diff --git a/indication_paths.json b/indication_paths.json
index 0a3311575..15a137f94 100644
--- a/indication_paths.json
+++ b/indication_paths.json
@@ -264016,5 +264016,2459 @@
       "https://go.drugbank.com/drugs/DB08984",
       "https://en.wikipedia.org/wiki/Etofenamate"
     ]
+  },
+  {
+    "directed": true,
+    "graph": {
+      "_id": "DB01182_MESH_D001281_1",
+      "disease": "Paroxysmal atrial fibrillation",
+      "disease_mesh": "MESH:D001281",
+      "drug": "propafenone",
+      "drug_mesh": "MESH:D011405",
+      "drugbank": "DB:DB01182"
+    },
+    "links": [
+      {
+        "key": "negatively regulates",
+        "source": "MESH:D011405",
+        "target": "InterPro:IPR001696"
+      },
+      {
+        "key": "increases transport of",
+        "source": "InterPro:IPR001696",
+        "target": "MESH:D012964"
+      },
+      {
+        "key": "positively regulates",
+        "source": "MESH:D012964",
+        "target": "GO:0086001"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0086001",
+        "target": "GO:0086003"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0086003",
+        "target": "HP:0004308"
+      },
+      {
+        "key": "manifestation of",
+        "source": "HP:0004308",
+        "target": "MESH:D001281"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:D011405",
+        "label": "Drug",
+        "name": "propafenone"
+      },
+      {
+        "id": "InterPro:IPR001696",
+        "label": "GeneFamily",
+        "name": "Voltage gated sodium channel, alpha subunit"
+      },
+      {
+        "id": "MESH:D012964",
+        "label": "ChemicalSubstance",
+        "name": "Sodium"
+      },
+      {
+        "id": "GO:0086001",
+        "label": "BiologicalProcess",
+        "name": "Cardiac muscle cell action potential"
+      },
+      {
+        "id": "GO:0086003",
+        "label": "BiologicalProcess",
+        "name": "cardiac muscle cell contraction"
+      },
+      {
+        "id": "HP:0004308",
+        "label": "PhenotypicFeature",
+        "name": "Ventricular arrhythmia"
+      },
+      {
+        "id": "MESH:D001281",
+        "label": "Disease",
+        "name": "Paroxysmal atrial fibrillation"
+      }
+    ],
+    "reference": [
+      "https://go.drugbank.com/drugs/DB01182",
+      "https://en.wikipedia.org/wiki/Propafenone"
+    ]
+  },
+  {
+    "directed": true,
+    "graph": {
+      "_id": "DB01394_MESH_D006073_1",
+      "disease": "Gout",
+      "disease_mesh": "MESH:D006073",
+      "drug": "colchicine",
+      "drug_mesh": "MESH:D003078",
+      "drugbank": "DB:DB01394"
+    },
+    "links": [
+      {
+        "key": "decreases activity of",
+        "source": "MESH:D003078",
+        "target": "UniProt:P07437"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P07437",
+        "target": "GO:0046785"
+      },
+      {
+        "key": "positively regulates",
+        "source": "GO:0046785",
+        "target": "REACT:R-HSA-844456"
+      },
+      {
+        "key": "positively regulates",
+        "source": "GO:0046785",
+        "target": "GO:0007266"
+      },
+      {
+        "key": "positively regulates",
+        "source": "REACT:R-HSA-844456",
+        "target": "GO:0006919"
+      },
+      {
+        "key": "positively regulates",
+        "source": "GO:0007266",
+        "target": "GO:0006919"
+      },
+      {
+        "key": "increases abundance of",
+        "source": "GO:0006919",
+        "target": "UniProt:P01584"
+      },
+      {
+        "key": "produced by",
+        "source": "UniProt:P01584",
+        "target": "CL:0000775"
+      },
+      {
+        "key": "produced by",
+        "source": "UniProt:P01584",
+        "target": "CL:0000576"
+      },
+      {
+        "key": "negatively regulates",
+        "source": "MESH:D003078",
+        "target": "GO:1990266"
+      },
+      {
+        "key": "negatively regulates",
+        "source": "MESH:D003078",
+        "target": "GO:0016176"
+      },
+      {
+        "key": "negatively regulates",
+        "source": "MESH:D003078",
+        "target": "GO:0030593"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0030593",
+        "target": "GO:0070942"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:1990266",
+        "target": "GO:0070942"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0016176",
+        "target": "GO:0070942"
+      },
+      {
+        "key": "caused by",
+        "source": "GO:0070942",
+        "target": "CL:0000775"
+      },
+      {
+        "key": "participates in",
+        "source": "CL:0000775",
+        "target": "GO:0045087"
+      },
+      {
+        "key": "participates in",
+        "source": "CL:0000576",
+        "target": "GO:0045087"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0045087",
+        "target": "GO:0006954"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0006954",
+        "target": "HP:0005059"
+      },
+      {
+        "key": "manifestation of",
+        "source": "HP:0005059",
+        "target": "MESH:D006073"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:D003078",
+        "label": "Drug",
+        "name": "colchicine"
+      },
+      {
+        "id": "UniProt:P07437",
+        "label": "Protein",
+        "name": "Tubulin beta chain"
+      },
+      {
+        "id": "GO:1990266",
+        "label": "BiologicalProcess",
+        "name": "neutrophil migration"
+      },
+      {
+        "id": "GO:0016176",
+        "label": "MolecularActivity",
+        "name": "superoxide-generating NADPH oxidase activator activity"
+      },
+      {
+        "id": "GO:0030593",
+        "label": "BiologicalProcess",
+        "name": "neutrophil chemotaxis"
+      },
+      {
+        "id": "GO:0007266",
+        "label": "BiologicalProcess",
+        "name": "Rho protein signal transduction"
+      },
+      {
+        "id": "REACT:R-HSA-844456",
+        "label": "Pathway",
+        "name": "The NLRP3 inflammasome"
+      },
+      {
+        "id": "GO:0046785",
+        "label": "BiologicalProcess",
+        "name": "Microtubule polymerization"
+      },
+      {
+        "id": "CL:0000775",
+        "label": "Cell",
+        "name": "Neutrophil"
+      },
+      {
+        "id": "CL:0000576",
+        "label": "Cell",
+        "name": "Monocyte"
+      },
+      {
+        "id": "GO:0045087",
+        "label": "BiologicalProcess",
+        "name": "innate immune response"
+      },
+      {
+        "id": "GO:0070942",
+        "label": "BiologicalProcess",
+        "name": "neutrophil mediated cytotoxicity"
+      },
+      {
+        "id": "GO:0007266",
+        "label": "BiologicalProcess",
+        "name": "Rho protein signal transduction"
+      },
+      {
+        "id": "GO:0006919",
+        "label": "BiologicalProcess",
+        "name": "activation of cysteine-type endopeptidase activity involved in apoptotic process"
+      },
+      {
+        "id": "UniProt:P01584",
+        "label": "Protein",
+        "name": "Interleukin-1 beta"
+      },
+      {
+        "id": "GO:0006954",
+        "label": "BiologicalProcess",
+        "name": "inflammatory response"
+      },
+      {
+        "id": "HP:0005059",
+        "label": "PhenotypicFeature",
+        "name": "Joint pain/Joint inflammation"
+      },
+      {
+        "id": "MESH:D006073",
+        "label": "Disease",
+        "name": "Gout"
+      }
+    ],
+    "reference": [
+      "https://go.drugbank.com/drugs/DB01394",
+      "https://en.wikipedia.org/wiki/Colchicine",
+      "https://pubmed.ncbi.nlm.nih.gov/25151572/",
+      "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656054/"
+    ]
+  },
+  {
+    "directed": true,
+    "graph": {
+      "_id": "DB01394_MESH_D010505_1",
+      "disease": "Familial Mediterranean fever",
+      "disease_mesh": "MESH:D010505",
+      "drug": "colchicine",
+      "drug_mesh": "MESH:D003078",
+      "drugbank": "DB:DB01394"
+    },
+    "links": [
+      {
+        "key": "decreases activity of",
+        "source": "MESH:D003078",
+        "target": "UniProt:P07437"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P07437",
+        "target": "GO:0046785"
+      },
+      {
+        "key": "positively regulates",
+        "source": "GO:0046785",
+        "target": "REACT:R-HSA-844456"
+      },
+      {
+        "key": "positively regulates",
+        "source": "GO:0046785",
+        "target": "GO:0007266"
+      },
+      {
+        "key": "positively regulates",
+        "source": "REACT:R-HSA-844456",
+        "target": "GO:0006919"
+      },
+      {
+        "key": "positively regulates",
+        "source": "GO:0007266",
+        "target": "GO:0006919"
+      },
+      {
+        "key": "increases abundance of",
+        "source": "GO:0006919",
+        "target": "UniProt:P01584"
+      },
+      {
+        "key": "produced by",
+        "source": "UniProt:P01584",
+        "target": "CL:0000775"
+      },
+      {
+        "key": "produced by",
+        "source": "UniProt:P01584",
+        "target": "CL:0000576"
+      },
+      {
+        "key": "negatively regulates",
+        "source": "MESH:D003078",
+        "target": "GO:1990266"
+      },
+      {
+        "key": "negatively regulates",
+        "source": "MESH:D003078",
+        "target": "GO:0016176"
+      },
+      {
+        "key": "negatively regulates",
+        "source": "MESH:D003078",
+        "target": "GO:0030593"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0030593",
+        "target": "GO:0070942"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:1990266",
+        "target": "GO:0070942"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0016176",
+        "target": "GO:0070942"
+      },
+      {
+        "key": "caused by",
+        "source": "GO:0070942",
+        "target": "CL:0000775"
+      },
+      {
+        "key": "participates in",
+        "source": "CL:0000775",
+        "target": "GO:0045087"
+      },
+      {
+        "key": "participates in",
+        "source": "CL:0000576",
+        "target": "GO:0045087"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0045087",
+        "target": "GO:0006954"
+      },
+      {
+        "key": "manifestation of",
+        "source": "GO:0006954",
+        "target": "MESH:D010505"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:D003078",
+        "label": "Drug",
+        "name": "colchicine"
+      },
+      {
+        "id": "UniProt:P07437",
+        "label": "Protein",
+        "name": "Tubulin beta chain"
+      },
+      {
+        "id": "GO:1990266",
+        "label": "BiologicalProcess",
+        "name": "neutrophil migration"
+      },
+      {
+        "id": "GO:0016176",
+        "label": "MolecularActivity",
+        "name": "superoxide-generating NADPH oxidase activator activity"
+      },
+      {
+        "id": "GO:0030593",
+        "label": "BiologicalProcess",
+        "name": "neutrophil chemotaxis"
+      },
+      {
+        "id": "GO:0007266",
+        "label": "BiologicalProcess",
+        "name": "Rho protein signal transduction"
+      },
+      {
+        "id": "REACT:R-HSA-844456",
+        "label": "Pathway",
+        "name": "The NLRP3 inflammasome"
+      },
+      {
+        "id": "GO:0046785",
+        "label": "BiologicalProcess",
+        "name": "Microtubule polymerization"
+      },
+      {
+        "id": "CL:0000775",
+        "label": "Cell",
+        "name": "Neutrophil"
+      },
+      {
+        "id": "CL:0000576",
+        "label": "Cell",
+        "name": "Monocyte"
+      },
+      {
+        "id": "GO:0045087",
+        "label": "BiologicalProcess",
+        "name": "innate immune response"
+      },
+      {
+        "id": "GO:0070942",
+        "label": "BiologicalProcess",
+        "name": "neutrophil mediated cytotoxicity"
+      },
+      {
+        "id": "GO:0007266",
+        "label": "BiologicalProcess",
+        "name": "Rho protein signal transduction"
+      },
+      {
+        "id": "GO:0006919",
+        "label": "BiologicalProcess",
+        "name": "activation of cysteine-type endopeptidase activity involved in apoptotic process"
+      },
+      {
+        "id": "UniProt:P01584",
+        "label": "Protein",
+        "name": "Interleukin-1 beta"
+      },
+      {
+        "id": "GO:0006954",
+        "label": "BiologicalProcess",
+        "name": "inflammatory response"
+      },
+      {
+        "id": "MESH:D010505",
+        "label": "Disease",
+        "name": "Familial Mediterranean fever"
+      }
+    ],
+    "reference": [
+      "https://go.drugbank.com/drugs/DB01394",
+      "https://en.wikipedia.org/wiki/Colchicine",
+      "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656054/"
+    ]
+  },
+  {
+    "directed": true,
+    "graph": {
+      "_id": "DB00043_MESH_D001249_1",
+      "disease": "Asthma",
+      "disease_mesh": "MESH:D001249",
+      "drug": "omalizumab",
+      "drug_mesh": "MESH:D000069444",
+      "drugbank": "DB:DB00043"
+    },
+    "links": [
+      {
+        "key": "decreases activity of",
+        "source": "MESH:D000069444",
+        "target": "GO:0019767"
+      },
+      {
+        "key": "part of",
+        "source": "GO:0019767",
+        "target": "UniProt:P01854"
+      },
+      {
+        "key": "expressed in",
+        "source": "UniProt:P01854",
+        "target": "CL:0000097"
+      },
+      {
+        "key": "expressed in",
+        "source": "UniProt:P01854",
+        "target": "CL:0000767"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "CL:0000097",
+        "target": "GO:0043303"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "CL:0000767",
+        "target": "GO:0002561"
+      },
+      {
+        "key": "caused by",
+        "source": "GO:0043303",
+        "target": "REACT:R-HSA-2454202"
+      },
+      {
+        "key": "caused by",
+        "source": "GO:0002561",
+        "target": "REACT:R-HSA-2454202"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "REACT:R-HSA-2454202",
+        "target": "GO:0002441"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "REACT:R-HSA-2454202",
+        "target": "GO:0002540"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0002441",
+        "target": "MESH:D001249"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0002540",
+        "target": "MESH:D001249"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:D000069444",
+        "label": "Drug",
+        "name": "omalizumab"
+      },
+      {
+        "id": "GO:0019767",
+        "label": "MolecularActivity",
+        "name": "IgE receptor activity"
+      },
+      {
+        "id": "UniProt:P01854",
+        "label": "Protein",
+        "name": "Immunoglobulin heavy constant epsilon"
+      },
+      {
+        "id": "CL:0000097",
+        "label": "Cell",
+        "name": "mast cell"
+      },
+      {
+        "id": "CL:0000767",
+        "label": "Cell",
+        "name": "basophill"
+      },
+      {
+        "id": "GO:0043303",
+        "label": "BiologicalProcess",
+        "name": "mast cell degranulation"
+      },
+      {
+        "id": "GO:0002561",
+        "label": "BiologicalProcess",
+        "name": "basophil degranulation"
+      },
