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wikipathways · Dec 24, 2024 · 5462c62 · 5462c62
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diff --git a/_data/WP137-datanodes.tsv b/_data/WP137-datanodes.tsv
@@ -1,15 +1,15 @@
 Label	Type	Identifier	Comment	Ensembl	NCBI gene	HGNC	UniProt	Wikidata	ChEBI	InChI	PubChem	ChemSpider	HMDB	KEGG	LipidMaps
-ATP	Metabolite	cas:1927-31-7	""					wikidata:Q201090	chebi:16284	inchikey:SUYVUBYJARFZHO-RRKCRQDMSA-N	pubchem.compound:15993	chemspider:15194	hmdb:HMDB0001532	kegg.compound:C00131	
-malonyl-CoA	Metabolite	cas:524-14-1	""					wikidata:Q27095293	chebi:15531	inchikey:LTYOQGRJFJAKNA-DVVLENMVSA-N	pubchem.compound:644066	chemspider:559121;chemspider:26330306	hmdb:HMDB0001175	kegg.compound:C00083;kegg.compound:C03188	lipidmaps:LMFA07050345;lipidmaps:LMFA07050031
 NADPH	Metabolite	cas:53-57-6	""					wikidata:Q26841327	chebi:16474	inchikey:ACFIXJIJDZMPPO-NNYOXOHSSA-N	pubchem.compound:5884	chemspider:5673	hmdb:HMDB0000221	kegg.compound:C00005	
-Coenzyme A	Metabolite	cas:64885-97-8	""					wikidata:Q412727	chebi:16848	inchikey:XXFFZHQKSZLLIT-NALJQGANSA-N	pubchem.compound:123996	chemspider:110515		kegg.compound:C00876	
-phosphate	Metabolite	cas:14265-44-2	""					wikidata:Q177811	chebi:26078;chebi:18367	inchikey:NBIIXXVUZAFLBC-UHFFFAOYSA-K;inchikey:NBIIXXVUZAFLBC-UHFFFAOYSA-N	pubchem.compound:1004;pubchem.compound:1061	chemspider:979;chemspider:1032	hmdb:HMDB0001429	kegg.compound:C00009	
 ADP	Metabolite	cas:58-64-0	""					wikidata:Q185253	chebi:16761	inchikey:XTWYTFMLZFPYCI-KQYNXXCUSA-N	pubchem.compound:6022	chemspider:5800	hmdb:HMDB0001341	kegg.compound:C00008	
+phosphate	Metabolite	cas:14265-44-2	""					wikidata:Q177811	chebi:26078;chebi:18367	inchikey:NBIIXXVUZAFLBC-UHFFFAOYSA-K;inchikey:NBIIXXVUZAFLBC-UHFFFAOYSA-N	pubchem.compound:1004;pubchem.compound:1061	chemspider:979;chemspider:1032	hmdb:HMDB0001429	kegg.compound:C00009	
 acetyl-CoA	Metabolite	cas:72-89-9	""					wikidata:Q715317	chebi:15351	inchikey:ZSLZBFCDCINBPY-ZSJPKINUSA-N	pubchem.compound:444493	chemspider:392413	hmdb:HMDB0001206	kegg.compound:C00024	lipidmaps:LMFA07050281
-ACC1	GeneProduct	sgd:S000005299	""	ensembl:YNR016C	ncbigene:855750		uniprot:Q00955								
-FAS2	GeneProduct	sgd:S000006152	""	ensembl:YPL231W	ncbigene:855845		uniprot:P19097								
-FAS1	GeneProduct	sgd:S000001665	""	ensembl:YKL182W	ncbigene:853653		uniprot:P07149								
