From 91a0560764b0eabb5a68b7baf7a8c77c2e7cf568 Mon Sep 17 00:00:00 2001 From: dede2021 Date: Tue, 29 Mar 2022 21:06:54 +0000 Subject: [PATCH] Commit from GitHub Actions (Update Indications on Merge) --- indication_paths.json | 734 ++++++++++++++++++++++++++++++++++++++++++ indication_paths.yaml | 466 +++++++++++++++++++++++++++ submission.yaml | 458 +------------------------- 3 files changed, 1201 insertions(+), 457 deletions(-) diff --git a/indication_paths.json b/indication_paths.json index ba0653cd6..da431ee87 100644 --- a/indication_paths.json +++ b/indication_paths.json @@ -307204,5 +307204,739 @@ "https://go.drugbank.com/drugs/DB00273#mechanism-of-action", "https://en.wikipedia.org/wiki/Lennox%E2%80%93Gastaut_syndrome" ] + }, + { + "directed": true, + "graph": { + "_id": "DB01076_MESH_D000787_1", + "disease": "Angina Pectoris", + "disease_mesh": "MESH:D000787", + "drug": "atorvastatin", + "drug_mesh": "MESH:D000069059", + "drugbank": "DB:DB01076" + }, + "links": [ + { + "key": "decreases activity of", + "source": "MESH:D000069059", + "target": "UniProt:P04035" + }, + { + "key": "positively regulates", + "source": "UniProt:P04035", + "target": "GO:0006695" + }, + { + "key": "increases abundance of", + "source": "GO:0006695", + "target": "MESH:D002784" + }, + { + "key": "positively correlated with", + "source": "MESH:D002784", + "target": "HP:0002621" + }, + { + "key": "contributes to", + "source": "HP:0002621", + "target": "MESH:D000787" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:D000069059", + "label": "Drug", + "name": "atorvastatin" + }, + { + "id": "UniProt:P04035", + "label": "Protein", + "name": "3-hydroxy-3-methylglutaryl-coenzyme A reductase" + }, + { + "id": "GO:0006695", + "label": "BiologicalProcess", + "name": "cholesterol biosynthetic process" + }, + { + "id": "MESH:D002784", + "label": "ChemicalSubstance", + "name": "Cholesterol" + }, + { + "id": "HP:0002621", + "label": "PhenotypicFeature", + "name": "Atherosclerosis" + }, + { + "id": "MESH:D000787", + "label": "Disease", + "name": "Angina Pectoris" + } + ], + "reference": [ + "https://go.drugbank.com/drugs/DB01076#mechanism-of-action", + "https://www.uniprot.org/uniprot/P04035#function", + "https://en.wikipedia.org/wiki/Atherosclerosis", + "https://en.wikipedia.org/wiki/Angina" + ] + }, + { + "directed": true, + "graph": { + "_id": "DB01076_MESH_D000788_1", + "disease": "Angina Pectoris, Variant", + "disease_mesh": "MESH:D000788", + "drug": "atorvastatin", + "drug_mesh": "MESH:D000069059", + "drugbank": "DB:DB01076" + }, + "links": [ + { + "key": "decreases activity of", + "source": "MESH:D000069059", + "target": "UniProt:P04035" + }, + { + "key": "positively regulates", + "source": "UniProt:P04035", + "target": "GO:0006695" + }, + { + "key": "increases abundance of", + "source": "GO:0006695", + "target": "MESH:D002784" + }, + { + "key": "positively correlated with", + "source": "MESH:D002784", + "target": "HP:0002621" + }, + { + "key": "contributes to", + "source": "HP:0002621", + "target": "MESH:D000788" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:D000069059", + "label": "Drug", + "name": "atorvastatin" + }, + { + "id": "UniProt:P04035", + "label": "Protein", + "name": "3-hydroxy-3-methylglutaryl-coenzyme A reductase" + }, + { + "id": "GO:0006695", + "label": "BiologicalProcess", + "name": "cholesterol biosynthetic process" + }, + { + "id": "MESH:D002784", + "label": "ChemicalSubstance", + "name": "Cholesterol" + }, + { + "id": "HP:0002621", + "label": "PhenotypicFeature", + "name": "Atherosclerosis" + }, + { + "id": "MESH:D000788", + "label": "Disease", + "name": "Angina Pectoris, Variant" + } + ], + "reference": [ + "https://go.drugbank.com/drugs/DB01076#mechanism-of-action", + "https://www.uniprot.org/uniprot/P04035#function", + "https://en.wikipedia.org/wiki/Atherosclerosis", + "https://en.wikipedia.org/wiki/Variant_angina" + ] + }, + { + "directed": true, + "graph": { + "_id": "DB01076_MESH_D001161_1", + "disease": "Arteriosclerosis", + "disease_mesh": "MESH:D001161", + "drug": "atorvastatin", + "drug_mesh": "MESH:D000069059", + "drugbank": "DB:DB01076" + }, + "links": [ + { + "key": "decreases activity of", + "source": "MESH:D000069059", + "target": "UniProt:P04035" + }, + { + "key": "positively regulates", + "source": "UniProt:P04035", + "target": "GO:0006695" + }, + { + "key": "increases abundance of", + "source": "GO:0006695", + "target": "MESH:D002784" + }, + { + "key": "positively correlated with", + "source": "MESH:D002784", + "target": "HP:0002621" + }, + { + "key": "manifestation of", + "source": "HP:0002621", + "target": "MESH:D001161" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:D000069059", + "label": "Drug", + "name": "atorvastatin" + }, + { + "id": "UniProt:P04035", + "label": "Protein", + "name": "3-hydroxy-3-methylglutaryl-coenzyme A reductase" + }, + { + "id": "GO:0006695", + "label": "BiologicalProcess", + "name": "cholesterol biosynthetic