[Text def] neural progenitor cell

[Caroline-99]

CL term
neural progenitor cell

CL core textual definition contradicts CxG definition regarding the self-renewal capacity of neural progenitor cells.

CL def: An undifferentiated cell that originates from a neural stem cell and has the capacity to generate multiple types of lineage-restricted progenitors but not to self-renew.

CxG def:
NPCs are characterized by their ability to self-renew through mitotic cell division in a process known as proliferation and possess the potential to differentiate into specific types of neural cells such as neurons, astrocytes, and oligodendrocytes. The type and number of cells that an NPC can produce depend on temporal and spatial signals in the nervous system microenvironment.

It seems that NPCs typically have limited self-renewal capacity compared to NSCs and eventually commit to differentiation. Therefore, the phrase "not to self-renew" is not accurate.

Suggested revision of textual definition
An undifferentiated cell derived from a neural stem cell, with a (limited?) capacity to self-renew and the ability to generate multiple types of lineage-restricted progenitors, contributing to the formation of neurons, astrocytes, and oligodendrocytes.

PMID: 37508487