+      {
+        "id": "REACT:R-HSA-2454202",
+        "label": "Pathway",
+        "name": "Allergen dependent IgE bound FCERI aggregation"
+      },
+      {
+        "id": "GO:0002540",
+        "label": "BiologicalProcess",
+        "name": "leukotriene production involved in inflammatory response"
+      },
+      {
+        "id": "GO:0002441",
+        "label": "BiologicalProcess",
+        "name": "histamine secretion involved in inflammatory response"
+      },
+      {
+        "id": "MESH:D001249",
+        "label": "Disease",
+        "name": "Asthma"
+      }
+    ],
+    "reference": [
+      "https://go.drugbank.com/drugs/DB00043",
+      "https://europepmc.org/article/pmc/pmc2478654",
+      "https://en.wikipedia.org/wiki/Omalizumab"
+    ]
+  },
+  {
+    "directed": true,
+    "graph": {
+      "_id": "DB00043_MESH_D000080223_1",
+      "disease": "Chronic idiopathic urticaria",
+      "disease_mesh": "MESH:D000080223",
+      "drug": "omalizumab",
+      "drug_mesh": "MESH:D000069444",
+      "drugbank": "DB:DB00043"
+    },
+    "links": [
+      {
+        "key": "decreases activity of",
+        "source": "MESH:D000069444",
+        "target": "GO:0019767"
+      },
+      {
+        "key": "part of",
+        "source": "GO:0019767",
+        "target": "UniProt:P01854"
+      },
+      {
+        "key": "expressed in",
+        "source": "UniProt:P01854",
+        "target": "CL:0000097"
+      },
+      {
+        "key": "expressed in",
+        "source": "UniProt:P01854",
+        "target": "CL:0000767"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "CL:0000097",
+        "target": "GO:0043303"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "CL:0000767",
+        "target": "GO:0002561"
+      },
+      {
+        "key": "caused by",
+        "source": "GO:0043303",
+        "target": "REACT:R-HSA-2454202"
+      },
+      {
+        "key": "caused by",
+        "source": "GO:0002561",
+        "target": "REACT:R-HSA-2454202"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "REACT:R-HSA-2454202",
+        "target": "GO:0002441"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "REACT:R-HSA-2454202",
+        "target": "GO:0002540"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0002441",
+        "target": "MESH:D000080223"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0002540",
+        "target": "MESH:D000080223"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:D000069444",
+        "label": "Drug",
+        "name": "omalizumab"
+      },
+      {
+        "id": "GO:0019767",
+        "label": "MolecularActivity",
+        "name": "IgE receptor activity"
+      },
+      {
+        "id": "UniProt:P01854",
+        "label": "Protein",
+        "name": "Immunoglobulin heavy constant epsilon"
+      },
+      {
+        "id": "CL:0000097",
+        "label": "Cell",
+        "name": "mast cell"
+      },
+      {
+        "id": "CL:0000767",
+        "label": "Cell",
+        "name": "basophill"
+      },
+      {
+        "id": "GO:0043303",
+        "label": "BiologicalProcess",
+        "name": "mast cell degranulation"
+      },
+      {
+        "id": "GO:0002561",
+        "label": "BiologicalProcess",
+        "name": "basophil degranulation"
+      },
+      {
+        "id": "REACT:R-HSA-2454202",
+        "label": "Pathway",
+        "name": "Allergen dependent IgE bound FCERI aggregation"
+      },
+      {
+        "id": "GO:0002540",
+        "label": "BiologicalProcess",
+        "name": "leukotriene production involved in inflammatory response"
+      },
+      {
+        "id": "GO:0002441",
+        "label": "BiologicalProcess",
+        "name": "histamine secretion involved in inflammatory response"
+      },
+      {
+        "id": "MESH:D000080223",
+        "label": "Disease",
+        "name": "Chronic idiopathic urticaria"
+      }
+    ],
+    "reference": [
+      "https://go.drugbank.com/drugs/DB00043",
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+      "https://en.wikipedia.org/wiki/Omalizumab"
+    ]
+  },
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+        "name": "epinephrine"
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+        "id": "GO:0042310",
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+        "name": "vasoconstriction"
+      },
+      {
+        "id": "UBERON:0001796",
+        "label": "GrossAnatomicalStructure",
+        "name": "Aqueous Humor"
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+      {
+        "id": "HP:0007906",
+        "label": "PhenotypicFeature",
+        "name": "Ocular Hypertension"
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+      {
+        "id": "MESH:D005902",
+        "label": "Disease",
+        "name": "Open-angle glaucoma"
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+        "id": "GO:0051899",
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+        "id": "GO:0019228",
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+        "name": "Sensory perception of pain"
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+    ]
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+      }
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+        "name": "Sodium channel protein type 10 subunit alpha"
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+        "label": "ChemicalSubstance",
+        "name": "Sodium"
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+        "name": "Voltage-gated sodium channel activity"
+      },
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+        "id": "GO:0051899",
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+        "name": "Membrane depolarization"
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+      {
+        "id": "GO:0019228",
+        "label": "BiologicalProcess",
+        "name": "Neuronal action potential"
+      },
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+        "id": "CL:0000198",
+        "label": "Cell",
+        "name": "Pain receptor cell"
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+      {
+        "id": "GO:0019233",
+        "label": "BiologicalProcess",
+        "name": "Sensory perception of pain"
+      },
+      {
+        "id": "MESH:D011537",
+        "label": "Drug",
+        "name": "Itching of skin"
+      }
+    ],
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+      "https://en.wikipedia.org/wiki/Benzocaine"
+    ]
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+        "target": "MESH:D014008"
+      }
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+        "name": "Sodium channel protein type 10 subunit alpha"
+      },
+      {
+        "id": "MESH:D012964",
+        "label": "ChemicalSubstance",
+        "name": "Sodium"
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+        "label": "BiologicalProcess",
+        "name": "Voltage-gated sodium channel activity"
+      },
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+        "id": "GO:0051899",
+        "label": "BiologicalProcess",
+        "name": "Membrane depolarization"
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+        "id": "GO:0019228",
+        "label": "BiologicalProcess",
+        "name": "Neuronal action potential"
+      },
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+        "label": "Cell",
+        "name": "Pain receptor cell"
+      },
+      {
+        "id": "GO:0019233",
+        "label": "BiologicalProcess",
+        "name": "Sensory perception of pain"
+      },
+      {
+        "id": "MESH:D014008",
+        "label": "Drug",
+        "name": "Tinea pedis"
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+      "https://en.wikipedia.org/wiki/Benzocaine"
+    ]
+  },
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+    "directed": true,
+    "graph": {
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+      "disease_mesh": "MESH:D008228",
+      "drug": "Pixantrone",
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+        "target": "MESH:D008228"
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+        "label": "Drug",
+        "name": "Pixantrone"
+      },
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+        "name": "DNA topoisomerase 2-alpha"
+      },
+      {
+        "id": "MESH:D018736",
+        "label": "ChemicalSubstance",
+        "name": "DNA adducts"
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+        "id": "GO:0006974",
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+        "name": "cellular response to DNA damage stimulus"
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+        "id": "GO:0030263",
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+        "name": "apoptotic chromosome condensation"
+      },
+      {
+        "id": "GO:0008219",
+        "label": "BiologicalProcess",
+        "name": "cell death"
+      },
+      {
+        "id": "CL:0001063",
+        "label": "Cell",
+        "name": "tumor cells"
+      },
+      {
+        "id": "MESH:D008228",
+        "label": "Disease",
+        "name": "Non-Hodgkin's lymphoma"
+      }
+    ],
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+      "https://en.wikipedia.org/wiki/Pixantrone"
+    ]
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+      "drug_mesh": "MESH:D004028",
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+        "key": "chemically similar to",
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+        "target": "MESH:D004967"
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+        "key": "increases activity of",
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+        "target": "REACT:R-HSA-9018519"
+      },
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+        "target": "HP:0030683"
+      },
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+        "target": "MESH:D059268"
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+        "label": "Protein",
+        "name": "Estrogen receptor alpha"
+      },
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+        "name": "Estrogen"
+      },
+      {
+        "id": "REACT:R-HSA-9018519",
+        "label": "Pathway",
+        "name": "Estrogen-dependent gene expression"
+      },
+      {
+        "id": "HP:0030683",
+        "label": "PhenotypicFeature",
+        "name": "Vaginitis"
+      },
+      {
+        "id": "MESH:D059268",
+        "label": "Disease",
+        "name": "Atrophic vaginitis"
+      }
+    ],
+    "reference": [
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+    ]
+  },
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+    "directed": true,
+    "graph": {
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+        "target": "MESH:D004414"
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+        "label": "Drug",
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+        "label": "Protein",
+        "name": "Estrogen receptor alpha"
+      },
+      {
+        "id": "MESH:D004967",
+        "label": "ChemicalSubstance",
+        "name": "Estrogen"
+      },
+      {
+        "id": "REACT:R-HSA-9018519",
+        "label": "Pathway",
+        "name": "Estrogen-dependent gene expression"
+      },
+      {
+        "id": "HP:0030016",
+        "label": "PhenotypicFeature",
+        "name": "Dyspareunia"
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+        "id": "MESH:D004414",
+        "label": "Disease",
+        "name": "Dyspareunia"
+      }
+    ],
+    "reference": [
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+    ]
+  },
+  {
+    "comment": "Polidocanol is a sclerosing agent indicated to treat uncomplicated spider veins. Sclerosing solutions cause the vein to scar, forcing blood to reroute through healthier veins. The collapsed vein is reabsorbed into local tissue and eventually fades (https://www.mayoclinic.org/tests-procedures/sclerotherapy/about/pac-20384592).",
+    "directed": true,
+    "graph": {
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+      "disease": "Venous varices",
+      "disease_mesh": "MESH:D014648",
+      "drug": "polidocanol",
+      "drug_mesh": "MESH:C008976",
+      "drugbank": "DB:DB06811"
+    },
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+        "target": "MESH:D012597"
+      },
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+        "source": "MESH:D012597",
+        "target": "HP:0100699"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "HP:0100699",
+        "target": "GO:0097709"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "GO:0097709",
+        "target": "HP:0002619"
+      },
+      {
+        "key": "manifestation of",
+        "source": "HP:0002619",
+        "target": "MESH:D014648"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:C008976",
+        "label": "Drug",
+        "name": "polidocanol"
+      },
+      {
+        "id": "MESH:D012597",
+        "label": "ChemicalSubstance",
+        "name": "Sclerosing Solutions"
+      },
+      {
+        "id": "HP:0100699",
+        "label": "PhenotypicFeature",
+        "name": "Scarring"
+      },
+      {
+        "id": "GO:0097709",
+        "label": "BiologicalProcess",
+        "name": "connective tissue replacement"
+      },
+      {
+        "id": "HP:0002619",
+        "label": "PhenotypicFeature",
+        "name": "Varicose veins"
+      },
+      {
+        "id": "MESH:D014648",
+        "label": "Disease",
+        "name": "Venous varices"
+      }
+    ],
+    "reference": [
+      "https://go.drugbank.com/drugs/DB06811",
+      "https://en.wikipedia.org/wiki/Polidocanol"
+    ]
+  },
+  {
+    "directed": true,
+    "graph": {
+      "_id": "DB11945_MESH_D015266_2",
+      "disease": "Merkel cell carcinoma",
+      "disease_mesh": "MESH:D015266",
+      "drug": "Avelumab",
+      "drug_mesh": "MESH:C000609138",
+      "drugbank": "DB:DB11945"
+    },
+    "links": [
+      {
+        "key": "decreases activity of",
+        "source": "MESH:C000609138",
+        "target": "UniProt:Q9NZQ7"
+      },
+      {
+        "key": "negatively regulates",
+        "source": "UniProt:Q9NZQ7",
+        "target": "GO:0042098"
+      },
+      {
+        "key": "negatively regulates",
+        "source": "UniProt:Q9NZQ7",
+        "target": "GO:0042110"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0042098",
+        "target": "GO:0002424"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "GO:0042110",
+        "target": "GO:0002424"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "GO:0002424",
+        "target": "MESH:D015266"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:C000609138",
+        "label": "Drug",
+        "name": "Avelumab"
+      },
+      {
+        "id": "UniProt:Q9NZQ7",
+        "label": "Protein",
+        "name": "Programmed cell death 1 ligand 1"
+      },
+      {
+        "id": "GO:0042098",
+        "label": "BiologicalProcess",
+        "name": "T cell proliferation"
+      },
+      {
+        "id": "GO:0042110",
+        "label": "BiologicalProcess",
+        "name": "T cell activation"
+      },
+      {
+        "id": "GO:0002424",
+        "label": "BiologicalProcess",
+        "name": "T cell mediated immune response to tumor cell"
+      },
+      {
+        "id": "MESH:D015266",
+        "label": "Disease",
+        "name": "Merkel cell carcinoma"
+      }
+    ],
+    "reference": [
+      "https://go.drugbank.com/drugs/DB11945",
+      "https://en.wikipedia.org/wiki/Avelumab"
+    ]
   }
 ]
\ No newline at end of file
diff --git a/indication_paths.yaml b/indication_paths.yaml
index 8fdd3bb19..67a2155f3 100644
--- a/indication_paths.yaml
+++ b/indication_paths.yaml
@@ -165900,3 +165900,1535 @@
     reference:
     - https://go.drugbank.com/drugs/DB08984
     - https://en.wikipedia.org/wiki/Etofenamate
+-   directed: true
+    graph:
+        _id: DB01182_MESH_D001281_1
+        disease: Paroxysmal atrial fibrillation
+        disease_mesh: MESH:D001281
+        drug: propafenone
+        drug_mesh: MESH:D011405
+        drugbank: DB:DB01182
+    links:
+    -   key: negatively regulates
+        source: MESH:D011405
+        target: InterPro:IPR001696
+    -   key: increases transport of
+        source: InterPro:IPR001696
+        target: MESH:D012964
+    -   key: positively regulates
+        source: MESH:D012964
+        target: GO:0086001
+    -   key: positively correlated with
+        source: GO:0086001
+        target: GO:0086003
+    -   key: positively correlated with
+        source: GO:0086003
+        target: HP:0004308
+    -   key: manifestation of
+        source: HP:0004308
+        target: MESH:D001281
+    multigraph: true
+    nodes:
+    -   id: MESH:D011405
+        label: Drug
+        name: propafenone
+    -   id: InterPro:IPR001696
+        label: GeneFamily
+        name: Voltage gated sodium channel, alpha subunit
+    -   id: MESH:D012964
+        label: ChemicalSubstance
+        name: Sodium
+    -   id: GO:0086001
+        label: BiologicalProcess
+        name: Cardiac muscle cell action potential
+    -   id: GO:0086003
+        label: BiologicalProcess
+        name: cardiac muscle cell contraction
+    -   id: HP:0004308
+        label: PhenotypicFeature
+        name: Ventricular arrhythmia
+    -   id: MESH:D001281
+        label: Disease
+        name: Paroxysmal atrial fibrillation
+    reference:
+    - https://go.drugbank.com/drugs/DB01182
+    - https://en.wikipedia.org/wiki/Propafenone
+-   directed: true
+    graph:
+        _id: DB01394_MESH_D006073_1
+        disease: Gout
+        disease_mesh: MESH:D006073
+        drug: colchicine
+        drug_mesh: MESH:D003078
+        drugbank: DB:DB01394
+    links:
+    -   key: decreases activity of
+        source: MESH:D003078
+        target: UniProt:P07437
+    -   key: positively regulates
+        source: UniProt:P07437
+        target: GO:0046785
+    -   key: positively regulates
+        source: GO:0046785
+        target: REACT:R-HSA-844456
+    -   key: positively regulates
+        source: GO:0046785
+        target: GO:0007266
+    -   key: positively regulates
+        source: REACT:R-HSA-844456
+        target: GO:0006919
+    -   key: positively regulates
+        source: GO:0007266
+        target: GO:0006919
+    -   key: increases abundance of
+        source: GO:0006919
+        target: UniProt:P01584
+    -   key: produced by
+        source: UniProt:P01584
+        target: CL:0000775
+    -   key: produced by
+        source: UniProt:P01584
+        target: CL:0000576
+    -   key: negatively regulates
+        source: MESH:D003078
+        target: GO:1990266
+    -   key: negatively regulates
+        source: MESH:D003078
+        target: GO:0016176
+    -   key: negatively regulates
+        source: MESH:D003078
+        target: GO:0030593
+    -   key: positively correlated with
+        source: GO:0030593
+        target: GO:0070942
+    -   key: positively correlated with
+        source: GO:1990266
+        target: GO:0070942
+    -   key: positively correlated with
+        source: GO:0016176
+        target: GO:0070942
+    -   key: caused by
+        source: GO:0070942
+        target: CL:0000775
+    -   key: participates in
+        source: CL:0000775
+        target: GO:0045087
+    -   key: participates in
+        source: CL:0000576
+        target: GO:0045087
+    -   key: positively correlated with
+        source: GO:0045087
+        target: GO:0006954
+    -   key: positively correlated with
+        source: GO:0006954
+        target: HP:0005059
+    -   key: manifestation of
+        source: HP:0005059
+        target: MESH:D006073
+    multigraph: true
+    nodes:
+    -   id: MESH:D003078
+        label: Drug
+        name: colchicine
+    -   id: UniProt:P07437
+        label: Protein
+        name: Tubulin beta chain
+    -   id: GO:1990266
+        label: BiologicalProcess
+        name: neutrophil migration
+    -   id: GO:0016176
+        label: MolecularActivity
+        name: superoxide-generating NADPH oxidase activator activity
+    -   id: GO:0030593
+        label: BiologicalProcess
+        name: neutrophil chemotaxis
+    -   id: GO:0007266
+        label: BiologicalProcess
+        name: Rho protein signal transduction
+    -   id: REACT:R-HSA-844456
+        label: Pathway
+        name: The NLRP3 inflammasome
+    -   id: GO:0046785
+        label: BiologicalProcess
+        name: Microtubule polymerization
+    -   id: CL:0000775
+        label: Cell
+        name: Neutrophil
+    -   id: CL:0000576
+        label: Cell
+        name: Monocyte
+    -   id: GO:0045087
+        label: BiologicalProcess
+        name: innate immune response
+    -   id: GO:0070942
+        label: BiologicalProcess
+        name: neutrophil mediated cytotoxicity
+    -   id: GO:0007266
+        label: BiologicalProcess
+        name: Rho protein signal transduction
+    -   id: GO:0006919
+        label: BiologicalProcess
+        name: activation of cysteine-type endopeptidase activity involved in apoptotic
+            process
+    -   id: UniProt:P01584
+        label: Protein
+        name: Interleukin-1 beta
+    -   id: GO:0006954
+        label: BiologicalProcess
+        name: inflammatory response
+    -   id: HP:0005059
+        label: PhenotypicFeature
+        name: Joint pain/Joint inflammation
+    -   id: MESH:D006073
+        label: Disease
+        name: Gout
+    reference:
+    - https://go.drugbank.com/drugs/DB01394
+    - https://en.wikipedia.org/wiki/Colchicine
+    - https://pubmed.ncbi.nlm.nih.gov/25151572/
+    - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656054/
+-   directed: true
+    graph:
+        _id: DB01394_MESH_D010505_1
+        disease: Familial Mediterranean fever
+        disease_mesh: MESH:D010505
+        drug: colchicine
+        drug_mesh: MESH:D003078
+        drugbank: DB:DB01394
+    links:
+    -   key: decreases activity of
+        source: MESH:D003078
+        target: UniProt:P07437
+    -   key: positively regulates
+        source: UniProt:P07437
+        target: GO:0046785
+    -   key: positively regulates
+        source: GO:0046785
+        target: REACT:R-HSA-844456
+    -   key: positively regulates
+        source: GO:0046785
+        target: GO:0007266
+    -   key: positively regulates
+        source: REACT:R-HSA-844456
+        target: GO:0006919
+    -   key: positively regulates
+        source: GO:0007266
+        target: GO:0006919
+    -   key: increases abundance of
+        source: GO:0006919
+        target: UniProt:P01584
+    -   key: produced by
+        source: UniProt:P01584
+        target: CL:0000775
+    -   key: produced by
+        source: UniProt:P01584
+        target: CL:0000576
+    -   key: negatively regulates
+        source: MESH:D003078
+        target: GO:1990266
+    -   key: negatively regulates
+        source: MESH:D003078
+        target: GO:0016176
+    -   key: negatively regulates
+        source: MESH:D003078
+        target: GO:0030593
+    -   key: positively correlated with
+        source: GO:0030593
+        target: GO:0070942
+    -   key: positively correlated with
+        source: GO:1990266
+        target: GO:0070942
+    -   key: positively correlated with
+        source: GO:0016176
+        target: GO:0070942
+    -   key: caused by
+        source: GO:0070942
+        target: CL:0000775
+    -   key: participates in
+        source: CL:0000775
+        target: GO:0045087
+    -   key: participates in
+        source: CL:0000576
+        target: GO:0045087
+    -   key: positively correlated with
+        source: GO:0045087
+        target: GO:0006954
+    -   key: manifestation of
+        source: GO:0006954
+        target: MESH:D010505
+    multigraph: true
+    nodes:
+    -   id: MESH:D003078
+        label: Drug
+        name: colchicine
+    -   id: UniProt:P07437
+        label: Protein
+        name: Tubulin beta chain
+    -   id: GO:1990266
+        label: BiologicalProcess
+        name: neutrophil migration
+    -   id: GO:0016176
+        label: MolecularActivity
+        name: superoxide-generating NADPH oxidase activator activity
+    -   id: GO:0030593
+        label: BiologicalProcess
+        name: neutrophil chemotaxis
+    -   id: GO:0007266
+        label: BiologicalProcess
+        name: Rho protein signal transduction
+    -   id: REACT:R-HSA-844456
+        label: Pathway
+        name: The NLRP3 inflammasome
+    -   id: GO:0046785
+        label: BiologicalProcess
+        name: Microtubule polymerization
+    -   id: CL:0000775
+        label: Cell
+        name: Neutrophil
+    -   id: CL:0000576
+        label: Cell
+        name: Monocyte
+    -   id: GO:0045087
+        label: BiologicalProcess
+        name: innate immune response
+    -   id: GO:0070942
+        label: BiologicalProcess
+        name: neutrophil mediated cytotoxicity
+    -   id: GO:0007266
+        label: BiologicalProcess
+        name: Rho protein signal transduction
+    -   id: GO:0006919
+        label: BiologicalProcess
+        name: activation of cysteine-type endopeptidase activity involved in apoptotic
+            process
+    -   id: UniProt:P01584
+        label: Protein
+        name: Interleukin-1 beta
+    -   id: GO:0006954
+        label: BiologicalProcess
+        name: inflammatory response
+    -   id: MESH:D010505
+        label: Disease
+        name: Familial Mediterranean fever
+    reference:
+    - https://go.drugbank.com/drugs/DB01394
+    - https://en.wikipedia.org/wiki/Colchicine
+    - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656054/
+-   directed: true
+    graph:
+        _id: DB00043_MESH_D001249_1
+        disease: Asthma
+        disease_mesh: MESH:D001249
+        drug: omalizumab
+        drug_mesh: MESH:D000069444
+        drugbank: DB:DB00043
+    links:
+    -   key: decreases activity of
+        source: MESH:D000069444
+        target: GO:0019767
+    -   key: part of
+        source: GO:0019767
+        target: UniProt:P01854
+    -   key: expressed in
+        source: UniProt:P01854
+        target: CL:0000097
+    -   key: expressed in
+        source: UniProt:P01854
+        target: CL:0000767
+    -   key: positively correlated with
+        source: CL:0000097
+        target: GO:0043303
+    -   key: positively correlated with
+        source: CL:0000767
+        target: GO:0002561
+    -   key: caused by
+        source: GO:0043303
+        target: REACT:R-HSA-2454202
+    -   key: caused by
+        source: GO:0002561
+        target: REACT:R-HSA-2454202
+    -   key: positively correlated with
+        source: REACT:R-HSA-2454202
+        target: GO:0002441
+    -   key: positively correlated with
+        source: REACT:R-HSA-2454202
+        target: GO:0002540
+    -   key: positively correlated with
+        source: GO:0002441
+        target: MESH:D001249
+    -   key: positively correlated with
+        source: GO:0002540
+        target: MESH:D001249
+    multigraph: true
+    nodes:
+    -   id: MESH:D000069444
+        label: Drug
+        name: omalizumab
+    -   id: GO:0019767
+        label: MolecularActivity
+        name: IgE receptor activity
+    -   id: UniProt:P01854
+        label: Protein
+        name: Immunoglobulin heavy constant epsilon
+    -   id: CL:0000097
+        label: Cell
+        name: mast cell
+    -   id: CL:0000767
+        label: Cell
+        name: basophill
+    -   id: GO:0043303
+        label: BiologicalProcess
+        name: mast cell degranulation
+    -   id: GO:0002561
+        label: BiologicalProcess
+        name: basophil degranulation
+    -   id: REACT:R-HSA-2454202
+        label: Pathway
+        name: Allergen dependent IgE bound FCERI aggregation
+    -   id: GO:0002540
+        label: BiologicalProcess
+        name: leukotriene production involved in inflammatory response
+    -   id: GO:0002441
+        label: BiologicalProcess
+        name: histamine secretion involved in inflammatory response
+    -   id: MESH:D001249
+        label: Disease
+        name: Asthma
+    reference:
+    - https://go.drugbank.com/drugs/DB00043
+    - https://europepmc.org/article/pmc/pmc2478654
+    - https://en.wikipedia.org/wiki/Omalizumab
+-   directed: true
+    graph:
+        _id: DB00043_MESH_D000080223_1
+        disease: Chronic idiopathic urticaria
+        disease_mesh: MESH:D000080223
+        drug: omalizumab
+        drug_mesh: MESH:D000069444
+        drugbank: DB:DB00043
+    links:
+    -   key: decreases activity of
+        source: MESH:D000069444
+        target: GO:0019767
+    -   key: part of
+        source: GO:0019767
+        target: UniProt:P01854
+    -   key: expressed in
+        source: UniProt:P01854
+        target: CL:0000097
+    -   key: expressed in
+        source: UniProt:P01854
+        target: CL:0000767
+    -   key: positively correlated with
+        source: CL:0000097
+        target: GO:0043303
+    -   key: positively correlated with
+        source: CL:0000767
+        target: GO:0002561
+    -   key: caused by
+        source: GO:0043303
+        target: REACT:R-HSA-2454202
+    -   key: caused by
+        source: GO:0002561
+        target: REACT:R-HSA-2454202
+    -   key: positively correlated with
+        source: REACT:R-HSA-2454202
+        target: GO:0002441
+    -   key: positively correlated with
+        source: REACT:R-HSA-2454202
+        target: GO:0002540
+    -   key: positively correlated with
+        source: GO:0002441
+        target: MESH:D000080223
+    -   key: positively correlated with
+        source: GO:0002540
+        target: MESH:D000080223
+    multigraph: true
+    nodes:
+    -   id: MESH:D000069444
+        label: Drug
+        name: omalizumab
+    -   id: GO:0019767
+        label: MolecularActivity
+        name: IgE receptor activity
+    -   id: UniProt:P01854
+        label: Protein
+        name: Immunoglobulin heavy constant epsilon
+    -   id: CL:0000097
+        label: Cell
+        name: mast cell
+    -   id: CL:0000767
+        label: Cell
+        name: basophill
+    -   id: GO:0043303
+        label: BiologicalProcess
+        name: mast cell degranulation
+    -   id: GO:0002561
+        label: BiologicalProcess
+        name: basophil degranulation
+    -   id: REACT:R-HSA-2454202
+        label: Pathway
+        name: Allergen dependent IgE bound FCERI aggregation
+    -   id: GO:0002540
+        label: BiologicalProcess
+        name: leukotriene production involved in inflammatory response
+    -   id: GO:0002441
+        label: BiologicalProcess
+        name: histamine secretion involved in inflammatory response
+    -   id: MESH:D000080223
+        label: Disease
+        name: Chronic idiopathic urticaria
+    reference:
+    - https://go.drugbank.com/drugs/DB00043
+    - https://europepmc.org/article/pmc/pmc2478654
+    - https://en.wikipedia.org/wiki/Omalizumab
+-   directed: true
+    graph:
+        _id: DB00179_MESH_D055623_1
+        disease: Actinic keratosis
+        disease_mesh: MESH:D055623
+        drug: masoprocol
+        drug_mesh: MESH:D009637
+        drugbank: DB:DB00179
+    links:
+    -   key: decreases activity of
+        source: MESH:D009637
+        target: UniProt:P42345
+    -   key: positively regulates
+        source: UniProt:P42345
+        target: REACT:R-HSA-166208
+    -   key: positively correlated with
+        source: REACT:R-HSA-166208
+        target: HP:0031377
+    -   key: causes
+        source: HP:0031377
+        target: MESH:D055623
+    multigraph: true
+    nodes:
+    -   id: MESH:D009637
+        label: Drug
+        name: masoprocol
+    -   id: UniProt:P42345
+        label: Protein
+        name: Serine/threonine-protein kinase mTOR
+    -   id: REACT:R-HSA-166208
+        label: Pathway
+        name: mTORC1-mediated signalling
+    -   id: HP:0031377
+        label: PhenotypicFeature
+        name: Abnormal cell proliferation
+    -   id: MESH:D055623
+        label: Disease
+        name: Actinic keratosis
+    reference:
+    - https://go.drugbank.com/drugs/DB00179
+    - http://europepmc.org/article/MED/23053656
+-   directed: true
+    graph:
+        _id: DB00341_MESH_D065631_1
+        disease: Allergic rhinitis
+        disease_mesh: MESH:D065631
+        drug: cetirizine
+        drug_mesh: MESH:D017332
+        drugbank: DB:DB00341
+    links:
+    -   key: decreases activity of
+        source: MESH:D017332
+        target: UniProt:P35367
+    -   key: positively regulates
+        source: UniProt:P35367
+        target: GO:0004969
+    -   key: participates in
+        source: GO:0004969
+        target: GO:0071420
+    -   key: positively correlated with
+        source: GO:0071420
+        target: GO:0006954
+    -   key: has phenotype
+        source: GO:0006954
+        target: HP:0031417
+    -   key: manifestation of
+        source: HP:0031417
+        target: MESH:D065631
+    multigraph: true
+    nodes:
+    -   id: MESH:D017332
+        label: Drug
+        name: cetirizine
+    -   id: UniProt:P35367
+        label: Protein
+        name: Histamine H1 receptor
+    -   id: GO:0004969
+        label: MolecularActivity
+        name: Histamine receptor activity
+    -   id: GO:0071420
+        label: BiologicalProcess
+        name: Cellular response to histamine
+    -   id: GO:0006954
+        label: BiologicalProcess
+        name: Inflammatory response
+    -   id: HP:0031417
+        label: PhenotypicFeature
+        name: Rhinorrhea
+    -   id: MESH:D065631
+        label: Disease
+        name: Allergic rhinitis
+    reference:
+    - https://go.drugbank.com/drugs/DB00341
+    - https://en.wikipedia.org/wiki/Cetirizine
+-   directed: true
+    graph:
+        _id: DB00341_MESH_D012912_1
+        disease: Sneezing
+        disease_mesh: MESH:D012912
+        drug: cetirizine
+        drug_mesh: MESH:D017332
+        drugbank: DB:DB00341
+    links:
+    -   key: decreases activity of
+        source: MESH:D017332
+        target: UniProt:P35367
+    -   key: participates in
+        source: UniProt:P35367
+        target: GO:0051381
+    -   key: positively regulates
+        source: GO:0051381
+        target: GO:0023041
+    -   key: located in
+        source: GO:0023041
+        target: UBERON:0000004
+    -   key: affected by
+        source: UBERON:0000004
+        target: UBERON:0001645
+    -   key: contributes to
+        source: UBERON:0001645
+        target: MESH:D012912
+    multigraph: true
+    nodes:
+    -   id: MESH:D017332
+        label: Drug
+        name: cetirizine
+    -   id: UniProt:P35367
+        label: Protein
+        name: Histamine H1 receptor
+    -   id: GO:0051381
+        label: MolecularActivity
+        name: Histamine binding
+    -   id: GO:0023041
+        label: BiologicalProcess
+        name: Neuronal signal transduction
+    -   id: UBERON:0000004
+        label: GrossAnatomicalStructure
+        name: Nose
+    -   alt_ids: MESH:D014276
+        id: UBERON:0001645
+        label: GrossAnatomicalStructure
+        name: Trigeminal nerve
+    -   id: MESH:D012912
+        label: Disease
+        name: Sneezing
+    reference:
+    - https://go.drugbank.com/drugs/DB00341
+    - https://en.wikipedia.org/wiki/Cetirizine
+-   directed: true
+    graph:
+        _id: DB00341_MESH_D012223_1
+        disease: Vasomotor rhinitis
+        disease_mesh: MESH:D012223
+        drug: cetirizine
+        drug_mesh: MESH:D017332
+        drugbank: DB:DB00341
+    links:
+    -   key: decreases activity of
+        source: MESH:D017332
+        target: UniProt:P35367
+    -   key: positively regulates
+        source: UniProt:P35367
+        target: GO:0004969
+    -   key: participates in
+        source: GO:0004969
+        target: GO:0071420
+    -   key: positively correlated with
+        source: GO:0071420
+        target: GO:0006954
+    -   key: has phenotype
+        source: GO:0006954
+        target: HP:0031417
+    -   key: manifestation of
+        source: HP:0031417
+        target: MESH:D012223
+    multigraph: true
+    nodes:
+    -   id: MESH:D017332
+        label: Drug
+        name: cetirizine
+    -   id: UniProt:P35367
+        label: Protein
+        name: Histamine H1 receptor
+    -   id: GO:0004969
+        label: MolecularActivity
+        name: Histamine receptor activity
+    -   id: GO:0071420
+        label: BiologicalProcess
+        name: Cellular response to histamine
+    -   id: GO:0006954
+        label: BiologicalProcess
+        name: Inflammatory response
+    -   id: HP:0031417
+        label: PhenotypicFeature
+        name: Rhinorrhea
+    -   id: MESH:D012223
+        label: Disease
+        name: Vasomotor rhinitis
+    reference:
+    - https://go.drugbank.com/drugs/DB00341
+    - https://en.wikipedia.org/wiki/Cetirizine
+-   directed: true
+    graph:
+        _id: DB00341_MESH_D000080223_1
+        disease: Chronic idiopathic urticaria
+        disease_mesh: MESH:D000080223
+        drug: cetirizine
+        drug_mesh: MESH:D017332
+        drugbank: DB:DB00341
+    links:
+    -   key: decreases activity of
+        source: MESH:D017332
+        target: UniProt:P35367
+    -   key: positively regulates
+        source: UniProt:P35367
+        target: GO:0004969
+    -   key: participates in
+        source: GO:0004969
+        target: GO:0071420
+    -   key: positively correlated with
+        source: GO:0071420
+        target: GO:0006954
+    -   key: positively correlated with
+        source: GO:0071420
+        target: GO:0043117
+    -   key: positively correlated with
+        source: GO:0071420
+        target: HP:0000969
+    -   key: manifestation of
+        source: HP:0000969
+        target: MESH:D000080223
+    -   key: manifestation of
+        source: GO:0043117
+        target: MESH:D000080223
+    -   key: causes
+        source: GO:0006954
+        target: MESH:D000080223
+    multigraph: true
+    nodes:
+    -   id: MESH:D017332
+        label: Drug
+        name: cetirizine
+    -   id: UniProt:P35367
+        label: Protein
+        name: Histamine H1 receptor
+    -   id: GO:0004969
+        label: MolecularActivity
+        name: Histamine receptor activity
+    -   id: GO:0071420
+        label: BiologicalProcess
+        name: Cellular response to histamine
+    -   id: GO:0006954
+        label: BiologicalProcess
+        name: Inflammatory response
+    -   id: GO:0043117
+        label: BiologicalProcess
+        name: Positive regulation of vascular permeability
+    -   id: HP:0000969
+        label: PhenotypicFeature
+        name: Edema
+    -   id: MESH:D000080223
+        label: Disease
+        name: Chronic idiopathic urticaria
+    reference:
+    - https://go.drugbank.com/drugs/DB00341
+    - https://en.wikipedia.org/wiki/Cetirizine
+-   directed: true
+    graph:
+        _id: DB00341_MESH_D003139_1
+        disease: Common cold
+        disease_mesh: MESH:D003139
+        drug: cetirizine
+        drug_mesh: MESH:D017332
+        drugbank: DB:DB00341
+    links:
+    -   key: decreases activity of
+        source: MESH:D017332
+        target: UniProt:P35367
+    -   key: positively regulates
+        source: UniProt:P35367
+        target: GO:0004969
+    -   key: participates in
+        source: GO:0004969
+        target: GO:0071420
+    -   key: positively correlated with
+        source: GO:0071420
+        target: GO:0006954
+    -   key: caused by
+        source: GO:0006954
+        target: NCBITaxon:10239
+    -   key: causes
+        source: NCBITaxon:10239
+        target: MESH:D003139
+    multigraph: true
+    nodes:
+    -   id: MESH:D017332
+        label: Drug
+        name: cetirizine
+    -   id: UniProt:P35367
+        label: Protein
+        name: Histamine H1 receptor
+    -   id: GO:0004969
+        label: MolecularActivity
+        name: Histamine receptor activity
+    -   id: GO:0071420
+        label: BiologicalProcess
+        name: Cellular response to histamine
+    -   id: GO:0006954
+        label: BiologicalProcess
+        name: Inflammatory response
+    -   id: NCBITaxon:10239
+        label: OrganismTaxon
+        name: Viruses
+    -   id: MESH:D003139
+        label: Disease
+        name: Common cold
+    reference:
+    - https://go.drugbank.com/drugs/DB00341
+    - https://en.wikipedia.org/wiki/Cetirizine
+-   directed: true
+    graph:
+        _id: DB00341_MESH_D006255_1
+        disease: Seasonal allergic rhinitis
+        disease_mesh: MESH:D006255
+        drug: cetirizine
+        drug_mesh: MESH:D017332
+        drugbank: DB:DB00341
+    links:
+    -   key: decreases activity of
+        source: MESH:D017332
+        target: UniProt:P35367
+    -   key: positively regulates
+        source: UniProt:P35367
+        target: GO:0004969
+    -   key: participates in
+        source: GO:0004969
+        target: GO:0071420
+    -   key: positively correlated with
+        source: GO:0071420
+        target: GO:0006954
+    -   key: has phenotype
+        source: GO:0006954
+        target: HP:0031417
+    -   key: manifestation of
+        source: HP:0031417
+        target: MESH:D006255
+    multigraph: true
+    nodes:
+    -   id: MESH:D017332
+        label: Drug
+        name: cetirizine
+    -   id: UniProt:P35367
+        label: Protein
+        name: Histamine H1 receptor
+    -   id: GO:0004969
+        label: MolecularActivity
+        name: Histamine receptor activity
+    -   id: GO:0071420
+        label: BiologicalProcess
+        name: Cellular response to histamine
+    -   id: GO:0006954
+        label: BiologicalProcess
+        name: Inflammatory response
+    -   id: HP:0031417
+        label: PhenotypicFeature
+        name: Rhinorrhea
+    -   id: MESH:D006255
+        label: Disease
+        name: Seasonal allergic rhinitis
+    reference:
+    - https://go.drugbank.com/drugs/DB00341
+    - https://en.wikipedia.org/wiki/Cetirizine
+-   directed: true
+    graph:
+        _id: DB00341_MESH_D003233_1
+        disease: Allergic conjunctivitis
+        disease_mesh: MESH:D003233
+        drug: cetirizine
+        drug_mesh: MESH:D017332
+        drugbank: DB:DB00341
+    links:
+    -   key: decreases activity of
+        source: MESH:D017332
+        target: UniProt:P35367
+    -   key: positively regulates
+        source: UniProt:P35367
+        target: GO:0004969
+    -   key: participates in
+        source: GO:0004969
+        target: GO:0071420
+    -   key: positively correlated with
+        source: GO:0071420
+        target: GO:0006954
+    -   key: causes
+        source: GO:0006954
+        target: MESH:D003233
+    multigraph: true
+    nodes:
+    -   id: MESH:D017332
+        label: Drug
+        name: cetirizine
+    -   id: UniProt:P35367
+        label: Protein
+        name: Histamine H1 receptor
+    -   id: GO:0004969
+        label: MolecularActivity
+        name: Histamine receptor activity
+    -   id: GO:0071420
+        label: BiologicalProcess
+        name: Cellular response to histamine
+    -   id: GO:0006954
+        label: BiologicalProcess
+        name: Inflammatory response
+    -   id: MESH:D003233
+        label: Disease
+        name: Allergic conjunctivitis
+    reference:
+    - https://go.drugbank.com/drugs/DB00341
+    - https://en.wikipedia.org/wiki/Cetirizine
+-   comment: Dipivefrin is a prodrug with little or no pharmacologically activity
+        until it is hydrolyzed into epinephrine inside the human eye.
+    directed: true
+    graph:
+        _id: DB00449_MESH_D005902_1
+        disease: Open-angle glaucoma
+        disease_mesh: MESH:D005902
+        drug: dipivefrine
+        drug_mesh: MESH:C015173
+        drugbank: DB:DB00449
+    links:
+    -   key: has metabolite
+        source: MESH:C015173
+        target: MESH:D004837
+    -   key: increases activity of
+        source: MESH:D004837
+        target: InterPro:IPR002233
+    -   key: participates in
+        source: InterPro:IPR002233
+        target: GO:0004935
+    -   key: positively regulates
+        source: GO:0004935
+        target: GO:0042310
+    -   key: negatively correlated with
+        source: GO:0042310
+        target: UBERON:0001796
+    -   key: positively correlated with
+        source: UBERON:0001796
+        target: HP:0007906
+    -   key: positively correlated with
+        source: HP:0007906
+        target: MESH:D005902
+    multigraph: true
+    nodes:
+    -   id: MESH:C015173
+        label: Drug
+        name: dipivefrine
+    -   id: MESH:D004837
+        label: ChemicalSubstance
+        name: epinephrine
+    -   id: InterPro:IPR002233
+        label: GeneFamily
+        name: Adrenoceptor family
+    -   id: GO:0004935
+        label: MolecularActivity
+        name: adrenergic receptor activity
+    -   id: GO:0042310
+        label: BiologicalProcess
+        name: vasoconstriction
+    -   id: UBERON:0001796
+        label: GrossAnatomicalStructure
+        name: Aqueous Humor
+    -   id: HP:0007906
+        label: PhenotypicFeature
+        name: Ocular Hypertension
+    -   id: MESH:D005902
+        label: Disease
+        name: Open-angle glaucoma
+    reference:
+    - https://go.drugbank.com/drugs/DB00449
+    - https://en.wikipedia.org/wiki/Dipivefrine
+-   comments: Oxcarbazepine is a prodrug, which is largely metabolised to its pharmacologically
+        active 10-monohydroxy derivative licarbazepine (sometimes abbreviated MHD).
