diff --git a/.travis.yml b/.travis.yml
index f58cecc..5ce4a00 100644
--- a/.travis.yml
+++ b/.travis.yml
@@ -3,8 +3,12 @@ python:
     - "2.7"
     - "3.3"
     - "3.4"
+env:
+    - TORNADO_VERSION=3.2.2
+    - TORNADO_VERSION=4.0.2
 install:
     - "pip install -r requirements.txt --use-mirrors"
+    - "pip install tornado==$TORNADO_VERSION"
     - "pip install pytest"
     - "pip install pytest-cov"
     - "pip install coverage"
diff --git a/README.md b/README.md
index c5941bf..12a884c 100644
--- a/README.md
+++ b/README.md
@@ -55,3 +55,12 @@ These dependencies can be satisfied by running `pip install -r requirements.txt`
 
 * [tornado](http://www.tornadoweb.org/en/stable/)
 * [jsonschema](https://python-jsonschema.readthedocs.org/en/latest/)
+
+
+## Running Tests
+
+```bash
+sudo pip2 install tox
+sudo pip3 install tox
+sudo tox  # Will run test matrix
+```
diff --git a/README.rst b/README.rst
index ae5f2e6..16fc62c 100644
--- a/README.rst
+++ b/README.rst
@@ -1,5 +1,5 @@
 .. contents::
-   :depth: 3
+   :depth: 3.0
 ..
 
 Tornado-JSON
@@ -79,6 +79,15 @@ These dependencies can be satisfied by running
 -  `tornado <http://www.tornadoweb.org/en/stable/>`__
 -  `jsonschema <https://python-jsonschema.readthedocs.org/en/latest/>`__
 
+Running Tests
+-------------
+
+.. code:: bash
+
+    sudo pip2 install tox
+    sudo pip3 install tox
+    sudo tox  # Will run test matrix
+
 .. |Build Status| image:: https://travis-ci.org/hfaran/Tornado-JSON.png?branch=master
    :target: https://travis-ci.org/hfaran/Tornado-JSON
 .. |PyPI version| image:: https://badge.fury.io/py/Tornado-JSON.png
diff --git a/maintenance.md b/maintenance.md
index fdac771..64a9a7d 100644
--- a/maintenance.md
+++ b/maintenance.md
@@ -3,21 +3,23 @@
 
 * Update README.rst
 
-    ```$ pandoc -s -t rst --toc README.md -o README.rst```
+    ```pandoc -s -t rst --toc README.md -o README.rst```
 
 * Install project with files.txt record
 
-    ```$ sudo python setup.py install --record files.txt```
+    ```sudo python setup.py install --record files.txt```
 
 * "uninstall" package installed with files.txt record
 
-    ```$ cat files.txt | sudo xargs rm -rf```
+    ```cat files.txt | sudo xargs rm -rf```
 
 * Generate/update base docs/ folder with Sphinx
 
-    ```$ sphinx-apidoc -F -o docs tornado_json```
+    ```sphinx-apidoc -F -o docs tornado_json```
 
 * Run tests from root project directory
 
-    ```$ py.test --cov="tornado_json" --cov-report=term --cov-report=html```
-    ```$ nosetests --with-cov --cov-report term-missing --cov tornado_json tests/```
+    * `py.test --cov="tornado_json" --cov-report=term --cov-report=html`
+    * `nosetests --with-cov --cov-report term-missing --cov tornado_json tests/`
+    * With `tox>=1.8.0` installed for both py27 and py34
+        * `sudo tox  # runs test matrix with py27,py34 and tornado322,402`
diff --git a/tornado_json/application.py b/tornado_json/application.py
index 155cb5f..c5b8775 100755
--- a/tornado_json/application.py
+++ b/tornado_json/application.py
@@ -1,6 +1,7 @@
 import tornado.web
 
 from tornado_json.api_doc_gen import api_doc_gen
+from tornado_json.constants import TORNADO_MAJOR
 
 
 class Application(tornado.web.Application):
@@ -21,9 +22,11 @@ def __init__(self, routes, settings, db_conn=None):
         # Generate API Documentation
         api_doc_gen(routes)
 
-        # Unless gzip was specifically set to False in settings, enable it
-        if "gzip" not in list(settings.keys()):
-            settings["gzip"] = True
+        # Unless compress_response was specifically set to False in
+        # settings, enable it
+        compress_response = "compress_response" if TORNADO_MAJOR >= 4 else "gzip"
+        if compress_response not in settings:
+            settings[compress_response] = True
 
         tornado.web.Application.__init__(
             self,
diff --git a/tornado_json/constants.py b/tornado_json/constants.py
index 8b2634d..3ed4698 100644
--- a/tornado_json/constants.py
+++ b/tornado_json/constants.py
@@ -1 +1,8 @@
+from tornado import version_info as tornado_version_info
+
+
+(TORNADO_MAJOR,
+ TORNADO_MINOR,
+ TORNADO_PATCH) = tornado_version_info[:3]
+
 HTTP_METHODS = ["get", "put", "post", "patch", "delete", "head", "options"]
diff --git a/tornado_json/schema.py b/tornado_json/schema.py
index e39fd6a..d8a501b 100644
--- a/tornado_json/schema.py
+++ b/tornado_json/schema.py
@@ -4,6 +4,11 @@
 from functools import wraps
 from tornado import gen
 from tornado.concurrent import Future
+try:
+    from tornado.concurrent import is_future
+except ImportError:
+    # For tornado 3.x.x
+    is_future = lambda x: isinstance(x, Future)
 
 from tornado_json.utils import container
 
@@ -62,7 +67,7 @@ def _wrapper(self, *args, **kwargs):
             output = rh_method(self, *args, **kwargs)
             # If the rh_method returned a Future a la `raise Return(value)`
             #   we grab the output.
-            if isinstance(output, Future):
+            if is_future(output):
                 output = yield output
 
             if output_schema is not None:
diff --git a/tox.ini b/tox.ini
index 095751b..856fae7 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,11 +1,12 @@
 [tox]
-envlist = py27
+envlist = {py27,py34}-tornado{322,402}
 
 [testenv]
 deps=
     pytest
     pytest-cov
-    tornado
+    tornado322: tornado==3.2.2
+    tornado402: tornado==4.0.2
     jsonschema
 
 commands=