+ATP	Metabolite	cas:1927-31-7	""					wikidata:Q201090	chebi:16284	inchikey:SUYVUBYJARFZHO-RRKCRQDMSA-N	pubchem.compound:15993	chemspider:15194	hmdb:HMDB0001532	kegg.compound:C00131	
+Coenzyme A	Metabolite	cas:64885-97-8	""					wikidata:Q412727	chebi:16848	inchikey:XXFFZHQKSZLLIT-NALJQGANSA-N	pubchem.compound:123996	chemspider:110515		kegg.compound:C00876	
+malonyl-CoA	Metabolite	cas:524-14-1	""					wikidata:Q27095293	chebi:15531	inchikey:LTYOQGRJFJAKNA-DVVLENMVSA-N	pubchem.compound:644066	chemspider:559121;chemspider:26330306	hmdb:HMDB0001175	kegg.compound:C00083;kegg.compound:C03188	lipidmaps:LMFA07050345;lipidmaps:LMFA07050031
+CEM1	GeneProduct	sgd:S000000863	""	ensembl:YER061C	ncbigene:856790		uniprot:P39525								
 MCT1	GeneProduct	sgd:S000005747	""	ensembl:YOR221C	ncbigene:854396		uniprot:Q12283								
+FAS1	GeneProduct	sgd:S000001665	""	ensembl:YKL182W	ncbigene:853653		uniprot:P07149								
+FAS2	GeneProduct	sgd:S000006152	""	ensembl:YPL231W	ncbigene:855845		uniprot:P19097								
+ACC1	GeneProduct	sgd:S000005299	""	ensembl:YNR016C	ncbigene:855750		uniprot:Q00955								
 HFA1	GeneProduct	sgd:S000004820	""	ensembl:YMR207C											
-CEM1	GeneProduct	sgd:S000000863	""	ensembl:YER061C	ncbigene:856790		uniprot:P39525								
 OAR1	GeneProduct	sgd:S000001538	""	ensembl:YKL055C	ncbigene:853810		uniprot:P35731								
diff --git a/_data/WP71-bibliography.tsv b/_data/WP71-bibliography.tsv
@@ -1 +1,2 @@
 ID	Database	Citation
+https://pathway.yeastgenome.org/YEAST/NEW-IMAGE?type=PATHWAY&object=LIPASYN-PWY-1	URL	
diff --git a/_data/WP71-datanodes.tsv b/_data/WP71-datanodes.tsv
@@ -1,7 +1,13 @@
 Label	Type	Identifier	Comment	Ensembl	NCBI gene	HGNC	UniProt	Wikidata	ChEBI	InChI	PubChem	ChemSpider	HMDB	KEGG	LipidMaps
-inositol 1,4,5-trisphosphate	Metabolite	cas:98102-63-7	""					wikidata:Q33129821		inchikey:MMWCIQZXVOZEGG-NCGNNJKGSA-N	pubchem.compound:123680				
-choline	Metabolite	cas:62-49-7	""					wikidata:Q193166	chebi:15354	inchikey:OEYIOHPDSNJKLS-UHFFFAOYSA-N	pubchem.compound:305	chemspider:299	hmdb:HMDB0000097	kegg.compound:C00114	
+1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate	Metabolite	pubchem.compound:24742074	""					wikidata:Q114851265		inchikey:CNWINRVXAYPOMW-WJUYXORRSA-I	pubchem.compound:24742074				
+H+	Metabolite	chebi:15378	""					wikidata:Q506710	chebi:15378	inchikey:GPRLSGONYQIRFK-UHFFFAOYSA-N	pubchem.compound:1038	chemspider:1010	hmdb:HMDB0059597	kegg.compound:C00080	
+inositol 1,4,5-trisphosphate	Metabolite	chebi:203600	""					wikidata:Q27225698	chebi:203600	inchikey:MMWCIQZXVOZEGG-XJTPDSDZSA-H	pubchem.compound:21761708	chemspider:10375590			
+H20	Metabolite	chebi:15377	""					wikidata:Q283	chebi:15377	inchikey:XLYOFNOQVPJJNP-UHFFFAOYSA-N	pubchem.compound:22247451;pubchem.compound:962	chemspider:937	hmdb:HMDB0002111	kegg.compound:C00001	
+1,2-diacyl-sn-glycerol	Metabolite	chebi:17815	""					wikidata:Q22082904	chebi:17815					kegg.compound:C00641	lipidmaps:LMGL02010000
+phosphatidylcholine	Metabolite	chebi:16110	""					wikidata:Q38133872	chebi:16110						
+phosphocholine	Metabolite	chebi:295975	""					wikidata:Q27225724	chebi:295975	inchikey:YHHSONZFOIEMCP-UHFFFAOYSA-M	pubchem.compound:3330960	chemspider:2578067			
+1,2-diacyl-sn-glycerol 3-phosphate	Metabolite	chebi:29089	""					wikidata:Q22083257	chebi:29089						lipidmaps:LMGP10010000
+choline	Metabolite	chebi:15354	""					wikidata:Q193166	chebi:15354	inchikey:OEYIOHPDSNJKLS-UHFFFAOYSA-N	pubchem.compound:305	chemspider:299	hmdb:HMDB0000097	kegg.compound:C00114	
 PLC1	GeneProduct	sgd:S000006189	""	ensembl:YPL268W	ncbigene:855860		uniprot:P32383								
 ISC1	GeneProduct	sgd:S000000821	""	ensembl:YER019W	ncbigene:856739		uniprot:P40015								
 SPO14	GeneProduct	sgd:S000001739	""	ensembl:YKR031C	ncbigene:853902		uniprot:P36126								
-SPO22	GeneProduct	sgd:S000001335	""	ensembl:YIL073C	ncbigene:854737		uniprot:P40511								
diff --git a/_pathways/WP137.md b/_pathways/WP137.md
@@ -10,50 +10,27 @@ authors:
 - Christine Chichester
 - Egonw
 - Eweitz
-description: 'Pyridoxal phosphate (PLP) is the active form of vitamin B<sub>6</sub>
-  and is a cofactor in many reactions  of amino acid metabolism. Pyridoxine (PN),
-  pyridoxamine (PM), pyridoxal (PL),  pyridoxine 5''-phosphate (PNP) and pyridoxamine
-  5''-phosphate (PMP) are all forms of  vitamin B<sub>6</sub> that can be converted
-  to PLP via the PLP salvage pathway.  Most unicellular organisms and plants can synthesize
-  PLP, whereas mammals cannot and require vitamin B<sub>6</sub> in their diet.  Thus
-  far, three PLP biosynthetic pathways have been characterized: the de novo PLP biosynthesis
-  pathway as characterized in <I>Escherichia coli</I> (CITS: [12686115]), the de novo
-  PLP biosynthesis pathway as being studied in fungi (CITS: [15483325],[14764090]),
-  and the PLP salvage pathway (CITS: [15483325], [17696614],[8764513],[9537380]).
-  <I>Saccharomyces cerevisiae</I> synthesize PLP via the fungal type de novo PLP synthesis
-  pathway and the PLP salvage pathway (CITS: [7896706], [17696614], [15483325], [14764090]).