process" + }, + { + "id": "MESH:D002784", + "label": "ChemicalSubstance", + "name": "Cholesterol" + }, + { + "id": "HP:0002621", + "label": "PhenotypicFeature", + "name": "Atherosclerosis" + }, + { + "id": "MESH:D001161", + "label": "Disease", + "name": "Arteriosclerosis" + } + ], + "reference": [ + "https://go.drugbank.com/drugs/DB01076#mechanism-of-action", + "https://www.uniprot.org/uniprot/P04035#function", + "https://en.wikipedia.org/wiki/Atherosclerosis", + "https://en.wikipedia.org/wiki/Arteriosclerosis" + ] + }, + { + "directed": true, + "graph": { + "_id": "DB01076_MESH_D006937_1", + "disease": "Hypercholesterolemia", + "disease_mesh": "MESH:D006937", + "drug": "atorvastatin", + "drug_mesh": "MESH:D000069059", + "drugbank": "DB:DB01076" + }, + "links": [ + { + "key": "decreases activity of", + "source": "MESH:D000069059", + "target": "UniProt:P04035" + }, + { + "key": "positively regulates", + "source": "UniProt:P04035", + "target": "GO:0006695" + }, + { + "key": "increases abundance of", + "source": "GO:0006695", + "target": "MESH:D002784" + }, + { + "key": "positively correlated with", + "source": "MESH:D002784", + "target": "HP:0003107" + }, + { + "key": "manifestation of", + "source": "HP:0003107", + "target": "MESH:D006937" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:D000069059", + "label": "Drug", + "name": "atorvastatin" + }, + { + "id": "UniProt:P04035", + "label": "Protein", + "name": "3-hydroxy-3-methylglutaryl-coenzyme A reductase" + }, + { + "id": "GO:0006695", + "label": "BiologicalProcess", + "name": "cholesterol biosynthetic process" + }, + { + "id": "MESH:D002784", + "label": "ChemicalSubstance", + "name": "Cholesterol" + }, + { + "id": "HP:0003107", + "label": "PhenotypicFeature", + "name": "Abnormal circulating cholesterol concentration" + }, + { + "id": "MESH:D006937", + "label": "Disease", + "name": "Hypercholesterolemia" + } + ], + "reference": [ + "https://go.drugbank.com/drugs/DB01076#mechanism-of-action", + "https://www.uniprot.org/uniprot/P04035#function", + "https://en.wikipedia.org/wiki/Hypercholesterolemia" + ] + }, + { + "directed": true, + "graph": { + "_id": "DB01076_MESH_D006950_1", + "disease": "Hyperlipidemia, Familial Combined", + "disease_mesh": "MESH:D006950", + "drug": "atorvastatin", + "drug_mesh": "MESH:D000069059", + "drugbank": "DB:DB01076" + }, + "links": [ + { + "key": "decreases activity of", + "source": "MESH:D000069059", + "target": "UniProt:P04035" + }, + { + "key": "increases activity of", + "source": "MESH:D000069059", + "target": "UniProt:P06858" + }, + { + "key": "positively regulates", + "source": "UniProt:P04035", + "target": "GO:0006695" + }, + { + "key": "positively regulates", + "source": "UniProt:P06858", + "target": "GO:0019433" + }, + { + "key": "increases abundance of", + "source": "GO:0006695", + "target": "MESH:D002784" + }, + { + "key": "decreases abundance of", + "source": "GO:0019433", + "target": "MESH:D014280" + }, + { + "key": "positively 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], + "reference": [ + "https://go.drugbank.com/drugs/DB01076#mechanism-of-action", + "https://www.uniprot.org/uniprot/P04035#function", + "https://www.uniprot.org/uniprot/P06858#function", + "https://pubmed.ncbi.nlm.nih.gov/15262189/", + "https://en.wikipedia.org/wiki/Hyperlipidemia" + ] + }, + { + "directed": true, + "graph": { + "_id": "DB01076_MESH_D006952_1", + "disease": "Hyperlipoproteinemia Type III", + "disease_mesh": "MESH:D006952", + "drug": "atorvastatin", + "drug_mesh": "MESH:D000069059", + "drugbank": "DB:DB01076" + }, + "links": [ + { + "key": "decreases activity of", + "source": "MESH:D000069059", + "target": "UniProt:P04035" + }, + { + "key": "increases activity of", + "source": "MESH:D000069059", + "target": "UniProt:P06858" + }, + { + "key": "positively regulates", + "source": "UniProt:P04035", + "target": "GO:0006695" + }, + { + "key": "positively regulates", + "source": "UniProt:P06858", + "target": "GO:0019433" + }, + { + "key": "increases abundance of", + "source": "GO:0006695", + "target": "MESH:D002784" + }, + { + "key": "decreases abundance of", + "source": "GO:0019433", + "target": "MESH:D014280" + }, + { + "key": "positively correlated with", + "source": "MESH:D002784", + "target": "MESH:D006952" + }, + { + "key": "positively correlated with", + "source": "MESH:D014280", + "target": "MESH:D006952" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:D000069059", + "label": "Drug", + "name": "atorvastatin" + }, + { + "id": "UniProt:P04035", + "label": "Protein", + "name": "3-hydroxy-3-methylglutaryl-coenzyme A reductase" + }, + { + "id": "UniProt:P06858", + "label": "Protein", + "name": "Lipoprotein lipase" + }, + { + "id": "GO:0006695", + "label": "BiologicalProcess", + "name": "cholesterol biosynthetic process" + }, + { + "id": "GO:0019433", + "label": "BiologicalProcess", + "name": "triglyceride catabolic