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Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)
A CD8 T cell subpopulation characterized by high expression of Granzyme H (GZMH) that is significantly expanded in systemic lupus erythematosus (SLE) patients. These cells exhibit a restricted TCR repertoire and show elevated expression of cytotoxic, exhaustion, and type 1 interferon-stimulated gene signatures compared to controls. Unlike other CD8 T cell populations, GZMH+ CD8 T cells can comprise up to 50% of all lymphocytes in some SLE patients. 35389781
Blood - UBERON:0001969
(Note: paper analyzed PBMCs from SLE patients, so believe this is the correct categorization.)
Your ORCID
0000-0002-3958-7465
Additional notes or concerns
Not a practicing immunologist and defer to the opinions of the experts.
Also opted to leave "alpha-beta" out because it is implied, but curious what the maintainers think.
The text was updated successfully, but these errors were encountered:
Please check that the term does not already exist by using the ontology search tool OLS:
https://www.ebi.ac.uk/ols4/ontologies/cl
Preferred term label
granzyme H-associated CD8 T cell
Synonyms (add reference(s), please)
granzyme H+ CD8 T cell - exact synonym PMID: 35389781
Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)
A CD8 T cell subpopulation characterized by high expression of Granzyme H (GZMH) that is significantly expanded in systemic lupus erythematosus (SLE) patients. These cells exhibit a restricted TCR repertoire and show elevated expression of cytotoxic, exhaustion, and type 1 interferon-stimulated gene signatures compared to controls. Unlike other CD8 T cell populations, GZMH+ CD8 T cells can comprise up to 50% of all lymphocytes in some SLE patients.
35389781
Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)
CD8-positive, alpha-beta memory T cell
Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)
Blood - UBERON:0001969
(Note: paper analyzed PBMCs from SLE patients, so believe this is the correct categorization.)
Your ORCID
0000-0002-3958-7465
Additional notes or concerns
Not a practicing immunologist and defer to the opinions of the experts.
Also opted to leave "alpha-beta" out because it is implied, but curious what the maintainers think.
The text was updated successfully, but these errors were encountered: