diff --git a/indication_paths.json b/indication_paths.json
index c746ec2b9..2f5a5a40d 100644
--- a/indication_paths.json
+++ b/indication_paths.json
@@ -235429,5 +235429,1748 @@
       "https://en.wikipedia.org/wiki/Sivelestat",
       "https://go.drugbank.com/drugs/DB12863"
     ]
+  },
+  {
+    "directed": true,
+    "graph": {
+      "_id": "DB11613_MESH_D019698_1",
+      "disease": "Chronic hepatitis C",
+      "disease_mesh": "MESH:D019698",
+      "drug": "velpatasvir",
+      "drug_mesh": "MESH:C000604171",
+      "drugbank": "DB:DB11613"
+    },
+    "links": [
+      {
+        "key": "negatively regulates",
+        "source": "MESH:C000604171",
+        "target": "UniProt:Q5L478"
+      },
+      {
+        "key": "molecularly interacts with",
+        "source": "UniProt:Q5L478",
+        "target": "MESH:C000618292"
+      },
+      {
+        "key": "increases abundance of",
+        "source": "MESH:C000618292",
+        "target": "MESH:C037178"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "MESH:C037178",
+        "target": "MESH:D002784"
+      },
+      {
+        "key": "located in",
+        "source": "MESH:D002784",
+        "target": "MESH:D000086969"
+      },
+      {
+        "key": "location of",
+        "source": "MESH:D000086969",
+        "target": "GO:0039694"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:Q5L478",
+        "target": "GO:0003968"
+      },
+      {
+        "key": "positively regulates",
+        "source": "GO:0003968",
+        "target": "GO:0039694"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:Q5L478",
+        "target": "GO:0004197"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:Q5L478",
+        "target": "GO:0004252"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0004197",
+        "target": "MESH:D014779"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0004252",
+        "target": "MESH:D014779"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "MESH:D014779",
+        "target": "MESH:D019065"
+      },
+      {
+        "key": "in taxon",
+        "source": "GO:0039694",
+        "target": "NCBITaxon:11103"
+      },
+      {
+        "key": "in taxon",
+        "source": "MESH:D019065",
+        "target": "NCBITaxon:11103"
+      },
+      {
+        "key": "causes",
+        "source": "NCBITaxon:11103",
+        "target": "MESH:D019698"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:C000604171",
+        "label": "Drug",
+        "name": "velpatasvir"
+      },
+      {
+        "id": "UniProt:Q5L478",
+        "label": "Protein",
+        "name": "Nonstructural protein 5A"
+      },
+      {
+        "id": "GO:0003968",
+        "label": "MolecularActivity",
+        "name": "RNA-directed 5'-3' RNA polymerase activity"
+      },
+      {
+        "id": "GO:0039694",
+        "label": "BiologicalProcess",
+        "name": "viral RNA genome replication"
+      },
+      {
+        "id": "MESH:C000618292",
+        "label": "Protein",
+        "name": "PI4KIIIalpha protein, human"
+      },
+      {
+        "id": "MESH:C037178",
+        "label": "ChemicalSubstance",
+        "name": "phosphatidylinositol 4-phosphate"
+      },
+      {
+        "id": "MESH:D002784",
+        "label": "ChemicalSubstance",
+        "name": "Cholesterol"
+      },
+      {
+        "id": "MESH:D000086969",
+        "label": "CellularComponent",
+        "name": "Viral Replication Compartments"
+      },
+      {
+        "id": "GO:0004197",
+        "label": "MolecularActivity",
+        "name": "cysteine-type endopeptidase activity"
+      },
+      {
+        "id": "GO:0004252",
+        "label": "MolecularActivity",
+        "name": "serine-type endopeptidase activity"
+      },
+      {
+        "id": "MESH:D014779",
+        "label": "BiologicalProcess",
+        "name": "Virus Replication"
+      },
+      {
+        "id": "MESH:D019065",
+        "label": "BiologicalProcess",
+        "name": "Virus Assembly"
+      },
+      {
+        "id": "NCBITaxon:11103",
+        "label": "OrganismTaxon",
+        "name": "Hepacivirus C"
+      },
+      {
+        "id": "MESH:D019698",
+        "label": "Disease",
+        "name": "Chronic hepatitis C"
+      }
+    ],
+    "reference": [
+      "https://go.drugbank.com/drugs/DB11613",
+      "https://en.wikipedia.org/wiki/Velpatasvir#Mechanism_of_action",
+      "https://en.wikipedia.org/wiki/Discovery_and_development_of_NS5A_inhibitors#Mechanism_of_action",
+      "https://en.wikipedia.org/wiki/Discovery_and_development_of_NS5A_inhibitors#Function",
+      "https://pubmed.ncbi.nlm.nih.gov/25384189/",
+      "https://www.ncbi.nlm.nih.gov/books/NBK1623/"
+    ]
+  },
+  {
+    "directed": true,
+    "graph": {
+      "_id": "DB01053_MESH_D012541_1",
+      "disease": "Scarlet fever",
+      "disease_mesh": "MESH:D012541",
+      "drug": "benzathine benzylpenicillin",
+      "drug_mesh": "MESH:D010401",
+      "drugbank": "DB:DB01053"
+    },
+    "links": [
+      {
+        "key": "negatively regulates",
+        "source": "MESH:D010401",
+        "target": "InterPro:IPR001460"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "InterPro:IPR001460",
+        "target": "GO:0009252"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0009252",
+        "target": "GO:0071555"
+      },
+      {
+        "key": "in taxon",
+        "source": "GO:0071555",
+        "target": "NCBITaxon:1314"
+      },
+      {
+        "key": "causes",
+        "source": "NCBITaxon:1314",
+        "target": "MESH:D012541"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "alt_ids": [
+          "DB:DBSALT002768"
+        ],
+        "alt_names": [
+          "Penicillin G Benzathine",
+          "Benzylpenicillin",
+          "Benzylpenicillin benzathine hydrate"
+        ],
+        "id": "MESH:D010401",
+        "label": "Drug",
+        "name": "benzathine benzylpenicillin"
+      },
+      {
+        "id": "InterPro:IPR001460",
+        "label": "GeneFamily",
+        "name": "Penicillin-binding protein, transpeptidase"
+      },
+      {
+        "id": "GO:0009252",
+        "label": "BiologicalProcess",
+        "name": "peptidoglycan biosynthetic process"
+      },
+      {
+        "id": "GO:0071555",
+        "label": "BiologicalProcess",
+        "name": "cell wall organization"
+      },
+      {
+        "id": "NCBITaxon:1314",
+        "label": "OrganismTaxon",
+        "name": "Streptococcus pyogenes"
+      },
+      {
+        "id": "MESH:D012541",
+        "label": "Disease",
+        "name": "Scarlet fever"
+      }
+    ],
+    "reference": [
+      "https://go.drugbank.com/drugs/DB01053"
+    ]
+  },
+  {
+    "directed": true,
+    "graph": {
+      "_id": "DB01053_MESH_D013290_1",
+      "disease": "Streptococcus pyogenes infection",
+      "disease_mesh": "MESH:D013290",
+      "drug": "benzathine benzylpenicillin",
+      "drug_mesh": "MESH:D010401",
+      "drugbank": "DB:DB01053"
+    },
+    "links": [
+      {
+        "key": "negatively regulates",
+        "source": "MESH:D010401",
+        "target": "InterPro:IPR001460"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "InterPro:IPR001460",
+        "target": "GO:0009252"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0009252",
+        "target": "GO:0071555"
+      },
+      {
+        "key": "in taxon",
+        "source": "GO:0071555",
+        "target": "NCBITaxon:1314"
+      },
+      {
+        "key": "causes",
+        "source": "NCBITaxon:1314",
+        "target": "MESH:D013290"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "alt_ids": [
+          "DB:DBSALT002768"
+        ],
+        "alt_names": [
+          "Penicillin G Benzathine",
+          "Benzylpenicillin",
+          "Benzylpenicillin benzathine hydrate"
+        ],
+        "id": "MESH:D010401",
+        "label": "Drug",
+        "name": "benzathine benzylpenicillin"
+      },
+      {
+        "id": "InterPro:IPR001460",
+        "label": "GeneFamily",
+        "name": "Penicillin-binding protein, transpeptidase"
+      },
+      {
+        "id": "GO:0009252",
+        "label": "BiologicalProcess",
+        "name": "peptidoglycan biosynthetic process"
+      },
+      {
+        "id": "GO:0071555",
+        "label": "BiologicalProcess",
+        "name": "cell wall organization"
+      },
+      {
+        "id": "NCBITaxon:1314",
+        "label": "OrganismTaxon",
+        "name": "Streptococcus pyogenes"
+      },
+      {
+        "id": "MESH:D013290",
+        "label": "Disease",
+        "name": "Streptococcus pyogenes infection"
+      }
+    ],
+    "reference": [
+      "https://go.drugbank.com/drugs/DB01053"
+    ]
+  },
+  {
+    "directed": true,
+    "graph": {
+      "_id": "DB01053_MESH_D004886_1",
+      "disease": "Erysipelas",
+      "disease_mesh": "MESH:D004886",
+      "drug": "benzathine benzylpenicillin",
+      "drug_mesh": "MESH:D010401",
+      "drugbank": "DB:DB01053"
+    },
+    "links": [
+      {
+        "key": "negatively regulates",
+        "source": "MESH:D010401",
+        "target": "InterPro:IPR001460"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "InterPro:IPR001460",
+        "target": "GO:0009252"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0009252",
+        "target": "GO:0071555"
+      },
+      {
+        "key": "in taxon",
+        "source": "GO:0071555",
+        "target": "NCBITaxon:1314"
+      },
+      {
+        "key": "causes",
+        "source": "NCBITaxon:1314",
+        "target": "MESH:D004886"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "alt_ids": [
+          "DB:DBSALT002768"
+        ],
+        "alt_names": [
+          "Penicillin G Benzathine",
+          "Benzylpenicillin",
+          "Benzylpenicillin benzathine hydrate"
+        ],
+        "id": "MESH:D010401",
+        "label": "Drug",
+        "name": "benzathine benzylpenicillin"
+      },
+      {
+        "id": "InterPro:IPR001460",
+        "label": "GeneFamily",
+        "name": "Penicillin-binding protein, transpeptidase"
+      },
+      {
+        "id": "GO:0009252",
+        "label": "BiologicalProcess",
+        "name": "peptidoglycan biosynthetic process"
+      },
+      {
+        "id": "GO:0071555",
+        "label": "BiologicalProcess",
+        "name": "cell wall organization"
+      },
+      {
+        "id": "NCBITaxon:1314",
+        "label": "OrganismTaxon",
+        "name": "Streptococcus pyogenes"
+      },
+      {
+        "id": "MESH:D004886",
+        "label": "Disease",
+        "name": "Erysipelas"
+      }
+    ],
+    "reference": [
+      "https://go.drugbank.com/drugs/DB01053"
+    ]
+  },
+  {
+    "directed": true,
+    "graph": {
+      "_id": "DB01053_MESH_D011018_1",
+      "disease": "Pneumococcal pneumonia",
+      "disease_mesh": "MESH:D011018",
+      "drug": "benzathine benzylpenicillin",
+      "drug_mesh": "MESH:D010401",
+      "drugbank": "DB:DB01053"
+    },
+    "links": [
+      {
+        "key": "negatively regulates",
