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diff --git a/_data/WP23-datanodes.tsv b/_data/WP23-datanodes.tsv
@@ -1,9 +1,11 @@
 Label	Type	Identifier	Comment	Ensembl	NCBI gene	HGNC	UniProt	Wikidata	ChEBI	InChI	PubChem	ChemSpider	HMDB	KEGG	LipidMaps
+PDPK2	Protein	ncbigene:653650	""												
+PDPK1	Protein	ncbigene:5170	""	ensembl:ENSG00000140992	ncbigene:5170	hgnc.symbol:PDPK1	uniprot:O15530;uniprot:H3BQ10;uniprot:E9PER6;uniprot:H3BPR5;uniprot:H3BQA3;uniprot:H3BNV5;uniprot:H3BPW1								
 REL	Protein	ncbigene:5966	""	ensembl:ENSG00000162924	ncbigene:5966	hgnc.symbol:REL	uniprot:Q04864								
 RELA	Protein	ncbigene:5970	""	ensembl:ENSG00000173039	ncbigene:5970	hgnc.symbol:RELA	uniprot:E9PNV4;uniprot:E9PRX2;uniprot:E9PJR1;uniprot:E9PJZ9;uniprot:E9PKV4;uniprot:A0A087X0W8;uniprot:E9PM47;uniprot:Q04206;uniprot:E9PI38;uniprot:E9PQS6;uniprot:E9PKH5;uniprot:E9PNK5;uniprot:Q2TAM5;uniprot:E9PMD5;uniprot:H0YCB4;uniprot:E9PSE4								
+NFKB1	Protein	ncbigene:4790	""	ensembl:ENSG00000109320	ncbigene:4790	hgnc.symbol:NFKB1	uniprot:A0A494C157;uniprot:A0A494C1E9;uniprot:P19838;uniprot:D6RC45;uniprot:D6RH30								
 CHUK	Protein	ncbigene:1147	""	ensembl:ENSG00000213341	ncbigene:1147	hgnc.symbol:CHUK	uniprot:O15111								
 IKBKG	Protein	ncbigene:8517	""	ensembl:ENSG00000269335	ncbigene:8517	hgnc.symbol:IKBKG	uniprot:C9JCG6;uniprot:A0A087X1K7;uniprot:D3DWY0;uniprot:C9J2V2;uniprot:A0A087WWQ9;uniprot:A0A087X0G7;uniprot:A0A087X1B1;uniprot:C9JN51;uniprot:A0A087WV30;uniprot:C9JH59;uniprot:Q9Y6K9;uniprot:A0A087WUW6								
-NFKB1	Protein	ncbigene:4790	""	ensembl:ENSG00000109320	ncbigene:4790	hgnc.symbol:NFKB1	uniprot:A0A494C157;uniprot:A0A494C1E9;uniprot:P19838;uniprot:D6RC45;uniprot:D6RH30								
 RAF1	Protein	ncbigene:5894	""	ensembl:ENSG00000132155	ncbigene:5894	hgnc.symbol:RAF1	uniprot:A0A0S2Z4L5;uniprot:P04049;uniprot:A0A0S2Z559;uniprot:A0A0B4J1W9;uniprot:H7C155;uniprot:L7RRS6								
 MAP3K7	Protein	ncbigene:6885	""	ensembl:ENSG00000135341	ncbigene:6885	hgnc.symbol:MAP3K7	uniprot:O43318								
 HRAS	Protein	ncbigene:3265	""	ensembl:ENSG00000174775	ncbigene:3265	hgnc.symbol:HRAS	uniprot:P01112;uniprot:A0A804HKM6;uniprot:X5D945;uniprot:A0A804HJ06;uniprot:A0A8C8MQR2								
@@ -63,14 +65,12 @@ MAX	Protein	ncbigene:4149	""	ensembl:ENSG00000125952	ncbigene:4149	hgnc.symbol:M
 BTK	Protein	ncbigene:695	""	ensembl:ENSG00000010671	ncbigene:695	hgnc.symbol:BTK	uniprot:Q3MS90;uniprot:Q5JY90;uniprot:Q06187;uniprot:Q3MS88;uniprot:Q3MS97;uniprot:Q3MS94								
 CDC42	Protein	ncbigene:998	""	ensembl:ENSG00000070831	ncbigene:998	hgnc.symbol:CDC42	uniprot:A0A3B3IRV0;uniprot:A0A494C1M1;uniprot:Q5JYX0;uniprot:A0A024RAE6;uniprot:A0A590UJK8;uniprot:A0A024RAA5;uniprot:P60953;uniprot:A0A494BZX6								
 CBL	Protein	ncbigene:867	""	ensembl:ENSG00000110395	ncbigene:867	hgnc.symbol:CBL	uniprot:A0A0U1RQX8;uniprot:P22681;uniprot:A0A0U1RR39;uniprot:A0A0U1RRJ5;uniprot:A0A1B0GW38								
-PDPK2	Protein	ncbigene:653650	""												
 MAPK4	Protein	ncbigene:5596	""	ensembl:ENSG00000141639	ncbigene:5596	hgnc.symbol:MAPK4	uniprot:B4DEW2;uniprot:P31152;uniprot:K7ELV1;uniprot:K7EN18								
 MAPK8	Protein	ncbigene:5599	""	ensembl:ENSG00000107643	ncbigene:5599	hgnc.symbol:MAPK8	uniprot:C9J762;uniprot:C9JWQ4;uniprot:A0A3B3IRW7;uniprot:A1L4K2;uniprot:P45983								
 MAPK9	Protein	ncbigene:5601	""	ensembl:ENSG00000050748	ncbigene:5601	hgnc.symbol:MAPK9	uniprot:D7R525;uniprot:D7R528;uniprot:J3KNK1;uniprot:E5RJ57;uniprot:P45984								
 BLNK	Protein	ncbigene:29760	""	ensembl:ENSG00000095585	ncbigene:29760	hgnc.symbol:BLNK	uniprot:Q8WV28;uniprot:Q2MD51;uniprot:K7EKR2;uniprot:Q2MD42;uniprot:Q2MD54;uniprot:Q2MD46;uniprot:Q2MD47;uniprot:Q2MD59								
 BLK	Protein	ncbigene:640	""	ensembl:ENSG00000136573	ncbigene:640	hgnc.symbol:BLK	uniprot:E9PJX5;uniprot:P51451								
 PIP5K1A	Protein	ncbigene:8394	""	ensembl:ENSG00000143398	ncbigene:8394	hgnc.symbol:PIP5K1A	uniprot:A2A5X0;uniprot:A6PW56;uniprot:A6PW57;uniprot:A6PW58;uniprot:E9PSF8;uniprot:Q99755								
-PDPK1	Protein	ncbigene:5170	""	ensembl:ENSG00000140992	ncbigene:5170	hgnc.symbol:PDPK1	uniprot:O15530;uniprot:H3BQ10;uniprot:E9PER6;uniprot:H3BPR5;uniprot:H3BQA3;uniprot:H3BNV5;uniprot:H3BPW1								
 TEC	Protein	ncbigene:7006	""	ensembl:ENSG00000135605	ncbigene:7006	hgnc.symbol:TEC	uniprot:D6RB75;uniprot:P42680;uniprot:D6RB05								
 CRKL	Protein	ncbigene:1399	""	ensembl:ENSG00000099942	ncbigene:1399	hgnc.symbol:CRKL	uniprot:P46109								
 PTPN18	Protein	ncbigene:26469	""	ensembl:ENSG00000072135	ncbigene:26469	hgnc.symbol:PTPN18	uniprot:E7EMB8;uniprot:F8WBM9;uniprot:Q99952								

diff --git a/_data/WP5491-datanodes.tsv b/_data/WP5491-datanodes.tsv
@@ -1,7 +1,7 @@
 Label	Type	Identifier	Comment	Ensembl	NCBI gene	HGNC	UniProt	Wikidata	ChEBI	InChI	PubChem	ChemSpider	HMDB	KEGG	LipidMaps
 BCR	GeneProduct	ensembl:ENSG00000186716	""	ensembl:ENSG00000186716	ncbigene:613	hgnc.symbol:BCR	uniprot:P11274;uniprot:H0Y554								
 SYK	GeneProduct	ensembl:ENSG00000165025	""	ensembl:ENSG00000165025	ncbigene:6850	hgnc.symbol:SYK	uniprot:P43405;uniprot:A0A024R273;uniprot:A0A024R244								
-LIN	GeneProduct	ensembl:ENSG00000186716	""	ensembl:ENSG00000186716	ncbigene:613	hgnc.symbol:BCR	uniprot:P11274;uniprot:H0Y554								
+LYN	GeneProduct	ensembl:ENSG00000254087	""	ensembl:ENSG00000254087	ncbigene:4067	hgnc.symbol:LYN	uniprot:P07948;uniprot:E5RJ37								
