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diff --git a/_data/WP5493-bibliography.tsv b/_data/WP5493-bibliography.tsv
@@ -0,0 +1,2 @@
+ID	Database	Citation
+19651622	Pubmed	"Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics. Pan C, Olsen JV, Daub H, Mann M. Mol Cell Proteomics. 2009 Dec;8(12):2796–808.  <a href=""http://www.ncbi.nlm.nih.gov/pubmed/19651622"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/19651622"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://scholia.toolforge.org/pubmed/19651622"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
diff --git a/_data/WP5493-datanodes.tsv b/_data/WP5493-datanodes.tsv
@@ -0,0 +1,46 @@
+Label	Type	Identifier	Comment	Ensembl	NCBI gene	HGNC	UniProt	Wikidata	ChEBI	InChI	PubChem	ChemSpider	HMDB	KEGG	LipidMaps
+SPAG1	GeneProduct	ncbigene:6674	""	ensembl:ENSG00000104450	ncbigene:6674	hgnc.symbol:SPAG1	uniprot:Q07617								
+BCR	GeneProduct	ncbigene:613	""	ensembl:ENSG00000186716	ncbigene:613	hgnc.symbol:BCR	uniprot:P11274;uniprot:H0Y554								
+BCL9	GeneProduct	ncbigene:607	""	ensembl:ENSG00000116128	ncbigene:607	hgnc.symbol:BCL9	uniprot:A0A804HI55;uniprot:A0A804HIV1;uniprot:A0A024QYY4;uniprot:O00512								
+ PIK3R1	GeneProduct	ncbigene:5295	""	ensembl:ENSG00000145675	ncbigene:5295	hgnc.symbol:PIK3R1	uniprot:P27986;uniprot:A0A2X0SFG1;uniprot:E5RGI8;uniprot:H0YBC2;uniprot:H0YB27;uniprot:E5RK66;uniprot:E5RJY0;uniprot:B3KWZ7;uniprot:E5RHI0								
+SOS1	GeneProduct	ncbigene:6654	""	ensembl:ENSG00000115904	ncbigene:6654	hgnc.symbol:SOS1	uniprot:G5E9C8;uniprot:Q07889;uniprot:C9K0N6								
+MAPK3	GeneProduct	ncbigene:5595	""	ensembl:ENSG00000102882	ncbigene:5595	hgnc.symbol:MAPK3	uniprot:B3KR49;uniprot:E9PBK7;uniprot:P27361;uniprot:E9PQW4;uniprot:H0YEX6;uniprot:E9PJF0;uniprot:L7RXH5;uniprot:E9PRH7;uniprot:H0YDH9								
+ABL1	GeneProduct	ncbigene:25	""	ensembl:ENSG00000097007	ncbigene:25	hgnc.symbol:ABL1	uniprot:A0A024R8E2;uniprot:R4GRW0;uniprot:P00519								
+CRKL	GeneProduct	ncbigene:1399	""	ensembl:ENSG00000099942	ncbigene:1399	hgnc.symbol:CRKL	uniprot:P46109								
+PXN	GeneProduct	ncbigene:5829	""	ensembl:ENSG00000089159	ncbigene:5829	hgnc.symbol:PXN	uniprot:F5GZ78;uniprot:F8W0G0;uniprot:A0A1B0GWE7;uniprot:F5H836;uniprot:F8W0K8;uniprot:F8W1E0;uniprot:P49023;uniprot:A0A140VJQ8;uniprot:A0A1B0GTU4;uniprot:A0A1B0GV30;uniprot:F8VZ39;uniprot:A0A1B0GU60								
+GRB2	GeneProduct	ncbigene:2885	""	ensembl:ENSG00000177885	ncbigene:2885	hgnc.symbol:GRB2	uniprot:P62993;uniprot:B0LPF3;uniprot:J3QRL5;uniprot:J3KT38;uniprot:J3QLF6								
+ PIK3CA	GeneProduct	ncbigene:5290	""	ensembl:ENSG00000121879	ncbigene:5290	hgnc.symbol:PIK3CA	uniprot:A0A2R8Y2F6;uniprot:C9JAM9;uniprot:A0A6Q8PGN9;uniprot:A0A6Q8PGV1;uniprot:C9J951;uniprot:P42336								
+VAV1	GeneProduct	ncbigene:7409	""	ensembl:ENSG00000141968	ncbigene:7409	hgnc.symbol:VAV1	uniprot:Q96D37;uniprot:P15498;uniprot:F5H5P4;uniprot:A0A0A0MR07								
+ARAF	GeneProduct	ncbigene:369	"OCR lexicon match: RAF"	ensembl:ENSG00000078061	ncbigene:369	hgnc.symbol:ARAF	uniprot:A0A024R178;uniprot:P10398								
+BRAF	GeneProduct	ncbigene:673	"OCR lexicon match: RAF"	ensembl:ENSG00000157764	ncbigene:673	hgnc.symbol:BRAF	uniprot:A0A2R8Y492;uniprot:A0A2R8Y8E0;uniprot:H7C4S5;uniprot:A0A2R8Y467;uniprot:A0A2R8YES9;uniprot:H7C560;uniprot:A0A2U3TZI2;uniprot:P15056;uniprot:A0A2R8YDP5;uniprot:H7C5K3;uniprot:A0A2R8Y679								
+RAF1	GeneProduct	ncbigene:5894	"OCR lexicon match: RAF"	ensembl:ENSG00000132155	ncbigene:5894	hgnc.symbol:RAF1	uniprot:A0A0S2Z4L5;uniprot:P04049;uniprot:A0A0S2Z559;uniprot:A0A0B4J1W9;uniprot:H7C155;uniprot:L7RRS6								
+KRAS	GeneProduct	ncbigene:3845	"OCR lexicon match: RAS"	ensembl:ENSG00000133703	ncbigene:3845	hgnc.symbol:KRAS	uniprot:G3V4K2;uniprot:A0A024RAV5;uniprot:P01116;uniprot:L7RSL8;uniprot:G3V5T7								
+HRAS	GeneProduct	ncbigene:3265	"OCR lexicon match: RAS"	ensembl:ENSG00000174775	ncbigene:3265	hgnc.symbol:HRAS	uniprot:P01112;uniprot:A0A804HKM6;uniprot:X5D945;uniprot:A0A804HJ06;uniprot:A0A8C8MQR2								
+NRAS	GeneProduct	ncbigene:4893	"OCR lexicon match: RAS"	ensembl:ENSG00000213281	ncbigene:4893	hgnc.symbol:NRAS	uniprot:Q5U091;uniprot:P01111								
+SHC1	GeneProduct	ncbigene:6464	"OCR lexicon match: SHC"	ensembl:ENSG00000160691	ncbigene:6464	hgnc.symbol:SHC1	uniprot:X6R6D0;uniprot:Q5T187;uniprot:H0Y539;uniprot:Q5T181;uniprot:Q5T182;uniprot:P29353;uniprot:Q5T188								
+SHC2	GeneProduct	ncbigene:25759	"OCR lexicon match: SHC"	ensembl:ENSG00000129946	ncbigene:25759	hgnc.symbol:SHC2	uniprot:K7ENB2;uniprot:K7EKS8;uniprot:P98077								
+SHC3	GeneProduct	ncbigene:53358	"OCR lexicon match: SHC"	ensembl:ENSG00000148082	ncbigene:53358	hgnc.symbol:SHC3	uniprot:Q92529;uniprot:Q5T7I8								
+SHC4	GeneProduct	ncbigene:399694	"OCR lexicon match: SHC"	ensembl:ENSG00000185634	ncbigene:399694	hgnc.symbol:SHC4	uniprot:H0YLU6;uniprot:Q6S5L8;uniprot:F5H5M1;uniprot:H0YLZ2								
+GAB2	GeneProduct	ncbigene:9846	"OCR lexicon match: GAB2"	ensembl:ENSG00000033327	ncbigene:9846	hgnc.symbol:GAB2	uniprot:E9PJE2;uniprot:Q9UQC2;uniprot:E9PJ26								
+BCL2	GeneProduct	ncbigene:596	"OCR lexicon match: BCL2"	ensembl:ENSG00000171791	ncbigene:596	hgnc.symbol:BCL2	uniprot:A0A7I2V3S7;uniprot:P10415;uniprot:A0A024R2B3;uniprot:A0A024R2C4;uniprot:A0A7I2V5Q7;uniprot:A0A7I2V4W1;uniprot:A0A7I2V5Q9								