+        "source": "MESH:D010401",
+        "target": "InterPro:IPR001460"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "InterPro:IPR001460",
+        "target": "GO:0009252"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0009252",
+        "target": "GO:0071555"
+      },
+      {
+        "key": "in taxon",
+        "source": "GO:0071555",
+        "target": "NCBITaxon:1313"
+      },
+      {
+        "key": "causes",
+        "source": "NCBITaxon:1313",
+        "target": "MESH:D011018"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "alt_ids": [
+          "DB:DBSALT002768"
+        ],
+        "alt_names": [
+          "Penicillin G Benzathine",
+          "Benzylpenicillin",
+          "Benzylpenicillin benzathine hydrate"
+        ],
+        "id": "MESH:D010401",
+        "label": "Drug",
+        "name": "benzathine benzylpenicillin"
+      },
+      {
+        "id": "InterPro:IPR001460",
+        "label": "GeneFamily",
+        "name": "Penicillin-binding protein, transpeptidase"
+      },
+      {
+        "id": "GO:0009252",
+        "label": "BiologicalProcess",
+        "name": "peptidoglycan biosynthetic process"
+      },
+      {
+        "id": "GO:0071555",
+        "label": "BiologicalProcess",
+        "name": "cell wall organization"
+      },
+      {
+        "id": "NCBITaxon:1313",
+        "label": "OrganismTaxon",
+        "name": "Streptococcus pneumoniae"
+      },
+      {
+        "id": "MESH:D011018",
+        "label": "Disease",
+        "name": "Pneumococcal pneumonia"
+      }
+    ],
+    "reference": [
+      "https://go.drugbank.com/drugs/DB01053"
+    ]
+  },
+  {
+    "directed": true,
+    "graph": {
+      "_id": "DB09063_MESH_D002289_1",
+      "disease": "Non-small cell lung cancer",
+      "disease_mesh": "MESH:D002289",
+      "drug": "ceritinib",
+      "drug_mesh": "MESH:C586847",
+      "drugbank": "DB:DB09063"
+    },
+    "links": [
+      {
+        "key": "decreases activity of",
+        "source": "MESH:C586847",
+        "target": "UniProt:Q9UM73"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:Q9UM73",
+        "target": "GO:0008283"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0008283",
+        "target": "MESH:D002289"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:C586847",
+        "label": "Drug",
+        "name": "ceritinib"
+      },
+      {
+        "id": "UniProt:Q9UM73",
+        "label": "Protein",
+        "name": "ALK tyrosine kinase receptor"
+      },
+      {
+        "id": "GO:0008283",
+        "label": "BiologicalProcess",
+        "name": "cell population proliferation"
+      },
+      {
+        "id": "MESH:D002289",
+        "label": "Disease",
+        "name": "Non-small cell lung cancer"
+      }
+    ],
+    "reference": [
+      "https://go.drugbank.com/drugs/DB09063",
+      "https://en.wikipedia.org/wiki/Ceritinib#Mechanism_of_action"
+    ]
+  },
+  {
+    "directed": true,
+    "graph": {
+      "_id": "DB00869_MESH_D009798_1",
+      "disease": "Ocular hypertension",
+      "disease_mesh": "MESH:D009798",
+      "drug": "dorzolamide",
+      "drug_mesh": "MESH:C062765",
+      "drugbank": "DB:DB00869"
+    },
+    "links": [
+      {
+        "key": "negatively regulates",
+        "source": "MESH:C062765",
+        "target": "UniProt:P00918"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P00918",
+        "target": "GO:0015701"
+      },
+      {
+        "key": "increases abundance of",
+        "source": "GO:0015701",
+        "target": "UBERON:0001796"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "UBERON:0001796",
+        "target": "MESH:D009798"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:C062765",
+        "label": "Drug",
+        "name": "dorzolamide"
+      },
+      {
+        "id": "UniProt:P00918",
+        "label": "Protein",
+        "name": "Carbonic anhydrase 2"
+      },
+      {
+        "id": "GO:0015701",
+        "label": "BiologicalProcess",
+        "name": "bicarbonate transport"
+      },
+      {
+        "id": "UBERON:0001796",
+        "label": "GrossAnatomicalStructure",
+        "name": "aqueous humor of eyeball"
+      },
+      {
+        "id": "MESH:D009798",
+        "label": "Disease",
+        "name": "Ocular hypertension"
+      }
+    ],
+    "reference": [
+      "https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL218490/",
+      "https://pubchem.ncbi.nlm.nih.gov/compound/5284549#section=Mechanism-of-Action",
+      "https://en.wikipedia.org/wiki/Glaucoma#Medication",
+      "https://www.aaopt.org/docs/knowledge-base/outline26514.doc?sfvrsn=5f863d3_0",
+      "https://en.wikipedia.org/wiki/Aqueous_humour#Clinical_significance"
+    ]
+  },
+  {
+    "directed": true,
+    "graph": {
+      "_id": "DB00869_MESH_D005902_1",
+      "disease": "Open-angle glaucoma",
+      "disease_mesh": "MESH:D005902",
+      "drug": "dorzolamide",
+      "drug_mesh": "MESH:C062765",
+      "drugbank": "DB:DB00869"
+    },
+    "links": [
+      {
+        "key": "negatively regulates",
+        "source": "MESH:C062765",
+        "target": "UniProt:P00918"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P00918",
+        "target": "GO:0015701"
+      },
+      {
+        "key": "increases abundance of",
+        "source": "GO:0015701",
+        "target": "UBERON:0001796"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "UBERON:0001796",
+        "target": "HP:0007906"
+      },
+      {
+        "key": "manifestation of",
+        "source": "HP:0007906",
+        "target": "MESH:D005902"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:C062765",
+        "label": "Drug",
+        "name": "dorzolamide"
+      },
+      {
+        "id": "UniProt:P00918",
+        "label": "Protein",
+        "name": "Carbonic anhydrase 2"
+      },
+      {
+        "id": "GO:0015701",
+        "label": "BiologicalProcess",
+        "name": "bicarbonate transport"
+      },
+      {
+        "id": "UBERON:0001796",
+        "label": "GrossAnatomicalStructure",
+        "name": "aqueous humor of eyeball"
+      },
+      {
+        "id": "HP:0007906",
+        "label": "PhenotypicFeature",
+        "name": "Ocular Hypertension"
+      },
+      {
+        "id": "MESH:D005902",
+        "label": "Disease",
+        "name": "Open-angle glaucoma"
+      }
+    ],
+    "reference": [
+      "https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL218490/",
+      "https://pubchem.ncbi.nlm.nih.gov/compound/5284549#section=Mechanism-of-Action",
+      "https://en.wikipedia.org/wiki/Glaucoma#Medication",
+      "https://www.aaopt.org/docs/knowledge-base/outline26514.doc?sfvrsn=5f863d3_0",
+      "https://en.wikipedia.org/wiki/Aqueous_humour#Clinical_significance"
+    ]
+  },
+  {
+    "directed": true,
+    "graph": {
+      "_id": "DB00841_MESH_D012770_1",
+      "disease": "Cardiogenic shock",
+      "disease_mesh": "MESH:D012770",
+      "drug": "dobutamine",
+      "drug_mesh": "MESH:D004280",
+      "drugbank": "DB:DB00841"
+    },
+    "links": [
+      {
+        "key": "positively regulates",
+        "source": "MESH:D004280",
+        "target": "UniProt:P08588"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P08588",
+        "target": "GO:0060047"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "GO:0060047",
+        "target": "HP:0002615"
+      },
+      {
+        "key": "manifestation of",
+        "source": "HP:0002615",
+        "target": "MESH:D012770"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:D004280",
+        "label": "Drug",
+        "name": "dobutamine"
+      },
+      {
+        "id": "UniProt:P08588",
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+    },
+    "links": [
+      {
+        "key": "negatively regulates",
+        "source": "MESH:D007213",
+        "target": "UniProt:P23219"
+      },
+      {
+        "key": "negatively regulates",
+        "source": "MESH:D007213",
+        "target": "UniProt:P35354"
+      },
+      {
+        "key": "participates in",
+        "source": "UniProt:P23219",
+        "target": "REACT:R-HSA-2162123"
+      },
+      {
+        "key": "participates in",
+        "source": "UniProt:P35354",
+        "target": "REACT:R-HSA-2162123"
+      },
+      {
+        "key": "increases abundance of",
+        "source": "REACT:R-HSA-2162123",
+        "target": "CHEBI:26333"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "CHEBI:26333",
+        "target": "GO:0097070"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "GO:0097070",
+        "target": "MESH:D004374"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:D007213",
+        "label": "Drug",
+        "name": "indomethacin"
+      },
+      {
+        "id": "UniProt:P23219",
+        "label": "Protein",
+        "name": "Prostaglandin G/H synthase 1"
+      },
+      {
+        "id": "UniProt:P35354",
+        "label": "Protein",
+        "name": "Prostaglandin G/H synthase 2"
+      },
+      {
+        "id": "REACT:R-HSA-2162123",
+        "label": "Pathway",
+        "name": "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"
+      },
+      {
+        "id": "CHEBI:26333",
+        "label": "ChemicalSubstance",
+        "name": "prostaglandin"
+      },
+      {
+        "id": "GO:0097070",
+        "label": "BiologicalProcess",
+        "name": "ductus arteriosus closure"
+      },
+      {
+        "id": "MESH:D004374",
+        "label": "Disease",
+        "name": "Patent ductus arteriosus"
+      }
+    ],
+    "reference": [
+      "https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL6/",
+      "https://en.wikipedia.org/wiki/Patent_ductus_arteriosus#Prostaglandin_inhibitors"
+    ]
+  },
+  {
+    "directed": true,
+    "graph": {
+      "_id": "DB00349_MESH_D065768_1",
+      "disease": "Lennox-Gastaut syndrome",
+      "disease_mesh": "MESH:D065768",
+      "drug": "clobazam",
+      "drug_mesh": "MESH:C012255",
+      "drugbank": "DB:DB00349"
+    },
+    "links": [
+      {
+        "key": "increases activity of",
+        "source": "MESH:C012255",
+        "target": "InterPro:IPR006028"
+      },
+      {
+        "key": "positively regulates",
+        "source": "InterPro:IPR006028",
+        "target": "GO:0051932"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "GO:0051932",
+        "target": "HP:0032792"
+      },
+      {
+        "key": "manifestation of",
+        "source": "HP:0032792",
+        "target": "MESH:D065768"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:C012255",
+        "label": "Drug",
+        "name": "clobazam"
+      },
+      {
+        "id": "InterPro:IPR006028",
+        "label": "GeneFamily",
+        "name": "Gamma-aminobutyric acid A receptor/Glycine receptor alpha"
+      },
+      {
+        "id": "GO:0051932",
+        "label": "BiologicalProcess",
+        "name": "synaptic transmission, GABAergic"
+      },
+      {
+        "id": "HP:0032792",
+        "label": "PhenotypicFeature",
+        "name": "Tonic seizure"
+      },
+      {
+        "id": "MESH:D065768",
+        "label": "Disease",
+        "name": "Lennox-Gastaut syndrome"
+      }
+    ],
+    "reference": [
+      "https://go.drugbank.com/drugs/DB00349",
+      "https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL70418/",
+      "https://en.wikipedia.org/wiki/Clobazam#Pharmacology"
+    ]
+  },
+  {
+    "directed": true,
+    "graph": {
+      "_id": "DB13783_MESH_D012216_1",
+      "disease": "Rheumatism",
+      "disease_mesh": "MESH:D012216",
+      "drug": "acemetacin",
+      "drug_mesh": "MESH:C026784",
+      "drugbank": "DB:DB13783"
+    },
+    "links": [
+      {
+        "key": "has metabolite",
+        "source": "MESH:C026784",
+        "target": "DB:DB00328"
+      },
+      {
+        "key": "negatively regulates",
+        "source": "DB:DB00328",
+        "target": "UniProt:P35354"
+      },
+      {
+        "key": "negatively regulates",
+        "source": "DB:DB00328",
+        "target": "UniProt:P23219"
+      },
+      {
+        "key": "participates in",
+        "source": "UniProt:P23219",
+        "target": "REACT:R-HSA-2162123"
+      },
+      {
+        "key": "participates in",
+        "source": "UniProt:P35354",
+        "target": "REACT:R-HSA-2162123"
+      },
+      {
+        "key": "increases abundance of",
+        "source": "REACT:R-HSA-2162123",
+        "target": "CHEBI:26333"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "CHEBI:26333",
+        "target": "GO:0006954"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "GO:0006954",
+        "target": "MESH:D012216"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "alt_ids": [
+          "MESH:C519896"
+        ],
+        "alt_names": [
+          "acemethacin"
+        ],
+        "id": "MESH:C026784",
+        "label": "Drug",
+        "name": "acemetacin"
+      },
+      {
+        "id": "DB:DB00328",
+        "label": "ChemicalSubstance",
+        "name": "Indomethacin"
+      },
+      {
+        "id": "UniProt:P23219",
+        "label": "Protein",
+        "name": "Prostaglandin G/H synthase 1"
+      },
+      {
+        "id": "UniProt:P35354",
+        "label": "Protein",
+        "name": "Prostaglandin G/H synthase 2"
+      },
+      {
+        "id": "REACT:R-HSA-2162123",
+        "label": "Pathway",
+        "name": "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"
+      },
+      {
+        "id": "CHEBI:26333",
+        "label": "ChemicalSubstance",
+        "name": "prostaglandin"
+      },
+      {
+        "id": "GO:0006954",
+        "label": "BiologicalProcess",
+        "name": "inflammatory response"
+      },
+      {
+        "id": "MESH:D012216",
+        "label": "Disease",
+        "name": "Rheumatism"
+      }
+    ],
+    "reference": [
+      "https://go.drugbank.com/drugs/DB13783"
+    ]
   }
 ]
\ No newline at end of file
diff --git a/indication_paths.yaml b/indication_paths.yaml
index 1c4c40fa5..0cbdcb1c1 100644
--- a/indication_paths.yaml
+++ b/indication_paths.yaml
@@ -148002,3 +148002,1094 @@
     reference:
     - https://en.wikipedia.org/wiki/Sivelestat
     - https://go.drugbank.com/drugs/DB12863
+-   directed: true
+    graph:
+        _id: DB11613_MESH_D019698_1
+        disease: Chronic hepatitis C
+        disease_mesh: MESH:D019698
+        drug: velpatasvir
+        drug_mesh: MESH:C000604171
+        drugbank: DB:DB11613
+    links:
+    -   key: negatively regulates
+        source: MESH:C000604171
+        target: UniProt:Q5L478
+    -   key: molecularly interacts with
+        source: UniProt:Q5L478
+        target: MESH:C000618292
+    -   key: increases abundance of
+        source: MESH:C000618292
+        target: MESH:C037178
+    -   key: positively correlated with
+        source: MESH:C037178
+        target: MESH:D002784
+    -   key: located in
+        source: MESH:D002784
+        target: MESH:D000086969
+    -   key: location of
+        source: MESH:D000086969
+        target: GO:0039694
+    -   key: positively regulates
+        source: UniProt:Q5L478
+        target: GO:0003968
+    -   key: positively regulates
+        source: GO:0003968
+        target: GO:0039694
+    -   key: positively regulates
+        source: UniProt:Q5L478
+        target: GO:0004197
+    -   key: positively regulates
+        source: UniProt:Q5L478
+        target: GO:0004252
+    -   key: positively correlated with
+        source: GO:0004197
+        target: MESH:D014779
+    -   key: positively correlated with
+        source: GO:0004252
+        target: MESH:D014779
+    -   key: positively correlated with
+        source: MESH:D014779
+        target: MESH:D019065
+    -   key: in taxon
+        source: GO:0039694
+        target: NCBITaxon:11103
+    -   key: in taxon
+        source: MESH:D019065
+        target: NCBITaxon:11103
+    -   key: causes
+        source: NCBITaxon:11103
+        target: MESH:D019698
+    multigraph: true
+    nodes:
+    -   id: MESH:C000604171
+        label: Drug
+        name: velpatasvir
+    -   id: UniProt:Q5L478
+        label: Protein
+        name: Nonstructural protein 5A
+    -   id: GO:0003968
+        label: MolecularActivity
+        name: RNA-directed 5'-3' RNA polymerase activity
+    -   id: GO:0039694
+        label: BiologicalProcess
+        name: viral RNA genome replication
+    -   id: MESH:C000618292
+        label: Protein
+        name: PI4KIIIalpha protein, human
+    -   id: MESH:C037178
+        label: ChemicalSubstance
+        name: phosphatidylinositol 4-phosphate
+    -   id: MESH:D002784
+        label: ChemicalSubstance
+        name: Cholesterol
+    -   id: MESH:D000086969
+        label: CellularComponent
+        name: Viral Replication Compartments
+    -   id: GO:0004197
+        label: MolecularActivity
+        name: cysteine-type endopeptidase activity
+    -   id: GO:0004252
+        label: MolecularActivity
+        name: serine-type endopeptidase activity
+    -   id: MESH:D014779
+        label: BiologicalProcess
+        name: Virus Replication
+    -   id: MESH:D019065
+        label: BiologicalProcess
+        name: Virus Assembly
+    -   id: NCBITaxon:11103
+        label: OrganismTaxon
+        name: Hepacivirus C
+    -   id: MESH:D019698
+        label: Disease
+        name: Chronic hepatitis C
+    reference:
+    - https://go.drugbank.com/drugs/DB11613
+    - https://en.wikipedia.org/wiki/Velpatasvir#Mechanism_of_action
+    - https://en.wikipedia.org/wiki/Discovery_and_development_of_NS5A_inhibitors#Mechanism_of_action
+    - https://en.wikipedia.org/wiki/Discovery_and_development_of_NS5A_inhibitors#Function
+    - https://pubmed.ncbi.nlm.nih.gov/25384189/
+    - https://www.ncbi.nlm.nih.gov/books/NBK1623/
+-   directed: true
+    graph:
+        _id: DB01053_MESH_D012541_1
+        disease: Scarlet fever
+        disease_mesh: MESH:D012541
+        drug: benzathine benzylpenicillin
+        drug_mesh: MESH:D010401
+        drugbank: DB:DB01053
+    links:
+    -   key: negatively regulates
+        source: MESH:D010401
+        target: InterPro:IPR001460
+    -   key: positively correlated with
+        source: InterPro:IPR001460
+        target: GO:0009252
+    -   key: positively correlated with
+        source: GO:0009252
+        target: GO:0071555
+    -   key: in taxon
+        source: GO:0071555
+        target: NCBITaxon:1314
+    -   key: causes
+        source: NCBITaxon:1314
+        target: MESH:D012541
+    multigraph: true
+    nodes:
+    -   alt_ids:
+        - DB:DBSALT002768
+        alt_names:
+        - Penicillin G Benzathine
+        - Benzylpenicillin
+        - Benzylpenicillin benzathine hydrate
+        id: MESH:D010401
+        label: Drug
+        name: benzathine benzylpenicillin
+    -   id: InterPro:IPR001460
+        label: GeneFamily
+        name: Penicillin-binding protein, transpeptidase
+    -   id: GO:0009252
+        label: BiologicalProcess
+        name: peptidoglycan biosynthetic process
+    -   id: GO:0071555
+        label: BiologicalProcess
+        name: cell wall organization
+    -   id: NCBITaxon:1314
+        label: OrganismTaxon
+        name: Streptococcus pyogenes
+    -   id: MESH:D012541
+        label: Disease
+        name: Scarlet fever
+    reference:
+    - https://go.drugbank.com/drugs/DB01053
+-   directed: true
+    graph:
+        _id: DB01053_MESH_D013290_1
+        disease: Streptococcus pyogenes infection
+        disease_mesh: MESH:D013290
+        drug: benzathine benzylpenicillin
+        drug_mesh: MESH:D010401
+        drugbank: DB:DB01053
+    links:
+    -   key: negatively regulates
+        source: MESH:D010401
+        target: InterPro:IPR001460
+    -   key: positively correlated with
+        source: InterPro:IPR001460
+        target: GO:0009252
+    -   key: positively correlated with
+        source: GO:0009252
+        target: GO:0071555
+    -   key: in taxon
+        source: GO:0071555
+        target: NCBITaxon:1314
+    -   key: causes
+        source: NCBITaxon:1314
+        target: MESH:D013290
+    multigraph: true
+    nodes:
+    -   alt_ids:
+        - DB:DBSALT002768
+        alt_names:
+        - Penicillin G Benzathine
+        - Benzylpenicillin
+        - Benzylpenicillin benzathine hydrate
+        id: MESH:D010401
+        label: Drug
+        name: benzathine benzylpenicillin
+    -   id: InterPro:IPR001460
+        label: GeneFamily
+        name: Penicillin-binding protein, transpeptidase
+    -   id: GO:0009252
+        label: BiologicalProcess
+        name: peptidoglycan biosynthetic process
+    -   id: GO:0071555
+        label: BiologicalProcess
+        name: cell wall organization
+    -   id: NCBITaxon:1314
+        label: OrganismTaxon
+        name: Streptococcus pyogenes
+    -   id: MESH:D013290
+        label: Disease
+        name: Streptococcus pyogenes infection
+    reference:
+    - https://go.drugbank.com/drugs/DB01053
+-   directed: true
+    graph:
+        _id: DB01053_MESH_D004886_1
+        disease: Erysipelas
+        disease_mesh: MESH:D004886
+        drug: benzathine benzylpenicillin
+        drug_mesh: MESH:D010401
+        drugbank: DB:DB01053
+    links:
+    -   key: negatively regulates
+        source: MESH:D010401
+        target: InterPro:IPR001460
+    -   key: positively correlated with
+        source: InterPro:IPR001460
+        target: GO:0009252
+    -   key: positively correlated with
+        source: GO:0009252
+        target: GO:0071555
+    -   key: in taxon
+        source: GO:0071555
+        target: NCBITaxon:1314
+    -   key: causes
+        source: NCBITaxon:1314
+        target: MESH:D004886
+    multigraph: true
+    nodes:
+    -   alt_ids:
+        - DB:DBSALT002768
+        alt_names:
+        - Penicillin G Benzathine
+        - Benzylpenicillin
+        - Benzylpenicillin benzathine hydrate
+        id: MESH:D010401
+        label: Drug
+        name: benzathine benzylpenicillin