 MEF2C	GeneProduct	ensembl:ENSG00000081189	""	ensembl:ENSG00000081189	ncbigene:4208	hgnc.symbol:MEF2C	uniprot:D6RCM6;uniprot:D6RG14;uniprot:A0A0D9SET2;uniprot:A0A1B0GV32;uniprot:Q06413;uniprot:A0A1B0GVI4;uniprot:D6R942;uniprot:A0A024RAL6;uniprot:A0A024RAL7;uniprot:D6RB91;uniprot:D6RJG6;uniprot:A0A0D9SGI5;uniprot:D6RC63;uniprot:D6RJA7;uniprot:A0A0D9SGF3;uniprot:A0A0D9SFD0;uniprot:D8L7E9;uniprot:A0A1B0GTW4;uniprot:A0A0R4J2G5;uniprot:A0A0D9SFV9;uniprot:D6RG21;uniprot:D6RJ95;uniprot:A0A0D9SG58								
 ID3	GeneProduct	ensembl:ENSG00000117318	""	ensembl:ENSG00000117318	ncbigene:3399	hgnc.symbol:ID3	uniprot:Q02535								
 BCL2L1	GeneProduct	ensembl:ENSG00000171552	""	ensembl:ENSG00000171552	ncbigene:598	hgnc.symbol:BCL2L1	uniprot:A0A7I2V597;uniprot:Q9H1R6;uniprot:A0A0S2Z3C5;uniprot:Q5QP59;uniprot:Q07817;uniprot:Q5TE63;uniprot:Q5QP56;uniprot:Q5TE64								
@@ -38,3 +38,13 @@ IRF8	GeneProduct	ensembl:ENSG00000140968	""	ensembl:ENSG00000140968	ncbigene:339
 CCND2	GeneProduct	ensembl:ENSG00000118971	""	ensembl:ENSG00000118971	ncbigene:894	hgnc.symbol:CCND2	uniprot:A0A6Q8PGZ3;uniprot:P30279								
 CCND3	GeneProduct	ensembl:ENSG00000112576	""	ensembl:ENSG00000112576	ncbigene:896	hgnc.symbol:CCND3	uniprot:H0Y8M4;uniprot:D6RDL3;uniprot:A0A1D5RMS0;uniprot:D6RI00;uniprot:Q5T8J1;uniprot:P30281;uniprot:D6RIX2;uniprot:D6RDF8								
 CDKN2A	GeneProduct	ensembl:ENSG00000147889	""	ensembl:ENSG00000147889	ncbigene:1029	hgnc.symbol:CDKN2A	uniprot:K7ENC6;uniprot:K7ES20;uniprot:J3QRG6;uniprot:Q8N726;uniprot:P42771;uniprot:K7PML8								
+TLR1	GeneProduct	ensembl:ENSG00000174125	"?"	ensembl:ENSG00000174125	ncbigene:7096	hgnc.symbol:TLR1	uniprot:D6RAP2;uniprot:D6RA99;uniprot:Q15399;uniprot:D6RF68;uniprot:D6RCE8								
+TLR3	GeneProduct	ensembl:ENSG00000164342	"?"	ensembl:ENSG00000164342	ncbigene:7098	hgnc.symbol:TLR3	uniprot:D6RA51;uniprot:O15455								
+TLR5	GeneProduct	ensembl:ENSG00000187554	"?"	ensembl:ENSG00000187554	ncbigene:7100	hgnc.symbol:TLR5	uniprot:A0A2R8Y7Z4;uniprot:B1AZ06;uniprot:A0A2R8Y4Q2;uniprot:O60602								
+TLR2	GeneProduct	ensembl:ENSG00000137462	"?"	ensembl:ENSG00000137462	ncbigene:7097	hgnc.symbol:TLR2	uniprot:A0A2R8Y4N9;uniprot:A0A2R8Y7R7;uniprot:A0A0S2Z4S4;uniprot:A0A0S2Z4L7;uniprot:O60603;uniprot:A0A2R8YHF6								
+TLR4	GeneProduct	ensembl:ENSG00000136869	"?"	ensembl:ENSG00000136869	ncbigene:7099	hgnc.symbol:TLR4	uniprot:O00206;uniprot:A0A2R8Y7P4								
+TLR6	GeneProduct	ensembl:ENSG00000174130	"?"	ensembl:ENSG00000174130	ncbigene:10333	hgnc.symbol:TLR6	uniprot:Q9Y2C9;uniprot:D6RAV7								
+TLR8	GeneProduct	ensembl:ENSG00000101916	"?"	ensembl:ENSG00000101916	ncbigene:51311	hgnc.symbol:TLR8	uniprot:Q9NR97								
+TLR7	GeneProduct	ensembl:ENSG00000196664	"?"	ensembl:ENSG00000196664	ncbigene:51284	hgnc.symbol:TLR7	uniprot:B2R9N9;uniprot:Q9NYK1								
