Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

[NTR] granzyme H-associated CD8 T cell #2875

Open
kennyworkman opened this issue Jan 6, 2025 · 0 comments · May be fixed by #2895
Open

[NTR] granzyme H-associated CD8 T cell #2875

kennyworkman opened this issue Jan 6, 2025 · 0 comments · May be fixed by #2895

Comments

@kennyworkman
Copy link

Please check that the term does not already exist by using the ontology search tool OLS:
https://www.ebi.ac.uk/ols4/ontologies/cl

Preferred term label
granzyme H-associated CD8 T cell

Synonyms (add reference(s), please)
granzyme H+ CD8 T cell - exact synonym PMID: 35389781

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)
A CD8 T cell subpopulation characterized by high expression of Granzyme H (GZMH) that is significantly expanded in systemic lupus erythematosus (SLE) patients. These cells exhibit a restricted TCR repertoire and show elevated expression of cytotoxic, exhaustion, and type 1 interferon-stimulated gene signatures compared to controls. Unlike other CD8 T cell populations, GZMH+ CD8 T cells can comprise up to 50% of all lymphocytes in some SLE patients.
35389781

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)
CD8-positive, alpha-beta memory T cell

Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)

Blood - UBERON:0001969
(Note: paper analyzed PBMCs from SLE patients, so believe this is the correct categorization.)

Your ORCID
0000-0002-3958-7465

Additional notes or concerns
Not a practicing immunologist and defer to the opinions of the experts.
Also opted to leave "alpha-beta" out because it is implied, but curious what the maintainers think.

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Projects
Development

Successfully merging a pull request may close this issue.

2 participants