+    -   id: InterPro:IPR001460
+        label: GeneFamily
+        name: Penicillin-binding protein, transpeptidase
+    -   id: GO:0009252
+        label: BiologicalProcess
+        name: peptidoglycan biosynthetic process
+    -   id: GO:0071555
+        label: BiologicalProcess
+        name: cell wall organization
+    -   id: NCBITaxon:1314
+        label: OrganismTaxon
+        name: Streptococcus pyogenes
+    -   id: MESH:D004886
+        label: Disease
+        name: Erysipelas
+    reference:
+    - https://go.drugbank.com/drugs/DB01053
+-   directed: true
+    graph:
+        _id: DB01053_MESH_D011018_1
+        disease: Pneumococcal pneumonia
+        disease_mesh: MESH:D011018
+        drug: benzathine benzylpenicillin
+        drug_mesh: MESH:D010401
+        drugbank: DB:DB01053
+    links:
+    -   key: negatively regulates
+        source: MESH:D010401
+        target: InterPro:IPR001460
+    -   key: positively correlated with
+        source: InterPro:IPR001460
+        target: GO:0009252
+    -   key: positively correlated with
+        source: GO:0009252
+        target: GO:0071555
+    -   key: in taxon
+        source: GO:0071555
+        target: NCBITaxon:1313
+    -   key: causes
+        source: NCBITaxon:1313
+        target: MESH:D011018
+    multigraph: true
+    nodes:
+    -   alt_ids:
+        - DB:DBSALT002768
+        alt_names:
+        - Penicillin G Benzathine
+        - Benzylpenicillin
+        - Benzylpenicillin benzathine hydrate
+        id: MESH:D010401
+        label: Drug
+        name: benzathine benzylpenicillin
+    -   id: InterPro:IPR001460
+        label: GeneFamily
+        name: Penicillin-binding protein, transpeptidase
+    -   id: GO:0009252
+        label: BiologicalProcess
+        name: peptidoglycan biosynthetic process
+    -   id: GO:0071555
+        label: BiologicalProcess
+        name: cell wall organization
+    -   id: NCBITaxon:1313
+        label: OrganismTaxon
+        name: Streptococcus pneumoniae
+    -   id: MESH:D011018
+        label: Disease
+        name: Pneumococcal pneumonia
+    reference:
+    - https://go.drugbank.com/drugs/DB01053
+-   directed: true
+    graph:
+        _id: DB09063_MESH_D002289_1
+        disease: Non-small cell lung cancer
+        disease_mesh: MESH:D002289
+        drug: ceritinib
+        drug_mesh: MESH:C586847
+        drugbank: DB:DB09063
+    links:
+    -   key: decreases activity of
+        source: MESH:C586847
+        target: UniProt:Q9UM73
+    -   key: positively regulates
+        source: UniProt:Q9UM73
+        target: GO:0008283
+    -   key: positively correlated with
+        source: GO:0008283
+        target: MESH:D002289
+    multigraph: true
+    nodes:
+    -   id: MESH:C586847
+        label: Drug
+        name: ceritinib
+    -   id: UniProt:Q9UM73
+        label: Protein
+        name: ALK tyrosine kinase receptor
+    -   id: GO:0008283
+        label: BiologicalProcess
+        name: cell population proliferation
+    -   id: MESH:D002289
+        label: Disease
+        name: Non-small cell lung cancer
+    reference:
+    - https://go.drugbank.com/drugs/DB09063
+    - https://en.wikipedia.org/wiki/Ceritinib#Mechanism_of_action
+-   directed: true
+    graph:
+        _id: DB00869_MESH_D009798_1
+        disease: Ocular hypertension
+        disease_mesh: MESH:D009798
+        drug: dorzolamide
+        drug_mesh: MESH:C062765
+        drugbank: DB:DB00869
+    links:
+    -   key: negatively regulates
+        source: MESH:C062765
+        target: UniProt:P00918
+    -   key: positively regulates
+        source: UniProt:P00918
+        target: GO:0015701
+    -   key: increases abundance of
+        source: GO:0015701
+        target: UBERON:0001796
+    -   key: positively correlated with
+        source: UBERON:0001796
+        target: MESH:D009798
+    multigraph: true
+    nodes:
+    -   id: MESH:C062765
+        label: Drug
+        name: dorzolamide
+    -   id: UniProt:P00918
+        label: Protein
+        name: Carbonic anhydrase 2
+    -   id: GO:0015701
+        label: BiologicalProcess
+        name: bicarbonate transport
+    -   id: UBERON:0001796
+        label: GrossAnatomicalStructure
+        name: aqueous humor of eyeball
+    -   id: MESH:D009798
+        label: Disease
+        name: Ocular hypertension
+    reference:
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL218490/
+    - https://pubchem.ncbi.nlm.nih.gov/compound/5284549#section=Mechanism-of-Action
+    - https://en.wikipedia.org/wiki/Glaucoma#Medication
+    - https://www.aaopt.org/docs/knowledge-base/outline26514.doc?sfvrsn=5f863d3_0
+    - https://en.wikipedia.org/wiki/Aqueous_humour#Clinical_significance
+-   directed: true
+    graph:
+        _id: DB00869_MESH_D005902_1
+        disease: Open-angle glaucoma
+        disease_mesh: MESH:D005902
+        drug: dorzolamide
+        drug_mesh: MESH:C062765
+        drugbank: DB:DB00869
+    links:
+    -   key: negatively regulates
+        source: MESH:C062765
+        target: UniProt:P00918
+    -   key: positively regulates
+        source: UniProt:P00918
+        target: GO:0015701
+    -   key: increases abundance of
+        source: GO:0015701
+        target: UBERON:0001796
+    -   key: positively correlated with
+        source: UBERON:0001796
+        target: HP:0007906
+    -   key: manifestation of
+        source: HP:0007906
+        target: MESH:D005902
+    multigraph: true
+    nodes:
+    -   id: MESH:C062765
+        label: Drug
+        name: dorzolamide
+    -   id: UniProt:P00918
+        label: Protein
+        name: Carbonic anhydrase 2
+    -   id: GO:0015701
+        label: BiologicalProcess
+        name: bicarbonate transport
+    -   id: UBERON:0001796
+        label: GrossAnatomicalStructure
+        name: aqueous humor of eyeball
+    -   id: HP:0007906
+        label: PhenotypicFeature
+        name: Ocular Hypertension
+    -   id: MESH:D005902
+        label: Disease
+        name: Open-angle glaucoma
+    reference:
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL218490/
+    - https://pubchem.ncbi.nlm.nih.gov/compound/5284549#section=Mechanism-of-Action
+    - https://en.wikipedia.org/wiki/Glaucoma#Medication
+    - https://www.aaopt.org/docs/knowledge-base/outline26514.doc?sfvrsn=5f863d3_0
+    - https://en.wikipedia.org/wiki/Aqueous_humour#Clinical_significance
+-   directed: true
+    graph:
+        _id: DB00841_MESH_D012770_1
+        disease: Cardiogenic shock
+        disease_mesh: MESH:D012770
+        drug: dobutamine
+        drug_mesh: MESH:D004280
+        drugbank: DB:DB00841
+    links:
+    -   key: positively regulates
+        source: MESH:D004280
+        target: UniProt:P08588
+    -   key: positively regulates
+        source: UniProt:P08588
+        target: GO:0060047
+    -   key: negatively correlated with
+        source: GO:0060047
+        target: HP:0002615
+    -   key: manifestation of
+        source: HP:0002615
+        target: MESH:D012770
+    multigraph: true
+    nodes:
+    -   id: MESH:D004280
+        label: Drug
+        name: dobutamine
+    -   id: UniProt:P08588
+        label: Protein
+        name: Beta-1 adrenergic receptor
+    -   id: GO:0060047
+        label: BiologicalProcess
+        name: heart contraction
+    -   id: HP:0002615
+        label: PhenotypicFeature
+        name: Hypotension
+    -   id: MESH:D012770
+        label: Disease
+        name: Cardiogenic shock
+    reference:
+    - https://pubchem.ncbi.nlm.nih.gov/compound/36811#section=Mechanism-of-Action
+    - https://en.wikipedia.org/wiki/Dobutamine#Pharmacology
+    - https://go.drugbank.com/drugs/DB00841#BE0000172
+    - https://en.wikipedia.org/wiki/Cardiogenic_shock#Signs_and_symptoms
+-   directed: true
+    graph:
+        _id: DB00328_MESH_D013717_1
+        disease: Tenosynovitis
+        disease_mesh: MESH:D013717
+        drug: indomethacin
+        drug_mesh: MESH:D007213
+        drugbank: DB:DB00328
+    links:
+    -   key: negatively regulates
+        source: MESH:D007213
+        target: UniProt:P23219
+    -   key: negatively regulates
+        source: MESH:D007213
+        target: UniProt:P35354
+    -   key: participates in
+        source: UniProt:P23219
+        target: REACT:R-HSA-2162123
+    -   key: participates in
+        source: UniProt:P35354
+        target: REACT:R-HSA-2162123
+    -   key: increases abundance of
+        source: REACT:R-HSA-2162123
+        target: CHEBI:26333
+    -   key: positively correlated with
+        source: CHEBI:26333
+        target: GO:0006954
+    -   key: positively correlated with
+        source: GO:0006954
+        target: MESH:D013717
+    multigraph: true
+    nodes:
+    -   id: MESH:D007213
+        label: Drug
+        name: indomethacin
+    -   id: UniProt:P23219
+        label: Protein
+        name: Prostaglandin G/H synthase 1
+    -   id: UniProt:P35354
+        label: Protein
+        name: Prostaglandin G/H synthase 2
+    -   id: REACT:R-HSA-2162123
+        label: Pathway
+        name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
+    -   id: CHEBI:26333
+        label: ChemicalSubstance
+        name: prostaglandin
+    -   id: GO:0006954
+        label: BiologicalProcess
+        name: inflammatory response
+    -   id: MESH:D013717
+        label: Disease
+        name: Tenosynovitis
+    reference:
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL6/
+-   directed: true
+    graph:
+        _id: DB00328_MESH_D002062_1
+        disease: Bursitis
+        disease_mesh: MESH:D002062
+        drug: indomethacin
+        drug_mesh: MESH:D007213
+        drugbank: DB:DB00328
+    links:
+    -   key: negatively regulates
+        source: MESH:D007213
+        target: UniProt:P23219
+    -   key: negatively regulates
+        source: MESH:D007213
+        target: UniProt:P35354
+    -   key: participates in
+        source: UniProt:P23219
+        target: REACT:R-HSA-2162123
+    -   key: participates in
+        source: UniProt:P35354
+        target: REACT:R-HSA-2162123
+    -   key: increases abundance of
+        source: REACT:R-HSA-2162123
+        target: CHEBI:26333
+    -   key: positively correlated with
+        source: CHEBI:26333
+        target: GO:0006954
+    -   key: positively correlated with
+        source: GO:0006954
+        target: MESH:D002062
+    multigraph: true
+    nodes:
+    -   id: MESH:D007213
+        label: Drug
+        name: indomethacin
+    -   id: UniProt:P23219
+        label: Protein
+        name: Prostaglandin G/H synthase 1
+    -   id: UniProt:P35354
+        label: Protein
+        name: Prostaglandin G/H synthase 2
+    -   id: REACT:R-HSA-2162123
+        label: Pathway
+        name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
+    -   id: CHEBI:26333
+        label: ChemicalSubstance
+        name: prostaglandin
+    -   id: GO:0006954
+        label: BiologicalProcess
+        name: inflammatory response
