This script is vastly outdated. I highly recommend you to treat your data with NanoASV instead of Epi2ME
https://github.com/ImagoXV/NanoASV
This piece of script (POS) might as well be a piece of shit, but it's working. Make sure you use it in a new empty directory. Just add your EPI2ME 16S barcoding output csv in the directory.
Run the code
There you go
Problems noted : Unclassified taxa are merged into one global unclassified one. That's really a shame, but EPI2ME does not give associated ASV ID or anything allowing us to climb back to clustering informations.