+MAP3K2	GeneProduct	ncbigene:10746	"OCR lexicon match: MEKK2"	ensembl:ENSG00000169967	ncbigene:10746	hgnc.symbol:MAP3K2	uniprot:Q9Y2U5;uniprot:A0A024RAH0								
+AKT1	GeneProduct	ncbigene:207	"OCR lexicon match: AKT"	ensembl:ENSG00000142208	ncbigene:207	hgnc.symbol:AKT1	uniprot:G3V3X1;uniprot:P31749;uniprot:G3V2I6;uniprot:A0A804HJM6;uniprot:B0LPE5;uniprot:A0A087WY56								
+AKT2	GeneProduct	ncbigene:208	"OCR lexicon match: AKT"	ensembl:ENSG00000105221	ncbigene:208	hgnc.symbol:AKT2	uniprot:M0QZK3;uniprot:J3QKW1;uniprot:A0A5F9ZHJ8;uniprot:E7EVP8;uniprot:J3KRI8;uniprot:C9JIJ1;uniprot:J3QLS6;uniprot:A8MX96;uniprot:C9JIF6;uniprot:A0A0A0MRF1;uniprot:J3QL45;uniprot:M0R0P9;uniprot:C9J258;uniprot:M0QZW8;uniprot:J3KTC6;uniprot:A0A1B0GXA2;uniprot:M0R275;uniprot:C9JC83;uniprot:J3KSY8;uniprot:J3KT31;uniprot:P31751;uniprot:C9JHS6;uniprot:J3KTP4;uniprot:M0R283								
+AKT3	GeneProduct	ncbigene:10000	"OCR lexicon match: AKT"	ensembl:ENSG00000117020	ncbigene:10000	hgnc.symbol:AKT3	uniprot:A0A7P0T8T9;uniprot:A0A7P0TBJ6;uniprot:A0A5F9ZHU3;uniprot:A0A7P0TB29;uniprot:Q9Y243;uniprot:A0A5F9ZHA9;uniprot:A0A5F9ZGY0;uniprot:A0A5F9ZGZ4;uniprot:A0A5K1VW74;uniprot:A0A7P0T872;uniprot:A0A7P0TB32								
+RPS6KA1	GeneProduct	ncbigene:6195	"OCR lexicon match: RSK"	ensembl:ENSG00000117676	ncbigene:6195	hgnc.symbol:RPS6KA1	uniprot:E9PMM7;uniprot:E9PPN6;uniprot:Q5SVM6;uniprot:E9PGT3;uniprot:Q15418;uniprot:E9PAN7;uniprot:A6NND1;uniprot:E9PPC1;uniprot:Q5SVM7								
+EIF4B	GeneProduct	ncbigene:1975	"OCR lexicon match: EIF4B"	ensembl:ENSG00000063046	ncbigene:1975	hgnc.symbol:EIF4B	uniprot:F8VX11;uniprot:F8VSC7;uniprot:E7EX17;uniprot:F8VRU1;uniprot:F8VYE9;uniprot:F8W0K0;uniprot:P23588;uniprot:F8VP89								
+MAPK11	GeneProduct	ncbigene:5600	""	ensembl:ENSG00000185386	ncbigene:5600	hgnc.symbol:MAPK11	uniprot:F8WDP4;uniprot:Q15759								
+HSPB1	GeneProduct	ncbigene:3315	"OCR lexicon match: HSP27"	ensembl:ENSG00000106211	ncbigene:3315	hgnc.symbol:HSPB1	uniprot:A0A6Q8PGY2;uniprot:A0A6Q8PF43;uniprot:A0A6Q8PHJ6;uniprot:C9J3N8;uniprot:A0A6Q8PFK8;uniprot:P04792;uniprot:A0A6Q8PFE7;uniprot:V9HW43;uniprot:A0A6Q8PH65;uniprot:A0A6Q8PGK1;uniprot:A0A6Q8PHA6								
+HSPB2	GeneProduct	ncbigene:3316	"OCR lexicon match: HSP27"	ensembl:ENSG00000170276	ncbigene:3316	hgnc.symbol:HSPB2	uniprot:Q16082								
+ATF2	GeneProduct	ncbigene:1386	"OCR lexicon match: ATF2"	ensembl:ENSG00000115966	ncbigene:1386	hgnc.symbol:ATF2	uniprot:C9JCI8;uniprot:E9PBF9;uniprot:H7C2N6;uniprot:P15336;uniprot:B8ZZU6;uniprot:F2Z2K2;uniprot:E9PEK8								
