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Missing functionality from ViennaRNA #14

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marcom opened this issue Jun 12, 2023 · 0 comments
Open
9 tasks

Missing functionality from ViennaRNA #14

marcom opened this issue Jun 12, 2023 · 0 comments

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@marcom
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marcom commented Jun 12, 2023

Some of these items might already work, but should still get their own testset in the tests/ dir.

ViennaRNA-2.5.0 and before

  • default temperature for DNA params is 37 °C (like for RNA), change to better default

Callback functions

  • subopt
  • pbacktrack
  • neighbours
  • more?

Windowed predictions

See also: #9

  • pf_window
  • pf_window_channel
  • bpp_window (using vrna_probs_window)
  • bpp_window_channel
  • zscore

Soft and hard constraints

  • soft constraints
  • hard constraints

G-quadruplexes

Duplex predictions

  • strand concentrations?

Multistrand predictions

  • strand concentrations

RNA-DNA hybrids

  • only duplexes?

Grammar callbacks

  • callbacks at various stages of recursions

ViennaRNA-2.6.0

https://github.com/ViennaRNA/ViennaRNA/releases/tag/v2.6.0

  • energies for modified bases (uses soft constraints callback), energy parameter modifications stored as json
  • adjust energies to different salt concentrations (Na+)
  • new soft constraints multi-callback dispatcher
@marcom marcom pinned this issue Jun 12, 2023
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