+    directed: true
+    graph:
+        _id: DB00776_MESH_D004828_1
+        disease: Localization-related epilepsy
+        disease_mesh: MESH:D004828
+        drug: oxcarbazepine
+        drug_mesh: MESH:C036006
+        drugbank: DB:DB00776
+    links:
+    -   key: has metabolite
+        source: MESH:C036006
+        target: CHEBI:701
+    -   key: decreases activity of
+        source: CHEBI:701
+        target: MESH:D061566
+    -   key: positively regulates
+        source: MESH:D061566
+        target: GO:0035725
+    -   key: positively regulates
+        source: GO:0035725
+        target: GO:0019228
+    -   key: positively correlated with
+        source: GO:0019228
+        target: HP:0011097
+    -   key: positively correlated with
+        source: HP:0011097
+        target: MESH:D004828
+    multigraph: true
+    nodes:
+    -   id: MESH:C036006
+        label: Drug
+        name: oxcarbazepine
+    -   id: CHEBI:701
+        label: ChemicalSubstance
+        name: licarbazepine
+    -   id: MESH:D061566
+        label: GeneFamily
+        name: Voltage-Gated Sodium Channels
+    -   id: GO:0035725
+        label: BiologicalProcess
+        name: sodium ion transmembrane transport
+    -   id: GO:0019228
+        label: BiologicalProcess
+        name: neuronal action potential
+    -   id: HP:0011097
+        label: PhenotypicFeature
+        name: Epileptic spasm
+    -   id: MESH:D004828
+        label: Disease
+        name: Localization-related epilepsy
+    reference:
+    - https://go.drugbank.com/drugs/DB00776
+    - https://en.wikipedia.org/wiki/Oxcarbazepine
+-   directed: true
+    graph:
+        _id: DB01086_MESH_D010612_1
+        disease: Sore throat symptom
+        disease_mesh: MESH:D010612
+        drug: benzocaine
+        drug_mesh: MESH:D001566
+        drugbank: DB:DB01086
+    links:
+    -   key: decreases activity of
+        source: MESH:D001566
+        target: UniProt:Q9Y5Y9
+    -   key: participates in
+        source: UniProt:Q9Y5Y9
+        target: GO:0005248
+    -   key: increases transport of
+        source: GO:0005248
+        target: MESH:D012964
+    -   key: positively correlated with
+        source: MESH:D012964
+        target: GO:0051899
+    -   key: positively regulates
+        source: GO:0051899
+        target: GO:0019228
+    -   key: occurs in
+        source: GO:0019228
+        target: CL:0000198
+    -   key: participates in
+        source: CL:0000198
+        target: GO:0019233
+    -   key: occurs in
+        source: GO:0019233
+        target: MESH:D010612
+    multigraph: true
+    nodes:
+    -   id: MESH:D001566
+        label: Drug
+        name: benzocaine
+    -   id: UniProt:Q9Y5Y9
+        label: Protein
+        name: Sodium channel protein type 10 subunit alpha
+    -   id: MESH:D012964
+        label: ChemicalSubstance
+        name: Sodium
+    -   id: GO:0005248
+        label: BiologicalProcess
+        name: Voltage-gated sodium channel activity
+    -   id: GO:0051899
+        label: BiologicalProcess
+        name: Membrane depolarization
+    -   id: GO:0019228
+        label: BiologicalProcess
+        name: Neuronal action potential
+    -   id: CL:0000198
+        label: Cell
+        name: Pain receptor cell
+    -   id: GO:0019233
+        label: BiologicalProcess
+        name: Sensory perception of pain
+    -   id: MESH:D010612
+        label: Drug
+        name: Sore throat symptom
+    reference:
+    - https://go.drugbank.com/drugs/DB01086
+    - https://en.wikipedia.org/wiki/Benzocaine
+-   directed: true
+    graph:
+        _id: DB01086_MESH_D003371_1
+        disease: Cough
+        disease_mesh: MESH:D003371
+        drug: benzocaine
+        drug_mesh: MESH:D001566
+        drugbank: DB:DB01086
+    links:
+    -   key: decreases activity of
+        source: MESH:D001566
+        target: UniProt:Q9Y5Y9
+    -   key: participates in
+        source: UniProt:Q9Y5Y9
+        target: GO:0005248
+    -   key: increases transport of
+        source: GO:0005248
+        target: MESH:D012964
+    -   key: positively correlated with
+        source: MESH:D012964
+        target: GO:0051899
+    -   key: positively regulates
+        source: GO:0051899
+        target: GO:0019228
+    -   key: occurs in
+        source: GO:0019228
+        target: CL:0000198
+    -   key: participates in
+        source: CL:0000198
+        target: GO:0019233
+    -   key: occurs in
+        source: GO:0019233
+        target: MESH:D003371
+    multigraph: true
+    nodes:
+    -   id: MESH:D001566
+        label: Drug
+        name: benzocaine
+    -   id: UniProt:Q9Y5Y9
+        label: Protein
+        name: Sodium channel protein type 10 subunit alpha
+    -   id: MESH:D012964
+        label: ChemicalSubstance
+        name: Sodium
+    -   id: GO:0005248
+        label: BiologicalProcess
+        name: Voltage-gated sodium channel activity
+    -   id: GO:0051899
+        label: BiologicalProcess
+        name: Membrane depolarization
+    -   id: GO:0019228
+        label: BiologicalProcess
+        name: Neuronal action potential
+    -   id: CL:0000198
+        label: Cell
+        name: Pain receptor cell
+    -   id: GO:0019233
+        label: BiologicalProcess
+        name: Sensory perception of pain
+    -   id: MESH:D003371
+        label: Drug
+        name: Cough
+    reference:
+    - https://go.drugbank.com/drugs/DB01086
+    - https://en.wikipedia.org/wiki/Benzocaine
+-   directed: true
+    graph:
+        _id: DB01086_MESH_D011537_1
+        disease: Itching of skin
+        disease_mesh: MESH:D011537
+        drug: benzocaine
+        drug_mesh: MESH:D001566
+        drugbank: DB:DB01086
+    links:
+    -   key: decreases activity of
+        source: MESH:D001566
+        target: UniProt:Q9Y5Y9
+    -   key: participates in
+        source: UniProt:Q9Y5Y9
+        target: GO:0005248
+    -   key: increases transport of
+        source: GO:0005248
+        target: MESH:D012964
+    -   key: positively correlated with
+        source: MESH:D012964
+        target: GO:0051899
+    -   key: positively regulates
+        source: GO:0051899
+        target: GO:0019228
+    -   key: occurs in
+        source: GO:0019228
+        target: CL:0000198
+    -   key: participates in
+        source: CL:0000198
+        target: GO:0019233
+    -   key: manifestation of
+        source: GO:0019233
+        target: MESH:D011537
+    multigraph: true
+    nodes:
+    -   id: MESH:D001566
+        label: Drug
+        name: benzocaine
+    -   id: UniProt:Q9Y5Y9
+        label: Protein
+        name: Sodium channel protein type 10 subunit alpha
+    -   id: MESH:D012964
+        label: ChemicalSubstance
+        name: Sodium
+    -   id: GO:0005248
+        label: BiologicalProcess
+        name: Voltage-gated sodium channel activity
+    -   id: GO:0051899
+        label: BiologicalProcess
+        name: Membrane depolarization
+    -   id: GO:0019228
+        label: BiologicalProcess
+        name: Neuronal action potential
+    -   id: CL:0000198
+        label: Cell
+        name: Pain receptor cell
+    -   id: GO:0019233
+        label: BiologicalProcess
+        name: Sensory perception of pain
+    -   id: MESH:D011537
+        label: Drug
+        name: Itching of skin
+    reference:
+    - https://go.drugbank.com/drugs/DB01086
+    - https://en.wikipedia.org/wiki/Benzocaine
+-   directed: true
+    graph:
+        _id: DB01086_MESH_D014008_1
+        disease: Tinea pedis
+        disease_mesh: MESH:D014008
+        drug: benzocaine
+        drug_mesh: MESH:D001566
+        drugbank: DB:DB01086
+    links:
+    -   key: decreases activity of
+        source: MESH:D001566
+        target: UniProt:Q9Y5Y9
+    -   key: participates in
+        source: UniProt:Q9Y5Y9
+        target: GO:0005248
+    -   key: increases transport of
+        source: GO:0005248
+        target: MESH:D012964
+    -   key: positively correlated with
+        source: MESH:D012964
+        target: GO:0051899
+    -   key: positively regulates
+        source: GO:0051899
+        target: GO:0019228
+    -   key: occurs in
+        source: GO:0019228
+        target: CL:0000198
+    -   key: participates in
+        source: CL:0000198
+        target: GO:0019233
+    -   key: occurs in
+        source: GO:0019233
+        target: MESH:D014008
+    multigraph: true
+    nodes:
+    -   id: MESH:D001566
+        label: Drug
+        name: benzocaine
+    -   id: UniProt:Q9Y5Y9
+        label: Protein
+        name: Sodium channel protein type 10 subunit alpha
+    -   id: MESH:D012964
+        label: ChemicalSubstance
+        name: Sodium
+    -   id: GO:0005248
+        label: BiologicalProcess
+        name: Voltage-gated sodium channel activity
+    -   id: GO:0051899
+        label: BiologicalProcess
+        name: Membrane depolarization
+    -   id: GO:0019228
+        label: BiologicalProcess
+        name: Neuronal action potential
+    -   id: CL:0000198
+        label: Cell
+        name: Pain receptor cell
+    -   id: GO:0019233
+        label: BiologicalProcess
+        name: Sensory perception of pain
+    -   id: MESH:D014008
+        label: Drug
+        name: Tinea pedis
+    reference:
+    - https://go.drugbank.com/drugs/DB01086
+    - https://en.wikipedia.org/wiki/Benzocaine
+-   comment: pixantrone has not yet received FDA approval in the United States, it
+        has been granted conditional marketing approval by the European Union.
+    directed: true
+    graph:
+        _id: DB06193_MESH_D008228_1
+        disease: Non-Hodgkin's lymphoma
+        disease_mesh: MESH:D008228
+        drug: Pixantrone
+        drug_mesh: MESH:C086548
+        drugbank: DB:DB06193
+    links:
+    -   key: increases abundance of
+        source: MESH:C086548
+        target: MESH:D018736
+    -   key: decreases activity of
+        source: MESH:D018736
+        target: UniProt:P11388
+    -   key: positively regulates
+        source: UniProt:P11388
+        target: GO:0006974
+    -   key: positively regulates
+        source: GO:0006974
+        target: GO:0030263
+    -   key: positively correlated with
+        source: GO:0030263
+        target: GO:0008219
+    -   key: decreases abundance of
+        source: GO:0008219
+        target: CL:0001063
+    -   key: manifestation of
+        source: CL:0001063
+        target: MESH:D008228
+    multigraph: true
+    nodes:
+    -   id: MESH:C086548
+        label: Drug
+        name: Pixantrone
+    -   id: UniProt:P11388
+        label: Protein
+        name: DNA topoisomerase 2-alpha
+    -   id: MESH:D018736
+        label: ChemicalSubstance
+        name: DNA adducts
+    -   id: GO:0006974
+        label: BiologicalProcess
+        name: cellular response to DNA damage stimulus
+    -   id: GO:0030263
+        label: BiologicalProcess
+        name: apoptotic chromosome condensation
+    -   id: GO:0008219
+        label: BiologicalProcess
+        name: cell death
+    -   id: CL:0001063
+        label: Cell
+        name: tumor cells
+    -   id: MESH:D008228
+        label: Disease
+        name: Non-Hodgkin's lymphoma
+    reference:
+    - https://go.drugbank.com/drugs/DB06193
+    - https://en.wikipedia.org/wiki/Pixantrone
+-   directed: true
+    graph:
+        _id: DB00890_MESH_D059268_1
+        disease: Atrophic vaginitis
+        disease_mesh: MESH:D059268
+        drug: dienestrol
+        drug_mesh: MESH:D004028
+        drugbank: DB:DB00890
+    links:
+    -   key: chemically similar to
+        source: MESH:D004028
+        target: MESH:D004967
+    -   key: increases activity of
+        source: MESH:D004967
+        target: UniProt:P03372
+    -   key: positively regulates
+        source: UniProt:P03372
+        target: REACT:R-HSA-9018519
+    -   key: negatively correlated with
+        source: REACT:R-HSA-9018519
+        target: HP:0030683
+    -   key: manifestation of
+        source: HP:0030683
+        target: MESH:D059268
+    multigraph: true
+    nodes:
+    -   id: MESH:D004028
+        label: Drug
+        name: dienestrol
+    -   id: UniProt:P03372
+        label: Protein
+        name: Estrogen receptor alpha
+    -   id: MESH:D004967
+        label: ChemicalSubstance
+        name: Estrogen
+    -   id: REACT:R-HSA-9018519
+        label: Pathway
+        name: Estrogen-dependent gene expression
+    -   id: HP:0030683
+        label: PhenotypicFeature
+        name: Vaginitis
+    -   id: MESH:D059268
+        label: Disease
+        name: Atrophic vaginitis
+    reference:
+    - https://go.drugbank.com/drugs/DB00890
+-   comment: dienestrol treatment is mainly recommended for post-menopausal dyspareunia.
+    directed: true
+    graph:
+        _id: DB00890_MESH_D004414_1
+        disease: Dyspareunia
+        disease_mesh: MESH:D004414
+        drug: dienestrol
+        drug_mesh: MESH:D004028
+        drugbank: DB:DB00890
+    links:
+    -   key: chemically similar to
+        source: MESH:D004028
+        target: MESH:D004967
+    -   key: increases activity of
+        source: MESH:D004967
+        target: UniProt:P03372
+    -   key: positively regulates
+        source: UniProt:P03372
+        target: REACT:R-HSA-9018519
+    -   key: negatively correlated with
+        source: REACT:R-HSA-9018519
+        target: HP:0030016
+    -   key: manifestation of
+        source: HP:0030016
+        target: MESH:D004414
+    multigraph: true
+    nodes:
+    -   id: MESH:D004028
+        label: Drug
+        name: dienestrol
+    -   id: UniProt:P03372
+        label: Protein
+        name: Estrogen receptor alpha
+    -   id: MESH:D004967
+        label: ChemicalSubstance
+        name: Estrogen
+    -   id: REACT:R-HSA-9018519
+        label: Pathway
+        name: Estrogen-dependent gene expression
+    -   id: HP:0030016
+        label: PhenotypicFeature
+        name: Dyspareunia
+    -   id: MESH:D004414
+        label: Disease
+        name: Dyspareunia
+    reference:
+    - https://go.drugbank.com/drugs/DB00890
+-   comment: Polidocanol is a sclerosing agent indicated to treat uncomplicated spider
+        veins. Sclerosing solutions cause the vein to scar, forcing blood to reroute
+        through healthier veins. The collapsed vein is reabsorbed into local tissue
+        and eventually fades (https://www.mayoclinic.org/tests-procedures/sclerotherapy/about/pac-20384592).
+    directed: true
+    graph:
+        _id: DB06811_MESH_D014648_1
+        disease: Venous varices
+        disease_mesh: MESH:D014648
+        drug: polidocanol
+        drug_mesh: MESH:C008976
+        drugbank: DB:DB06811
+    links:
+    -   key: chemically similar to
+        source: MESH:C008976
+        target: MESH:D012597
+    -   key: causes
+        source: MESH:D012597
+        target: HP:0100699
+    -   key: positively correlated with
+        source: HP:0100699
+        target: GO:0097709
+    -   key: negatively correlated with
+        source: GO:0097709
+        target: HP:0002619
+    -   key: manifestation of
+        source: HP:0002619
+        target: MESH:D014648
+    multigraph: true
+    nodes:
+    -   id: MESH:C008976
+        label: Drug
+        name: polidocanol
+    -   id: MESH:D012597
+        label: ChemicalSubstance
+        name: Sclerosing Solutions
+    -   id: HP:0100699
+        label: PhenotypicFeature
+        name: Scarring
+    -   id: GO:0097709
+        label: BiologicalProcess
+        name: connective tissue replacement
+    -   id: HP:0002619