+TLR9	GeneProduct	ensembl:ENSG00000239732	"?"	ensembl:ENSG00000239732	ncbigene:54106	hgnc.symbol:TLR9	uniprot:Q9NR96								
+TLR10	GeneProduct	ensembl:ENSG00000174123	"?"	ensembl:ENSG00000174123	ncbigene:81793	hgnc.symbol:TLR10	uniprot:A0A024R9W4;uniprot:D6RHW6;uniprot:Q9BXR5								
diff --git a/_pathways/WP23.md b/_pathways/WP23.md
@@ -97,15 +97,15 @@ description: 'The functional B-cell receptor is a multi-protein complex consisti
   A. (2010). NetPath: A public resource of curated signal transduction pathways. <i>Genome
   Biology</i>. 11:R3.  Proteins on this pathway have targeted assays available via
   the [https://assays.cancer.gov/available_assays?wp_id=WP23 CPTAC Assay Portal]'
-last-edited: 2024-09-23
+last-edited: 2024-11-20
 ndex: 6ec414d7-8b5f-11eb-9e72-0ac135e8bacf
 organisms:
 - Homo sapiens
 redirect_from:
 - /index.php/Pathway:WP23
 - /instance/WP23
-- /instance/WP23_r135532
-revision: r135532
+- /instance/WP23_r135863
+revision: r135863
 schema-jsonld:
 - '@context': https://schema.org/
   '@id': https://wikipathways.github.io/pathways/WP23.html

diff --git a/_pathways/WP4746.md b/_pathways/WP4746.md
@@ -1,28 +1,28 @@
 ---
 annotations:
-- id: CL:0002258
-  parent: animal cell
-  type: Cell Type Ontology
-  value: thyroid follicular cell
-- id: PW:0000013
-  parent: disease pathway
-  type: Pathway Ontology
-  value: disease pathway
-- id: CL:0000540
-  parent: animal cell
-  type: Cell Type Ontology
-  value: neuron
 - id: PW:0001200
   parent: signaling pathway
   type: Pathway Ontology
   value: thyroid-stimulating hormone signaling pathway
+- id: PW:0000013
+  parent: disease pathway
+  type: Pathway Ontology
+  value: disease pathway
 - id: DOID:0050328
   type: Disease Ontology
   value: congenital hypothyroidism
 - id: CL:0000125
   parent: animal cell
   type: Cell Type Ontology
   value: glial cell
+- id: CL:0000540
+  parent: animal cell
+  type: Cell Type Ontology
+  value: neuron
+- id: CL:0002258
+  parent: animal cell
+  type: Cell Type Ontology
+  value: thyroid follicular cell
 authors:
 - Rik-lahaije
 - Fehrhart
@@ -34,36 +34,36 @@ citedin: ''
 communities:
 - Diseases
 - RareDiseases
-description: Congenital hypothyroidism is a genetic hormonal disorder regarding the
-  thyroid hormone. Due dyshormonogenesis, the production of the thyroid hormones is
-  impaired resulting in increased birth weight, reduced LDL breakdown, decreased lipolysis,
-  impaired glucose metabolism and decreased body temperature. Above, an overview of
-  thyroid hormones production occurring in thyroid gland and their relevant downstream
-  signalling is displayed. As the legend states, genes known te be affected by mutations
-  leading to congenital hypothyroidism are colored red.