+    -   id: MESH:D002062
+        label: Disease
+        name: Bursitis
+    reference:
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL6/
+-   directed: true
+    graph:
+        _id: DB00328_MESH_D001172_1
+        disease: Rheumatoid arthritis
+        disease_mesh: MESH:D001172
+        drug: indomethacin
+        drug_mesh: MESH:D007213
+        drugbank: DB:DB00328
+    links:
+    -   key: negatively regulates
+        source: MESH:D007213
+        target: UniProt:P23219
+    -   key: negatively regulates
+        source: MESH:D007213
+        target: UniProt:P35354
+    -   key: participates in
+        source: UniProt:P23219
+        target: REACT:R-HSA-2162123
+    -   key: participates in
+        source: UniProt:P35354
+        target: REACT:R-HSA-2162123
+    -   key: increases abundance of
+        source: REACT:R-HSA-2162123
+        target: CHEBI:26333
+    -   key: positively correlated with
+        source: CHEBI:26333
+        target: GO:0006954
+    -   key: positively correlated with
+        source: GO:0006954
+        target: MESH:D001172
+    multigraph: true
+    nodes:
+    -   id: MESH:D007213
+        label: Drug
+        name: indomethacin
+    -   id: UniProt:P23219
+        label: Protein
+        name: Prostaglandin G/H synthase 1
+    -   id: UniProt:P35354
+        label: Protein
+        name: Prostaglandin G/H synthase 2
+    -   id: REACT:R-HSA-2162123
+        label: Pathway
+        name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
+    -   id: CHEBI:26333
+        label: ChemicalSubstance
+        name: prostaglandin
+    -   id: GO:0006954
+        label: BiologicalProcess
+        name: inflammatory response
+    -   id: MESH:D001172
+        label: Disease
+        name: Rheumatoid arthritis
+    reference:
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL6/
+-   directed: true
+    graph:
+        _id: DB00328_MESH_D013167_1
+        disease: Ankylosing spondylitis
+        disease_mesh: MESH:D013167
+        drug: indomethacin
+        drug_mesh: MESH:D007213
+        drugbank: DB:DB00328
+    links:
+    -   key: negatively regulates
+        source: MESH:D007213
+        target: UniProt:P23219
+    -   key: negatively regulates
+        source: MESH:D007213
+        target: UniProt:P35354
+    -   key: participates in
+        source: UniProt:P23219
+        target: REACT:R-HSA-2162123
+    -   key: participates in
+        source: UniProt:P35354
+        target: REACT:R-HSA-2162123
+    -   key: increases abundance of
+        source: REACT:R-HSA-2162123
+        target: CHEBI:26333
+    -   key: positively correlated with
+        source: CHEBI:26333
+        target: GO:0006954
+    -   key: positively correlated with
+        source: GO:0006954
+        target: MESH:D013167
+    multigraph: true
+    nodes:
+    -   id: MESH:D007213
+        label: Drug
+        name: indomethacin
+    -   id: UniProt:P23219
+        label: Protein
+        name: Prostaglandin G/H synthase 1
+    -   id: UniProt:P35354
+        label: Protein
+        name: Prostaglandin G/H synthase 2
+    -   id: REACT:R-HSA-2162123
+        label: Pathway
+        name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
+    -   id: CHEBI:26333
+        label: ChemicalSubstance
+        name: prostaglandin
+    -   id: GO:0006954
+        label: BiologicalProcess
+        name: inflammatory response
+    -   id: MESH:D013167
+        label: Disease
+        name: Ankylosing spondylitis
+    reference:
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL6/
+-   directed: true
+    graph:
+        _id: DB00328_MESH_D006073_1
+        disease: Gout
+        disease_mesh: MESH:D006073
+        drug: indomethacin
+        drug_mesh: MESH:D007213
+        drugbank: DB:DB00328
+    links:
+    -   key: negatively regulates
+        source: MESH:D007213
+        target: UniProt:P23219
+    -   key: negatively regulates
+        source: MESH:D007213
+        target: UniProt:P35354
+    -   key: participates in
+        source: UniProt:P23219
+        target: REACT:R-HSA-2162123
+    -   key: participates in
+        source: UniProt:P35354
+        target: REACT:R-HSA-2162123
+    -   key: increases abundance of
+        source: REACT:R-HSA-2162123
+        target: CHEBI:26333
+    -   key: positively correlated with
+        source: CHEBI:26333
+        target: GO:0006954
+    -   key: positively correlated with
+        source: GO:0006954
+        target: MESH:D006073
+    multigraph: true
+    nodes:
+    -   id: MESH:D007213
+        label: Drug
+        name: indomethacin
+    -   id: UniProt:P23219
+        label: Protein
+        name: Prostaglandin G/H synthase 1
+    -   id: UniProt:P35354
+        label: Protein
+        name: Prostaglandin G/H synthase 2
+    -   id: REACT:R-HSA-2162123
+        label: Pathway
+        name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
+    -   id: CHEBI:26333
+        label: ChemicalSubstance
+        name: prostaglandin
+    -   id: GO:0006954
+        label: BiologicalProcess
+        name: inflammatory response
+    -   id: MESH:D006073
+        label: Disease
+        name: Gout
+    reference:
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL6/
+-   directed: true
+    graph:
+        _id: DB00328_MESH_D052256_1
+        disease: Tendinitis
+        disease_mesh: MESH:D052256
+        drug: indomethacin
+        drug_mesh: MESH:D007213
+        drugbank: DB:DB00328
+    links:
+    -   key: negatively regulates
+        source: MESH:D007213
+        target: UniProt:P23219
+    -   key: negatively regulates
+        source: MESH:D007213
+        target: UniProt:P35354
+    -   key: participates in
+        source: UniProt:P23219
+        target: REACT:R-HSA-2162123
+    -   key: participates in
+        source: UniProt:P35354
+        target: REACT:R-HSA-2162123
+    -   key: increases abundance of
+        source: REACT:R-HSA-2162123
+        target: CHEBI:26333
+    -   key: positively correlated with
+        source: CHEBI:26333
+        target: GO:0006954
+    -   key: positively correlated with
+        source: GO:0006954
+        target: MESH:D052256
+    multigraph: true
+    nodes:
+    -   id: MESH:D007213
+        label: Drug
+        name: indomethacin
+    -   id: UniProt:P23219
+        label: Protein
+        name: Prostaglandin G/H synthase 1
+    -   id: UniProt:P35354
+        label: Protein
+        name: Prostaglandin G/H synthase 2
+    -   id: REACT:R-HSA-2162123
+        label: Pathway
+        name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
+    -   id: CHEBI:26333
+        label: ChemicalSubstance
+        name: prostaglandin
+    -   id: GO:0006954
+        label: BiologicalProcess
+        name: inflammatory response
+    -   id: MESH:D052256
+        label: Disease
+        name: Tendinitis
+    reference:
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL6/
+-   directed: true
+    graph:
+        _id: DB00328_MESH_D013585_1
+        disease: Synovitis
+        disease_mesh: MESH:D013585
+        drug: indomethacin
+        drug_mesh: MESH:D007213
+        drugbank: DB:DB00328
+    links:
+    -   key: negatively regulates
+        source: MESH:D007213
+        target: UniProt:P23219
+    -   key: negatively regulates
+        source: MESH:D007213
+        target: UniProt:P35354
+    -   key: participates in
+        source: UniProt:P23219
+        target: REACT:R-HSA-2162123
+    -   key: participates in
+        source: UniProt:P35354
+        target: REACT:R-HSA-2162123
+    -   key: increases abundance of
+        source: REACT:R-HSA-2162123
+        target: CHEBI:26333
+    -   key: positively correlated with
+        source: CHEBI:26333
+        target: GO:0006954
+    -   key: positively correlated with
+        source: GO:0006954
+        target: MESH:D013585
+    multigraph: true
+    nodes:
+    -   id: MESH:D007213
+        label: Drug
+        name: indomethacin
+    -   id: UniProt:P23219
+        label: Protein
+        name: Prostaglandin G/H synthase 1
+    -   id: UniProt:P35354
+        label: Protein
+        name: Prostaglandin G/H synthase 2
+    -   id: REACT:R-HSA-2162123
+        label: Pathway
+        name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
+    -   id: CHEBI:26333
+        label: ChemicalSubstance
+        name: prostaglandin
+    -   id: GO:0006954
+        label: BiologicalProcess
+        name: inflammatory response
+    -   id: MESH:D013585
+        label: Disease
+        name: Synovitis
+    reference:
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL6/
+-   directed: true
+    graph:
+        _id: DB00328_MESH_D010003_1
+        disease: Osteoarthritis
+        disease_mesh: MESH:D010003
+        drug: indomethacin
+        drug_mesh: MESH:D007213
+        drugbank: DB:DB00328
+    links:
+    -   key: negatively regulates
+        source: MESH:D007213
+        target: UniProt:P23219
+    -   key: negatively regulates
+        source: MESH:D007213
+        target: UniProt:P35354
+    -   key: participates in
+        source: UniProt:P23219
+        target: REACT:R-HSA-2162123
+    -   key: participates in
+        source: UniProt:P35354
+        target: REACT:R-HSA-2162123
+    -   key: increases abundance of
+        source: REACT:R-HSA-2162123
+        target: CHEBI:26333
+    -   key: positively correlated with
+        source: CHEBI:26333
+        target: GO:0006954
+    -   key: positively correlated with
+        source: GO:0006954
+        target: MESH:D010003
+    multigraph: true
+    nodes:
+    -   id: MESH:D007213
+        label: Drug
+        name: indomethacin
+    -   id: UniProt:P23219
+        label: Protein
+        name: Prostaglandin G/H synthase 1
+    -   id: UniProt:P35354
+        label: Protein
+        name: Prostaglandin G/H synthase 2
+    -   id: REACT:R-HSA-2162123
+        label: Pathway
+        name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
+    -   id: CHEBI:26333
+        label: ChemicalSubstance
+        name: prostaglandin
+    -   id: GO:0006954
+        label: BiologicalProcess
+        name: inflammatory response
+    -   id: MESH:D010003
+        label: Disease
+        name: Osteoarthritis
+    reference:
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL6/
+-   directed: true
+    graph:
+        _id: DB00328_MESH_D004374_1
+        disease: Patent ductus arteriosus
+        disease_mesh: MESH:D004374
+        drug: indomethacin
+        drug_mesh: MESH:D007213
+        drugbank: DB:DB00328
+    links:
+    -   key: negatively regulates
+        source: MESH:D007213
+        target: UniProt:P23219
+    -   key: negatively regulates
+        source: MESH:D007213
+        target: UniProt:P35354
+    -   key: participates in
+        source: UniProt:P23219
+        target: REACT:R-HSA-2162123
+    -   key: participates in
+        source: UniProt:P35354
+        target: REACT:R-HSA-2162123
+    -   key: increases abundance of
+        source: REACT:R-HSA-2162123
+        target: CHEBI:26333
+    -   key: negatively correlated with
+        source: CHEBI:26333
+        target: GO:0097070
+    -   key: negatively correlated with
+        source: GO:0097070
+        target: MESH:D004374
+    multigraph: true
+    nodes:
+    -   id: MESH:D007213
+        label: Drug
+        name: indomethacin
+    -   id: UniProt:P23219
+        label: Protein
+        name: Prostaglandin G/H synthase 1
+    -   id: UniProt:P35354
+        label: Protein
+        name: Prostaglandin G/H synthase 2
+    -   id: REACT:R-HSA-2162123
+        label: Pathway
+        name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
+    -   id: CHEBI:26333
+        label: ChemicalSubstance
+        name: prostaglandin
+    -   id: GO:0097070
+        label: BiologicalProcess
+        name: ductus arteriosus closure
+    -   id: MESH:D004374
+        label: Disease
+        name: Patent ductus arteriosus
+    reference:
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL6/
+    - https://en.wikipedia.org/wiki/Patent_ductus_arteriosus#Prostaglandin_inhibitors
+-   directed: true
+    graph:
+        _id: DB00349_MESH_D065768_1
+        disease: Lennox-Gastaut syndrome
+        disease_mesh: MESH:D065768
+        drug: clobazam
+        drug_mesh: MESH:C012255
+        drugbank: DB:DB00349
+    links:
+    -   key: increases activity of
+        source: MESH:C012255
+        target: InterPro:IPR006028
+    -   key: positively regulates
+        source: InterPro:IPR006028
+        target: GO:0051932
+    -   key: negatively correlated with
+        source: GO:0051932
+        target: HP:0032792
+    -   key: manifestation of
+        source: HP:0032792
+        target: MESH:D065768
+    multigraph: true
+    nodes:
+    -   id: MESH:C012255
+        label: Drug
+        name: clobazam
+    -   id: InterPro:IPR006028
+        label: GeneFamily
+        name: Gamma-aminobutyric acid A receptor/Glycine receptor alpha
+    -   id: GO:0051932
+        label: BiologicalProcess
+        name: synaptic transmission, GABAergic
+    -   id: HP:0032792
+        label: PhenotypicFeature
+        name: Tonic seizure
+    -   id: MESH:D065768
+        label: Disease
+        name: Lennox-Gastaut syndrome
+    reference:
+    - https://go.drugbank.com/drugs/DB00349
+    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL70418/
+    - https://en.wikipedia.org/wiki/Clobazam#Pharmacology
+-   directed: true
+    graph:
+        _id: DB13783_MESH_D012216_1
+        disease: Rheumatism
+        disease_mesh: MESH:D012216
+        drug: acemetacin
+        drug_mesh: MESH:C026784
+        drugbank: DB:DB13783
+    links:
+    -   key: has metabolite
+        source: MESH:C026784
+        target: DB:DB00328
+    -   key: negatively regulates
+        source: DB:DB00328
+        target: UniProt:P35354
+    -   key: negatively regulates
+        source: DB:DB00328
+        target: UniProt:P23219
+    -   key: participates in
+        source: UniProt:P23219
+        target: REACT:R-HSA-2162123
+    -   key: participates in
+        source: UniProt:P35354
+        target: REACT:R-HSA-2162123
+    -   key: increases abundance of
+        source: REACT:R-HSA-2162123
+        target: CHEBI:26333
+    -   key: negatively correlated with
+        source: CHEBI:26333
+        target: GO:0006954
+    -   key: negatively correlated with
+        source: GO:0006954
+        target: MESH:D012216
+    multigraph: true
+    nodes:
+    -   alt_ids:
+        - MESH:C519896
+        alt_names:
+        - acemethacin
+        id: MESH:C026784
+        label: Drug
+        name: acemetacin
+    -   id: DB:DB00328
+        label: ChemicalSubstance
+        name: Indomethacin
+    -   id: UniProt:P23219
+        label: Protein
+        name: Prostaglandin G/H synthase 1
+    -   id: UniProt:P35354
+        label: Protein
+        name: Prostaglandin G/H synthase 2
+    -   id: REACT:R-HSA-2162123
+        label: Pathway
+        name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
+    -   id: CHEBI:26333
+        label: ChemicalSubstance
+        name: prostaglandin
+    -   id: GO:0006954
+        label: BiologicalProcess
+        name: inflammatory response
+    -   id: MESH:D012216
+        label: Disease
+        name: Rheumatism
+    reference:
+    - https://go.drugbank.com/drugs/DB13783
diff --git a/submission.yaml b/submission.yaml
index e4d4e764a..8b1378917 100644
--- a/submission.yaml
+++ b/submission.yaml
@@ -1,1059 +1 @@
-- directed: true
-  graph:
-    disease: Chronic hepatitis C
-    disease_mesh: MESH:D019698
-    drug: velpatasvir
-    drug_mesh: MESH:C000604171
-    drugbank: DB:DB11613
-  links:
-    - key: negatively regulates
-      source: MESH:C000604171
-      target: UniProt:Q5L478
-    - key: molecularly interacts with
-      source: UniProt:Q5L478
-      target: MESH:C000618292
-    - key: increases abundance of
-      source: MESH:C000618292
-      target: MESH:C037178
-    - key: positively correlated with
-      source: MESH:C037178
-      target: MESH:D002784
-    - key: located in
-      source: MESH:D002784
-      target: MESH:D000086969
-    - key: location of
-      source: MESH:D000086969
-      target: GO:0039694
-    - key: positively regulates
-      source: UniProt:Q5L478
-      target: GO:0003968
-    - key: positively regulates
-      source: GO:0003968
-      target: GO:0039694
-    - key: positively regulates
-      source: UniProt:Q5L478
-      target: GO:0004197
-    - key: positively regulates
-      source: UniProt:Q5L478
-      target: GO:0004252
-    - key: positively correlated with
-      source: GO:0004197
-      target: MESH:D014779
-    - key: positively correlated with
-      source: GO:0004252
-      target: MESH:D014779
-    - key: positively correlated with
-      source: MESH:D014779
-      target: MESH:D019065
-    - key: in taxon
-      source: GO:0039694
-      target: NCBITaxon:11103
-    - key: in taxon
-      source: MESH:D019065
-      target: NCBITaxon:11103
-    - key: causes
-      source: NCBITaxon:11103
-      target: MESH:D019698
-  multigraph: true
-  nodes:
-    - id: MESH:C000604171
-      label: Drug
-      name: velpatasvir
-    - id: UniProt:Q5L478
-      label: Protein
-      name: Nonstructural protein 5A
-    - id: GO:0003968
-      label: MolecularActivity
-      name: RNA-directed 5'-3' RNA polymerase activity
-    - id: GO:0039694
-      label: BiologicalProcess
-      name: viral RNA genome replication
-    - id: MESH:C000618292
-      label: Protein
-      name: PI4KIIIalpha protein, human
-    - id: MESH:C037178
-      label: ChemicalSubstance
-      name: phosphatidylinositol 4-phosphate
-    - id: MESH:D002784
-      label: ChemicalSubstance
-      name: Cholesterol
-    - id: MESH:D000086969
-      label: CellularComponent
-      name: Viral Replication Compartments
-    - id: GO:0004197
-      label: MolecularActivity
-      name: cysteine-type endopeptidase activity
-    - id: GO:0004252
-      label: MolecularActivity
-      name: serine-type endopeptidase activity
-    - id: MESH:D014779
-      label: BiologicalProcess
-      name: Virus Replication
-    - id: MESH:D019065
-      label: BiologicalProcess
-      name: Virus Assembly
-    - id: NCBITaxon:11103
-      label: OrganismTaxon
-      name: Hepacivirus C
-    - id: MESH:D019698
-      label: Disease
-      name: Chronic hepatitis C
-  reference:
-    - https://go.drugbank.com/drugs/DB11613
-    - https://en.wikipedia.org/wiki/Velpatasvir#Mechanism_of_action
-    - https://en.wikipedia.org/wiki/Discovery_and_development_of_NS5A_inhibitors#Mechanism_of_action
-    - https://en.wikipedia.org/wiki/Discovery_and_development_of_NS5A_inhibitors#Function
-    - https://pubmed.ncbi.nlm.nih.gov/25384189/
-    - https://www.ncbi.nlm.nih.gov/books/NBK1623/
-- directed: true
-  graph:
-    disease: Scarlet fever
-    disease_mesh: MESH:D012541
-    drug: benzathine benzylpenicillin
-    drug_mesh: MESH:D010401
-    drugbank: DB:DB01053
-  links:
-    - key: negatively regulates
-      source: MESH:D010401
-      target: InterPro:IPR001460
-    - key: positively correlated with
-      source: InterPro:IPR001460
-      target: GO:0009252
-    - key: positively correlated with
-      source: GO:0009252
-      target: GO:0071555
-    - key: in taxon
-      source: GO:0071555
-      target: NCBITaxon:1314
-    - key: causes
-      source: NCBITaxon:1314
-      target: MESH:D012541
-  multigraph: true
-  nodes:
-    - id: MESH:D010401
-      label: Drug
-      name: benzathine benzylpenicillin
-      alt_names:
-        - Penicillin G Benzathine
-        - Benzylpenicillin
-        - Benzylpenicillin benzathine hydrate
-      alt_ids:
-        - DB:DBSALT002768
-    - id: InterPro:IPR001460
-      label: GeneFamily
-      name: Penicillin-binding protein, transpeptidase
-    - id: GO:0009252
-      label: BiologicalProcess
-      name: peptidoglycan biosynthetic process
-    - id: GO:0071555
-      label: BiologicalProcess
-      name: cell wall organization
-    - id: NCBITaxon:1314
-      label: OrganismTaxon
-      name: Streptococcus pyogenes
-    - id: MESH:D012541
-      label: Disease
-      name: Scarlet fever
-  reference: https://go.drugbank.com/drugs/DB01053
-- directed: true
-  graph:
-    disease: Streptococcus pyogenes infection
-    disease_mesh: MESH:D013290
-    drug: benzathine benzylpenicillin
-    drug_mesh: MESH:D010401
-    drugbank: DB:DB01053
-  links:
-    - key: negatively regulates
-      source: MESH:D010401
-      target: InterPro:IPR001460
-    - key: positively correlated with
-      source: InterPro:IPR001460
-      target: GO:0009252
-    - key: positively correlated with
-      source: GO:0009252
-      target: GO:0071555
-    - key: in taxon
-      source: GO:0071555
-      target: NCBITaxon:1314
-    - key: causes
-      source: NCBITaxon:1314
-      target: MESH:D013290
-  multigraph: true
-  nodes:
-    - id: MESH:D010401
-      label: Drug
-      name: benzathine benzylpenicillin
-      alt_names:
-        - Penicillin G Benzathine
-        - Benzylpenicillin
-        - Benzylpenicillin benzathine hydrate
-      alt_ids:
-        - DB:DBSALT002768
-    - id: InterPro:IPR001460
-      label: GeneFamily
-      name: Penicillin-binding protein, transpeptidase
-    - id: GO:0009252
-      label: BiologicalProcess
-      name: peptidoglycan biosynthetic process
-    - id: GO:0071555
-      label: BiologicalProcess
-      name: cell wall organization
-    - id: NCBITaxon:1314
-      label: OrganismTaxon
-      name: Streptococcus pyogenes
-    - id: MESH:D013290
-      label: Disease
-      name: Streptococcus pyogenes infection
-  reference: https://go.drugbank.com/drugs/DB01053
-- directed: true
-  graph:
-    disease: Erysipelas
-    disease_mesh: MESH:D004886
-    drug: benzathine benzylpenicillin
-    drug_mesh: MESH:D010401
-    drugbank: DB:DB01053
-  links:
-    - key: negatively regulates
