You signed in with another tab or window. Reload to refresh your session.You signed out in another tab or window. Reload to refresh your session.You switched accounts on another tab or window. Reload to refresh your session.Dismiss alert
HMMER weights IUPAC degenerate emissions using the reciprocal of the perplexity of the underlying match state (see esl_abc_FExpectScore function in HMMER3 source)
This has the effect that the "score" for those emissions is the expectation of what you'd get if you randomized X's using the underlying emission distribution - much to the chagrin of Roger Sewell, who argued they should be treated as missing data (Sean's counterargument is that this
would reward their alignment to the model) - this is an old argument
Practically (as noted by @jordisr) this affects <1% of sequences, but for full hmmer compatibility we ought to include it.
The text was updated successfully, but these errors were encountered:
HMMER weights IUPAC degenerate emissions using the reciprocal of the perplexity of the underlying match state (see
esl_abc_FExpectScore
function in HMMER3 source)This has the effect that the "score" for those emissions is the expectation of what you'd get if you randomized X's using the underlying emission distribution - much to the chagrin of Roger Sewell, who argued they should be treated as missing data (Sean's counterargument is that this
would reward their alignment to the model) - this is an old argument
Practically (as noted by @jordisr) this affects <1% of sequences, but for full hmmer compatibility we ought to include it.
The text was updated successfully, but these errors were encountered: