Skip to content

Commit

Permalink
Fixes #2875 NTR-granzyme H-associated CD8 T cell
Browse files Browse the repository at this point in the history
Added a new term
  • Loading branch information
Caroline-99 committed Jan 10, 2025
1 parent 564c237 commit 91f1519
Show file tree
Hide file tree
Showing 2 changed files with 15 additions and 1 deletion.
13 changes: 13 additions & 0 deletions src/ontology/cl-edit.owl
Original file line number Diff line number Diff line change
Expand Up @@ -3145,6 +3145,7 @@ Declaration(Class(obo:CL_4052028))
Declaration(Class(obo:CL_4052029))
Declaration(Class(obo:CL_4052030))
Declaration(Class(obo:CL_4052031))
Declaration(Class(obo:CL_4052032))
Declaration(Class(obo:CL_4052048))
Declaration(Class(obo:CL_4052049))
Declaration(Class(obo:CP_0000000))
Expand Down Expand Up @@ -3206,6 +3207,7 @@ Declaration(Class(obo:PR_000002030))
Declaration(Class(obo:PR_000002123))
Declaration(Class(obo:PR_000003264))
Declaration(Class(obo:PR_000003472))
Declaration(Class(obo:PR_000003490))
Declaration(Class(obo:PR_000004691))
Declaration(Class(obo:PR_000004919))
Declaration(Class(obo:PR_000005444))
Expand Down Expand Up @@ -33490,6 +33492,17 @@ AnnotationAssertion(rdfs:label obo:CL_4052031 "respiratory airway secretory cell
SubClassOf(obo:CL_4052031 obo:CL_1100001)
SubClassOf(obo:CL_4052031 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002051))

# Class: obo:CL_4052032 (granzyme H-associated CD8 T cell)

AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:35389781") obo:IAO_0000115 obo:CL_4052032 "A CD8 T cell characterized by high expression of Granzyme H (GZMH), significantly expanded in systemic lupus erythematosus (SLE) patients. This cell exhibits a restricted TCR repertoire and elevated expression of cytotoxic, exhaustion, and type I interferon-stimulated gene signatures compared to controls. Unlike other CD8 T cell populations, GZMH+ CD8 T cells can comprise up to 50% of all lymphocytes in some SLE patients.")
AnnotationAssertion(terms:contributor obo:CL_4052032 <https://orcid.org/0000-0002-3958-7465>)
AnnotationAssertion(terms:contributor obo:CL_4052032 <https://orcid.org/0009-0000-8480-9277>)
AnnotationAssertion(terms:date obo:CL_4052032 "2025-01-10T10:14:31Z"^^xsd:dateTime)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:35389781") oboInOwl:hasExactSynonym obo:CL_4052032 "granzyme H+ CD8 T cell")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:35389781") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_4052032 "GZMH+ CD8+ T cell")
AnnotationAssertion(rdfs:label obo:CL_4052032 "granzyme H-associated CD8 T cell")
EquivalentClasses(obo:CL_4052032 ObjectIntersectionOf(obo:CL_0000909 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000003490)))

# Class: obo:CL_4052048 (intercalated cell of salivary gland)

AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:30855909") Annotation(oboInOwl:hasDbXref "PMID:35799078") Annotation(oboInOwl:hasDbXref "PMID:36726292") Annotation(oboInOwl:hasDbXref "PMID:37724716") obo:IAO_0000115 obo:CL_4052048 "A cuboidal epithelial cell that is part of the intercalated duct of salivary gland. This cell expresses proteins commonly associated with acinar cells and displays calcium signaling characteristics similar to secretory cells, indicating an active role in the secretory process rather than ion reabsorption.")
Expand Down
3 changes: 2 additions & 1 deletion src/ontology/imports/pr_terms.txt
Original file line number Diff line number Diff line change
Expand Up @@ -50,4 +50,5 @@ PR:000016626
PR:000003472
PR:000012318
PR:000064867
PR:000001440
PR:000001440
PR:000003490

0 comments on commit 91f1519

Please sign in to comment.