-  Extracellular PN, PL and PM are transported into the cell by Tpn1p, a member of
-  the purine-cytosine permease family (CITS: [12649274]).  SOURCE: SGD pathways, http://pathway.yeastgenome.org/server.html'
-last-edited: 2021-05-20
+- Khanspers
+citedin: ''
+communities: []
+description: 'SOURCE: SGD pathways, http://pathway.yeastgenome.org/server.html'
+last-edited: 2024-12-24
+ndex: null
 organisms:
 - Saccharomyces cerevisiae
 redirect_from:
 - /index.php/Pathway:WP137
 - /instance/WP137
-- /instance/WP137_r117288
-revision: r117288
+- /instance/WP137_r136183
+revision: r136183
 schema-jsonld:
 - '@context': https://schema.org/
   '@id': https://wikipathways.github.io/pathways/WP137.html
   '@type': Dataset
   creator:
     '@type': Organization
     name: WikiPathways
-  description: 'Pyridoxal phosphate (PLP) is the active form of vitamin B<sub>6</sub>
-    and is a cofactor in many reactions  of amino acid metabolism. Pyridoxine (PN),
-    pyridoxamine (PM), pyridoxal (PL),  pyridoxine 5''-phosphate (PNP) and pyridoxamine
-    5''-phosphate (PMP) are all forms of  vitamin B<sub>6</sub> that can be converted
-    to PLP via the PLP salvage pathway.  Most unicellular organisms and plants can
-    synthesize PLP, whereas mammals cannot and require vitamin B<sub>6</sub> in their
-    diet.  Thus far, three PLP biosynthetic pathways have been characterized: the
-    de novo PLP biosynthesis pathway as characterized in <I>Escherichia coli</I> (CITS:
-    [12686115]), the de novo PLP biosynthesis pathway as being studied in fungi (CITS:
-    [15483325],[14764090]), and the PLP salvage pathway (CITS: [15483325], [17696614],[8764513],[9537380]).
-    <I>Saccharomyces cerevisiae</I> synthesize PLP via the fungal type de novo PLP
-    synthesis pathway and the PLP salvage pathway (CITS: [7896706], [17696614], [15483325],
-    [14764090]). Extracellular PN, PL and PM are transported into the cell by Tpn1p,
-    a member of the purine-cytosine permease family (CITS: [12649274]).  SOURCE: SGD
-    pathways, http://pathway.yeastgenome.org/server.html'
+  description: 'SOURCE: SGD pathways, http://pathway.yeastgenome.org/server.html'
   keywords:
   - ACC1
   - ADP

diff --git a/_pathways/WP4030.md b/_pathways/WP4030.md
@@ -1,13 +1,13 @@
 ---
 annotations:
-- id: CL:0000188
-  parent: native cell
-  type: Cell Type Ontology
-  value: cell of skeletal muscle
 - id: PW:0001118
   parent: classic metabolic pathway
   type: Pathway Ontology
   value: altered energy metabolic pathway
+- id: CL:0000188
+  parent: native cell
+  type: Cell Type Ontology
+  value: cell of skeletal muscle
 authors:
 - I6095275
 - MaintBot
@@ -35,15 +35,15 @@ description: 'The short-chain fatty acids (SCFA) acetate, propionate and butyrat
   transporter type 4 (GLUT4) and decreases glycolysis. In addition to AMPK activation,
   SCFA might also induce peroxisome proliferator activated receptor delta (PPARD)
   expression, another process contributing to enhanced fat oxidation levels.    '
-last-edited: 2024-12-21
+last-edited: 2024-12-24
 ndex: 331ac03a-8b69-11eb-9e72-0ac135e8bacf
 organisms:
 - Homo sapiens
 redirect_from:
 - /index.php/Pathway:WP4030
 - /instance/WP4030
-- /instance/WP4030_r136154
-revision: r136154
+- /instance/WP4030_r136176
+revision: r136176
 schema-jsonld:
 - '@context': https://schema.org/
   '@id': https://wikipathways.github.io/pathways/WP4030.html

diff --git a/_pathways/WP71.md b/_pathways/WP71.md
@@ -4,38 +4,78 @@ annotations:
   parent: classic metabolic pathway
   type: Pathway Ontology
   value: glycerophospholipid metabolic pathway
+- id: PW:0000002
+  parent: classic metabolic pathway
+  type: Pathway Ontology
+  value: classic metabolic pathway
 authors:
 - J.Heckman
 - MaintBot
 - Egonw
 - Ddigles
-description: ''
-last-edited: 2013-07-12