+CBL	GeneProduct	ncbigene:867	"OCR lexicon match: CBL"	ensembl:ENSG00000110395	ncbigene:867	hgnc.symbol:CBL	uniprot:A0A0U1RQX8;uniprot:P22681;uniprot:A0A0U1RR39;uniprot:A0A0U1RRJ5;uniprot:A0A1B0GW38								
+CRK	GeneProduct	ncbigene:1398	"OCR lexicon match: CRK"	ensembl:ENSG00000167193	ncbigene:1398	hgnc.symbol:CRK	uniprot:L7RT18;uniprot:A0A0S2Z3Q4;uniprot:P46108;uniprot:I3L297;uniprot:A0A0S2Z3K9								
+PTK2	GeneProduct	ncbigene:5747	"OCR lexicon match: FAK"	ensembl:ENSG00000169398	ncbigene:5747	hgnc.symbol:PTK2	uniprot:E5RJN1;uniprot:H0YB16;uniprot:E5RIR5;uniprot:H0YBP1;uniprot:E7ESA6;uniprot:H0YB33;uniprot:H0YB99;uniprot:E5RG54;uniprot:A0A1D5RMT1;uniprot:E5RI72;uniprot:E5RJP0;uniprot:E5RGP1;uniprot:H0YBZ1;uniprot:E5RGA6;uniprot:E5RJI4;uniprot:H0YAS0;uniprot:Q05397;uniprot:E5RHK7;uniprot:E5RII9;uniprot:E9PEI4;uniprot:E5RJQ2;uniprot:E5RH48;uniprot:E5RI03;uniprot:E5RIK4;uniprot:E5RH08;uniprot:E5RI29;uniprot:E5RG86;uniprot:B4DWJ1;uniprot:E5RH01;uniprot:E5RG66;uniprot:E5RFW9;uniprot:E5RHD8;uniprot:E5RG80								
+BCAR1	GeneProduct	ncbigene:9564	"OCR lexicon match: CAS"	ensembl:ENSG00000050820	ncbigene:9564	hgnc.symbol:BCAR1	uniprot:P56945;uniprot:H3BVF0;uniprot:H3BSB2;uniprot:H3BU42;uniprot:H3BTB0;uniprot:H3BTL5;uniprot:H3BQJ7;uniprot:H3BSY4;uniprot:F5H855;uniprot:H3BN62								
+MEF2C	GeneProduct	ncbigene:4208	"OCR lexicon match: MEF2C"	ensembl:ENSG00000081189	ncbigene:4208	hgnc.symbol:MEF2C	uniprot:D6RCM6;uniprot:D6RG14;uniprot:A0A0D9SET2;uniprot:A0A1B0GV32;uniprot:Q06413;uniprot:A0A1B0GVI4;uniprot:D6R942;uniprot:A0A024RAL6;uniprot:A0A024RAL7;uniprot:D6RB91;uniprot:D6RJG6;uniprot:A0A0D9SGI5;uniprot:D6RC63;uniprot:D6RJA7;uniprot:A0A0D9SGF3;uniprot:A0A0D9SFD0;uniprot:D8L7E9;uniprot:A0A1B0GTW4;uniprot:A0A0R4J2G5;uniprot:A0A0D9SFV9;uniprot:D6RG21;uniprot:D6RJ95;uniprot:A0A0D9SG58								
+SRC	GeneProduct	ncbigene:6714	"OCR lexicon match: SRC"	ensembl:ENSG00000197122	ncbigene:6714	hgnc.symbol:SRC	uniprot:P12931								
+BCLAF1	GeneProduct	ncbigene:9774	"OCR lexicon match: BCLAF1"	ensembl:ENSG00000029363	ncbigene:9774	hgnc.symbol:BCLAF1	uniprot:E9PKI6;uniprot:E9PQN2;uniprot:Q9NYF8;uniprot:E9PJA7;uniprot:H0YF00;uniprot:H0YF14;uniprot:A0A1W2PQ43;uniprot:E9PK91;uniprot:H0YF63;uniprot:E9PK09								
+MAPK1	GeneProduct	ncbigene:5594	""	ensembl:ENSG00000100030	ncbigene:5594	hgnc.symbol:MAPK1	uniprot:P28482;uniprot:Q1HBJ4								
+INPP5D	GeneProduct	ncbigene:3635	""	ensembl:ENSG00000168918	ncbigene:3635	hgnc.symbol:INPP5D	uniprot:H7C403;uniprot:H0Y5Q9;uniprot:Q92835;uniprot:R4GMN8								
+DOK1	GeneProduct	ncbigene:1796	""	ensembl:ENSG00000115325	ncbigene:1796	hgnc.symbol:DOK1	uniprot:Q99704;uniprot:H7C093								