+        label: PhenotypicFeature
+        name: Varicose veins
+    -   id: MESH:D014648
+        label: Disease
+        name: Venous varices
+    reference:
+    - https://go.drugbank.com/drugs/DB06811
+    - https://en.wikipedia.org/wiki/Polidocanol
+-   directed: true
+    graph:
+        _id: DB11945_MESH_D015266_2
+        disease: Merkel cell carcinoma
+        disease_mesh: MESH:D015266
+        drug: Avelumab
+        drug_mesh: MESH:C000609138
+        drugbank: DB:DB11945
+    links:
+    -   key: decreases activity of
+        source: MESH:C000609138
+        target: UniProt:Q9NZQ7
+    -   key: negatively regulates
+        source: UniProt:Q9NZQ7
+        target: GO:0042098
+    -   key: negatively regulates
+        source: UniProt:Q9NZQ7
+        target: GO:0042110
+    -   key: positively correlated with
+        source: GO:0042098
+        target: GO:0002424
+    -   key: positively correlated with
+        source: GO:0042110
+        target: GO:0002424
+    -   key: negatively correlated with
+        source: GO:0002424
+        target: MESH:D015266
+    multigraph: true
+    nodes:
+    -   id: MESH:C000609138
+        label: Drug
+        name: Avelumab
+    -   id: UniProt:Q9NZQ7
+        label: Protein
+        name: Programmed cell death 1 ligand 1
+    -   id: GO:0042098
+        label: BiologicalProcess
+        name: T cell proliferation
+    -   id: GO:0042110
+        label: BiologicalProcess
+        name: T cell activation
+    -   id: GO:0002424
+        label: BiologicalProcess
+        name: T cell mediated immune response to tumor cell
+    -   id: MESH:D015266
+        label: Disease
+        name: Merkel cell carcinoma
+    reference:
+    - https://go.drugbank.com/drugs/DB11945
+    - https://en.wikipedia.org/wiki/Avelumab
diff --git a/submission.yaml b/submission.yaml
index 47ef30436..8b1378917 100644
--- a/submission.yaml
+++ b/submission.yaml
@@ -1,1570 +1 @@
--   directed: true
-    graph:
-        disease: Paroxysmal atrial fibrillation
-        disease_mesh: MESH:D001281
-        drug: propafenone
-        drug_mesh: MESH:D011405
-        drugbank: DB:DB01182
-    links:
-    -   key: negatively regulates
-        source: MESH:D011405
-        target: InterPro:IPR001696
-    -   key: increases transport of
-        source: InterPro:IPR001696
-        target: MESH:D012964
-    -   key: positively regulates
-        source: MESH:D012964
-        target: GO:0086001
-    -   key: positively correlated with
-        source: GO:0086001
-        target: GO:0086003
-    -   key: positively correlated with
-        source: GO:0086003
-        target: HP:0004308
-    -   key: manifestation of
-        source: HP:0004308
-        target: MESH:D001281
-    multigraph: true
-    nodes:
-    -   id: MESH:D011405
-        label: Drug
-        name: propafenone
-    -   id: InterPro:IPR001696
-        label: GeneFamily
-        name: Voltage gated sodium channel, alpha subunit
-    -   id: MESH:D012964
-        label: ChemicalSubstance
-        name: Sodium
-    -   id: GO:0086001
-        label: BiologicalProcess
-        name: Cardiac muscle cell action potential
-    -   id: GO:0086003
-        label: BiologicalProcess
-        name: cardiac muscle cell contraction
-    -   id: HP:0004308
-        label: PhenotypicFeature
-        name: Ventricular arrhythmia
-    -   id: MESH:D001281
-        label: Disease
-        name: Paroxysmal atrial fibrillation
-    reference:
-    - https://go.drugbank.com/drugs/DB01182
-    - https://en.wikipedia.org/wiki/Propafenone
--   directed: true
-    graph:
-        disease: Gout
-        disease_mesh: MESH:D006073
-        drug: colchicine
-        drug_mesh: MESH:D003078
-        drugbank: DB:DB01394
-    links:
-    -   key: decreases activity of
-        source: MESH:D003078
-        target: UniProt:P07437
-    -   key: positively regulates
-        source: UniProt:P07437
-        target: GO:0046785
-    -   key: positively regulates
-        source: GO:0046785
-        target: REACT:R-HSA-844456
-    -   key: positively regulates
-        source: GO:0046785
-        target: GO:0007266
-    -   key: positively regulates
-        source: REACT:R-HSA-844456
-        target: GO:0006919
-    -   key: positively regulates
-        source: GO:0007266
-        target: GO:0006919
-    -   key: increases abundance of
-        source: GO:0006919
-        target: UniProt:P01584
-    -   key: produced by
-        source: UniProt:P01584
-        target: CL:0000775
-    -   key: produced by
-        source: UniProt:P01584
-        target: CL:0000576
-    -   key: negatively regulates
-        source: MESH:D003078
-        target: GO:1990266
-    -   key: negatively regulates
-        source: MESH:D003078
-        target: GO:0016176
-    -   key: negatively regulates
-        source: MESH:D003078
-        target: GO:0030593
-    -   key: positively correlated with
-        source: GO:0030593
-        target: GO:0070942
-    -   key: positively correlated with
-        source: GO:1990266
-        target: GO:0070942
-    -   key: positively correlated with
-        source: GO:0016176
-        target: GO:0070942
-    -   key: caused by
-        source: GO:0070942
-        target: CL:0000775
-    -   key: participates in
-        source: CL:0000775
-        target: GO:0045087
-    -   key: participates in
-        source: CL:0000576
-        target: GO:0045087
-    -   key: positively correlated with
-        source: GO:0045087
-        target: GO:0006954
-    -   key: positively correlated with
-        source: GO:0006954
-        target: HP:0005059
-    -   key: manifestation of
-        source: HP:0005059
-        target: MESH:D006073
-    multigraph: true
-    nodes:
-    -   id: MESH:D003078
-        label: Drug
-        name: colchicine
-    -   id: UniProt:P07437
-        label: Protein
-        name: Tubulin beta chain
-    -   id: GO:1990266
-        label: BiologicalProcess
-        name: neutrophil migration
-    -   id: GO:0016176
-        label: MolecularActivity
-        name: superoxide-generating NADPH oxidase activator activity
-    -   id: GO:0030593
-        label: BiologicalProcess
-        name: neutrophil chemotaxis
-    -   id: GO:0007266
-        label: BiologicalProcess
-        name: Rho protein signal transduction
-    -   id: REACT:R-HSA-844456
-        label: Pathway
-        name: The NLRP3 inflammasome
-    -   id: GO:0046785
-        label: BiologicalProcess
-        name: Microtubule polymerization
-    -   id: CL:0000775
-        label: Cell
-        name: Neutrophil
-    -   id: CL:0000576
-        label: Cell
-        name: Monocyte
-    -   id: GO:0045087
-        label: BiologicalProcess
-        name: innate immune response
-    -   id: GO:0070942
-        label: BiologicalProcess
-        name: neutrophil mediated cytotoxicity
-    -   id: GO:0007266
-        label: BiologicalProcess
-        name: Rho protein signal transduction
-    -   id: GO:0006919
-        label: BiologicalProcess
-        name: activation of cysteine-type endopeptidase activity involved in apoptotic process
-    -   id: UniProt:P01584
-        label: Protein
-        name: Interleukin-1 beta
-    -   id: GO:0006954
-        label: BiologicalProcess
-        name: inflammatory response
-    -   id: HP:0005059
-        label: PhenotypicFeature
-        name: Joint pain/Joint inflammation
-    -   id: MESH:D006073
-        label: Disease
-        name: Gout
-    reference:
-    - https://go.drugbank.com/drugs/DB01394
-    - https://en.wikipedia.org/wiki/Colchicine
-    - https://pubmed.ncbi.nlm.nih.gov/25151572/
-    - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656054/
--   directed: true
-    graph:
-        disease: Familial Mediterranean fever
-        disease_mesh: MESH:D010505
-        drug: colchicine
-        drug_mesh: MESH:D003078
-        drugbank: DB:DB01394
-    links:
-    -   key: decreases activity of
-        source: MESH:D003078
-        target: UniProt:P07437
-    -   key: positively regulates
-        source: UniProt:P07437
-        target: GO:0046785
-    -   key: positively regulates
-        source: GO:0046785
-        target: REACT:R-HSA-844456
-    -   key: positively regulates
-        source: GO:0046785
-        target: GO:0007266
-    -   key: positively regulates
-        source: REACT:R-HSA-844456
-        target: GO:0006919
-    -   key: positively regulates
-        source: GO:0007266
-        target: GO:0006919
-    -   key: increases abundance of
-        source: GO:0006919
-        target: UniProt:P01584
-    -   key: produced by
-        source: UniProt:P01584
-        target: CL:0000775
-    -   key: produced by
-        source: UniProt:P01584
-        target: CL:0000576
-    -   key: negatively regulates
-        source: MESH:D003078
-        target: GO:1990266
-    -   key: negatively regulates
-        source: MESH:D003078
-        target: GO:0016176
-    -   key: negatively regulates
-        source: MESH:D003078
-        target: GO:0030593
-    -   key: positively correlated with
-        source: GO:0030593
-        target: GO:0070942
-    -   key: positively correlated with
-        source: GO:1990266
-        target: GO:0070942
-    -   key: positively correlated with
-        source: GO:0016176
-        target: GO:0070942
-    -   key: caused by
-        source: GO:0070942
-        target: CL:0000775
-    -   key: participates in
-        source: CL:0000775
-        target: GO:0045087
-    -   key: participates in
-        source: CL:0000576
-        target: GO:0045087
-    -   key: positively correlated with
-        source: GO:0045087
-        target: GO:0006954
-    -   key: manifestation of
-        source: GO:0006954
-        target: MESH:D010505
-    multigraph: true
-    nodes:
-    -   id: MESH:D003078
-        label: Drug
-        name: colchicine
-    -   id: UniProt:P07437
-        label: Protein
-        name: Tubulin beta chain
-    -   id: GO:1990266
-        label: BiologicalProcess
-        name: neutrophil migration
-    -   id: GO:0016176
-        label: MolecularActivity
-        name: superoxide-generating NADPH oxidase activator activity
-    -   id: GO:0030593
-        label: BiologicalProcess
-        name: neutrophil chemotaxis
-    -   id: GO:0007266
-        label: BiologicalProcess
-        name: Rho protein signal transduction
-    -   id: REACT:R-HSA-844456
-        label: Pathway
-        name: The NLRP3 inflammasome
-    -   id: GO:0046785
-        label: BiologicalProcess
-        name: Microtubule polymerization
-    -   id: CL:0000775
-        label: Cell
-        name: Neutrophil
-    -   id: CL:0000576
-        label: Cell
-        name: Monocyte
-    -   id: GO:0045087
-        label: BiologicalProcess
-        name: innate immune response
-    -   id: GO:0070942
-        label: BiologicalProcess
-        name: neutrophil mediated cytotoxicity
-    -   id: GO:0007266
-        label: BiologicalProcess
-        name: Rho protein signal transduction
-    -   id: GO:0006919
-        label: BiologicalProcess
-        name: activation of cysteine-type endopeptidase activity involved in apoptotic process
-    -   id: UniProt:P01584
-        label: Protein
-        name: Interleukin-1 beta
-    -   id: GO:0006954
-        label: BiologicalProcess
-        name: inflammatory response
-    -   id: MESH:D010505
-        label: Disease
-        name: Familial Mediterranean fever
-    reference:
-    - https://go.drugbank.com/drugs/DB01394
-    - https://en.wikipedia.org/wiki/Colchicine
-    - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656054/
--   directed: true
-    graph:
-        disease: Asthma
-        disease_mesh: MESH:D001249
-        drug: omalizumab
-        drug_mesh: MESH:D000069444
-        drugbank: DB:DB00043
-    links:
-    -   key: decreases activity of
-        source: MESH:D000069444
-        target: GO:0019767
-    -   key: part of
-        source: GO:0019767
-        target: UniProt:P01854
-    -   key: expressed in
-        source: UniProt:P01854
-        target: CL:0000097
-    -   key: expressed in
-        source: UniProt:P01854
-        target: CL:0000767
-    -   key: positively correlated with
-        source: CL:0000097
-        target: GO:0043303
-    -   key: positively correlated with
-        source: CL:0000767
-        target: GO:0002561
-    -   key: caused by
-        source: GO:0043303
-        target: REACT:R-HSA-2454202
-    -   key: caused by
-        source: GO:0002561
-        target: REACT:R-HSA-2454202
-    -   key: positively correlated with
-        source: REACT:R-HSA-2454202
-        target: GO:0002441
-    -   key: positively correlated with
-        source: REACT:R-HSA-2454202
-        target: GO:0002540
-    -   key: positively correlated with
-        source: GO:0002441
-        target: MESH:D001249
-    -   key: positively correlated with
-        source: GO:0002540
-        target: MESH:D001249
-    multigraph: true
-    nodes:
-    -   id: MESH:D000069444
-        label: Drug
-        name: omalizumab
-    -   id: GO:0019767
-        label: MolecularActivity
-        name: IgE receptor activity
-    -   id: UniProt:P01854
-        label: Protein
-        name: Immunoglobulin heavy constant epsilon
-    -   id: CL:0000097
-        label: Cell
-        name: mast cell
-    -   id: CL:0000767
-        label: Cell
-        name: basophill
-    -   id: GO:0043303
-        label: BiologicalProcess
-        name: mast cell degranulation
-    -   id: GO:0002561
-        label: BiologicalProcess
-        name: basophil degranulation
-    -   id: REACT:R-HSA-2454202
-        label: Pathway
-        name: Allergen dependent IgE bound FCERI aggregation
-    -   id: GO:0002540
-        label: BiologicalProcess
-        name: leukotriene production involved in inflammatory response
-    -   id: GO:0002441
-        label: BiologicalProcess
-        name: histamine secretion involved in inflammatory response
-    -   id: MESH:D001249
-        label: Disease
-        name: Asthma
-    reference:
-    - https://go.drugbank.com/drugs/DB00043
-    - https://europepmc.org/article/pmc/pmc2478654
-    - https://en.wikipedia.org/wiki/Omalizumab
--   directed: true
-    graph:
-        disease: Chronic idiopathic urticaria
-        disease_mesh: MESH:D000080223
-        drug: omalizumab
-        drug_mesh: MESH:D000069444
-        drugbank: DB:DB00043
-    links:
-    -   key: decreases activity of
-        source: MESH:D000069444
-        target: GO:0019767
-    -   key: part of
-        source: GO:0019767
-        target: UniProt:P01854
-    -   key: expressed in
-        source: UniProt:P01854
-        target: CL:0000097
-    -   key: expressed in
-        source: UniProt:P01854
-        target: CL:0000767
-    -   key: positively correlated with
-        source: CL:0000097
-        target: GO:0043303
-    -   key: positively correlated with
-        source: CL:0000767
-        target: GO:0002561
-    -   key: caused by
-        source: GO:0043303
-        target: REACT:R-HSA-2454202
-    -   key: caused by
-        source: GO:0002561
-        target: REACT:R-HSA-2454202
-    -   key: positively correlated with
-        source: REACT:R-HSA-2454202
-        target: GO:0002441
-    -   key: positively correlated with
-        source: REACT:R-HSA-2454202
-        target: GO:0002540
-    -   key: positively correlated with
-        source: GO:0002441
-        target: MESH:D000080223
-    -   key: positively correlated with
-        source: GO:0002540