+- Khanspers
+citedin: ''
+communities: []
+description: 'In addition to being a primary structural components of cell membranes,
+  phospholipids may also be thought of as a reservoir of signaling molecules. Hydrolysis
+  of phosphatidylinositol 4,5-biphosphate (PIP2) by phospholipase C, for instance,
+  generates the signaling molecules inositol triphosphate (IP3) and diacylglycerol
+  (DAG). S. cerevisiae catalyzes this reaction via Plc1p, a phosphatidylinositol-specific
+  phospholipase C involved in a variety of biological processes including nutrient
+  sensing and filamentous growth. On the other hand, degradation of phosphatidylcholine
+  (PC) by phospholipase D (Spo14p) yields phosphatidic acid and choline; this activity
+  generates PA required for sporulation in S. cerevisiae. A phospholipase C specific
+  for PC has yet to be identified in S. cerevisiae, however PC may also serve as substrate
+  for phospholipases B (Plb1-3p and Nte1p), which hydrolyze PC to yield glycerophosphocholine
+  (GPC) and two fatty acids. Both phospholipases B and D are thought to mediate PC
+  turnover in yeast, and phospholipase B (as Plb1p) has also been implicated in acyl
+  chain remodeling.  Source: https://pathway.yeastgenome.org/'
+last-edited: 2024-12-24
+ndex: null
 organisms:
 - Saccharomyces cerevisiae
 redirect_from:
 - /index.php/Pathway:WP71
 - /instance/WP71
-- /instance/WP71_r70049
-revision: r70049
+- /instance/WP71_r136181
+revision: r136181
 schema-jsonld:
 - '@context': https://schema.org/
   '@id': https://wikipathways.github.io/pathways/WP71.html
   '@type': Dataset
   creator:
     '@type': Organization
     name: WikiPathways
-  description: ''
+  description: 'In addition to being a primary structural components of cell membranes,
+    phospholipids may also be thought of as a reservoir of signaling molecules. Hydrolysis
+    of phosphatidylinositol 4,5-biphosphate (PIP2) by phospholipase C, for instance,
+    generates the signaling molecules inositol triphosphate (IP3) and diacylglycerol
+    (DAG). S. cerevisiae catalyzes this reaction via Plc1p, a phosphatidylinositol-specific
+    phospholipase C involved in a variety of biological processes including nutrient
+    sensing and filamentous growth. On the other hand, degradation of phosphatidylcholine
+    (PC) by phospholipase D (Spo14p) yields phosphatidic acid and choline; this activity
+    generates PA required for sporulation in S. cerevisiae. A phospholipase C specific
+    for PC has yet to be identified in S. cerevisiae, however PC may also serve as
+    substrate for phospholipases B (Plb1-3p and Nte1p), which hydrolyze PC to yield
+    glycerophosphocholine (GPC) and two fatty acids. Both phospholipases B and D are
+    thought to mediate PC turnover in yeast, and phospholipase B (as Plb1p) has also
+    been implicated in acyl chain remodeling.  Source: https://pathway.yeastgenome.org/'
   keywords:
+  - 1,2-diacyl-sn-glycerol
+  - 1,2-diacyl-sn-glycerol 3-phosphate
+  - 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
+  - H+
+  - H20
   - ISC1
   - PLC1
   - SPO14
-  - SPO22
   - choline
   - inositol 1,4,5-trisphosphate
+  - phosphatidylcholine
+  - phosphocholine
   license: CC0
-  name: Lipases biosynthesis
+  name: Phospholipids degradation
 seo: CreativeWork
-title: Lipases biosynthesis
+title: Phospholipids degradation
 wpid: WP71
 ---
diff --git a/assets/img/WP137/WP137-thumb.png b/assets/img/WP137/WP137-thumb.png
diff --git a/assets/img/WP4030/WP4030-thumb.png b/assets/img/WP4030/WP4030-thumb.png
diff --git a/assets/img/WP71/WP71-thumb.png b/assets/img/WP71/WP71-thumb.png
Original file line number	Diff line number	Diff line change
		@@ -1 +1,2 @@
		ID Database Citation
		https://pathway.yeastgenome.org/YEAST/NEW-IMAGE?type=PATHWAY&object=LIPASYN-PWY-1 URL