+MAPK14	GeneProduct	ncbigene:1432	""	ensembl:ENSG00000112062	ncbigene:1432	hgnc.symbol:MAPK14	uniprot:L7RSM2;uniprot:B5TY33;uniprot:Q16539;uniprot:B4E0K5;uniprot:E7EX54;uniprot:H7C4E2;uniprot:A0A024RD15								
diff --git a/_pathways/WP4842.md b/_pathways/WP4842.md
@@ -1,27 +1,27 @@
 ---
 annotations:
-- id: CL:0000216
-  parent: native cell
-  type: Cell Type Ontology
-  value: Sertoli cell
+- id: DOID:1414
+  type: Disease Ontology
+  value: ovarian dysfunction
 - id: PW:0000003
   parent: signaling pathway
   type: Pathway Ontology
   value: signaling pathway
-- id: DOID:1414
-  type: Disease Ontology
-  value: ovarian dysfunction
-- id: DOID:1923
-  type: Disease Ontology
-  value: disorder of sexual development
-- id: DOID:1876
-  parent: disease of mental health
-  type: Disease Ontology
-  value: sexual dysfunction
 - id: CL:0000501
   parent: animal cell
   type: Cell Type Ontology
   value: granulosa cell
+- id: CL:0000216
+  parent: native cell
+  type: Cell Type Ontology
+  value: Sertoli cell
+- id: DOID:1876
+  parent: disease of mental health
+  type: Disease Ontology
+  value: sexual dysfunction
+- id: DOID:1923
+  type: Disease Ontology
+  value: disorder of sexual development
 authors:
 - WoltersAAT1804
 - Fehrhart
@@ -59,15 +59,15 @@ description: 'Multiple genes in the genital ridge are of importance for the form
   in itself is stimulated by NR5A1 and also stimulates the formation of 5-dihydrotestosterone
   (DHT). The stimulation of DHT is catalysed by SRD5A1. These factors together induce
   the formation of internal and external male genitalia. '
-last-edited: 2024-07-26
+last-edited: 2024-11-19
 ndex: 93cc5f51-8b6e-11eb-9e72-0ac135e8bacf
 organisms:
 - Homo sapiens
 redirect_from:
 - /index.php/Pathway:WP4842
 - /instance/WP4842
-- /instance/WP4842_r134660
-revision: r134660
+- /instance/WP4842_r135851
+revision: r135851
 schema-jsonld:
 - '@context': https://schema.org/
   '@id': https://wikipathways.github.io/pathways/WP4842.html

diff --git a/_pathways/WP5493.md b/_pathways/WP5493.md
@@ -0,0 +1,96 @@
+---
+annotations:
+- id: PW:0000298
+  parent: signaling pathway
+  type: Pathway Ontology
+  value: altered growth factor signaling pathway
+- id: PW:0000706
+  parent: disease pathway
+  type: Pathway Ontology
+  value: leukemia pathway
+authors:
+- Khanspers
+citedin: ''
+communities: []
+description: 'Effect of dasatinib on the BCR-ABL signaling pathway, showing phosphorylation
+  sites that were found to be suppressed by Dasatinib are shown (Pan et al). Key signaling
+  events in the three major MAPK cascades were suppressed, including the activation