-last-edited: 2024-11-13
+description: Congenital hypothyroidism is a genetic hormonal disorder of the thyroid
+  hormone. Due to dyshormonogenesis, the production of the thyroid hormones is impaired
+  resulting in increased birth weight, reduced LDL breakdown, decreased lipolysis,
+  impaired glucose metabolism and decreased body temperature. This pathway diagram
+  shows an overview of thyroid hormones production in thyroid gland and their relevant
+  downstream signaling. Genes affected by mutations leading to congenital hypothyroidism
+  are colored red.
+last-edited: 2024-11-20
 ndex: d34671b8-8b6c-11eb-9e72-0ac135e8bacf
 organisms:
 - Homo sapiens
 redirect_from:
 - /index.php/Pathway:WP4746
 - /instance/WP4746
-- /instance/WP4746_r135823
-revision: r135823
+- /instance/WP4746_r135857
+revision: r135857
 schema-jsonld:
 - '@context': https://schema.org/
   '@id': https://wikipathways.github.io/pathways/WP4746.html
   '@type': Dataset
   creator:
     '@type': Organization
     name: WikiPathways
-  description: Congenital hypothyroidism is a genetic hormonal disorder regarding
-    the thyroid hormone. Due dyshormonogenesis, the production of the thyroid hormones
-    is impaired resulting in increased birth weight, reduced LDL breakdown, decreased
-    lipolysis, impaired glucose metabolism and decreased body temperature. Above,
-    an overview of thyroid hormones production occurring in thyroid gland and their
-    relevant downstream signalling is displayed. As the legend states, genes known
-    te be affected by mutations leading to congenital hypothyroidism are colored red.
+  description: Congenital hypothyroidism is a genetic hormonal disorder of the thyroid
+    hormone. Due to dyshormonogenesis, the production of the thyroid hormones is impaired
+    resulting in increased birth weight, reduced LDL breakdown, decreased lipolysis,
+    impaired glucose metabolism and decreased body temperature. This pathway diagram
+    shows an overview of thyroid hormones production in thyroid gland and their relevant
+    downstream signaling. Genes affected by mutations leading to congenital hypothyroidism
+    are colored red.
   keywords:
   - AC
   - ACTL6B

diff --git a/_pathways/WP4842.md b/_pathways/WP4842.md
@@ -3,25 +3,25 @@ annotations:
 - id: DOID:1414
   type: Disease Ontology
   value: ovarian dysfunction
-- id: PW:0000003
-  parent: signaling pathway
-  type: Pathway Ontology
-  value: signaling pathway
 - id: CL:0000501
   parent: animal cell
   type: Cell Type Ontology
   value: granulosa cell
-- id: CL:0000216
-  parent: native cell
-  type: Cell Type Ontology
-  value: Sertoli cell
 - id: DOID:1876
   parent: disease of mental health
   type: Disease Ontology
   value: sexual dysfunction
+- id: PW:0000003
+  parent: signaling pathway
+  type: Pathway Ontology
+  value: signaling pathway
 - id: DOID:1923
   type: Disease Ontology
   value: disorder of sexual development
+- id: CL:0000216
+  parent: native cell
+  type: Cell Type Ontology
+  value: Sertoli cell
 authors:
 - WoltersAAT1804
 - Fehrhart
@@ -59,15 +59,15 @@ description: 'Multiple genes in the genital ridge are of importance for the form
   in itself is stimulated by NR5A1 and also stimulates the formation of 5-dihydrotestosterone
   (DHT). The stimulation of DHT is catalysed by SRD5A1. These factors together induce
   the formation of internal and external male genitalia. '
-last-edited: 2024-11-19
+last-edited: 2024-11-20
 ndex: 93cc5f51-8b6e-11eb-9e72-0ac135e8bacf
 organisms:
 - Homo sapiens
 redirect_from:
 - /index.php/Pathway:WP4842
 - /instance/WP4842
