REGENIE v4.0 and survival analysis, what comes next?

[Ojami]

Hi Joelle,

First of all, thank you for the excellent implementation of survival analysis in REGENIE! I have three questions:

1. Is there any plan to add left-truncation to the REGENIE survival analyses? Currently, this is apparently only addressed by BayesW.

2. Is there any plan to include competing risks (e.g., Fine-Gray)? I understand that this poses a significant computational burden, but there are faster implementations of subdistribution hazard models available, such as fastcmprsk, here or here.

3. What about more complicated scenarios such as time-to-event (TTE), when patients are followed up after a diagnosis to the event (which is more related to question 1), as opposed to age-at-onset (AAO), which seems to be case covered so far by most tools.

Best/Oveis