process" + }, + { + "id": "MESH:D002784", + "label": "ChemicalSubstance", + "name": "Cholesterol" + }, + { + "id": "MESH:D014280", + "label": "ChemicalSubstance", + "name": "Triglycerides" + }, + { + "id": "MESH:D006952", + "label": "Disease", + "name": "Hyperlipoproteinemia Type III" + } + ], + "reference": [ + "https://go.drugbank.com/drugs/DB01076#mechanism-of-action", + "https://www.uniprot.org/uniprot/P04035#function", + "https://www.uniprot.org/uniprot/P06858#function", + "https://pubmed.ncbi.nlm.nih.gov/15262189/", + "https://en.wikipedia.org/wiki/Familial_dysbetalipoproteinemia" + ] + }, + { + "directed": true, + "graph": { + "_id": "DB01076_MESH_D015228_1", + "disease": "Hypertriglyceridemia", + "disease_mesh": "MESH:D015228", + "drug": "atorvastatin", + "drug_mesh": "MESH:D000069059", + "drugbank": "DB:DB01076" + }, + "links": [ + { + "key": "increases activity of", + "source": "MESH:D000069059", + "target": "UniProt:P06858" + }, + { + "key": "positively regulates", + "source": "UniProt:P06858", + "target": "GO:0019433" + }, + { + "key": "decreases abundance of", + "source": "GO:0019433", + "target": "MESH:D014280" + }, + { + "key": "positively correlated with", + "source": "MESH:D014280", + "target": "MESH:D015228" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:D000069059", + "label": "Drug", + "name": "atorvastatin" + }, + { + "id": "UniProt:P06858", + "label": "Protein", + "name": "Lipoprotein lipase" + }, + { + "id": "GO:0019433", + "label": "BiologicalProcess", + "name": "triglyceride catabolic process" + }, + { + "id": "MESH:D014280", + "label": "ChemicalSubstance", + "name": "Triglycerides" + }, + { + "id": "MESH:D015228", + "label": "Disease", + "name": "Hypertriglyceridemia" + } + ], + "reference": [ + "https://go.drugbank.com/drugs/DB01076#mechanism-of-action", + "https://www.uniprot.org/uniprot/P06858#function", + "https://pubmed.ncbi.nlm.nih.gov/15262189/", + "https://en.wikipedia.org/wiki/Hypertriglyceridemia" + ] + }, + { + "directed": true, + "graph": { + "_id": "DB01076_MESH_D020521_1", + "disease": "Stroke", + "disease_mesh": "MESH:D020521", + "drug": "atorvastatin", + "drug_mesh": "MESH:D000069059", + "drugbank": "DB:DB01076" + }, + "links": [ + { + "key": "decreases activity of", + "source": "MESH:D000069059", + "target": "UniProt:P04035" + }, + { + "key": "positively regulates", + "source": "UniProt:P04035", + "target": "GO:0006695" + }, + { + "key": "increases abundance of", + "source": "GO:0006695", + "target": "MESH:D002784" + }, + { + "key": "positively correlated with", + "source": "MESH:D002784", + "target": "HP:0002621" + }, + { + "key": "contributes to", + "source": "HP:0002621", + "target": "HP:0002637" + }, + { + "key": "manifestation of", + "source": "HP:0002637", + "target": "MESH:D020521" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:D000069059", + "label": "Drug", + "name": "atorvastatin" + }, + { + "id": "UniProt:P04035", + "label": "Protein", + "name": "3-hydroxy-3-methylglutaryl-coenzyme A reductase" + }, + { + "id": "GO:0006695", + "label": "BiologicalProcess", + "name": "cholesterol biosynthetic process" + }, + { + "id": "MESH:D002784", + "label": "ChemicalSubstance", + "name": "Cholesterol" + }, + { + "id": "HP:0002621", + "label": "PhenotypicFeature", + "name": "Atherosclerosis" + }, + { + "id": "HP:0002637", + "label": "PhenotypicFeature", + "name": "Cerebral ischemia" + }, + { + "id": "MESH:D020521", + "label": "Disease", + "name": "Stroke" + } + ], + "reference": [ + "https://go.drugbank.com/drugs/DB01076#mechanism-of-action", + "https://www.uniprot.org/uniprot/P04035#function", + "https://en.wikipedia.org/wiki/Atherosclerosis", + "https://en.wikipedia.org/wiki/Brain_ischemia", + "https://en.wikipedia.org/wiki/Stroke" + ] + }, + { + "directed": true, + "graph": { + "_id": "DB09526_MESH_D008548_1", + "disease": "Melanosis", + "disease_mesh": "MESH:D008548", + "drug": "hydroquinone", + "drug_mesh": "MESH:C031927", + "drugbank": "DB:DB09526" + }, + "links": [ + { + "key": "decreases activity of", + "source": "MESH:C031927", + "target": "UniProt:P14679" + }, + { + "key": "positively regulates", + "source": "UniProt:P14679", + "target": "GO:0042438" + }, + { + "key": "increases abundance of", + "source": "GO:0042438", + "target": "MESH:D008543" + }, + { + "key": "positively correlated with", + "source": "MESH:D008543", + "target": "MESH:D008548" + } + ], + "multigraph": true, + "nodes": [ + { + "id": "MESH:C031927", + "label": "Drug", + "name": "hydroquinone" + }, + { + "id": "UniProt:P14679", + "label": "Protein", + "name": "Tyrosinase" + }, + { + "id": "GO:0042438", + "label": "BiologicalProcess", + "name": "melanin biosynthetic process" + }, + { + "id": "MESH:D008543", + "label": "ChemicalSubstance", + "name": "Melanins" + }, + { + "id": "MESH:D008548", + "label": "Disease", + "name": "Melanosis" + } + ], + "reference": [ + "https://go.drugbank.com/drugs/DB09526#mechanism-of-action", + "https://www.uniprot.org/uniprot/P14679#function", + "https://en.wikipedia.org/wiki/Melanosis" + ] } ] \ No newline at end of file diff --git a/indication_paths.yaml b/indication_paths.yaml index c4f0d8c31..17cfe458d 100644 --- a/indication_paths.yaml +++ b/indication_paths.yaml @@ -193102,3 +193102,469 @@ reference: - https://go.drugbank.com/drugs/DB00273#mechanism-of-action - https://en.wikipedia.org/wiki/Lennox%E2%80%93Gastaut_syndrome +- directed: true + graph: + _id: DB01076_MESH_D000787_1 + disease: Angina Pectoris + disease_mesh: MESH:D000787 + drug: atorvastatin + drug_mesh: MESH:D000069059 + drugbank: DB:DB01076 + links: + - key: decreases activity of + source: MESH:D000069059 + target: UniProt:P04035 + - key: positively regulates + source: UniProt:P04035 + target: GO:0006695 + - key: increases abundance of + source: GO:0006695 + target: MESH:D002784 + - key: positively correlated with + source: MESH:D002784 + target: HP:0002621 + - key: contributes to + source: HP:0002621 + target: MESH:D000787 + multigraph: true + nodes: + - id: MESH:D000069059 + label: Drug + name: atorvastatin + - id: UniProt:P04035 + label: Protein + name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase + - id: GO:0006695 + label: BiologicalProcess + name: cholesterol biosynthetic process + - id: MESH:D002784 + label: ChemicalSubstance + name: Cholesterol + - id: HP:0002621 + label: PhenotypicFeature + name: Atherosclerosis + - id: MESH:D000787 + label: Disease + name: Angina Pectoris + reference: + - https://go.drugbank.com/drugs/DB01076#mechanism-of-action + - https://www.uniprot.org/uniprot/P04035#function + - https://en.wikipedia.org/wiki/Atherosclerosis + - https://en.wikipedia.org/wiki/Angina +- directed: true + graph: + _id: DB01076_MESH_D000788_1 + disease: Angina Pectoris, Variant + disease_mesh: MESH:D000788 + drug: atorvastatin + drug_mesh: MESH:D000069059 + drugbank: DB:DB01076 + links: + - key: decreases activity of + source: MESH:D000069059 + target: UniProt:P04035 + - key: positively regulates + source: UniProt:P04035 + target: GO:0006695 + - key: increases abundance of + source: GO:0006695 + target: MESH:D002784 + - key: positively correlated with + source: MESH:D002784 + target: HP:0002621 + - key: contributes to + source: HP:0002621 + target: MESH:D000788 + multigraph: true + nodes: + - id: MESH:D000069059 + label: Drug + name: atorvastatin + - id: UniProt:P04035 + label: Protein + name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase + - id: GO:0006695 + label: BiologicalProcess + name: cholesterol biosynthetic process + - id: MESH:D002784 + label: ChemicalSubstance + name: Cholesterol + - id: HP:0002621 + label: PhenotypicFeature + name: Atherosclerosis + - id: MESH:D000788 + label: Disease + name: Angina Pectoris, Variant + reference: + - https://go.drugbank.com/drugs/DB01076#mechanism-of-action + - https://www.uniprot.org/uniprot/P04035#function + - https://en.wikipedia.org/wiki/Atherosclerosis + - https://en.wikipedia.org/wiki/Variant_angina +- directed: true + graph: + _id: DB01076_MESH_D001161_1 + disease: Arteriosclerosis + disease_mesh: MESH:D001161 + drug: atorvastatin + drug_mesh: MESH:D000069059 + drugbank: DB:DB01076 + links: + - key: decreases activity of + source: MESH:D000069059 + target: UniProt:P04035 + - key: positively regulates + source: UniProt:P04035 + target: GO:0006695 + - key: increases abundance of + source: GO:0006695 + target: MESH:D002784 + - key: positively correlated with + source: MESH:D002784 + target: HP:0002621 + - key: manifestation of + source: HP:0002621 + target: MESH:D001161 + multigraph: true + nodes: + - id: MESH:D000069059 + label: Drug + name: atorvastatin + - id: UniProt:P04035 + label: Protein + name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase + - id: GO:0006695 + label: BiologicalProcess + name: cholesterol biosynthetic process + - id: MESH:D002784 + label: ChemicalSubstance + name: Cholesterol + - id: HP:0002621 + label: PhenotypicFeature + name: Atherosclerosis + - id: MESH:D001161 + label: Disease + name: Arteriosclerosis + reference: + - https://go.drugbank.com/drugs/DB01076#mechanism-of-action + - https://www.uniprot.org/uniprot/P04035#function + - https://en.wikipedia.org/wiki/Atherosclerosis + - https://en.wikipedia.org/wiki/Arteriosclerosis +- directed: true + graph: + _id: DB01076_MESH_D006937_1 + disease: Hypercholesterolemia + disease_mesh: MESH:D006937 + drug: atorvastatin + drug_mesh: MESH:D000069059 + drugbank: DB:DB01076 + links: + - key: decreases activity of + source: MESH:D000069059 + target: UniProt:P04035 + - key: positively regulates + source: UniProt:P04035 + target: GO:0006695 + - key: increases abundance of + source: GO:0006695 + target: MESH:D002784 + - key: positively correlated with + source: MESH:D002784 + target: HP:0003107 + - key: manifestation of + source: HP:0003107 + target: MESH:D006937 + multigraph: true + nodes: + - id: MESH:D000069059 + label: Drug + name: atorvastatin + - id: UniProt:P04035 + label: Protein + name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase + - id: GO:0006695 + label: BiologicalProcess + name: cholesterol biosynthetic process + - id: MESH:D002784 + label: ChemicalSubstance + name: Cholesterol + - id: HP:0003107 + label: PhenotypicFeature + name: Abnormal circulating cholesterol concentration + - id: MESH:D006937 + label: Disease + name: Hypercholesterolemia + reference: + - https://go.drugbank.com/drugs/DB01076#mechanism-of-action + - https://www.uniprot.org/uniprot/P04035#function + - https://en.wikipedia.org/wiki/Hypercholesterolemia +- directed: true + graph: + _id: DB01076_MESH_D006950_1 + disease: Hyperlipidemia, Familial Combined + disease_mesh: MESH:D006950 + drug: atorvastatin + drug_mesh: MESH:D000069059 + drugbank: DB:DB01076 + links: + - key: decreases activity of + source: MESH:D000069059 + target: UniProt:P04035 + - key: increases activity of + source: MESH:D000069059 + target: UniProt:P06858 + - key: positively regulates + source: UniProt:P04035 + target: GO:0006695 + - key: positively regulates + source: UniProt:P06858 + target: GO:0019433 + - key: increases abundance of + source: GO:0006695 + target: MESH:D002784 + - key: decreases abundance of + source: GO:0019433 + target: MESH:D014280 + - key: positively correlated with + source: MESH:D002784 + target: MESH:D006950 + - key: positively correlated with + source: MESH:D014280 + target: MESH:D006950 + multigraph: true + nodes: + - id: MESH:D000069059 + label: Drug + name: atorvastatin + - id: UniProt:P04035 + label: Protein + name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase + - id: UniProt:P06858 + label: Protein + name: Lipoprotein lipase + - id: GO:0006695 + label: BiologicalProcess + name: cholesterol biosynthetic process + - id: GO:0019433 + label: BiologicalProcess + name: triglyceride catabolic process + - id: MESH:D002784 + label: ChemicalSubstance + name: Cholesterol + - id: MESH:D014280 + label: ChemicalSubstance + name: Triglycerides + - id: MESH:D006950 + label: Disease + name: Hyperlipidemia, Familial Combined + reference: + - https://go.drugbank.com/drugs/DB01076#mechanism-of-action + - https://www.uniprot.org/uniprot/P04035#function + - https://www.uniprot.org/uniprot/P06858#function + - https://pubmed.ncbi.nlm.nih.gov/15262189/ + - https://en.wikipedia.org/wiki/Hyperlipidemia +- directed: true + graph: + _id: DB01076_MESH_D006952_1 + disease: Hyperlipoproteinemia Type III + disease_mesh: MESH:D006952 + drug: atorvastatin + drug_mesh: MESH:D000069059 + drugbank: DB:DB01076 + links: + - key: decreases activity of + source: MESH:D000069059 + target: UniProt:P04035 + - key: increases activity of + source: MESH:D000069059 + target: UniProt:P06858 + - key: positively regulates + source: UniProt:P04035 + target: GO:0006695 + - key: positively regulates + source: UniProt:P06858 + target: GO:0019433 + - key: increases abundance of + source: GO:0006695 + target: MESH:D002784 + - key: decreases abundance of + source: GO:0019433 + target: MESH:D014280 + - key: positively correlated with + source: MESH:D002784 + target: MESH:D006952 + - key: positively correlated with + source: MESH:D014280 + target: MESH:D006952 + multigraph: true + nodes: + - id: MESH:D000069059 + label: Drug + name: atorvastatin + - id: UniProt:P04035 + label: Protein + name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase + - id: UniProt:P06858 + label: Protein + name: Lipoprotein lipase + - id: GO:0006695 + label: BiologicalProcess + name: cholesterol biosynthetic process + - id: GO:0019433 + label: BiologicalProcess + name: triglyceride catabolic process + - id: MESH:D002784 + label: ChemicalSubstance + name: Cholesterol + - id: MESH:D014280 + label: ChemicalSubstance + name: Triglycerides + - id: MESH:D006952 + label: Disease + name: Hyperlipoproteinemia Type III + reference: + - https://go.drugbank.com/drugs/DB01076#mechanism-of-action + - https://www.uniprot.org/uniprot/P04035#function + - https://www.uniprot.org/uniprot/P06858#function + - https://pubmed.ncbi.nlm.nih.gov/15262189/ + - https://en.wikipedia.org/wiki/Familial_dysbetalipoproteinemia +- directed: true + graph: + _id: DB01076_MESH_D015228_1 + disease: Hypertriglyceridemia + disease_mesh: MESH:D015228 + drug: atorvastatin + drug_mesh: MESH:D000069059 + drugbank: DB:DB01076 + links: + - key: increases activity of + source: MESH:D000069059 + target: UniProt:P06858 + - key: positively regulates + source: UniProt:P06858 + target: GO:0019433 + - key: decreases abundance of + source: GO:0019433 + target: MESH:D014280 + - key: positively correlated with + source: MESH:D014280 + target: MESH:D015228 + multigraph: true + nodes: + - id: MESH:D000069059 + label: Drug + name: atorvastatin + - id: UniProt:P06858 + label: Protein + name: Lipoprotein lipase + - id: GO:0019433 + label: BiologicalProcess + name: triglyceride catabolic process + - id: MESH:D014280 + label: ChemicalSubstance + name: Triglycerides + - id: MESH:D015228 + label: Disease + name: Hypertriglyceridemia + reference: + - https://go.drugbank.com/drugs/DB01076#mechanism-of-action + - https://www.uniprot.org/uniprot/P06858#function + - https://pubmed.ncbi.nlm.nih.gov/15262189/ + - https://en.wikipedia.org/wiki/Hypertriglyceridemia +- directed: true + graph: + _id: DB01076_MESH_D020521_1 + disease: Stroke + disease_mesh: MESH:D020521 + drug: atorvastatin + drug_mesh: MESH:D000069059 + drugbank: DB:DB01076 + links: + - key: decreases activity of + source: MESH:D000069059 + target: UniProt:P04035 + - key: positively regulates + source: UniProt:P04035 + target: GO:0006695 + - key: increases abundance of + source: GO:0006695 + target: MESH:D002784 + - key: positively correlated with + source: MESH:D002784 + target: HP:0002621 + - key: contributes to + source: HP:0002621 + target: HP:0002637 + - key: manifestation of + source: HP:0002637 + target: MESH:D020521 + multigraph: true + nodes: + - id: MESH:D000069059 + label: Drug + name: atorvastatin + - id: UniProt:P04035 + label: Protein + name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase + - id: GO:0006695 + label: BiologicalProcess + name: cholesterol biosynthetic process + - id: MESH:D002784 + label: ChemicalSubstance + name: Cholesterol + - id: HP:0002621 + label: PhenotypicFeature + name: Atherosclerosis + - id: HP:0002637 + label: PhenotypicFeature + name: Cerebral ischemia + - id: MESH:D020521 + label: Disease + name: Stroke + reference: + - https://go.drugbank.com/drugs/DB01076#mechanism-of-action + - https://www.uniprot.org/uniprot/P04035#function + - https://en.wikipedia.org/wiki/Atherosclerosis + - https://en.wikipedia.org/wiki/Brain_ischemia + - https://en.wikipedia.org/wiki/Stroke +- directed: true + graph: + _id: DB09526_MESH_D008548_1 + disease: Melanosis + disease_mesh: MESH:D008548 + drug: hydroquinone + drug_mesh: MESH:C031927 + drugbank: DB:DB09526 + links: + - key: decreases activity of + source: MESH:C031927 + target: UniProt:P14679 + - key: positively regulates + source: UniProt:P14679 + target: GO:0042438 + - key: increases abundance of + source: GO:0042438 + target: MESH:D008543 + - key: positively correlated with + source: MESH:D008543 + target: MESH:D008548 + multigraph: true + nodes: + - id: MESH:C031927 + label: Drug + name: hydroquinone + - id: UniProt:P14679 + label: Protein + name: Tyrosinase + - id: GO:0042438 + label: BiologicalProcess + name: melanin biosynthetic process + - id: MESH:D008543 + label: ChemicalSubstance + name: Melanins + - id: MESH:D008548 + label: Disease + name: Melanosis + reference: + - https://go.drugbank.com/drugs/DB09526#mechanism-of-action + - https://www.uniprot.org/uniprot/P14679#function + - https://en.wikipedia.org/wiki/Melanosis diff --git a/submission.yaml b/submission.yaml index f36bac852..8b1378917 100644 --- a/submission.yaml +++ b/submission.yaml @@ -1,457 +1 @@ -- directed: true - graph: - disease: Angina Pectoris - disease_mesh: MESH:D000787 - drug: atorvastatin - drug_mesh: MESH:D000069059 - drugbank: DB:DB01076 - links: - - key: decreases activity of - source: MESH:D000069059 - target: UniProt:P04035 - - key: positively regulates - source: UniProt:P04035 - target: GO:0006695 - - key: increases abundance of - source: GO:0006695 - target: MESH:D002784 - - key: positively correlated with - source: MESH:D002784 - target: HP:0002621 - - key: contributes to - source: HP:0002621 - target: MESH:D000787 - multigraph: true - nodes: - - id: MESH:D000069059 - label: Drug - name: atorvastatin - - id: UniProt:P04035 - label: Protein - name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase - - id: GO:0006695 - label: BiologicalProcess - name: cholesterol biosynthetic process - - id: MESH:D002784 - label: ChemicalSubstance - name: Cholesterol - - id: HP:0002621 - label: PhenotypicFeature - name: Atherosclerosis - - id: MESH:D000787 - label: Disease - name: Angina Pectoris - reference: - - https://go.drugbank.com/drugs/DB01076#mechanism-of-action - - https://www.uniprot.org/uniprot/P04035#function - - https://en.wikipedia.org/wiki/Atherosclerosis - - https://en.wikipedia.org/wiki/Angina -- directed: true - graph: - disease: Angina Pectoris, Variant - disease_mesh: MESH:D000788 - drug: atorvastatin - drug_mesh: MESH:D000069059 - drugbank: DB:DB01076 - links: - - key: decreases activity of - source: MESH:D000069059 - target: UniProt:P04035 - - key: positively regulates - source: UniProt:P04035 - target: GO:0006695 - - key: increases abundance of - source: GO:0006695 - target: MESH:D002784 - - key: positively correlated with - source: MESH:D002784 - target: HP:0002621 - - key: contributes to - source: HP:0002621 - target: MESH:D000788 - multigraph: true - nodes: - - id: MESH:D000069059 - label: Drug - name: atorvastatin - - id: UniProt:P04035 - label: Protein - name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase - - id: GO:0006695 - label: BiologicalProcess - name: cholesterol biosynthetic process - - id: MESH:D002784 - label: ChemicalSubstance - name: Cholesterol - - id: HP:0002621 - label: PhenotypicFeature - name: Atherosclerosis - - id: MESH:D000788 - label: Disease - name: Angina Pectoris, Variant - reference: - - https://go.drugbank.com/drugs/DB01076#mechanism-of-action - - https://www.uniprot.org/uniprot/P04035#function - - https://en.wikipedia.org/wiki/Atherosclerosis - - https://en.wikipedia.org/wiki/Variant_angina -- directed: true - graph: - disease: Arteriosclerosis - disease_mesh: MESH:D001161 - drug: atorvastatin - drug_mesh: MESH:D000069059 - drugbank: DB:DB01076 - links: - - key: decreases activity of - source: MESH:D000069059 - target: UniProt:P04035 - - key: positively regulates - source: UniProt:P04035 - target: GO:0006695 - - key: increases abundance of - source: GO:0006695 - target: MESH:D002784 - - key: positively correlated with - source: MESH:D002784 - target: HP:0002621 - - key: manifestation of - source: HP:0002621 - target: MESH:D001161 - multigraph: true - nodes: - - id: MESH:D000069059 - label: Drug - name: atorvastatin - - id: UniProt:P04035 - label: Protein - name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase - - id: GO:0006695 - label: BiologicalProcess - name: cholesterol biosynthetic process - - id: MESH:D002784 - label: ChemicalSubstance - name: Cholesterol - - id: HP:0002621 - label: PhenotypicFeature - name: Atherosclerosis - - id: MESH:D001161 - label: Disease - name: Arteriosclerosis - reference: - - https://go.drugbank.com/drugs/DB01076#mechanism-of-action - - https://www.uniprot.org/uniprot/P04035#function - - https://en.wikipedia.org/wiki/Atherosclerosis - - https://en.wikipedia.org/wiki/Arteriosclerosis -- directed: true - graph: - disease: Hypercholesterolemia - disease_mesh: MESH:D006937 - drug: atorvastatin - drug_mesh: MESH:D000069059 - drugbank: DB:DB01076 - links: - - key: decreases activity of - source: MESH:D000069059 - target: UniProt:P04035 - - key: positively regulates - source: UniProt:P04035 - target: GO:0006695 - - key: increases abundance of - source: GO:0006695 - target: MESH:D002784 - - key: positively correlated with - source: MESH:D002784 - target: HP:0003107 - - key: manifestation of - source: HP:0003107 - target: MESH:D006937 - multigraph: true - nodes: - - id: MESH:D000069059 - label: Drug - name: atorvastatin - - id: UniProt:P04035 - label: Protein - name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase - - id: GO:0006695 - label: BiologicalProcess - name: cholesterol biosynthetic process - - id: MESH:D002784 - label: ChemicalSubstance - name: Cholesterol - - id: HP:0003107 - label: PhenotypicFeature - name: Abnormal circulating cholesterol concentration - - id: MESH:D006937 - label: Disease - name: Hypercholesterolemia - reference: - - https://go.drugbank.com/drugs/DB01076#mechanism-of-action - - https://www.uniprot.org/uniprot/P04035#function - - https://en.wikipedia.org/wiki/Hypercholesterolemia -- directed: true - graph: - disease: Hyperlipidemia, Familial Combined - disease_mesh: MESH:D006950 - drug: atorvastatin - drug_mesh: MESH:D000069059 - drugbank: DB:DB01076 - links: - - key: decreases activity of - source: MESH:D000069059 - target: UniProt:P04035 - - key: increases activity of - source: MESH:D000069059 - target: UniProt:P06858 - - key: positively regulates - source: UniProt:P04035 - target: GO:0006695 - - key: positively regulates - source: UniProt:P06858 - target: GO:0019433 - - key: increases abundance of - source: GO:0006695 - target: MESH:D002784 - - key: decreases abundance of - source: GO:0019433 - target: MESH:D014280 - - key: positively correlated with - source: MESH:D002784 - target: MESH:D006950 - - key: positively correlated with - source: MESH:D014280 - target: MESH:D006950 - multigraph: true - nodes: - - id: MESH:D000069059 - label: Drug - name: atorvastatin - - id: UniProt:P04035 - label: Protein - name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase - - id: UniProt:P06858 - label: Protein - name: Lipoprotein lipase - - id: GO:0006695 - label: BiologicalProcess - name: cholesterol biosynthetic process - - id: GO:0019433 - label: BiologicalProcess - name: triglyceride catabolic process - - id: MESH:D002784 - label: ChemicalSubstance - name: Cholesterol - - id: MESH:D014280 - label: ChemicalSubstance - name: Triglycerides - - id: MESH:D006950 - label: Disease - name: Hyperlipidemia, Familial Combined - reference: - - https://go.drugbank.com/drugs/DB01076#mechanism-of-action - - https://www.uniprot.org/uniprot/P04035#function - - https://www.uniprot.org/uniprot/P06858#function - - https://pubmed.ncbi.nlm.nih.gov/15262189/ - - https://en.wikipedia.org/wiki/Hyperlipidemia -- directed: true - graph: - disease: Hyperlipoproteinemia Type III - disease_mesh: MESH:D006952 - drug: atorvastatin - drug_mesh: MESH:D000069059 - drugbank: DB:DB01076 - links: - - key: decreases activity of - source: MESH:D000069059 - target: UniProt:P04035 - - key: increases