-      source: MESH:D010401
-      target: InterPro:IPR001460
-    - key: positively correlated with
-      source: InterPro:IPR001460
-      target: GO:0009252
-    - key: positively correlated with
-      source: GO:0009252
-      target: GO:0071555
-    - key: in taxon
-      source: GO:0071555
-      target: NCBITaxon:1314
-    - key: causes
-      source: NCBITaxon:1314
-      target: MESH:D004886
-  multigraph: true
-  nodes:
-    - id: MESH:D010401
-      label: Drug
-      name: benzathine benzylpenicillin
-      alt_names:
-        - Penicillin G Benzathine
-        - Benzylpenicillin
-        - Benzylpenicillin benzathine hydrate
-      alt_ids:
-        - DB:DBSALT002768
-    - id: InterPro:IPR001460
-      label: GeneFamily
-      name: Penicillin-binding protein, transpeptidase
-    - id: GO:0009252
-      label: BiologicalProcess
-      name: peptidoglycan biosynthetic process
-    - id: GO:0071555
-      label: BiologicalProcess
-      name: cell wall organization
-    - id: NCBITaxon:1314
-      label: OrganismTaxon
-      name: Streptococcus pyogenes
-    - id: MESH:D004886
-      label: Disease
-      name: Erysipelas
-  reference: https://go.drugbank.com/drugs/DB01053
-- directed: true
-  graph:
-    disease: Pneumococcal pneumonia
-    disease_mesh: MESH:D011018
-    drug: benzathine benzylpenicillin
-    drug_mesh: MESH:D010401
-    drugbank: DB:DB01053
-  links:
-    - key: negatively regulates
-      source: MESH:D010401
-      target: InterPro:IPR001460
-    - key: positively correlated with
-      source: InterPro:IPR001460
-      target: GO:0009252
-    - key: positively correlated with
-      source: GO:0009252
-      target: GO:0071555
-    - key: in taxon
-      source: GO:0071555
-      target: NCBITaxon:1313
-    - key: causes
-      source: NCBITaxon:1313
-      target: MESH:D011018
-  multigraph: true
-  nodes:
-    - id: MESH:D010401
-      label: Drug
-      name: benzathine benzylpenicillin
-      alt_names:
-        - Penicillin G Benzathine
-        - Benzylpenicillin
-        - Benzylpenicillin benzathine hydrate
-      alt_ids:
-        - DB:DBSALT002768
-    - id: InterPro:IPR001460
-      label: GeneFamily
-      name: Penicillin-binding protein, transpeptidase
-    - id: GO:0009252
-      label: BiologicalProcess
-      name: peptidoglycan biosynthetic process
-    - id: GO:0071555
-      label: BiologicalProcess
-      name: cell wall organization
-    - id: NCBITaxon:1313
-      label: OrganismTaxon
-      name: Streptococcus pneumoniae
-    - id: MESH:D011018
-      label: Disease
-      name: Pneumococcal pneumonia
-  reference: https://go.drugbank.com/drugs/DB01053
-- directed: true
-  graph:
-    disease: Non-small cell lung cancer
-    disease_mesh: MESH:D002289
-    drug: ceritinib
-    drug_mesh: MESH:C586847
-    drugbank: DB:DB09063
-  links:
-    - key: decreases activity of
-      source: MESH:C586847
-      target: UniProt:Q9UM73
-    - key: positively regulates
-      source: UniProt:Q9UM73
-      target: GO:0008283
-    - key: positively correlated with
-      source: GO:0008283
-      target: MESH:D002289
-  multigraph: true
-  nodes:
-    - id: MESH:C586847
-      label: Drug
-      name: ceritinib
-    - id: UniProt:Q9UM73
-      label: Protein
-      name: ALK tyrosine kinase receptor
-    - id: GO:0008283
-      label: BiologicalProcess
-      name: cell population proliferation
-    - id: MESH:D002289
-      label: Disease
-      name: Non-small cell lung cancer
-  reference:
-    - https://go.drugbank.com/drugs/DB09063
-    - https://en.wikipedia.org/wiki/Ceritinib#Mechanism_of_action
-- directed: true
-  graph:
-    disease: Ocular hypertension
-    disease_mesh: MESH:D009798
-    drug: dorzolamide
-    drug_mesh: MESH:C062765
-    drugbank: DB:DB00869
-  links:
-    - key: negatively regulates
-      source: MESH:C062765
-      target: UniProt:P00918
-    - key: positively regulates
-      source: UniProt:P00918
-      target: GO:0015701
-    - key: increases abundance of
-      source: GO:0015701
-      target: UBERON:0001796
-    - key: positively correlated with
-      source: UBERON:0001796
-      target: MESH:D009798
-  multigraph: true
-  nodes:
-    - id: MESH:C062765
-      label: Drug
-      name: dorzolamide
-    - id: UniProt:P00918
-      label: Protein
-      name: Carbonic anhydrase 2
-    - id: GO:0015701
-      label: BiologicalProcess
-      name: bicarbonate transport
-    - id: UBERON:0001796
-      label: GrossAnatomicalStructure
-      name: aqueous humor of eyeball
-    - id: MESH:D009798
-      label: Disease
-      name: Ocular hypertension
-  reference:
-    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL218490/
-    - https://pubchem.ncbi.nlm.nih.gov/compound/5284549#section=Mechanism-of-Action
-    - https://en.wikipedia.org/wiki/Glaucoma#Medication
-    - https://www.aaopt.org/docs/knowledge-base/outline26514.doc?sfvrsn=5f863d3_0
-    - https://en.wikipedia.org/wiki/Aqueous_humour#Clinical_significance
-- directed: true
-  graph:
-    disease: Open-angle glaucoma
-    disease_mesh: MESH:D005902
-    drug: dorzolamide
-    drug_mesh: MESH:C062765
-    drugbank: DB:DB00869
-  links:
-    - key: negatively regulates
-      source: MESH:C062765
-      target: UniProt:P00918
-    - key: positively regulates
-      source: UniProt:P00918
-      target: GO:0015701
-    - key: increases abundance of
-      source: GO:0015701
-      target: UBERON:0001796
-    - key: positively correlated with
-      source: UBERON:0001796
-      target: HP:0007906
-    - key: manifestation of
-      source: HP:0007906
-      target: MESH:D005902
-  multigraph: true
-  nodes:
-    - id: MESH:C062765
-      label: Drug
-      name: dorzolamide
-    - id: UniProt:P00918
-      label: Protein
-      name: Carbonic anhydrase 2
-    - id: GO:0015701
-      label: BiologicalProcess
-      name: bicarbonate transport
-    - id: UBERON:0001796
-      label: GrossAnatomicalStructure
-      name: aqueous humor of eyeball
-    - id: HP:0007906
-      label: PhenotypicFeature
-      name: Ocular Hypertension
-    - id: MESH:D005902
-      label: Disease
-      name: Open-angle glaucoma
-  reference:
-    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL218490/
-    - https://pubchem.ncbi.nlm.nih.gov/compound/5284549#section=Mechanism-of-Action
-    - https://en.wikipedia.org/wiki/Glaucoma#Medication
-    - https://www.aaopt.org/docs/knowledge-base/outline26514.doc?sfvrsn=5f863d3_0
-    - https://en.wikipedia.org/wiki/Aqueous_humour#Clinical_significance
-- directed: true
-  graph:
-    disease: Cardiogenic shock
-    disease_mesh: MESH:D012770
-    drug: dobutamine
-    drug_mesh: MESH:D004280
-    drugbank: DB:DB00841
-  links:
-    - key: positively regulates
-      source: MESH:D004280
-      target: UniProt:P08588
-    - key: positively regulates
-      source: UniProt:P08588
-      target: GO:0060047
-    - key: negatively correlated with
-      source: GO:0060047
-      target: HP:0002615
-    - key: manifestation of
-      source: HP:0002615
-      target: MESH:D012770
-  multigraph: true
-  nodes:
-    - id: MESH:D004280
-      label: Drug
-      name: dobutamine
-    - id: UniProt:P08588
-      label: Protein
-      name: Beta-1 adrenergic receptor
-    - id: GO:0060047
-      label: BiologicalProcess
-      name: heart contraction
-    - id: HP:0002615
-      label: PhenotypicFeature
-      name: Hypotension
-    - id: MESH:D012770
-      label: Disease
-      name: Cardiogenic shock
-  reference:
-    - https://pubchem.ncbi.nlm.nih.gov/compound/36811#section=Mechanism-of-Action
-    - https://en.wikipedia.org/wiki/Dobutamine#Pharmacology
-    - https://go.drugbank.com/drugs/DB00841#BE0000172
-    - https://en.wikipedia.org/wiki/Cardiogenic_shock#Signs_and_symptoms
-- directed: true
-  graph:
-    disease: Tenosynovitis
-    disease_mesh: MESH:D013717
-    drug: indomethacin
-    drug_mesh: MESH:D007213
-    drugbank: DB:DB00328
-  links:
-    - key: negatively regulates
-      source: MESH:D007213
-      target: UniProt:P23219
-    - key: negatively regulates
-      source: MESH:D007213
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P23219
-      target: REACT:R-HSA-2162123
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: CHEBI:26333
-    - key: positively correlated with
-      source: CHEBI:26333
-      target: GO:0006954
-    - key: positively correlated with
-      source: GO:0006954
-      target: MESH:D013717
-  multigraph: true
-  nodes:
-    - id: MESH:D007213
-      label: Drug
-      name: indomethacin
-    - id: UniProt:P23219
-      label: Protein
-      name: Prostaglandin G/H synthase 1
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: CHEBI:26333
-      label: ChemicalSubstance
-      name: prostaglandin
-    - id: GO:0006954
-      label: BiologicalProcess
-      name: inflammatory response
-    - id: MESH:D013717
-      label: Disease
-      name: Tenosynovitis
-  reference: https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL6/
-- directed: true
-  graph:
-    disease: Bursitis
-    disease_mesh: MESH:D002062
-    drug: indomethacin
-    drug_mesh: MESH:D007213
-    drugbank: DB:DB00328
-  links:
-    - key: negatively regulates
-      source: MESH:D007213
-      target: UniProt:P23219
-    - key: negatively regulates
-      source: MESH:D007213
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P23219
-      target: REACT:R-HSA-2162123
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: CHEBI:26333
-    - key: positively correlated with
-      source: CHEBI:26333
-      target: GO:0006954
-    - key: positively correlated with
-      source: GO:0006954
-      target: MESH:D002062
-  multigraph: true
-  nodes:
-    - id: MESH:D007213
-      label: Drug
-      name: indomethacin
-    - id: UniProt:P23219
-      label: Protein
-      name: Prostaglandin G/H synthase 1
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: CHEBI:26333
-      label: ChemicalSubstance
-      name: prostaglandin
-    - id: GO:0006954
-      label: BiologicalProcess
-      name: inflammatory response
-    - id: MESH:D002062
-      label: Disease
-      name: Bursitis
-  reference: https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL6/
-- directed: true
-  graph:
-    disease: Rheumatoid arthritis
-    disease_mesh: MESH:D001172
-    drug: indomethacin
-    drug_mesh: MESH:D007213
-    drugbank: DB:DB00328
-  links:
-    - key: negatively regulates
-      source: MESH:D007213
-      target: UniProt:P23219
-    - key: negatively regulates
-      source: MESH:D007213
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P23219
-      target: REACT:R-HSA-2162123
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: CHEBI:26333
-    - key: positively correlated with
-      source: CHEBI:26333
-      target: GO:0006954
-    - key: positively correlated with
-      source: GO:0006954
-      target: MESH:D001172
-  multigraph: true
-  nodes:
-    - id: MESH:D007213