-- /instance/WP4842_r135851
-revision: r135851
+- /instance/WP4842_r135854
+revision: r135854
 schema-jsonld:
 - '@context': https://schema.org/
   '@id': https://wikipathways.github.io/pathways/WP4842.html

diff --git a/_pathways/WP4872.md b/_pathways/WP4872.md
@@ -3,20 +3,20 @@ annotations:
 - id: DOID:14450
   type: Disease Ontology
   value: 46 XX gonadal dysgenesis
+- id: PW:0000650
+  parent: signaling pathway
+  type: Pathway Ontology
+  value: signaling pathway pertinent to development
 - id: DOID:14448
   type: Disease Ontology
   value: 46,XY sex reversal
-- id: PW:0000003
-  parent: signaling pathway
-  type: Pathway Ontology
-  value: signaling pathway
 - id: DOID:14447
   type: Disease Ontology
   value: gonadal dysgenesis
-- id: PW:0000650
+- id: PW:0000003
   parent: signaling pathway
   type: Pathway Ontology
-  value: signaling pathway pertinent to development
+  value: signaling pathway
 authors:
 - Tilmans
 - Fehrhart
@@ -26,15 +26,15 @@ communities: []
 description: 'This pathway summarizes the differential signaling in sex development
   in the human fetus. Disorders of sex development can derive from dysfunction of
   one or more genes in this pathway. '
-last-edited: 2024-05-22
+last-edited: 2024-11-20
 ndex: d525b162-8b6f-11eb-9e72-0ac135e8bacf
 organisms:
 - Homo sapiens
 redirect_from:
 - /index.php/Pathway:WP4872
 - /instance/WP4872
-- /instance/WP4872_r129657
-revision: r129657
+- /instance/WP4872_r135856
+revision: r135856
 schema-jsonld:
 - '@context': https://schema.org/
   '@id': https://wikipathways.github.io/pathways/WP4872.html

diff --git a/_pathways/WP5445.md b/_pathways/WP5445.md
@@ -1,56 +1,56 @@
 ---
 annotations:
-- id: PW:0000539
-  parent: regulatory pathway
-  type: Pathway Ontology
-  value: ghrelin system pathway
+- id: CL:0005018
+  parent: native cell
+  type: Cell Type Ontology
+  value: ghrelin secreting cell
 - id: CL:1000222
   parent: animal cell
   type: Cell Type Ontology
   value: stomach neuroendocrine cell
+- id: CL:0000584
+  parent: native cell
+  type: Cell Type Ontology
+  value: enterocyte
 - id: PW:0000003
   parent: signaling pathway
   type: Pathway Ontology
   value: signaling pathway
+- id: CL:0000540
+  parent: animal cell
+  type: Cell Type Ontology
+  value: neuron
+- id: PW:0000365
+  parent: regulatory pathway
+  type: Pathway Ontology
+  value: melanocortin system pathway
 - id: CL:0002279
   parent: native cell
   type: Cell Type Ontology
   value: type L enteroendocrine cell
-- id: CL:0005018
-  parent: native cell
-  type: Cell Type Ontology
-  value: ghrelin secreting cell
 - id: CL:0000136
   parent: native cell
   type: Cell Type Ontology
   value: fat cell
-- id: CL:0000584
-  parent: native cell
-  type: Cell Type Ontology
-  value: enterocyte
-- id: PW:0000365
+- id: PW:0000539
   parent: regulatory pathway
   type: Pathway Ontology
-  value: melanocortin system pathway
-- id: CL:0000540
-  parent: animal cell
-  type: Cell Type Ontology
-  value: neuron
+  value: ghrelin system pathway
 authors:
 - Eweitz
 citedin: ''
 communities: []
 description: Effect of gut hormones on brain signaling that controls food intake.  Based
   on Figure 1 in https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959457/.
-last-edited: 2024-03-16
+last-edited: 2024-11-20
 ndex: null
 organisms:
 - Homo sapiens
 redirect_from:
 - /index.php/Pathway:WP5445
 - /instance/WP5445
-- /instance/WP5445_r129193
-revision: r129193
+- /instance/WP5445_r135860
+revision: r135860
 schema-jsonld:
 - '@context': https://schema.org/
   '@id': https://wikipathways.github.io/pathways/WP5445.html