activity of - source: MESH:D000069059 - target: UniProt:P06858 - - key: positively regulates - source: UniProt:P04035 - target: GO:0006695 - - key: positively regulates - source: UniProt:P06858 - target: GO:0019433 - - key: increases abundance of - source: GO:0006695 - target: MESH:D002784 - - key: decreases abundance of - source: GO:0019433 - target: MESH:D014280 - - key: positively correlated with - source: MESH:D002784 - target: MESH:D006952 - - key: positively correlated with - source: MESH:D014280 - target: MESH:D006952 - multigraph: true - nodes: - - id: MESH:D000069059 - label: Drug - name: atorvastatin - - id: UniProt:P04035 - label: Protein - name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase - - id: UniProt:P06858 - label: Protein - name: Lipoprotein lipase - - id: GO:0006695 - label: BiologicalProcess - name: cholesterol biosynthetic process - - id: GO:0019433 - label: BiologicalProcess - name: triglyceride catabolic process - - id: MESH:D002784 - label: ChemicalSubstance - name: Cholesterol - - id: MESH:D014280 - label: ChemicalSubstance - name: Triglycerides - - id: MESH:D006952 - label: Disease - name: Hyperlipoproteinemia Type III - reference: - - https://go.drugbank.com/drugs/DB01076#mechanism-of-action - - https://www.uniprot.org/uniprot/P04035#function - - https://www.uniprot.org/uniprot/P06858#function - - https://pubmed.ncbi.nlm.nih.gov/15262189/ - - https://en.wikipedia.org/wiki/Familial_dysbetalipoproteinemia -- directed: true - graph: - disease: Hypertriglyceridemia - disease_mesh: MESH:D015228 - drug: atorvastatin - drug_mesh: MESH:D000069059 - drugbank: DB:DB01076 - links: - - key: increases activity of - source: MESH:D000069059 - target: UniProt:P06858 - - key: positively regulates - source: UniProt:P06858 - target: GO:0019433 - - key: decreases abundance of - source: GO:0019433 - target: MESH:D014280 - - key: positively correlated with - source: MESH:D014280 - target: MESH:D015228 - multigraph: true - nodes: - - id: MESH:D000069059 - label: Drug - name: atorvastatin - - id: UniProt:P06858 - label: Protein - name: Lipoprotein lipase - - id: GO:0019433 - label: BiologicalProcess - name: triglyceride catabolic process - - id: MESH:D014280 - label: ChemicalSubstance - name: Triglycerides - - id: MESH:D015228 - label: Disease - name: Hypertriglyceridemia - reference: - - https://go.drugbank.com/drugs/DB01076#mechanism-of-action - - https://www.uniprot.org/uniprot/P06858#function - - https://pubmed.ncbi.nlm.nih.gov/15262189/ - - https://en.wikipedia.org/wiki/Hypertriglyceridemia -- directed: true - graph: - disease: Stroke - disease_mesh: MESH:D020521 - drug: atorvastatin - drug_mesh: MESH:D000069059 - drugbank: DB:DB01076 - links: - - key: decreases activity of - source: MESH:D000069059 - target: UniProt:P04035 - - key: positively regulates - source: UniProt:P04035 - target: GO:0006695 - - key: increases abundance of - source: GO:0006695 - target: MESH:D002784 - - key: positively correlated with - source: MESH:D002784 - target: HP:0002621 - - key: contributes to - source: HP:0002621 - target: HP:0002637 - - key: manifestation of - source: HP:0002637 - target: MESH:D020521 - multigraph: true - nodes: - - id: MESH:D000069059 - label: Drug - name: atorvastatin - - id: UniProt:P04035 - label: Protein - name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase - - id: GO:0006695 - label: BiologicalProcess - name: cholesterol biosynthetic process - - id: MESH:D002784 - label: ChemicalSubstance - name: Cholesterol - - id: HP:0002621 - label: PhenotypicFeature - name: Atherosclerosis - - id: HP:0002637 - label: PhenotypicFeature - name: Cerebral ischemia - - id: MESH:D020521 - label: Disease - name: Stroke - reference: - - https://go.drugbank.com/drugs/DB01076#mechanism-of-action - - https://www.uniprot.org/uniprot/P04035#function - - https://en.wikipedia.org/wiki/Atherosclerosis - - https://en.wikipedia.org/wiki/Brain_ischemia - - https://en.wikipedia.org/wiki/Stroke -- directed: true - graph: - disease: Melanosis - disease_mesh: MESH:D008548 - drug: hydroquinone - drug_mesh: MESH:C031927 - drugbank: DB:DB09526 - links: - - key: decreases activity of - source: MESH:C031927 - target: UniProt:P14679 - - key: positively regulates - source: UniProt:P14679 - target: GO:0042438 - - key: increases abundance of - source: GO:0042438 - target: MESH:D008543 - - key: positively correlated with - source: MESH:D008543 - target: MESH:D008548 - multigraph: true - nodes: - - id: MESH:C031927 - label: Drug - name: hydroquinone - - id: UniProt:P14679 - label: Protein - name: Tyrosinase - - id: GO:0042438 - label: BiologicalProcess - name: melanin biosynthetic process - - id: MESH:D008543 - label: ChemicalSubstance - name: Melanins - - id: MESH:D008548 - label: Disease - name: Melanosis - reference: - - https://go.drugbank.com/drugs/DB09526#mechanism-of-action - - https://www.uniprot.org/uniprot/P14679#function - - https://en.wikipedia.org/wiki/Melanosis +