-      label: Drug
-      name: indomethacin
-    - id: UniProt:P23219
-      label: Protein
-      name: Prostaglandin G/H synthase 1
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: CHEBI:26333
-      label: ChemicalSubstance
-      name: prostaglandin
-    - id: GO:0006954
-      label: BiologicalProcess
-      name: inflammatory response
-    - id: MESH:D001172
-      label: Disease
-      name: Rheumatoid arthritis
-  reference: https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL6/
-- directed: true
-  graph:
-    disease: Ankylosing spondylitis
-    disease_mesh: MESH:D013167
-    drug: indomethacin
-    drug_mesh: MESH:D007213
-    drugbank: DB:DB00328
-  links:
-    - key: negatively regulates
-      source: MESH:D007213
-      target: UniProt:P23219
-    - key: negatively regulates
-      source: MESH:D007213
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P23219
-      target: REACT:R-HSA-2162123
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: CHEBI:26333
-    - key: positively correlated with
-      source: CHEBI:26333
-      target: GO:0006954
-    - key: positively correlated with
-      source: GO:0006954
-      target: MESH:D013167
-  multigraph: true
-  nodes:
-    - id: MESH:D007213
-      label: Drug
-      name: indomethacin
-    - id: UniProt:P23219
-      label: Protein
-      name: Prostaglandin G/H synthase 1
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: CHEBI:26333
-      label: ChemicalSubstance
-      name: prostaglandin
-    - id: GO:0006954
-      label: BiologicalProcess
-      name: inflammatory response
-    - id: MESH:D013167
-      label: Disease
-      name: Ankylosing spondylitis
-  reference: https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL6/
-- directed: true
-  graph:
-    disease: Gout
-    disease_mesh: MESH:D006073
-    drug: indomethacin
-    drug_mesh: MESH:D007213
-    drugbank: DB:DB00328
-  links:
-    - key: negatively regulates
-      source: MESH:D007213
-      target: UniProt:P23219
-    - key: negatively regulates
-      source: MESH:D007213
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P23219
-      target: REACT:R-HSA-2162123
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: CHEBI:26333
-    - key: positively correlated with
-      source: CHEBI:26333
-      target: GO:0006954
-    - key: positively correlated with
-      source: GO:0006954
-      target: MESH:D006073
-  multigraph: true
-  nodes:
-    - id: MESH:D007213
-      label: Drug
-      name: indomethacin
-    - id: UniProt:P23219
-      label: Protein
-      name: Prostaglandin G/H synthase 1
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: CHEBI:26333
-      label: ChemicalSubstance
-      name: prostaglandin
-    - id: GO:0006954
-      label: BiologicalProcess
-      name: inflammatory response
-    - id: MESH:D006073
-      label: Disease
-      name: Gout
-  reference: https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL6/
-- directed: true
-  graph:
-    disease: Tendinitis
-    disease_mesh: MESH:D052256
-    drug: indomethacin
-    drug_mesh: MESH:D007213
-    drugbank: DB:DB00328
-  links:
-    - key: negatively regulates
-      source: MESH:D007213
-      target: UniProt:P23219
-    - key: negatively regulates
-      source: MESH:D007213
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P23219
-      target: REACT:R-HSA-2162123
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: CHEBI:26333
-    - key: positively correlated with
-      source: CHEBI:26333
-      target: GO:0006954
-    - key: positively correlated with
-      source: GO:0006954
-      target: MESH:D052256
-  multigraph: true
-  nodes:
-    - id: MESH:D007213
-      label: Drug
-      name: indomethacin
-    - id: UniProt:P23219
-      label: Protein
-      name: Prostaglandin G/H synthase 1
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: CHEBI:26333
-      label: ChemicalSubstance
-      name: prostaglandin
-    - id: GO:0006954
-      label: BiologicalProcess
-      name: inflammatory response
-    - id: MESH:D052256
-      label: Disease
-      name: Tendinitis
-  reference: https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL6/
-- directed: true
-  graph:
-    disease: Synovitis
-    disease_mesh: MESH:D013585
-    drug: indomethacin
-    drug_mesh: MESH:D007213
-    drugbank: DB:DB00328
-  links:
-    - key: negatively regulates
-      source: MESH:D007213
-      target: UniProt:P23219
-    - key: negatively regulates
-      source: MESH:D007213
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P23219
-      target: REACT:R-HSA-2162123
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: CHEBI:26333
-    - key: positively correlated with
-      source: CHEBI:26333
-      target: GO:0006954
-    - key: positively correlated with
-      source: GO:0006954
-      target: MESH:D013585
-  multigraph: true
-  nodes:
-    - id: MESH:D007213
-      label: Drug
-      name: indomethacin
-    - id: UniProt:P23219
-      label: Protein
-      name: Prostaglandin G/H synthase 1
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: CHEBI:26333
-      label: ChemicalSubstance
-      name: prostaglandin
-    - id: GO:0006954
-      label: BiologicalProcess
-      name: inflammatory response
-    - id: MESH:D013585
-      label: Disease
-      name: Synovitis
-  reference: https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL6/
-- directed: true
-  graph:
-    disease: Osteoarthritis
-    disease_mesh: MESH:D010003
-    drug: indomethacin
-    drug_mesh: MESH:D007213
-    drugbank: DB:DB00328
-  links:
-    - key: negatively regulates
-      source: MESH:D007213
-      target: UniProt:P23219
-    - key: negatively regulates
-      source: MESH:D007213
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P23219
-      target: REACT:R-HSA-2162123
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: CHEBI:26333
-    - key: positively correlated with
-      source: CHEBI:26333
-      target: GO:0006954
-    - key: positively correlated with
-      source: GO:0006954
-      target: MESH:D010003
-  multigraph: true
-  nodes:
-    - id: MESH:D007213
-      label: Drug
-      name: indomethacin
-    - id: UniProt:P23219
-      label: Protein
-      name: Prostaglandin G/H synthase 1
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: CHEBI:26333
-      label: ChemicalSubstance
-      name: prostaglandin
-    - id: GO:0006954
-      label: BiologicalProcess
-      name: inflammatory response
-    - id: MESH:D010003
-      label: Disease
-      name: Osteoarthritis
-  reference: https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL6/
-- directed: true
-  graph:
-    disease: Patent ductus arteriosus
-    disease_mesh: MESH:D004374
-    drug: indomethacin
-    drug_mesh: MESH:D007213
-    drugbank: DB:DB00328
-  links:
-    - key: negatively regulates
-      source: MESH:D007213
-      target: UniProt:P23219
-    - key: negatively regulates
-      source: MESH:D007213
-      target: UniProt:P35354
-    - key: participates in
-      source: UniProt:P23219
-      target: REACT:R-HSA-2162123
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: CHEBI:26333
-    - key: negatively correlated with
-      source: CHEBI:26333
-      target: GO:0097070
-    - key: negatively correlated with
-      source: GO:0097070
-      target: MESH:D004374
-  multigraph: true
-  nodes:
-    - id: MESH:D007213
-      label: Drug
-      name: indomethacin
-    - id: UniProt:P23219
-      label: Protein
-      name: Prostaglandin G/H synthase 1
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: CHEBI:26333
-      label: ChemicalSubstance
-      name: prostaglandin
-    - id: GO:0097070
-      label: BiologicalProcess
-      name: ductus arteriosus closure
-    - id: MESH:D004374
-      label: Disease
-      name: Patent ductus arteriosus
-  reference:
-    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL6/
-    - https://en.wikipedia.org/wiki/Patent_ductus_arteriosus#Prostaglandin_inhibitors
-- directed: true
-  graph:
-    disease: Lennox-Gastaut syndrome
-    disease_mesh: MESH:D065768
-    drug: clobazam
-    drug_mesh: MESH:C012255
-    drugbank: DB:DB00349
-  links:
-    - key: increases activity of
-      source: MESH:C012255
-      target: InterPro:IPR006028
-    - key: positively regulates
-      source: InterPro:IPR006028
-      target: GO:0051932
-    - key: negatively correlated with
-      source: GO:0051932
-      target: HP:0032792
-    - key: manifestation of
-      source: HP:0032792
-      target: MESH:D065768
-  multigraph: true
-  nodes:
-    - id: MESH:C012255
-      label: Drug
-      name: clobazam
-    - id: InterPro:IPR006028
-      label: GeneFamily
-      name: Gamma-aminobutyric acid A receptor/Glycine receptor alpha
-    - id: GO:0051932
-      label: BiologicalProcess
-      name: synaptic transmission, GABAergic
-    - id: HP:0032792
-      label: PhenotypicFeature
-      name: Tonic seizure
-    - id: MESH:D065768
-      label: Disease
-      name: Lennox-Gastaut syndrome
-  reference:
-    - https://go.drugbank.com/drugs/DB00349
-    - https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL70418/
-    - https://en.wikipedia.org/wiki/Clobazam#Pharmacology
-- directed: true
-  graph:
-    disease: Rheumatism
-    disease_mesh: MESH:D012216
-    drug: acemetacin
-    drug_mesh: MESH:C026784
-    drugbank: DB:DB13783
-  links:
-    - key: has metabolite
-      source: MESH:C026784
-      target: DB:DB00328
-    - key: negatively regulates
-      source: DB:DB00328
-      target: UniProt:P35354
-    - key: negatively regulates
-      source: DB:DB00328
-      target: UniProt:P23219
-    - key: participates in
-      source: UniProt:P23219
-      target: REACT:R-HSA-2162123
-    - key: participates in
-      source: UniProt:P35354
-      target: REACT:R-HSA-2162123
-    - key: increases abundance of
-      source: REACT:R-HSA-2162123
-      target: CHEBI:26333
-    - key: negatively correlated with
-      source: CHEBI:26333
-      target: GO:0006954
-    - key: negatively correlated with
-      source: GO:0006954
-      target: MESH:D012216
-  multigraph: true
-  nodes:
-    - id: MESH:C026784
-      label: Drug
-      name: acemetacin
-      alt_ids:
-        - MESH:C519896
-      alt_names:
-        - acemethacin
-    - id: DB:DB00328
-      label: ChemicalSubstance
-      name: Indomethacin
-    - id: UniProt:P23219
-      label: Protein
-      name: Prostaglandin G/H synthase 1
-    - id: UniProt:P35354
-      label: Protein
-      name: Prostaglandin G/H synthase 2
-    - id: REACT:R-HSA-2162123
-      label: Pathway
-      name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
-    - id: CHEBI:26333
-      label: ChemicalSubstance
-      name: prostaglandin
-    - id: GO:0006954
-      label: BiologicalProcess
-      name: inflammatory response
-    - id: MESH:D012216
-      label: Disease
-      name: Rheumatism
-  reference: https://go.drugbank.com/drugs/DB13783