-        target: MESH:D000080223
-    multigraph: true
-    nodes:
-    -   id: MESH:D000069444
-        label: Drug
-        name: omalizumab
-    -   id: GO:0019767
-        label: MolecularActivity
-        name: IgE receptor activity
-    -   id: UniProt:P01854
-        label: Protein
-        name: Immunoglobulin heavy constant epsilon
-    -   id: CL:0000097
-        label: Cell
-        name: mast cell
-    -   id: CL:0000767
-        label: Cell
-        name: basophill
-    -   id: GO:0043303
-        label: BiologicalProcess
-        name: mast cell degranulation
-    -   id: GO:0002561
-        label: BiologicalProcess
-        name: basophil degranulation
-    -   id: REACT:R-HSA-2454202
-        label: Pathway
-        name: Allergen dependent IgE bound FCERI aggregation
-    -   id: GO:0002540
-        label: BiologicalProcess
-        name: leukotriene production involved in inflammatory response
-    -   id: GO:0002441
-        label: BiologicalProcess
-        name: histamine secretion involved in inflammatory response
-    -   id: MESH:D000080223
-        label: Disease
-        name: Chronic idiopathic urticaria
-    reference:
-    - https://go.drugbank.com/drugs/DB00043
-    - https://europepmc.org/article/pmc/pmc2478654
-    - https://en.wikipedia.org/wiki/Omalizumab
--   directed: true
-    graph:
-        disease: Actinic keratosis
-        disease_mesh: MESH:D055623
-        drug: masoprocol
-        drug_mesh: MESH:D009637
-        drugbank: DB:DB00179
-    links:
-    -   key: decreases activity of
-        source: MESH:D009637
-        target: UniProt:P42345
-    -   key: positively regulates
-        source: UniProt:P42345
-        target: REACT:R-HSA-166208
-    -   key: positively correlated with
-        source: REACT:R-HSA-166208
-        target: HP:0031377
-    -   key: causes
-        source: HP:0031377
-        target: MESH:D055623
-    multigraph: true
-    nodes:
-    -   id: MESH:D009637
-        label: Drug
-        name: masoprocol
-    -   id: UniProt:P42345
-        label: Protein
-        name: Serine/threonine-protein kinase mTOR
-    -   id: REACT:R-HSA-166208
-        label: Pathway
-        name: mTORC1-mediated signalling
-    -   id: HP:0031377
-        label: PhenotypicFeature
-        name: Abnormal cell proliferation
-    -   id: MESH:D055623
-        label: Disease
-        name: Actinic keratosis
-    reference:
-    - https://go.drugbank.com/drugs/DB00179
-    - http://europepmc.org/article/MED/23053656
--   directed: true
-    graph:
-        disease: Allergic rhinitis
-        disease_mesh: MESH:D065631
-        drug: cetirizine
-        drug_mesh: MESH:D017332
-        drugbank: DB:DB00341
-    links:
-    -   key: decreases activity of
-        source: MESH:D017332
-        target: UniProt:P35367
-    -   key: positively regulates
-        source: UniProt:P35367
-        target: GO:0004969
-    -   key: participates in
-        source: GO:0004969
-        target: GO:0071420
-    -   key: positively correlated with
-        source: GO:0071420
-        target: GO:0006954
-    -   key: has phenotype
-        source: GO:0006954
-        target: HP:0031417
-    -   key: manifestation of
-        source: HP:0031417
-        target: MESH:D065631
-    multigraph: true
-    nodes:
-    -   id: MESH:D017332
-        label: Drug
-        name: cetirizine
-    -   id: UniProt:P35367
-        label: Protein
-        name: Histamine H1 receptor
-    -   id: GO:0004969
-        label: MolecularActivity
-        name: Histamine receptor activity
-    -   id: GO:0071420
-        label: BiologicalProcess
-        name: Cellular response to histamine
-    -   id: GO:0006954
-        label: BiologicalProcess
-        name: Inflammatory response
-    -   id: HP:0031417
-        label: PhenotypicFeature
-        name: Rhinorrhea
-    -   id: MESH:D065631
-        label: Disease
-        name: Allergic rhinitis
-    reference:
-    - https://go.drugbank.com/drugs/DB00341
-    - https://en.wikipedia.org/wiki/Cetirizine
--   directed: true
-    graph:
-        disease: Sneezing
-        disease_mesh: MESH:D012912
-        drug: cetirizine
-        drug_mesh: MESH:D017332
-        drugbank: DB:DB00341
-    links:
-    -   key: decreases activity of
-        source: MESH:D017332
-        target: UniProt:P35367
-    -   key: participates in
-        source: UniProt:P35367
-        target: GO:0051381
-    -   key: positively regulates
-        source: GO:0051381
-        target: GO:0023041
-    -   key: located in
-        source: GO:0023041
-        target: UBERON:0000004
-    -   key: affected by
-        source: UBERON:0000004
-        target: UBERON:0001645
-    -   key: contributes to
-        source: UBERON:0001645
-        target: MESH:D012912
-    multigraph: true
-    nodes:
-    -   id: MESH:D017332
-        label: Drug
-        name: cetirizine
-    -   id: UniProt:P35367
-        label: Protein
-        name: Histamine H1 receptor
-    -   id: GO:0051381
-        label: MolecularActivity
-        name: Histamine binding
-    -   id: GO:0023041
-        label: BiologicalProcess
-        name: Neuronal signal transduction
-    -   id: UBERON:0000004
-        label: GrossAnatomicalStructure
-        name: Nose
-    -   alt_ids: MESH:D014276
-        id: UBERON:0001645
-        label: GrossAnatomicalStructure
-        name: Trigeminal nerve
-    -   id: MESH:D012912
-        label: Disease
-        name: Sneezing
-    reference:
-    - https://go.drugbank.com/drugs/DB00341
-    - https://en.wikipedia.org/wiki/Cetirizine
--   directed: true
-    graph:
-        disease: Vasomotor rhinitis
-        disease_mesh: MESH:D012223
-        drug: cetirizine
-        drug_mesh: MESH:D017332
-        drugbank: DB:DB00341
-    links:
-    -   key: decreases activity of
-        source: MESH:D017332
-        target: UniProt:P35367
-    -   key: positively regulates
-        source: UniProt:P35367
-        target: GO:0004969
-    -   key: participates in
-        source: GO:0004969
-        target: GO:0071420
-    -   key: positively correlated with
-        source: GO:0071420
-        target: GO:0006954
-    -   key: has phenotype
-        source: GO:0006954
-        target: HP:0031417
-    -   key: manifestation of
-        source: HP:0031417
-        target: MESH:D012223
-    multigraph: true
-    nodes:
-    -   id: MESH:D017332
-        label: Drug
-        name: cetirizine
-    -   id: UniProt:P35367
-        label: Protein
-        name: Histamine H1 receptor
-    -   id: GO:0004969
-        label: MolecularActivity
-        name: Histamine receptor activity
-    -   id: GO:0071420
-        label: BiologicalProcess
-        name: Cellular response to histamine
-    -   id: GO:0006954
-        label: BiologicalProcess
-        name: Inflammatory response
-    -   id: HP:0031417
-        label: PhenotypicFeature
-        name: Rhinorrhea
-    -   id: MESH:D012223
-        label: Disease
-        name: Vasomotor rhinitis
-    reference:
-    - https://go.drugbank.com/drugs/DB00341
-    - https://en.wikipedia.org/wiki/Cetirizine
--   directed: true
-    graph:
-        disease: Chronic idiopathic urticaria
-        disease_mesh: MESH:D000080223
-        drug: cetirizine
-        drug_mesh: MESH:D017332
-        drugbank: DB:DB00341
-    links:
-    -   key: decreases activity of
-        source: MESH:D017332
-        target: UniProt:P35367
-    -   key: positively regulates
-        source: UniProt:P35367
-        target: GO:0004969
-    -   key: participates in
-        source: GO:0004969
-        target: GO:0071420
-    -   key: positively correlated with
-        source: GO:0071420
-        target: GO:0006954
-    -   key: positively correlated with
-        source: GO:0071420
-        target: GO:0043117
-    -   key: positively correlated with
-        source: GO:0071420
-        target: HP:0000969
-    -   key: manifestation of
-        source: HP:0000969
-        target: MESH:D000080223
-    -   key: manifestation of
-        source: GO:0043117
-        target: MESH:D000080223
-    -   key: causes
-        source: GO:0006954
-        target: MESH:D000080223
-    multigraph: true
-    nodes:
-    -   id: MESH:D017332
-        label: Drug
-        name: cetirizine
-    -   id: UniProt:P35367
-        label: Protein
-        name: Histamine H1 receptor
-    -   id: GO:0004969
-        label: MolecularActivity
-        name: Histamine receptor activity
-    -   id: GO:0071420
-        label: BiologicalProcess
-        name: Cellular response to histamine
-    -   id: GO:0006954
-        label: BiologicalProcess
-        name: Inflammatory response
-    -   id: GO:0043117
-        label: BiologicalProcess
-        name: Positive regulation of vascular permeability
-    -   id: HP:0000969
-        label: PhenotypicFeature
-        name: Edema
-    -   id: MESH:D000080223
-        label: Disease
-        name: Chronic idiopathic urticaria
-    reference:
-    - https://go.drugbank.com/drugs/DB00341
-    - https://en.wikipedia.org/wiki/Cetirizine
--   directed: true
-    graph:
-        disease: Common cold
-        disease_mesh: MESH:D003139
-        drug: cetirizine
-        drug_mesh: MESH:D017332
-        drugbank: DB:DB00341
-    links:
-    -   key: decreases activity of
-        source: MESH:D017332
-        target: UniProt:P35367
-    -   key: positively regulates
-        source: UniProt:P35367
-        target: GO:0004969
-    -   key: participates in
-        source: GO:0004969
-        target: GO:0071420
-    -   key: positively correlated with
-        source: GO:0071420
-        target: GO:0006954
-    -   key: caused by
-        source: GO:0006954
-        target: NCBITaxon:10239
-    -   key: causes
-        source: NCBITaxon:10239
-        target: MESH:D003139
-    multigraph: true
-    nodes:
-    -   id: MESH:D017332
-        label: Drug
-        name: cetirizine
-    -   id: UniProt:P35367
-        label: Protein
-        name: Histamine H1 receptor
-    -   id: GO:0004969
-        label: MolecularActivity
-        name: Histamine receptor activity
-    -   id: GO:0071420
-        label: BiologicalProcess
-        name: Cellular response to histamine
-    -   id: GO:0006954
-        label: BiologicalProcess
-        name: Inflammatory response
-    -   id: NCBITaxon:10239
-        label: OrganismTaxon
-        name: Viruses
-    -   id: MESH:D003139
-        label: Disease
-        name: Common cold
-    reference:
-    - https://go.drugbank.com/drugs/DB00341
-    - https://en.wikipedia.org/wiki/Cetirizine
--   directed: true
-    graph:
-        disease: Seasonal allergic rhinitis
-        disease_mesh: MESH:D006255
-        drug: cetirizine
-        drug_mesh: MESH:D017332
-        drugbank: DB:DB00341
-    links:
-    -   key: decreases activity of
-        source: MESH:D017332
-        target: UniProt:P35367
-    -   key: positively regulates
-        source: UniProt:P35367
-        target: GO:0004969
-    -   key: participates in
-        source: GO:0004969
-        target: GO:0071420
-    -   key: positively correlated with
-        source: GO:0071420
-        target: GO:0006954
-    -   key: has phenotype
-        source: GO:0006954
-        target: HP:0031417
-    -   key: manifestation of
-        source: HP:0031417
-        target: MESH:D006255
-    multigraph: true
-    nodes:
-    -   id: MESH:D017332
-        label: Drug
-        name: cetirizine
-    -   id: UniProt:P35367
-        label: Protein
-        name: Histamine H1 receptor
-    -   id: GO:0004969
-        label: MolecularActivity
-        name: Histamine receptor activity
-    -   id: GO:0071420
-        label: BiologicalProcess
-        name: Cellular response to histamine
-    -   id: GO:0006954
-        label: BiologicalProcess
-        name: Inflammatory response
-    -   id: HP:0031417
-        label: PhenotypicFeature
-        name: Rhinorrhea
-    -   id: MESH:D006255
-        label: Disease
-        name: Seasonal allergic rhinitis
-    reference:
-    - https://go.drugbank.com/drugs/DB00341
-    - https://en.wikipedia.org/wiki/Cetirizine
--   directed: true
-    graph:
-        disease: Allergic conjunctivitis
-        disease_mesh: MESH:D003233
-        drug: cetirizine
-        drug_mesh: MESH:D017332
-        drugbank: DB:DB00341
-    links:
-    -   key: decreases activity of
-        source: MESH:D017332
-        target: UniProt:P35367
-    -   key: positively regulates
-        source: UniProt:P35367
-        target: GO:0004969
-    -   key: participates in
-        source: GO:0004969
-        target: GO:0071420
-    -   key: positively correlated with
-        source: GO:0071420
-        target: GO:0006954
-    -   key: causes
-        source: GO:0006954
-        target: MESH:D003233
-    multigraph: true
-    nodes:
-    -   id: MESH:D017332
-        label: Drug
-        name: cetirizine
-    -   id: UniProt:P35367
-        label: Protein
-        name: Histamine H1 receptor
-    -   id: GO:0004969
-        label: MolecularActivity
-        name: Histamine receptor activity
-    -   id: GO:0071420
-        label: BiologicalProcess
-        name: Cellular response to histamine
-    -   id: GO:0006954
-        label: BiologicalProcess
-        name: Inflammatory response
-    -   id: MESH:D003233
-        label: Disease
-        name: Allergic conjunctivitis
-    reference:
-    - https://go.drugbank.com/drugs/DB00341
-    - https://en.wikipedia.org/wiki/Cetirizine
--   comment: Dipivefrin is a prodrug with little or no pharmacologically 
-        activity until it is hydrolyzed into epinephrine inside the human eye.
-    directed: true
-    graph:
-        disease: Open-angle glaucoma
-        disease_mesh: MESH:D005902
-        drug: dipivefrine
-        drug_mesh: MESH:C015173
-        drugbank: DB:DB00449
-    links:
-    -   key: has metabolite
-        source: MESH:C015173
-        target: MESH:D004837
-    -   key: increases activity of
-        source: MESH:D004837
-        target: InterPro:IPR002233
-    -   key: participates in
-        source: InterPro:IPR002233
-        target: GO:0004935
-    -   key: positively regulates
-        source: GO:0004935
-        target: GO:0042310
-    -   key: negatively correlated with
-        source: GO:0042310
-        target: UBERON:0001796
-    -   key: positively correlated with
-        source: UBERON:0001796
-        target: HP:0007906
-    -   key: positively correlated with
-        source: HP:0007906
-        target: MESH:D005902
-    multigraph: true
-    nodes:
-    -   id: MESH:C015173
-        label: Drug
-        name: dipivefrine
-    -   id: MESH:D004837
-        label: ChemicalSubstance
-        name: epinephrine
-    -   id: InterPro:IPR002233
-        label: GeneFamily
-        name: Adrenoceptor family
-    -   id: GO:0004935
-        label: MolecularActivity
-        name: adrenergic receptor activity
-    -   id: GO:0042310
-        label: BiologicalProcess
-        name: vasoconstriction
-    -   id: UBERON:0001796
-        label: GrossAnatomicalStructure
-        name: Aqueous Humor
-    -   id: HP:0007906
-        label: PhenotypicFeature
-        name: Ocular Hypertension
-    -   id: MESH:D005902
-        label: Disease
-        name: Open-angle glaucoma
-    reference:
-    - https://go.drugbank.com/drugs/DB00449
-    - https://en.wikipedia.org/wiki/Dipivefrine
--   comments: Oxcarbazepine is a prodrug, which is largely metabolised to its pharmacologically active
-         10-monohydroxy derivative licarbazepine (sometimes abbreviated MHD).
