001172 - multigraph: true - nodes: - - id: MESH:C496892 - label: Drug - name: Magnesium salicylate - - id: UniProt:P23219 - label: Protein - name: Cox-1 - - id: UniProt:P35354 - label: Protein - name: Cox-2 - - id: MESH:D011453 - label: ChemicalSubstance - name: Prostaglandins - - id: GO:0006954 - label: BiologicalProcess - name: Inflammatory response - - id: MESH:D001172 - label: Disease - name: Rheumatoid arthritis - reference: https://go.drugbank.com/drugs/DB01397 -- directed: true - graph: - disease: Headache disorder - disease_mesh: MESH:D020773 - drug: Magnesium salicylate - drug_mesh: MESH:C496892 - drugbank: DB:DB01397 - links: - - key: decreases activity of - source: MESH:C496892 - target: UniProt:P23219 - - key: decreases activity of - source: MESH:C496892 - target: UniProt:P35354 - - key: increases abundance of - source: UniProt:P23219 - target: MESH:D011453 - - key: increases abundance of - source: UniProt:P35354 - target: MESH:D011453 - - key: positively regulates - source: MESH:D011453 - target: GO:0006954 - - key: causes - source: GO:0006954 - target: MESH:D010146 - - key: manifestation of - source: MESH:D010146 - target: MESH:D020773 - multigraph: true - nodes: - - id: MESH:C496892 - label: Drug - name: Magnesium salicylate - - id: UniProt:P23219 - label: Protein - name: Cox-1 - - id: UniProt:P35354 - label: Protein - name: Cox-2 - - id: MESH:D011453 - label: ChemicalSubstance - name: Prostaglandins - - id: GO:0006954 - label: BiologicalProcess - name: Inflammatory response - - id: MESH:D010146 - label: Disease - name: Pain - - id: MESH:D020773 - label: Disease - name: Headache disorder - reference: https://go.drugbank.com/drugs/DB01397 -- directed: true - graph: - disease: Vernal conjunctivitis - disease_mesh: MESH:D003233 - drug: Lodoxamide - drug_mesh: MESH:C021702,MESH:C022028 - drugbank: DB:DB06794 - links: - - key: negatively regulates - source: DB:DB06794 - target: GO:0043303 - - key: positively regulates - source: GO:0043303 - target: GO:0001821 - - key: positively regulates - source: GO:0001821 - target: GO:0006954 - - key: causes - source: GO:0006954 - target: MESH:D003233 - multigraph: true - nodes: - - id: DB:DB06794 - label: Drug - name: Lodoxamide - - id: GO:0043303 - label: BiologicalProcess - name: Mast cell degranulation - - id: GO:0001821 - label: BiologicalProcess - name: Histamine secretion - - id: GO:0006954 - label: BiologicalProcess - name: Inflammatory response - - id: MESH:D003233 - label: Disease - name: Vernal conjunctivitis - reference: https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201266/ https://go.drugbank.com/drugs/DB06794 -- directed: true - graph: - disease: Constipation - disease_mesh: MESH:D003248 - drug: Sodium phosphate - drug_mesh: MESH:C018279 - drugbank: DB:DB09449 - links: - - key: positively regulates - source: MESH:C018279 - target: GO:0120054 - - key: negatively correlated with - source: GO:0120054 - target: MESH:D003248 - multigraph: true - nodes: - - id: MESH:C018279 - label: Drug - name: Sodium phosphate - - id: GO:0120054 - label: BiologicalProcess - name: Intestinal motility - - id: MESH:D003248 - label: Disease - name: Constipation - reference: https://go.drugbank.com/drugs/DB09449 +