+  loop phosphorylation sites of p38α/β (MAPK11) and ERK1/2 (MAPK1/MAPK3).  Based on
+  fig 6 from https://pmc.ncbi.nlm.nih.gov/articles/PMC2816010/Phosphorylation site
+  information is based on the left-side panel in the figure; not all sites could be
+  verified in independent sources (e.g. PhosphositePlus). '
+last-edited: 2024-11-19
+ndex: null
+organisms:
+- Homo sapiens
+redirect_from:
+- /index.php/Pathway:WP5493
+- /instance/WP5493
+- /instance/WP5493_r135850
+revision: r135850
+schema-jsonld:
+- '@context': https://schema.org/
+  '@id': https://wikipathways.github.io/pathways/WP5493.html
+  '@type': Dataset
+  creator:
+    '@type': Organization
+    name: WikiPathways
+  description: 'Effect of dasatinib on the BCR-ABL signaling pathway, showing phosphorylation
+    sites that were found to be suppressed by Dasatinib are shown (Pan et al). Key
+    signaling events in the three major MAPK cascades were suppressed, including the
+    activation loop phosphorylation sites of p38α/β (MAPK11) and ERK1/2 (MAPK1/MAPK3).  Based
+    on fig 6 from https://pmc.ncbi.nlm.nih.gov/articles/PMC2816010/Phosphorylation
+    site information is based on the left-side panel in the figure; not all sites
+    could be verified in independent sources (e.g. PhosphositePlus). '
+  keywords:
+  - ' PIK3CA'
+  - ' PIK3R1'
+  - ABL1
+  - AKT1
+  - AKT2
+  - AKT3
+  - ARAF
+  - ATF2
+  - BCAR1
+  - BCL2
+  - BCL9
+  - BCLAF1
+  - BCR
+  - BRAF
+  - CBL
+  - CRK
+  - CRKL
+  - DOK1
+  - EIF4B
+  - GAB2
+  - GRB2
+  - HRAS
+  - HSPB1
+  - HSPB2
+  - INPP5D
+  - KRAS
+  - MAP3K2
+  - MAPK1
+  - MAPK11
+  - MAPK14
+  - MAPK3
+  - MEF2C
+  - NRAS
+  - PTK2
+  - PXN
+  - RAF1
+  - RPS6KA1
+  - SHC1
+  - SHC2
+  - SHC3
+  - SHC4
+  - SOS1
+  - SPAG1
+  - SRC
+  - VAV1
+  license: CC0
+  name: Effect of dasatinib on the BCR-ABL signaling pathway
+seo: CreativeWork
+title: Effect of dasatinib on the BCR-ABL signaling pathway
+wpid: WP5493
+---
diff --git a/assets/img/WP4842/WP4842-thumb.png b/assets/img/WP4842/WP4842-thumb.png
diff --git a/assets/img/WP5493/WP5493-thumb.png b/assets/img/WP5493/WP5493-thumb.png
Original file line number	Diff line number	Diff line change
		@@ -0,0 +1,2 @@
		ID Database Citation
		19651622 Pubmed "Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics. Pan C, Olsen JV, Daub H, Mann M. Mol Cell Proteomics. 2009 Dec;8(12):2796–808. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/19651622"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/19651622"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://scholia.toolforge.org/pubmed/19651622"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"