-    directed: true
-    graph:
-        disease: Localization-related epilepsy
-        disease_mesh: MESH:D004828
-        drug: oxcarbazepine
-        drug_mesh: MESH:C036006
-        drugbank: DB:DB00776
-    links:
-    -   key: has metabolite
-        source: MESH:C036006
-        target: CHEBI:701
-    -   key: decreases activity of
-        source: CHEBI:701
-        target: MESH:D061566
-    -   key: positively regulates
-        source: MESH:D061566
-        target: GO:0035725
-    -   key: positively regulates
-        source: GO:0035725
-        target: GO:0019228
-    -   key: positively correlated with
-        source: GO:0019228
-        target: HP:0011097
-    -   key: positively correlated with
-        source: HP:0011097
-        target: MESH:D004828
-    multigraph: true
-    nodes:
-    -   id: MESH:C036006
-        label: Drug
-        name: oxcarbazepine
-    -   id: CHEBI:701
-        label: ChemicalSubstance
-        name: licarbazepine
-    -   id: MESH:D061566
-        label: GeneFamily
-        name: Voltage-Gated Sodium Channels
-    -   id: GO:0035725
-        label: BiologicalProcess
-        name: sodium ion transmembrane transport
-    -   id: GO:0019228
-        label: BiologicalProcess
-        name: neuronal action potential
-    -   id: HP:0011097
-        label: PhenotypicFeature
-        name: Epileptic spasm
-    -   id: MESH:D004828
-        label: Disease
-        name: Localization-related epilepsy
-    reference:
-    - https://go.drugbank.com/drugs/DB00776
-    - https://en.wikipedia.org/wiki/Oxcarbazepine
--   directed: true
-    graph:
-        disease: Sore throat symptom
-        disease_mesh: MESH:D010612
-        drug: benzocaine
-        drug_mesh: MESH:D001566
-        drugbank: DB:DB01086
-    links:
-    -   key: decreases activity of
-        source: MESH:D001566
-        target: UniProt:Q9Y5Y9
-    -   key: participates in
-        source: UniProt:Q9Y5Y9
-        target: GO:0005248
-    -   key: increases transport of
-        source: GO:0005248
-        target: MESH:D012964
-    -   key: positively correlated with
-        source: MESH:D012964
-        target: GO:0051899
-    -   key: positively regulates
-        source: GO:0051899
-        target: GO:0019228
-    -   key: occurs in
-        source: GO:0019228
-        target: CL:0000198
-    -   key: participates in
-        source: CL:0000198
-        target: GO:0019233
-    -   key: occurs in
-        source: GO:0019233
-        target: MESH:D010612
-    multigraph: true
-    nodes:
-    -   id: MESH:D001566
-        label: Drug
-        name: benzocaine
-    -   id: UniProt:Q9Y5Y9
-        label: Protein
-        name: Sodium channel protein type 10 subunit alpha
-    -   id: MESH:D012964
-        label: ChemicalSubstance
-        name: Sodium
-    -   id: GO:0005248
-        label: BiologicalProcess
-        name: Voltage-gated sodium channel activity
-    -   id: GO:0051899
-        label: BiologicalProcess
-        name: Membrane depolarization
-    -   id: GO:0019228
-        label: BiologicalProcess
-        name: Neuronal action potential
-    -   id: CL:0000198
-        label: Cell
-        name: Pain receptor cell
-    -   id: GO:0019233
-        label: BiologicalProcess
-        name: Sensory perception of pain
-    -   id: MESH:D010612
-        label: Drug
-        name: Sore throat symptom
-    reference:
-    - https://go.drugbank.com/drugs/DB01086
-    - https://en.wikipedia.org/wiki/Benzocaine
--   directed: true
-    graph:
-        disease: Cough
-        disease_mesh: MESH:D003371
-        drug: benzocaine
-        drug_mesh: MESH:D001566
-        drugbank: DB:DB01086
-    links:
-    -   key: decreases activity of
-        source: MESH:D001566
-        target: UniProt:Q9Y5Y9
-    -   key: participates in
-        source: UniProt:Q9Y5Y9
-        target: GO:0005248
-    -   key: increases transport of
-        source: GO:0005248
-        target: MESH:D012964
-    -   key: positively correlated with
-        source: MESH:D012964
-        target: GO:0051899
-    -   key: positively regulates
-        source: GO:0051899
-        target: GO:0019228
-    -   key: occurs in
-        source: GO:0019228
-        target: CL:0000198
-    -   key: participates in
-        source: CL:0000198
-        target: GO:0019233
-    -   key: occurs in
-        source: GO:0019233
-        target: MESH:D003371
-    multigraph: true
-    nodes:
-    -   id: MESH:D001566
-        label: Drug
-        name: benzocaine
-    -   id: UniProt:Q9Y5Y9
-        label: Protein
-        name: Sodium channel protein type 10 subunit alpha
-    -   id: MESH:D012964
-        label: ChemicalSubstance
-        name: Sodium
-    -   id: GO:0005248
-        label: BiologicalProcess
-        name: Voltage-gated sodium channel activity
-    -   id: GO:0051899
-        label: BiologicalProcess
-        name: Membrane depolarization
-    -   id: GO:0019228
-        label: BiologicalProcess
-        name: Neuronal action potential
-    -   id: CL:0000198
-        label: Cell
-        name: Pain receptor cell
-    -   id: GO:0019233
-        label: BiologicalProcess
-        name: Sensory perception of pain
-    -   id: MESH:D003371
-        label: Drug
-        name: Cough
-    reference:
-    - https://go.drugbank.com/drugs/DB01086
-    - https://en.wikipedia.org/wiki/Benzocaine
--   directed: true
-    graph:
-        disease: Itching of skin
-        disease_mesh: MESH:D011537
-        drug: benzocaine
-        drug_mesh: MESH:D001566
-        drugbank: DB:DB01086
-    links:
-    -   key: decreases activity of
-        source: MESH:D001566
-        target: UniProt:Q9Y5Y9
-    -   key: participates in
-        source: UniProt:Q9Y5Y9
-        target: GO:0005248
-    -   key: increases transport of
-        source: GO:0005248
-        target: MESH:D012964
-    -   key: positively correlated with
-        source: MESH:D012964
-        target: GO:0051899
-    -   key: positively regulates
-        source: GO:0051899
-        target: GO:0019228
-    -   key: occurs in
-        source: GO:0019228
-        target: CL:0000198
-    -   key: participates in
-        source: CL:0000198
-        target: GO:0019233
-    -   key: manifestation of
-        source: GO:0019233
-        target: MESH:D011537
-    multigraph: true
-    nodes:
-    -   id: MESH:D001566
-        label: Drug
-        name: benzocaine
-    -   id: UniProt:Q9Y5Y9
-        label: Protein
-        name: Sodium channel protein type 10 subunit alpha
-    -   id: MESH:D012964
-        label: ChemicalSubstance
-        name: Sodium
-    -   id: GO:0005248
-        label: BiologicalProcess
-        name: Voltage-gated sodium channel activity
-    -   id: GO:0051899
-        label: BiologicalProcess
-        name: Membrane depolarization
-    -   id: GO:0019228
-        label: BiologicalProcess
-        name: Neuronal action potential
-    -   id: CL:0000198
-        label: Cell
-        name: Pain receptor cell
-    -   id: GO:0019233
-        label: BiologicalProcess
-        name: Sensory perception of pain
-    -   id: MESH:D011537
-        label: Drug
-        name: Itching of skin
-    reference:
-    - https://go.drugbank.com/drugs/DB01086
-    - https://en.wikipedia.org/wiki/Benzocaine
--   directed: true
-    graph:
-        disease: Tinea pedis
-        disease_mesh: MESH:D014008
-        drug: benzocaine
-        drug_mesh: MESH:D001566
-        drugbank: DB:DB01086
-    links:
-    -   key: decreases activity of
-        source: MESH:D001566
-        target: UniProt:Q9Y5Y9
-    -   key: participates in
-        source: UniProt:Q9Y5Y9
-        target: GO:0005248
-    -   key: increases transport of
-        source: GO:0005248
-        target: MESH:D012964
-    -   key: positively correlated with
-        source: MESH:D012964
-        target: GO:0051899
-    -   key: positively regulates
-        source: GO:0051899
-        target: GO:0019228
-    -   key: occurs in
-        source: GO:0019228
-        target: CL:0000198
-    -   key: participates in
-        source: CL:0000198
-        target: GO:0019233
-    -   key: occurs in
-        source: GO:0019233
-        target: MESH:D014008
-    multigraph: true
-    nodes:
-    -   id: MESH:D001566
-        label: Drug
-        name: benzocaine
-    -   id: UniProt:Q9Y5Y9
-        label: Protein
-        name: Sodium channel protein type 10 subunit alpha
-    -   id: MESH:D012964
-        label: ChemicalSubstance
-        name: Sodium
-    -   id: GO:0005248
-        label: BiologicalProcess
-        name: Voltage-gated sodium channel activity
-    -   id: GO:0051899
-        label: BiologicalProcess
-        name: Membrane depolarization
-    -   id: GO:0019228
-        label: BiologicalProcess
-        name: Neuronal action potential
-    -   id: CL:0000198
-        label: Cell
-        name: Pain receptor cell
-    -   id: GO:0019233
-        label: BiologicalProcess
-        name: Sensory perception of pain
-    -   id: MESH:D014008
-        label: Drug
-        name: Tinea pedis
-    reference:
-    - https://go.drugbank.com/drugs/DB01086
-    - https://en.wikipedia.org/wiki/Benzocaine
--   directed: true
-    graph:
-        disease: Tinea pedis
-        disease_mesh: MESH:D014008
-        drug: benzocaine
-        drug_mesh: MESH:D001566
-        drugbank: DB:DB01086
-    links:
-    -   key: decreases activity of
-        source: MESH:D001566
-        target: UniProt:Q9Y5Y9
-    -   key: participates in
-        source: UniProt:Q9Y5Y9
-        target: GO:0005248
-    -   key: increases transport of
-        source: GO:0005248
-        target: MESH:D012964
-    -   key: positively correlated with
-        source: MESH:D012964
-        target: GO:0051899
-    -   key: positively regulates
-        source: GO:0051899
-        target: GO:0019228
-    -   key: occurs in
-        source: GO:0019228
-        target: CL:0000198
-    -   key: participates in
-        source: CL:0000198
-        target: GO:0019233
-    -   key: occurs in
-        source: GO:0019233
-        target: MESH:D014008
-    multigraph: true
-    nodes:
-    -   id: MESH:D001566
-        label: Drug
-        name: benzocaine
-    -   id: UniProt:Q9Y5Y9
-        label: Protein
-        name: Sodium channel protein type 10 subunit alpha
-    -   id: MESH:D012964
-        label: ChemicalSubstance
-        name: Sodium
-    -   id: GO:0005248
-        label: BiologicalProcess
-        name: Voltage-gated sodium channel activity
-    -   id: GO:0051899
-        label: BiologicalProcess
-        name: Membrane depolarization
-    -   id: GO:0019228
-        label: BiologicalProcess
-        name: Neuronal action potential
-    -   id: CL:0000198
-        label: Cell
-        name: Pain receptor cell
-    -   id: GO:0019233
-        label: BiologicalProcess
-        name: Sensory perception of pain
-    -   id: MESH:D014008
-        label: Drug
-        name: Tinea pedis
-    reference:
-    - https://go.drugbank.com/drugs/DB01086
-    - https://en.wikipedia.org/wiki/Benzocaine
--   comment:  pixantrone has not yet received FDA approval in the United States, it has been granted conditional
-              marketing approval by the European Union.
-    directed: true
-    graph:
-        disease: Non-Hodgkin's lymphoma
-        disease_mesh: MESH:D008228
-        drug: Pixantrone
-        drug_mesh: MESH:C086548
-        drugbank: DB:DB06193
-    links:
-    -   key: increases abundance of
-        source: MESH:C086548
-        target: MESH:D018736
-    -   key: decreases activity of
-        source: MESH:D018736
-        target: UniProt:P11388
-    -   key: positively regulates
-        source: UniProt:P11388
-        target: GO:0006974
-    -   key: positively regulates
-        source: GO:0006974
-        target: GO:0030263
-    -   key: positively correlated with
-        source: GO:0030263
-        target: GO:0008219
-    -   key: decreases abundance of
-        source: GO:0008219
-        target: CL:0001063
-    -   key: manifestation of
-        source: CL:0001063
-        target: MESH:D008228
-    multigraph: true
-    nodes:
-    -   id: MESH:C086548
-        label: Drug
-        name: Pixantrone
-    -   id: UniProt:P11388
-        label: Protein
-        name: DNA topoisomerase 2-alpha
-    -   id: MESH:D018736
-        label: ChemicalSubstance
-        name: DNA adducts
-    -   id: GO:0006974
-        label: BiologicalProcess
-        name: cellular response to DNA damage stimulus
-    -   id: GO:0030263
-        label: BiologicalProcess
-        name: apoptotic chromosome condensation
-    -   id: GO:0008219
-        label: BiologicalProcess
-        name: cell death
-    -   id: CL:0001063
-        label: Cell
-        name: tumor cells
-    -   id: MESH:D008228
-        label: Disease
-        name: Non-Hodgkin's lymphoma
-    reference:
-    - https://go.drugbank.com/drugs/DB06193
-    - https://en.wikipedia.org/wiki/Pixantrone
--   directed: true
-    graph:
-        disease: Atrophic vaginitis
-        disease_mesh: MESH:D059268
-        drug: dienestrol
-        drug_mesh: MESH:D004028
-        drugbank: DB:DB00890
-    links:
-    -   key: chemically similar to
-        source: MESH:D004028
-        target: MESH:D004967
-    -   key: increases activity of
-        source: MESH:D004967
-        target: UniProt:P03372
-    -   key: positively regulates
-        source: UniProt:P03372
-        target: REACT:R-HSA-9018519
-    -   key: negatively correlated with
-        source: REACT:R-HSA-9018519
-        target: HP:0030683
-    -   key: manifestation of
-        source: HP:0030683
-        target: MESH:D059268
-    multigraph: true
-    nodes:
-    -   id: MESH:D004028
-        label: Drug
-        name: dienestrol
-    -   id: UniProt:P03372
-        label: Protein
-        name: Estrogen receptor alpha
-    -   id: MESH:D004967
-        label: ChemicalSubstance
-        name: Estrogen
-    -   id: REACT:R-HSA-9018519
-        label: Pathway
-        name: Estrogen-dependent gene expression
-    -   id: HP:0030683
-        label: PhenotypicFeature
-        name: Vaginitis
-    -   id: MESH:D059268
-        label: Disease
-        name: Atrophic vaginitis
-    reference:
-    - https://go.drugbank.com/drugs/DB00890
--   comment: dienestrol treatment is mainly recommended for post-menopausal dyspareunia.
-    directed: true
-    graph:
-        disease: Dyspareunia
-        disease_mesh: MESH:D004414
-        drug: dienestrol
-        drug_mesh: MESH:D004028
-        drugbank: DB:DB00890
-    links:
-    -   key: chemically similar to
-        source: MESH:D004028
-        target: MESH:D004967
-    -   key: increases activity of
-        source: MESH:D004967
-        target: UniProt:P03372
-    -   key: positively regulates
-        source: UniProt:P03372
-        target: REACT:R-HSA-9018519
-    -   key: negatively correlated with
-        source: REACT:R-HSA-9018519
-        target: HP:0030016
-    -   key: manifestation of
-        source: HP:0030016
-        target: MESH:D004414
-    multigraph: true
-    nodes:
-    -   id: MESH:D004028
-        label: Drug
-        name: dienestrol
-    -   id: UniProt:P03372
-        label: Protein
-        name: Estrogen receptor alpha
-    -   id: MESH:D004967
-        label: ChemicalSubstance
-        name: Estrogen
-    -   id: REACT:R-HSA-9018519
-        label: Pathway
-        name: Estrogen-dependent gene expression
-    -   id: HP:0030016
-        label: PhenotypicFeature
-        name: Dyspareunia
-    -   id: MESH:D004414
-        label: Disease
-        name: Dyspareunia
-    reference:
-    - https://go.drugbank.com/drugs/DB00890
--   comment: Polidocanol is a sclerosing agent indicated to treat uncomplicated spider veins.
-        Sclerosing solutions cause the vein to scar, forcing blood to reroute
-        through healthier veins. The collapsed vein is reabsorbed into local tissue
-        and eventually fades (https://www.mayoclinic.org/tests-procedures/sclerotherapy/about/pac-20384592).
-    directed: true
-    graph:
-        disease: Venous varices
-        disease_mesh: MESH:D014648
-        drug: polidocanol
-        drug_mesh: MESH:C008976
-        drugbank: DB:DB06811
-    links:
-    -   key: chemically similar to
-        source: MESH:C008976
-        target: MESH:D012597
-    -   key: causes
-        source: MESH:D012597
-        target: HP:0100699
-    -   key: positively correlated with
-        source: HP:0100699
-        target: GO:0097709
-    -   key: negatively correlated with
-        source: GO:0097709
-        target: HP:0002619
-    -   key: manifestation of
-        source: HP:0002619
-        target: MESH:D014648
-    multigraph: true
-    nodes:
-    -   id: MESH:C008976
-        label: Drug
-        name: polidocanol
-    -   id: MESH:D012597
-        label: ChemicalSubstance
-        name: Sclerosing Solutions
-    -   id: HP:0100699
-        label: PhenotypicFeature
-        name: Scarring
-    -   id: GO:0097709
-        label: BiologicalProcess
-        name: connective tissue replacement
-    -   id: HP:0002619
-        label: PhenotypicFeature
-        name: Varicose veins
-    -   id: MESH:D014648
-        label: Disease
-        name: Venous varices
-    reference:
-    - https://go.drugbank.com/drugs/DB06811
-    - https://en.wikipedia.org/wiki/Polidocanol
--   directed: true
-    graph:
-        disease: Merkel cell carcinoma
-        disease_mesh: MESH:D015266
-        drug: Avelumab
-        drug_mesh: MESH:C000609138
-        drugbank: DB:DB11945
-    links:
-    -   key: decreases activity of
-        source: MESH:C000609138
-        target: UniProt:Q9NZQ7
-    -   key: negatively regulates
-        source: UniProt:Q9NZQ7
-        target: GO:0042098
-    -   key: negatively regulates
-        source: UniProt:Q9NZQ7
-        target: GO:0042110
-    -   key: positively correlated with
-        source: GO:0042098
-        target: GO:0002424
-    -   key: positively correlated with
-        source: GO:0042110
-        target: GO:0002424
-    -   key: negatively correlated with
-        source: GO:0002424
-        target: MESH:D015266
-    multigraph: true
-    nodes:
-    -   id: MESH:C000609138
-        label: Drug
-        name: Avelumab
-    -   id: UniProt:Q9NZQ7
-        label: Protein
-        name: Programmed cell death 1 ligand 1
-    -   id: GO:0042098
-        label: BiologicalProcess
-        name: T cell proliferation
-    -   id: GO:0042110
-        label: BiologicalProcess
-        name: T cell activation
-    -   id: GO:0002424
-        label: BiologicalProcess
-        name: T cell mediated immune response to tumor cell
-    -   id: MESH:D015266
-        label: Disease
-        name: Merkel cell carcinoma
-    reference:
-    - https://go.drugbank.com/drugs/DB11945
-    - https://en.wikipedia.org/wiki/Avelumab
+